翁啟惠博士
姓名 翁啟惠博士
現任 合聘特聘研究員 (與美國加州Scripps研究院合聘)
所屬單位 Carbohydrate chemistry and biology, AI-assisted glycosylation research and development

Ph.D. in Chemistry, MIT, 1979-1982
名片
研究方向/領域

研究方向/領域

Chemical Biology and Drug Discovery

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Current interest is centered on the development of discovery tools for understanding the role of biological glycosylation in cancer progression, bacterial and viral infection, neurodegenerative disorder and immune response. Programmable one-pot synthesis as well as chemo-enzymatic synthesis of oligosaccharides and homogeneous glycoproteins, and design of glycan microarrays and glycosylation probes are among the tools being developed for the study of cell-surface glycoconjugates. The ultimate goal of our research is to identify novel glycan targets for therapeutic development, including the AI-assisted development of carbohydrate-based vaccines, homogeneous antibodies with optimized effector functions, and inhibitors of immune checkpoints, key enzymes involved in the biosynthesis of glycan targets.

這是一張圖片


我們的研究工作主要著重於化學生物及新藥研發。從瞭解致病基因的功能及機制去設計並合成分子來進一步研究其與標的物的作用，進而研發出新的檢測方法及新 藥。目前重點放在瞭解醣分子在細胞表面所扮演的角色，醣蛋白合成方法的發展，醣晶片的設計與應用，及酵素抑制劑的設計與合成。希望將來能發展新的藥物以供 抗癌、抗病毒與抗細菌的研究。

 
經歷
  • 2019-present Scripps Family Chair Professor, Department of Chemistry, The Scripps Research Institute, La Jolla, California
  • 2006-2016 President, Academia Sinica, Taipei, Taiwan
  • 2003-2006 Director, The Genomics Research Center, Academia Sinica, Taipei, Taiwan
  • 2003-present Distinguished Professor, Genomics Research Center, Academia Sinica, Taipei, Taiwan
  • 1991-1999 Head, Frontier Research Program on Glycotechnology, Institute of Physical and Chemical Research (RIKEN), Japan
  • 1996-2006 Member, The Skaggs Institute for Chemical Biology, The Scripps Research Institute
  • 1989-2006 Professor and Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute
  • 1983-1989 Assistant Professor through Professor of Chemistry, Texas A&M University
  • 1982-1983 Postdoctoral Fellow, Harvard University
榮譽
  • 2025 Bio Asia Award
  • 2022 Tetrahedron Prize for Creativity in Organic Synthesis
  • 2021 Welch Award in Chemistry
  • 2015 The Royal Society of Chemistry Robert Robinson Award, UK
  • 2014 Elected Fellow of the U.S. National Academy of Inventors
  • 2014 The Wolf Prize in Chemistry
  • 2012 Nikkei Asia Prize for Science, Technology and Innovation
  • 2012 The American Chemical Society Arthur C. Cope Award
  • 2012 The American Chemical Society Arthur C. Cope Award
  • 2010 Elected Associate Member of the European Molecular Biology Organization (EMBO)
  • 1993-2010 Editor-in-Chief, Bioorganic & Medicinal Chemistry
  • 2008 The F. A. Cotton Medal for Excellence in Chemical Research
  • 2005 American Chemical Society Award for Creative Work in Synthetic Organic Chemistry
  • 2002 Elected Member of the National Academy of Sciences, USA
  • 2000 Presidential Green Chemistry Award, USA
  • 1999 The International Enzyme Engineering Award
  • 1999 American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry
  • 1998 American Chemical Society Harrison Howe Award in Chemistry
  • 1996 Elected Member of the American Academy of Arts and Sciences
  • 1994 Elected Member of Academia Sinica, Taipei
  • 1994 The IUPAC International Carbohydrate Award
  • 1986 Presidential Young Investigator in Chemistry
  • 1985 Searle Scholar Award in Biomedical Sciences
  • H.-W. Huang, Y.-F. Zeng, V. S. Shivatare, T.-H. Tseng, C.-H. Wong, 2025, "Cell-based glycoengineering for production of homogeneous and specific glycoform enriched antibodies with improved effector functions", Proceedings of the National Academy of Sciences of the United States of America,122 (8), e2423853122. (SCIE)
  • R. Li, P. Chen, Y.-F. Zeng, T.-H. Tseng, V. Gannedi, L. Krasnova, C.-H. Wong, 2025, “Expedient Assembly of Multiantennary N-Glycans from Common N-Glycan Cores with Orthogonal Protection for the Profiling of Glycan-Binding Proteins.”, Journal of the American Chemical Society, 147(15), 12937-12948. (SCIE) (IF: 15; SCI ranking: 9.6%)
  • C.-C. Kung, J. Lo, K.-S. Liao, C.-Y. Wu, L.-C. Cheng, C. Chung, T.-L. Hsu, C. Ma, C.-H. Wong, 2025, “Expression of Human β3GalT5-1 in Insect Cells as Active Glycoforms for the Efficient Synthesis of Cancer-Associated Globo-Series Glycans”, Journal of the American Chemical Society, 147, 10864-10874. (SCIE) (IF: 15; SCI ranking: 9.6%)
  • J. Lo, C.-C. Kung, T.-J., C.-H. Wong, C. Ma, 2025, “Structure-Based Mechanism and Specificity of Human Galactosyltransferase β3GalT5”, Journal of the American Chemical Society, 147, 10875-10885. (SCIE) (IF: 15; SCI ranking: 9.6%)
  • N.-Y. Chen, C.-W. Lin, T.-Y. Lai, C.-Y. Wu, P.-C. Liao, T.-L. Hsu, C.-H. Wong, 2024, “Increased expression of SSEA-4 on TKI-resistant non-small cell lung cancer with EGFR-T790M mutation.”, Proceedings of the National Academy of Sciences of the United States of America, 121(5), e2313397121. (SCIE)
  • C.-Y. Fan, S.-W. Wang, C. Chung, J.-Y. Chen, C.-Y. Chang, Y.-C. Chen, T.-L. Hsu, T.-R. Cheng, C.-H. Wong, 2024, “Synthesis of a dendritic cell-targeted self-assembled polymeric nanoparticle for selective delivery of mRNA vaccines to elicit enhanced immune responses.”, Chemical science, 15(29), 11626-11632. (SCIE)
  • C.-W. Cheng, C.-Y. Wu, S.-W. Wang, J.-Y. Chen, C.-C. Kung, K.-S. Liao, C.-H. Wong, 2023, “Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA).”, Proceedings of the National Academy of Sciences of the United States of America, 120(49), e2314392120. (SCIE)
  • S.-W. Wang, Y.-A. Ko, C.-Y. Chen, K.-S. Liao, Y.-H. Chang, H.-Y. Lee, Y.-H. Yu, Y.-H. Lih, Y.-Y. Cheng, H.-H. Lin , T.-L. Hsu, C.-Y. Wu, K.-I. Lin, C.-H. Wong, 2023, “Mechanism of Antigen Presentation and Specificity of Antibody Cross-Reactivity Elicited by an Oligosaccharide-Conjugate Cancer Vaccine.”, Journal of the American Chemical Society, 145(17), 9840-9849. (SCIE)
  • V.-S. Shivatare , P.-K. Chuang , T.-H. Tseng , Y.-F. Zeng , H.-W. Huang , G. Veeranjaneyulu , H.-C. Wu , C.-H. Wong, 2023, “Study on antibody Fc-glycosylation for optimal effector functions.”, Chemical communications (Cambridge, England), 59, 5555-5558.
  • H.-Y. Huang, H.-Y. Liao, X. Chen, C.-W. Cheng, S.-W. Wang, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, H.-H. Ma, Y.-H. Chang, C.-Y. Tsai, P.-Y. Huang, S.-Y. Chang, T.-L. Chao, H.-C. Kao, Y.-M. Tsai, Y.-H. Chen, C.-Y. Chen, K.-C. Lee, C.-Y. Wu, J.-T. Jan, T.-J. R. Cheng, K.-I. Lin*, C. Ma, and C.-H. Wong, 2022, “Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models.”, Science translational medicine, 14(639), eabm0899. (SCIE)
  • H.-Y. Liao, S.-C. Wang, Y.-A. Koa, K.-I. Lin, C. Ma, T.-J. R. Cheng, and C.-H. Wong, 2020, “Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes”, Proceedings of the National Academy of Sciences, 117(30), 17757-17763.
  • W.-F. Wang, M.-Y. Jade Lu, T.-J. R. Cheng, Y.-C. Tang, Y.-C. Teng, T.-Y. Hwa, Y.-H. Chen, M.-Y. Li, M.-H. Wu, P.-C. Chuang, R. Jou, C.-H. Wong, and W.-H. Li, 2020, “Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome”, Genome Biology and Evolution, 12(2), 3890-3905. (SCIE)
  • H.-J. Lo, L. Krasnova, S. Dey, T. Cheng, H. Liu, T.-I. Tsai, K. B. Wu, C.-Y. Wu, and C.-H. Wong, 2019, “Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing alpha2,6-Linked 3F(ax)-Neu5Ac.”, Journal of the American Chemical Society, 141(16), 6484-6488. (SCIE)
  • Y.-C. Tseng, C.-Y. Wu, M.-L. Liu, T.-H. Chen, W.-L. Chiang, Y.-H. Yu, J.-T. Jan, K.-I. Lin, C.-H. Wong and C. Ma, 2019, “Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections.”, Proceedings of the National Academy of Sciences of the United States of America, 116(10), 4200-4205. (SCIE)
  • P.-K. Chuang, M. Hsiao, T.-L. Hsu, C.-F. Chang, C.-Y. Wu, B.-R. Chen, H.-W. Huang, K.-S. Liao, C.-C. Chen, C.-L. Chen, S.-M. Yang, C. W. Kuo, P. Chen, P.-T. Chiu, I.-J. Chen, J.-S. Lai, C.-D. T. Yu, and C.-H. Wong, 2019, “Signaling pathway of globo-series glycosphingolipids and beta1,3-galactosyltransferase V (beta3GalT5) in breast cancer.”, Proceedings of the National Academy of Sciences of the United States of America, 116(9), 3518-3523. (SCIE)
  • W.-S. Wu, W.-C. Cheng, T.-R. Cheng, C.-H. Wong, 2018, “Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase.”, Journal of the American Chemical Society, 140(8), 2752-2755. (SCIE)
  • C.-W. Cheng, Y. Zhou, W.-H. Pan, S. Dey, C.-Y. Wu, W.-L. Hsu, and C.-H. Wong, 2018, “Hierarchical and programmable one-pot automated synthesis of oligosaccharides”, Nature Communications, 9, 5202. (SCIE)
  • P.-W. Lo, J.-J. Shie, C.-H. Chen, C.-Y. Wu, T.-L. Hsu, C.-H. Wong, 2018, “O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2”, Proceedings of the National Academy of Sciences of the United States of America, 115(28), 7302-7307. (SCIE)
  • Y.-W. Huang, H.-I. Yang, Y.-T. Wu, T.-L. Hsu, T.-W. Lin, J. Kelly, C.-H. Wong, 2017, “Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency”, Journal of the American Chemical Society, 139(37), 12947-12955. (SCIE)
  • T. H. Tseng, T.-W. Lin, C.-Y. Chen, C.-H. Chen, J.-L. Lin, T.-L. Hsu, C.-H. Wong, 2017, “Substrate Preference and Interplay of Fucosyltransferase 8 and N-Acetylglucosaminyltransferases”, Journal of the American Chemical Society, 139(28), 9431-9434. (SCIE)
  • S. S. Shivatare, S.-H. Chang, T.-I. Tsai, S. Y. Tseng, Y.-S. Lin, Y.-Y. Cheng, C.-T. Ren, S. Pawar, C.-S. Tsai, H.-W. Shi, Y.-F. Zeng, C.-H. Liang, P. D. Kwong, D. R. Burton, C.-Y. Wu and C.-H. Wong, 2016, “Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies”, Nature Chemistry, 8(4), 338-346. (SCIE)
  • S. Danishefsky, Y.-K. Shue, M. Chang, C.-H. Wong, 2015, “Development of Globo-H Cancer Vaccine”, Accounts of Chemical Research, 48(3), 643-652. (SCIE)
  • J.-J. Shie, Y.-C. Liu, Y.−M. Lee, C. Lim, J.-M. Fang, C.-H. Wong, 2014, “An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation”, Journal of the American Chemical Society, 136(28), 9953-9961. (SCIE)
  • Y.-W. Lou, P.-Y. Wang, S.-C. Yeh, P.-K. Chuang, S.-T. Li, C.-Y. Wu, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2014, “Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers”, Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2482-2487. (SCIE)
  • J.-R. Chen, Y.-H. Yu, Y.-C. Tseng, W.-L. Chiang, M.-F. Chiang, Y.-A. Ko, Y.-K. Chiu, S.-H. Ma, C.-Y. Wu, J.-T. Jan, K.-I. Lin, C. Ma and C.-H. Wong, 2014, “Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections”, Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2476-2481. (SCIE)
  • Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu, C.-H. Wong, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, Proceedings of the National Academy of Sciences of the United States of America, 110(7), 2517-2522. (SCIE)
  • C.-Y. Chen, Y.-H. Jan, Y.-H. Juan, C.-J. Yang, M.-S. Huang, C.-J. Yu, P.-C. Yang, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2013, “Fucosyltransferase 8 as a Functional Regulator of Non-Small Cell Lung Cancer”, Proceedings of the National Academy of Sciences of the United States of America, 110(2), 630-635. (SCIE)
  • C.-Y. Huang, H.-W. Shih, L-Y. Lin, Y.-W. Tien, T.-J. R. Cheng, W.-C. Cheng, C.-H. Wong and C. Ma, 2012, “Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis”, Proceedings of the National Academy of Sciences of the United States of America, 109(17), 6496-6501. (SCIE)
  • Y.-C. Liu, H.-Y. Yen, C.-Y. Chen, C.-H. Chen, P.-F. Cheng, Y.-H. Juan, C.-H. Chen, K.-H. Khoo, C.-J. Yu, P.-C. Yang, T.-L. Hsu, C.-H. Wong, 2011, “Sialylation and Fucosylation of Epidermal Growth Factor Receptor Suppress its Dimerization and Activation in Lung Cancer Cells”, Proceedings of the National Academy of Sciences of the United States of America, 108(28), 11332-11337. (SCIE)
  • C.-H. Hsu, S.-C. Hung, C.-Y. Wu, and C.-H. Wong, 2011, “Toward Automated Oligosaccharide Synthesis”, Angewandte Chemie-International Edition, 50(50), 11872-11923. (SCIE)
  • S.-H. Chang, J.-L. Han, Susan Y. Tseng, H.-Y. Lee, C.-W. Lin, Y.-C. Lin, W.-Y. Jeng, A. H.-J. Wang, C.-Y. Wu, C.-H. Wong, 2010, “Glycan Array on Aluminum Oxide Coated Glass Slides Through Phosphonate Chemistry”, Journal of the American Chemical Society, 132(38),13371-13380. (SCIE)
  • M. Sawa, T.-L. Hsu, T. Itoh, M. Sugiyama, S. R. Hanson, P. K. Vogt, and C.-H. Wong, 2006, “Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo”, Proceedings of the National Academy of Sciences of the United States of America, 103(33), 12371-12376. (SCIE)
  • K. M. Koeller, C. H. Wong, 2001, “Enzymes for chemical synthesis”, Nature, 409, 232-240. (SCIE)
  • A. Heine, G. DeSantis, J. G. Luz, M. Mitchell, C. H. Wong and I. A. Wilson, 2001, “Observation of covalent intermediates in an enzyme mechanism at atomic resolution”, Science, 294, 369-374. (SCIE)
  • P. Sears, C. H. Wong, 2001, “Toward automated synthesis of oligosaccharides and glycoproteins”, Science, 291, 2344-2350. (SCIE)
翁啟惠實驗室
年度 書名
2025 Krasnova Larissa, (Wong Chi-Huey)*, Methods in Molecular Biology, Making Universal Vaccines and Antibodies Through Glycoengineering, Humana, 35-50, Jan. 2025