Wendy W. Hwang-Verslues EMBO Molecular Medicine
Chien-Jen Chen PNAS
Che Alex Ma Nature Communications
Chun-Mei Hu Nature Communications
Shang-Cheng Hung Journal of the American Chemical Society
Chien-Jen Chen, Hwai-I Yang GUT
Yun-Ru (Ruby) Chen Journal of Molecular Biology
Chun-Mei Hu Cancer Gene Therapy
Che Ma, Chi-Huey Wong Journal of the American Chemical Society
Chi-Huey Wong, Che Ma Journal of the American Chemical Society
Ovarian clear cell carcinomas (OCCC), particularly cases retaining wild-type ARID1A expression, are chemo-resistant and lack specific therapies. We identified circadian gene BMAL2 as a critical oncogene that promotes OCCC tumorigenesis by preventing endogenous DNA damage.
Breast cancer has long been the most common cancer among women in Taiwan and in many developed countries, with a recent trend toward younger onset. A research team led by Academician Chien-Jen Chen, Distinguished Research Fellow at the Genomics Research Center of Academia Sinica, in collaboration with the National Health Research Institutes (NHRI) and several universities in Taiwan, has completed a large-scale, 20-year study on breast cancer risk assessment. The findings were published in the Proceedings of the National Academy of Sciences (PNAS) in March 2026.
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