陳建仁博士
姓名 陳建仁博士
現任 特聘研究員
所屬單位
流行病學、人類遺傳學、公共衛生、預防醫學

Sc.D., Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA, 1983
M.P.H., Graduate Institute of Public Health, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC, 1977
B.Sc., Department of Zoology, College of Science, National Taiwan University, Taipei, Taiwan, ROC, 1973
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研究方向/領域

研究方向/領域

我們的研究室的工作主要聚焦於分子及基因體流行病學，包括：

  • 肝細胞癌、子宮頸癌、鼻咽癌風險預測模式的長期追蹤研究，涵蓋B型及C型肝炎病毒、人類乳突病毒、Epstein-Barr病毒的慢性感染標記，以及宿主的易罹癌基因型和生活型態特徵
  • 慢性砷中毒誘發健康危害的分子與基因體生物標記：遺傳與環境交互作用分析
  • 肝細胞癌、子宮頸癌與鼻咽癌的全基因組關聯分析與多基因風險評分
  • 台灣癌症防治相關國家計畫的成效評估

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經歷
  • 2024-present Distinguished Research Fellow, Genomics Research Center, Academia Sinica, Taiwan
  • 2023-2024 Premier, Executive Yuan, Taiwan
  • 2020-2023 Distinguished Research Fellow, Genomics Research Center, Academia Sinica, Taiwan
  • 2016-2020 Vice President, Office of President, Taiwan
  • 2011-2015 Vice President, Academia Sinica, Taiwan
  • 2006-2015 Distinguished Research Fellow, Genomics Research Center, Academia Sinica, Taiwan
  • 2006-2008 Minister, National Science Council, Taiwan
  • 2003-2005 Minister, Department of Health, Taiwan
  • 2002-2003 Deputy Minister, National Science Council, Taiwan
  • 1999-2002 Dean, College of Public Health, National Taiwan University, Taiwan
  • 1997-1999 Director General, Division of Life Sciences, National Science Council, Taiwan
  • 1994-1997 Founding Director, Graduate Institute of Epidemiology, National Taiwan University College of Public Health, Taiwan
  • 1994-2006 Professor, Graduate Institute of Epidemiology, National Taiwan University College of Public Health, Taiwan
  • 1993-1994 Director, Graduate Institute of Public Health, National Taiwan University College of Public Health, Taiwan
  • 1986-1993 Professor, Graduate Institute of Public Health, National Taiwan University College of Medicine, Taiwan
  • 1983-1986 Associate Professor, Graduate Institute of Public Health, National Taiwan University College of Medicine, Taiwan
榮譽
  • 2024 Order of Propitious Clouds with Special Grand Cordon, Office of the President, Taiwan
  • 2021 Academician, Pontifical Academy of Sciences, Vatican
  • 2020 Order of Dr. Sun Yat-sen with Grand Cordon, Office of the President, Taiwan
  • 2020 Honorary Doctor of Science, National Sun Yet-Sen University, Taiwan
  • 2020 Honorary Doctor of Philosophy, Kaohsiung Medical University, Taiwan
  • 2017 International Member, National Academy of Sciences, USA
  • 2016 Distinguished Service Medal (First Class), Academia Sinica, Taiwan
  • 2014 Honorary Doctor of Philosophy, China Medical University, Taiwan
  • 2014 Prof. Juei-Low Sung Award, Asia-Pacific Primary Liver Cancer Expert Meeting, Taiwan
  • 2013 Outstanding Achievement Award in Science and Technology, Executive Yuan, Taiwan
  • 2013 Knight, Pontifical Equestrian Order of St. Gregory the Great, Vatican
  • 2012 Knowledge for the World Award, Johns Hopkins University, USA
  • 2012 Science Profession Medal (First Rank), National Science Council, Taiwan
  • 2011 Prof. Vikit Viranuvatti Lecturer, Gastroenterological Association of Thailand, Thailand
  • 2011 Excellence in Cancer Prevention Award, Taiwan Joint Cancer Conference, Taiwan
  • 2010 Knight, Equestrian Order of the Holy Sepulcher of Jerusalem, Vatican
  • 2010 Outstanding Merit Award, Wang Ming-Ning Memorial Foundation, Taiwan
  • 2010 Member, Delta Omega Honorary Society in Public Health, Johns Hopkins University, USA
  • 2009 Science and Engineering Achievement Award, Taiwanese-American Foundation, USA
  • 2009 Officier dans l’Ordre des Palmes Academiques, Ministry of Education, France
  • 2008 Dr. DV Datta Memorial Oration, National Association for the Study of the Liver, India
  • 2008 Cutter Lecturer on Preventive Medicine, Harvard University, USA
  • 2007 Honorary Member, Mongolian Academy of Sciences, Mongolia
  • 2005 Member, World Academy of Sciences, Italy
  • 2005 Presidential Science Prize, Office of the President, Taiwan
  • 2005 Achievement Medal (First Rank), Executive Yuan, Taiwan
  • 2005 Health Medal (First Rank), Department of Health, Taiwan
  • 2003 Outstanding Research Fellow Award, National Science Council, Taiwan
  • 2001 ISI Citation Classic Award, ISI Thomas Scientific, USA
  • 1998 Academician, Academia Sinica, Taiwan
  • 1997 Academic Award, Ministry of Education, Taiwan
  • 1997-2002 National Chair Professor, Ministry of Education, Taiwan
  • 1995-1999 Outstanding Scholar, Foundation for Outstanding Scholarship, Taiwan
  • 1992 Outstanding Teaching Award, Ministry of Education, Taiwan
  • 1989 Fogarty International Research Fellowship, US National Institute of Health, USA
  • 1986-1996 Outstanding Research Fellow Award, National Science Council, Taiwan
  • Kim GA, Lim YS*, Han S, Choi GH, Choi WM, Choi J, Sinn DH, Paik YH, Lee JH, Lee YB, Cho JY, Heo NY, Yuen MF, Wong VW, Chan SL, Yang HI, (Chen CJ, Viral Load-Based Prediction of Hepatocellular Carcinoma Risk in Noncirrhotic Patients With Chronic Hepatitis B : A Multinational Study for the Development and External Validation of a New Prognostic Model., Annals of internal medicine, vol. 177(10), 1308-1318, 2024
  • Jhuang JR, Lee CH, Chiang CJ, (Chen CJ, Lee WC*, Reduced burden of Arsenic-Related cancers after water mitigation in Taiwan., Environment international, vol. 185, 108542, 2024
  • Yang JJ, Wen W, Zahed H, Zheng W, Lan Q, Abe SK, Rahman MS, Islam MR, Saito E, Gupta PC, Tamakoshi A, Koh WP, Gao YT, Sakata R, Tsuji I, Malekzadeh R, Sugawara Y, Kim J, Ito H, Nagata C, You SL, Park SK, Yuan JM, Shin MH, Kweon SS, Yi SW, Pednekar MS, Kimura T, Cai H, Lu Y, Etemadi A, Kanemura S, Wada K, (Chen CJ, Shin A, Wang R, Ahn YO, Shin MH, Ohrr H, Sheikh M, Blechter B, Ahsan H, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Inoue M, Kang D, Robbins HA, Shu XO*, Lung Cancer Risk Prediction Models for Asian Ever-Smokers., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, vol. 19(3), 451-464, 2024
  • Chang GC, Chiu CH, Yu CJ, Chang YC, Chang YH, Hsu KH, Wu YC, Chen CY, Hsu HH, Wu MT, Yang CT, Chong IW, Lin YC, Hsia TC, Lin MC, Su WC, Lin CB, Lee KY, Wei YF, Lan GY, Chan WP, Wang KL, Wu MH, Tsai HH, Chian CF, Lai RS, Shih JY, Wang CL, Hsu JS, Chen KC, Chen CK, Hsia JY, Peng CK, Tang EK, Hsu CL, Chou TY, Shen WC, Tsai YH, Tsai CM, Chen YM, Lee YC, Chen HY, Yu SL, (Chen CJ, Wan YL, Hsiung CA, Yang PC*, Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study., The Lancet. Respiratory medicine, vol. 12(2), 141-152, 2024
  • Downward GS*, Hystad P, Tasmin S, Abe SK, Saito E, Rahman MS, Islam MR, Gupta PC, Sawada N, Malekzadeh R, You SL, Ahsan H, Park SK, Pednekar MS, Tsugane S, Etemadi A, (Chen CJ, Shin A, Chen Y, Boffetta P, Chia KS, Matsuo K, Qiao YL, Rothman N, Zheng W, Inoue M, Kang D, Lan Q, Vermeulen RCH, Long-term exposure to particulate matter and all-cause and cause-specific mortality in an analysis of multiple Asian cohorts., Environment international, vol. 189, 108803, 2024
  • Lee MH*, Chen YT, Huang YH, Lu SN, Yang TH, Huang JF, Yin SC, Yeh ML, Huang CF, Dai CY, Chuang WL, Yu ML, Yang HI, Chen HY, (Chen CJ, Chronic Viral Hepatitis B and C Outweigh MASLD in the Associated Risk of Cirrhosis and HCC., Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, vol. 22(6), 1275-1285.e2, 2024
  • Polaris Observatory Collaborators (D. Razavi-Shearer*, (Chen CJ, et al., Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories., Journal of hepatology, vol. 80(2), 232-242, 2024
  • Chen CL*, Yang WS, Yang HI, Chen CF, Wang LY, Lu SN, Kao JH, Chen PJ, (Chen CJ, Plasma Adiponectin Levels in Relation to Chronic Hepatitis B Infection Progression to Liver Cancer Milestones: A Prospective Study, Liver Cancer, vol. 10(6), 1-17, 2024
  • Hsieh YC, Pan MH, Jeng WJ*, Hu HH, Liu J, Mizokami M, (Chen CJ, Yang HI, Serum HBcrAg and Hepatocellular Carcinoma in a Taiwanese Population Seronegative for HBsAg and Anti-HCV., Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, vol. 21(5), 1303-1313.e11, 2023
  • Blechter B*, Chien LH, Chen TY, Chang IS, Choudhury PP, Hsiao CF, Shu XO, Wong JYY, Chen KY, Chang GC, Tsai YH, Su WC, Huang MS, Chen YM, Chen CY, Hung HH, Hu JW, Shi J, Zheng W, Rositch AF, (Chen CJ, Chatterjee N, Yang PC, Rothman N, Hsiung CA, Lan Q, Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan., JAMA network open, vol. 6(11), e2339254, 2023
  • Chien RN, Lu SN, Hui-Min Wu G, Yang WW, Pwu RF, Liu CL, Cheng KP, Chen SC, (Chen CJ*, Policy and Strategy for Hepatitis C Virus Elimination at the National Level: Experience in Taiwan., The Journal of infectious diseases, vol. 228(Suppl 3), S180-S188, 2023
  • Lou PJ, Jacky Lam WK, Hsu WL, Pfeiffer RM, Yu KJ, Chan CML, Lee VCT, Chen TC, Terng SD, Tsou YA, Leu YS, Liao LJ, Chang YL, Chien YC, Wang CP, Lin CY, Hua CH, Lee JC, Yang TL, Hsiao CH, Wu MS, Tsai MH, Cheng HC, Hildesheim A, (Chen CJ, Chan KCA*, Liu Z, Performance and Operational Feasibility of Epstein-Barr Virus-Based Screening for Detection of Nasopharyngeal Carcinoma: Direct Comparison of Two Alternative Approaches., Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol. 41(26), 4257-4266, 2023
  • Liao PJ, Lee CH, Wang SL, Chiou HY, (Chen CJ, Seak CJ, Wu IW, Hsu KH*, Low-to-Moderate Arsenic Exposure and Urothelial Tract Cancers with a Long Latent Period of Follow-Up in an Arseniasis Area., Journal of epidemiology and global health, vol. 13(4), 807-815, 2023
  • Chien-Jen Chen*, Taiwan's pandemic vice-president - from lab bench to public office and back., Nature, vol. 603(7900), 203, 2022
  • Chiang Chun-Ju, Jhuang Jing-Rong, Yang Ya-Wen, Zhuang Bo-Zhi, You San-Lin, Lee Wen-Chung, Chen Chien-Jen*, 2022, “Association of Nationwide Hepatitis B Vaccination and Antiviral Therapy Programs With End-Stage Liver Disease Burden in Taiwan”, JAMA Network Open, 5(7), e2222367. (SCIE)
  • Tsai TL, Kuo CC, Hsu LI, Tsai SF, Chiou HY, Chen CJ*, Hsu KH, Wang SL, 2021, “Association between arsenic exposure, DNA damage, and urological cancers incidence: A long-term follow-up study of residents in an arseniasis endemic area of northeastern Taiwan.”, Chemosphere, 266, 129094. (SCIE)
  • Hsu WL, Chien YC, Huang YT, Yu KJ, Ko JY, Lin CY, Tsou YA, Leu YS, Liao LJ, Chang YL, Su JY, Liu Z, Wang CP, Terng SD, Hua CH, Lee JC, Yang TL, Kate Hsiao CH, Wu MS, Tsai MH, Liu MJ, Lou PJ, Hildesheim A, Chen CJ*, 2020, “Cigarette smoking increases the risk of nasopharyngeal carcinoma through the elevated level of IgA antibody against Epstein-Barr virus capsid antigen: A mediation analysis.”, Cancer Medicine, 9(5), 1867-1876. (SCIE)
  • Chuang SC, Chen HC, Sun CW, Chen YA, Wang YH, Chiang CJ, Chen CC, Wang SL, Chen CJ*, Hsiung CA, 2020, “Phthalate exposure and prostate cancer in a population-based nested case-control study.”, ENVIRONMENTAL RESEARCH, 181, 108902. (SCIE)
  • Chang MH*, You SL, Chen CJ, Liu CJ, Lee CM, Lin SM, Chu HC, Wu TC, Yang SS, Kuo HS, Chen DS, the Taiwan Hepatoma Study Group, 2009, “Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study”, J Natl Cancer Inst, 101(19), 1348-1355.
  • Chen CJ*, Yang HI, Ioleje UH, 2009, “Hepatitis B virus DNA levels and outcomes in chronic hepatitis B ”, Hepatology, 49,S72-S84. (SCIE)
  • Fwu CW, Chien YC, Kirk GD, Nelson KE, You SL, Kuo HS, Feinleib M, Chen CJ*, 2009, “Hepatitis B virus infection and hepatocellular carcinoma among parous Taiwanese women: nationwide cohort study”, J Natl Cancer Inst, 101, 1019-1027.
  • Yang HI, Yeh SH, Chen PJ, Iloeje UH, Jen CL, Wang LY, Lu SN, You SL, Chen DS,, 2008, “Association between Hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma”, J Natl Cancer I, 100, 1134-1143.
  • Lin W, Wang SL, Wu HJ, Chang KH, Yeh P, Chen CJ, Guo HR, 2008, “Associations between arsenic in drinking water and pterygium in southwestern Taiwan”, Environ Health Perspect, 116, 952-955. (SCIE)
  • Chen CL, Yang HI, Yang WS, Liu CJ, Chen PJ, You SL, Wang LY, Sun CA, Lu SN,, 2008, “Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C virus infection: a follow-up study in Taiwan”, Gastroenterology, 135,111-121. (SCIE)
  • F. I. Hsieh, T. S. Hwang, Y. C. Hsieh, H. C. Lo, C. T. Su, H. S. Hsu, H. Y. Chiou and C. J. Chen, 2008, “Risk of erectile dysfunction induced by arsenic through well water consumption in Taiwan”, Environ Health Perspect, 116, 532-536. (SCIE)
  • U. H. Iloeje, H. I. Yang, C. L. Jen, J. Su, L. Y. Wang, S. L. You, C. J. Chen, for the REVEAL–HBV Study Group, 2007, “Risk and predictors of mortality associated with chronic hepatitis B infection”, Clin Gastroenterol Hepatol, 5, 921-931.
  • U. H. Iloeje, H. I. Yang, J. Su, C. L. Jen, S. L. You and C. J. Chen, 2006, “Predicting cirrhosis risk based on the level of circulating hepatitis B viral load”, Gastroenterology, 130, 678-686. (SCIE)
  • C. J. Chen, H. I. Yang, J. Su, C. L. Jen, S. L. You, S. N. Lu, G. T. Huang and U. H. Iloeje, 2006, “Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level”, JAMA, 295, 65-73.
  • M. W. Yu, S. H. Yeh, P. J. Chen, Y. F. Liaw, C. L. Lin, C. J. Liu, W. L. Shih, J. H. Kao, D. S. Chen and C. J. Chen, 2005, “Genotype and DNA levels of hepatitis B virus and the risk of hepatocellular carcinoma”, J Natl Cancer Inst, 97, 265-272.
  • H. I. Yang, S. N. Lu, S. L. You, C. A. Sun, L. Y. Wang, K. Hsiao, P. J. Chen, D. S. Chen, Y. F. Liaw and C. J. Chen*, 2002, “Hepatitis B e antigens and the risk of hepatocellular carcinoma”, New Engl J Med, 347, 168-174. (SCIE)
  • Y. C. Chien, J. Y. Chen, M. Y. Liu, H. I. Yang, M. M. Hsu, C. J. Chen* and C. S. Yang, 2001, “Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men”, New Engl J Med, 345, 1877-1882. (SCIE)
  • K. H. Morales, L. Ryan*, T. L. Kuo, M. M. Wu and C. J. Chen, 2000, “Risk of internal cancers from arsenic in drinking water”, Environ Health Perspect, 108, 655-661. (SCIE)
  • C. J. Chen*, M. W. Yu and Y. F. Liaw, 1997, “Epidemiological characteristics and risk factors of hepatocellular carcinoma”, J Gastroenterol Hepatol, 12, S294-S308.
  • M. H. Chang*, C. J. Chen, M. S. Lai, M. S. Kong, T. C. Wu, D. C. Liang, H. M. Hsu, W. Y. Shau, D. S. Chen and Taiwan Childhood Hepatoma Study Group, 1997, “Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children”, New Engl J Med, 336, 1855-1859. (SCIE)
  • H. Y. Chiou, Y. M. Hsueh, K. F. Liaw, S. F. Horng, M. H. Chiang, Y. S. Pu, J. S. N. Lin, C. H. Huang and C. J. Chen*, 1995, “Incidence of internal cancers and ingested inorganic arsenic: A seven-year follow-up study in Taiwan”, Cancer Res, 55, 1296-1300. (SCIE)
  • C. J. Chen*, Y. M. Hsueh, M. S. Lai, M. P. Hsu, M. M. Wu and T. Y. Tai, 1995, “Increased prevalence of hypertension and long-term arsenic exposure”, Hypertension, 25, 53-60. (SCIE)
  • Y. J. Zhang, W. Jiang, C. J. Chen, C. S. Lee, S. M. Kahn, R. M. Santella and I. B. Weinstein*, 1993, “Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma”, Biochem Biophys Res Commun, 196, 1010-1016.
  • C. J. Chen*, C. W. Chen, M. M. Wu and T. L. Kuo, 1992, “Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water”, Brit J Cancer, 66, 888-892. (SCIE)
  • C. J. Chen* and C. J. Wang, 1990, “Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms”, Cancer Res, 50, 5470-5474. (SCIE)
  • M. M. Wu, T. L. Kuo, Y. H. Hwang and C. J. Chen*, 1989, “Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases”, Am J Epidemiol, 130, 1123-1132. (SCIE)
  • C. J. Chen*, T. L. Kuo and M. M. Wu, 1988, “Arsenic and cancers (letter)”, Lancet, 1, 414-415. (SCIE)
  • C. J. Chen*, M. M. Wu, S. S. Lee, J. D. Wang, S. H. Cheng and H. Y. Wu, 1988, “Atherogenicity and carcinogenicity of high-arsenic artesian well water: Multiple risk factors and related malignant neoplasms of blackfoot disease”, Arteriosclerosis, 8, 452-460.
  • C. J. Chen, Y. C. Chuang, S. L. You, T. M. Lin and H. Y. Wu, 1986, “A retrospective study on malignant neoplasms of bladder, lung and liver in blackfoot disease endemic area in Taiwan”, Br J Cancer, 53, 399-405.
  • C. J. Chen*, Y. C. Chuang, T. M. Lin and H. Y. Wu, 1985, “Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: High-arsenic artesian well water and cancers”, Cancer Res, 45, 5895-5899. (SCIE)