Selected Publications

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Year Paper Title
2005 Cheung EC, Melanson-Drapeau L, Cregan SP, Vanderluit JL, Ferguson KL, McIntosh WC, Park DS, Bennett SA, Slack RS, Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms., The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 25(6), 1324-34, 2005
2005 Jun Li, Ying-Chih Chang*, Preparation of End-Grafted Polymer Brushes by Nitroxide-Mediated Free Radical Polymerization of Vaporized Vinyl Monomers, LANGMUIR, vol. 21, 9562-9567, 2005
2005 L. R. Chen, Y. C. Wang, Y. W. Lin, S. Y. Chou, S. F. Chen, L. T. Liu, C. J. Kuo, T. S. Chen, S. H. Juang, Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors, Bioorg Med Chem Lett, vol. 15, 3058-3062, 2005
2005 J. J. Shie, J. M. Fang, T.H. Kuo, C. J. Kuo, P. H. Liang, H. J. Huang, J.T. Jan, Y. S. Cheng, C. H. Wong, Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, 5240-5252, 2005
2005 Shie, J. J., Fang, J. M., Kuo, C. J., Kuo, T. H., Liang, P. H., Huang, H. J., Yang, W. B., Lin, C. H., Chen, J. L., Wu, Y. T., Wong, C. H., Discovery of Potent Anilide Inhibitors against the Severe Acute Respiratory Syndrome 3CL Protease., J Med Chem, vol. 48(13), 4469-4473, 2005
2005 Chun-Ping Lu, Yi-Ning Lai, S.-H. Wu, Wei-Man Wang, Jean-Yin Chen, Lee-Chiang Lo, Design of a Mechanism-Based Probe for Neuraminidase to Capture Influenza Viruses, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 44, 6888-6892, 2005
2005 An-Tai Wu, Yi-Ping Yu, Wei Zou, S.-H. Wu, 9-O-Sulfation on α-NeuAc-(2-8)-NeuAc and inter-residue lactonization, CARBOHYDRATE RESEARCH, vol. 340, 1219-1223, 2005
2005 Chen AY, Shih SJ, Garriques LN, Rothenberg ML, (Hsiao M, Curran DP, Silatecan DB-67 is a novel DNA topoisomerase I-targeted radiation sensitizer, Mol Cancer Ther, vol. 4, 317-324. Cite 10, 2005
2005 C. Y. Wu, A. Brik, S. K. Wang, Y. H. Chen, Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ, Chembiochem, vol. 6, 2176-2180, 2005
2005 Brik, A., Wu, C. Y., Best, M. D., Wong, C. H., Tetrabutylammonium fluoride-assisted rapid N(9)-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ., Bioorganic & medicinal chemistry, vol. 13(15), 4622-4626, 2005
2005 G. T. Fan, Y. S. Pan. K. C. Lu, Y. P. Cheng, W. C. Lin, S. Lin, S. H. Lin, J. M. Fang, C. C. Lin Wong, C. H., Fang, J. M., C. C. Lin, Synthesis of alpha-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes., Tetrahedron, vol. 61, 1855-1862, 2005
2005 G. T. Fan, Y. S. Pan. K. C. Lu, Y. P. Cheng, W. C. Lin, S. Lin, S. H. Lin, J. M. Fang, C. C. Lin, Synthesis of ?galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes, Tetrahedron, vol. 61, 1855-1862, 2005
2005 G. W. Xing, D. Wu, M. A. Poles, A. Horowitz, M. Tsuji, D. D. Ho, Synthesis and human NKT cell stimulating properties of 3-O-sulfo-alpha/beta-galactosylceramides, Bioorganic & medicinal chemistry, vol. 13, 2907-2916, 2005
2005 Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Kumar V, Wilson IA, Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity., The Journal of experimental medicine, vol. 202(11), 1517-26, 2005
2005 S. H. Wei, H. Rosen, M. P. Matheu, M. G. Sanna, S. K. Wang, E. Jo, I. Parker, M. D. Cahalan, Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses, Nat Immunol, vol. 6, 1228-1235, 2005
2005 Y. Kinjo, D. Wu, G. Kim, G. W. Xing, M. A. Poles, D. D. Ho, M. Tsuji, K. Kawahara, M. Kronenberg, Recognition of bacterial glycosphingolipids by natural killer T cells, Nature, vol. 434, 520-525, 2005
2005 Sinchaikul, S., Pan, F. M., Cheng, C. W., Wong, C. H., Fang, J. M., Tseng, M. J., Chen, S. T., Protein microarray using alpha-amino acids as metal tags on chips., Bioorg Med Chem Lett, vol. 15(5), 1413-1416, 2005
2005 Protein glycosylation: new challenges and opportunities, J Org Chem, vol. 70, 4219-4225, 2005
2005 J. J. Shie, J. M. Fang, T. H. Kuo, C. J. Kuo, P. H. Liang, H. J. Huang, Y. T. Wu, J. T. Jan, Y. S.E. Cheng, Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters., Bioorganic & medicinal chemistry, vol. 13, 5240–5252, 2005
2005 M. M. Numa, L. V. Lee, C. C. Hsu, K. E. Bower, Identification of novel anthrax lethal factor inhibitors generated by combinatorial Pictet-Spengler reaction followed by screening in situ, Chembiochem, vol. 6, 1002-1006, 2005
2005 Sawkar AR, Adamski-Werner SL, Cheng WC, Beutler E, Zimmer KP, Kelly JW, Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles., Chemistry & biology, vol. 12(11), 1235-44, 2005
2005 A.R. Sawkar, S.L. Adamski-Werner, W.-C. Cheng, E. Beutler, K.-P. Zimmer, J.W. Kelly, Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles, Chem. Biol, vol. 12(11), 1235–1244, 2005
2005 M. Fridman, V. Belakhov, L. V. Lee, F. S. Liang, T. Baasov, Dual effect of synthetic aminoglycosides: antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor, Angewandte chemie-international edition, vol. 44, 447-452, 2005
2005 D. A. Calarese, H. K. Lee, C. Y. Huang, M. D. Best, R. D. Astronomo, R. L. Stanfield, H. Katinger, D. R. Burton, I. A. Wilson, Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 13372–13377, 2005
2005 J. J. Shie, J. M. Fang, C. J. Kuo, T. H. Kuo, P. H. Liang, H. J. Huang, W. B. Yang, C. H. Lin, J. L. Chen, Y. T. Wu, Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease, J Med Chem, vol. 48, 4469-4473, 2005
2005 C.-C. Hsu, Y. Zhang, M. Wada, D. Franke, Directed evolution of d-sialic acid aldolase l-3-deoxy-manno-2-octulosonic acid (l-KDO) aldolases, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 9122-9126, 2005
2005 C. C. Hsu, Y. Zhang, M. Wada, D. Franke, Directed evolution of D-sialic acid aldolase L-3-deoxy-manno-2-octulosonic acid (L-KDO) aldolases, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 9122–9126, 2005
2005 D. Wu, G. W. Xing, M. A. Poles, A. Horowitz, Y. Kinjo, B. Sullivan, V. Bodmer Narkevitch, O. Plettenburg, M. Kronenberg, M. Tsuji, D. D. Ho, Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 1351-1356, 2005
2005 Scanlan C, Calarese D, Lee HK, Blixt O, Wilson I, Burton D, Dwek R, Rudd P, Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design., Advances in experimental medicine and biology, vol. 564, 7-8, 2005
2005 T. J. Tolbert, D. Franke, A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as TEV protease cleavable fusion protein, Bioorganic & medicinal chemistry, vol. 13, 909-915, 2005
2005 H. N. Yu, D. A. Thayer, M. C. Galan, A general strategy toward S-linked glycopeptides, Angewandte chemie-international edition, vol. 44, 4596-4599, 2005
2005 A. Brik, J. Alexandratos, Y. C. Lin, J. H. Elder, A. J. Olson, A. Wlodawer, D. S. Goodsell, 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors, Chembiochem, vol. 6, 1167-1169, 2005
2005 T.K.Tang, P.J. Mark, S.T. Chen, M.H. Hou, M.H. Hong, F.M. Pan, H.M.Yu, J.H. Chen, C.W.Yao, A.H.J.Wang, Biochemical and immunological studies of nucleocapsid proteins of severee acute respiratory syndrome and 229E human coronaviruses, Proteomics, vol. 5(4), 925-937, 2005
2005 C. H. Lin, H. C. Lin, W. B. Yang, exo-Glycal Chemistry: General Aspects and Synthetic Applications for Biochemical Use, Current Topics in Medicinal Chemistry, vol. 5, 1431-1457, 2005
2005 Shie, J. J., Fang, J. M., Kuo, C. J., Kuo, T. H., Liang, P. H., Huang, H. J., Yang, W. B., Lin, C. H., Chen, J. L., Wu, Y. T., Wong, C. H., Discovery of Potent Anilide Inhibitors against the Severe Acute Respiratory Syndrome 3CL Protease., J Med Chem, vol. 48(13), 4469-4473, 2005
2005 J. J. Shie, J. M. Fang, C. J. Kuo, T. H. Kuo, P. H. Liang, H. J. Huang, W. B. Yang, C. H. Lin, J. L. Chen, Y. T. Wu, C. H. Wong, Discovery of Potent Anilide Inhibitors Against the Severe Acute Respiratory Syndrome 3CL Protease, J. Med. Chem, vol. 48, 4469-4473, 2005
2005 S. C. Sue, (C. F. Chang, Y. T. Huang, C. Y. Chou, T. H. Huang, Challenges in NMR-based structural genomics, Physica A, vol. 350, 12-27, 2005
2005 Kouza, M., (Chang, C. F., Hayryan, S., Yu, T. H., Li, M. S., Huang, T. H., Hu, C. K., Folding of the Protein Domain hbSBD., Biophys J, vol. 89(5), 3353-3361, 2005
2005 Chang, C. K., Sue, S. C., Yu, T. H., Hsieh, C. M., Tsai, C. K., Chiang, Y. C., Lee, S. J., Hsiao, H. H., Wu, W. J., (Chang, C. F., Huang, T. H., The dimer interface of the SARS coronavirus nucleocapsid protein adapts a porcine respiratory and reproductive syndrome virus-like structure., FEBS Lett, vol. 579(25), 5663-5668, 2005
2005 Mahajan, A., Yuan, C., Pike, B. L., Heierhorst, J., (Chang, C. F., Tsai, M. D., FHA domain-ligand interactions: importance of integrating chemical and biological approaches., J Am Chem Soc, vol. 127(42), 14572-14573, 2005
2005 O. P. Charkin, N. M. Klimenko, T. P. Nguyen, D. O. Charkin, Y.-S. Wang, S.-C. Wei, H.-C. Chang, S. H. Lin, Theoretical study of fragmentation of heme and its ion with successive removal of carboxymethyl groups, Russian Journal of Inorganic Chemistry, vol. 50 (9), 1398-1407, 2005
2005 R.Y.L. Wang, (C. N. Shen, M. H. Lin, D. Tosh, C. H. Shih, Hepatocyte-like cells transdifferentiated from a pancreatic origin can support replication of hepatitis B virus, Journal of virology, vol. 79, 13116-13128, 2005
2005 Lo YC, (Lin SC, Shaw JF, Liaw YC*, Substrate specificities of Escherichia coli thioesterase I/protease I/lysophospholipase L1 are governed by its switch loop movement., Biochemistry, vol. 44(6), 1971-1979, 2005
2005 M. Shapiro-Shelef, K. I. Lin, D. Savitsky, J. Liao, K. Calame, Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow, J Exp Med, vol. 202, 1471-1476, 2005
2005 Ke PY, Kuo YY, Hu CM, Chang ZF., Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability. , GENES & DEVELOPMENT, vol. 19, 1920-1933, 2005
2005 Kulkarni, S. S.; Liu, Y.-H.; Hung, S.-C., Neighboring Group Participation of 9-Anthracenylmethyl Group in Glycosylation: Preparation of Unusual C-Glycosides, J. Org. Chem., vol. 70, 2808–2811, 2005
2005 Kulkarni, S. S.; Hung, S.-C., Metal Trifluoromethanesulfonates as Versatile Catalysts in Carbohydrate Synthesis, Lett. Org. Chem., vol. 2, 670–677, 2005
2005 Shie, C.-R.; Tzeng, Z.-H.; Kulkarni, S. S.; Uang, B.-J.; Hsu, C.-Y.; Hung, S.-C., Cu(OTf)2 as an Efficient and Dual-Purpose Catalyst in the Regioselective Reductive Ring Opening of Benzylidene Acetals, Angewandte Chemie-International Edition, vol. 44, 1665–1668, 2005
2005 Chen, Y.-Y.; Luo, S.-Y.; Hung, S.-C.; Chan, S. I.; Tzou, D.-L. M., C-13 solid-state NMR chemical shift anisotropy analysis of the anomeric carbon in carbohydrates , Carbohydrate Research, vol. 340, 723-729, 2005
2005 Chen, F. C., Chuang, T. J.*, ESTviewer: a web interface for visualizing mouse, rat, cattle, pig and chicken conserved ESTs in human genes and human alternatively spliced variants., Bioinformatics, vol. 21(10), 2510-2513, 2005
2005 M. Butsch Kovacic, M. Martin, X. Gao, T. Fuksenko, C. J. Chen, Y. J. Cheng, J. Y. Chen, R. Apple, A. Hildesheim, M. Carrington, Variation of the killer cell immunoglobulin-like receptors and HLA-C genes in nasopharyngeal carcinoma, Cancer Epidemiol Biomarkers Prev, vol. 14, 2673-2677, 2005
2005 T. I. Chen, Y. L. Lee, S. L. You, C. J. Chen, C. Y. Hsieh, S. C. Chen, Utilization factors and effects of national health insurance on cervical Pap smear tests in Taiwan, Taiwan J Public Health, vol. 24, 440-451, 2005
2005 C. P. Wen, S. P. Tsai, T. Y. Cheng, C. J. Chen, D. T. Levy, H. J. Yang, M. P. Eriksen, Uncovering the relation between betel quid chewing and cigarette smoking in Taiwan, Tobacco Control, vol. 14 (Suppl. 1): 16-22, 2005
2005 C. J. Chen, Time-dependent events in natural history of occult hepatitis B virus infection: Importance of population-based long-term follow-up study with repeated measurements, J Hepatol, vol. 42, 438-440, 2005
2005 C. Y. Wu, M. S. Wu, C. J. Chen, M. C. Li, J. T. Lin, G. H. Chen, The interaction of H. pylori infection and NSAIDs in cyclooxygenase-2 mRNA expression in gastric antral, corpus mucosa and gastric ulcer edge, J Clin Gastroenterol, vol. 39, 50-55, 2005
2005 C. P. Wen, S. P. Tsai, C. J. Chen, T. Y. Cheng, M. C. Tsai, D. T. Levy, Smoking attributable mortality for Taiwan and its projection to 2020 under different smoking scenarios, Tobacco Control, vol. 14 Suppl 1, i76-i80, 2005
2005 Y. J. Zhang, Y. Chen, H. Ahsan, R. M. Lunn, S. Chen, P. H. Lee, C. J. Chen, R. M. Santella, Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma, Cancer Lett, vol. 221, 135-143, 2005
2005 M. H. Chang, T. Chen, H. M. Hsu, T.C. Wu, M. S. Kong, D. C. Liang, Y. H. Ni, C. J. Chen, D. S. Chen, Prevention of hepatocellular carcinoma by universal vaccination against hepatitis B virus: the effect and problems, Clin Cancer Res, vol. 11, 7953-7957, 2005
2005 Y. F. Shih, C. H. Hsiao, S. H. Wen, L. L. Lin, C. J. Chen, P. T. Hung, Prevalence of anisometropia in Taiwanese schoolchildren, J Formos Med Assoc, vol. 104, 412-417, 2005
2005 W. Y. Lin, Y. C. Chou, M. H. Wu, Y. L. Jeng, H. B. Huang, S. L. You, T. Y. Chu, C. J. Chen, C. A. Sun, Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: A nested case-control study in Taiwan, Cancer Detect Prev, vol. 29, 427-432, 2005
2005 M. S. Wu, C. J. Chen, J. T. Lin, Host-environment interactions: their impact on progression from gastric inflammation to carcinogenesis and on development of new approaches to prevent and treat gastric cancer, Cancer Epidemiol Biomarkers Prev, vol. 14, 1878-1882, 2005
2005 M. W. Yu, S. H. Yeh, P. J. Chen, Y. F. Liaw, C. L. Lin, C. J. Liu, W. L. Shih, J. H. Kao, D. S. Chen, C. J. Chen, Genotype and DNA levels of hepatitis B virus and the risk of hepatocellular carcinoma, J Natl Cancer Inst, vol. 97, 265-272, 2005
2005 S. C. Lin, Y. C. Chou, M. H. Wu, C. C. Wu, W. Y. Lin, C. P. Yu, J. C. Yu, S. L. You, C. J. Chen, C. A. Sun, Genetic variants of myeloperoxidase and catechol-O-methyltransferase and Breast cancer risk, Eur J Cancer Prev, vol. 14, 257-261, 2005
2005 Y. M. Hsueh, P. Lin, H. W. Chen, H. S. Shiue, C. J. Chung, C. T. Tsai, Y. K. Huang, H. Y. Chiou, C. J. Chen, Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension, J Toxicol Environ Health A, vol. 68, 1471-1484, 2005
2005 T. J. Lin, F. C. Hwang, C. J. Chen, W. T. Chiu, C. K. Chang, Familial hypertensive intracerebral hemorrhage in connection with autosomal dominant polycystic kidney disease, J Clin Neurosci, vol. 12, 474-477, 2005
2005 C. P. Wen, S. P. Tsai, T. Y. Cheng, H. T. Chan, W. S. I. Chung, C. J. Chen, Excess injury mortality among smokers: a neglected tobacco hazard, Tobacco Control, vol. 14 Suppl 1, i28-i32, 2005
2005 X. R. Yang, S. Diehl, R. Pfeiffer, C. J. Chen, W. L. Hsu, M. Dosemeci, Y. J. Cheng, B. Sun, A. M. Goldstein, The CAGEN Study Team, A. Hildesheim, Evaluation of risk factors for nasopharyngeal cancer in a family study in Taiwan, Cancer Epidemiol Biomarkers Prev, vol. 14, 900-905, 2005
2005 C. F. Jan, C. J. Chen, H. H. Chen, Causes of increased mortality from hepatocellular carcinoma in high incidence country: Taiwan experience, J Gastroenterol Hepatol, vol. 20, 521-526, 2005
2005 C. J. Chen, L. I. Hsu, W. L. Shih, Y. H. Hsu, M. P. Tseng, Y. C. Lin, W. L. Chou, C. Y. Chen, C. Y. Lee, L. H. Wang, Y. C. Cheng, C. L. Chen, S. Y. Chen, I. H. Wang, Y. M. Hsueh, H. Y. Chiou, M. M. Wu, Biomarkers of exposure, effect and susceptibility of arsenic-induced health hazards in Taiwan, Toxicol Appl Pharmacol, vol. 206, 198-206, 2005
2005 J. M. Lee, M. T. Wu, Y. C. Lee, S. Y. Yang, J. S. Chen, H. H. Hsu, P. M. Huang, S. W. Kuo, C. J. Lee, C. J. Chen, Association of GSTP1 polymorphism and survival for esophageal cancer, Clin Cancer Res, vol. 11, 4749-4753, 2005
2005 C. C. Chen, S. Y. Yang, C. J. Liu, C. L. Lin, Y. F. Liaw, S. M. Lin, S. D. Lee, P. J. Chen, C. J. Chen, M. W. Yu, Association of cytokine and DNA repair gene polymorphisms with hepatitis B-related hepatocellular carcinoma, Int J Epidemiol, vol. 34, 1310-1318, 2005
2005 Y. C. Hsieh, C. T. Hong, Y. H. Wang, C. J. Chen, H. Y. Chiou, Association between carotid atherosclerosis and inflammatory gene polymorphisms among residents in an arseniasis-endemic area, Taiwan J Public Health, vol. 24, 64-72, 2005
2005 J. M. Chiou, S. L. Wang, C. J. Chen, C. R. Deng, W. Lin, T. Y. Tai, Arsenic ingestion and increased microvascular diseases risk: Observation from southwestern arseniasis-endemic area in Taiwan, Int J Epidemiol, vol. 35, 936-943, 2005
2005 C. H. Tseng, Y. K. Huang, Y. L. Huang, C. J. Chung, M. H. Yang, C. J. Chen, Y. M. Hueh, Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan, Toxicol Appl Pharmacol, vol. 206, 299-308, 2005
2005 T. Burckin, R. Nagel, Y. Mandel-Gutfreund, L. Shiue, T. Clark, J.-L. Chong, T.-H. Chang, S. Squazzo, G. Hartzog, M. Jr. Ares, Exploring functional relationships between components of the transcription, splicing, and mRNA export machineries by gene expression phenotype analysis, Nat. Struct. Mol. Biol, vol. 12, 175-182, 2005