Tsung-Lin Li, Ph.D.
Name Tsung-Lin Li, Ph.D.
Incumbent Professor
所屬單位 Division Director of Chemical Biology


Ph.D., Chemistry, University of Cambridge (UK), 2004
NCLscan:
研究方向/領域

RESEARCH INTERESTS

Natural product chemistry

Research in the Li lab encompasses a broad spectrum of natural product chemistry in particular in the scopes of elucidation and manipulation of biosynthetic pathways to vital natural products. Natural product chemistry had its genesis in the study of naturally occurring substances, and this remains intellectual challenge and certainly a constant source of information. Current targets include glycopeptides (mannopeptimycin, enduracidine, A40926, teicoplanin, chloroeremomycin), aminoglycosides (moenomycin, minosaminomycin), and marine toxin (tetrodotoxin).

Microbial pathogenicity

The lab is also involved in a multidisciplinary study for characterizing mechanisms of microbial pathogenicity. The current targeted microbe is Klebsiella pneaumoniae K1, which is the major causative bacterium of hospital-acquired, debilitated and immuno-compromised infections in Taiwan. Its complete genome has been sequenced recently. The overall goal of the program project is to understand the relationship between virulence, CPS (capsular polysaccharide) structure, and biosynthesis of the CPS.
 

Current Research Targe
Current Research Target

 

Current Research Targe
Proposed CPS assembly machinery

 

EDUCATION AND POSITIONS HELD
  • 2023-present Division Director of Chemical Biology, GRC, Academia Sinica, Taiwan
  • 2019-2023 Deputy Director, Genomics Research Center, Academia Sinica
  • 2019-present Professor, Genomics Research Center, Academia Sinica
  • 2011-2019 Associate Professor, Genomics Research Center, Academia Sinica
  • 2010-present Adjunct Assistant/Associate/Professor, Marine Biotechnology Center, National Sun Yat-sen University
  • 2009-present Adjunct Assistant/Associate/Professor, Biotechnology Center, National Chung Hsing University
  • 2007-2011 Assistant Professor, Genomics Research Center, Academia Sinica
  • 2004-2007 Assistant Professor, Biotechnology, Food Science, National Taiwan Ocean University
  • 2004 Postdoctoral Fellow, Genomics Research Center
  • 2003-2004 Associate Research Scientist, University of Cambridge
  • 1998-2000 Specialist, Microbiology Division, National Laboratories of Foods and Drugs, Department of Health, Executive Yuan, Taipei, Taiwan
  • 1995-1997 Teaching assistant, Food Science & Technology, The Ohio State University
  • 1991-1995 Specialist, Chemistry Division, National Laboratories of Foods & Drugs, Department of Health, Executive Yuan, Taipei, Taiwan
  • 1991 Specialist, National Quarantine Service, Department of Health, Executive Yuan, Taipei, Taiwan
HONORS
  • 2023 NSTC Outstanding Research Award
  • 2020-2024 Investigator Award (Academia Sinica)
  • 2014-2018 Career Development Award (Academia Sinica)
  • 2012-2015 Career Development Award (National Health Research Institutes)
  • 2018 Academia Sinica Significant Research
  • 2014 Academia Sinica Significant Research
  • 2011 Academia Sinica Significant Research
  • 2007 Academia Sinica Major Discovery
  • 1998 Overseas PhD Fellowship (in Chemistry, Ministry of Education, MOE)
  • 1998 National Certificate in Hygiene Analysis, Advanced National Senior Civil Service Examination (Examination Yuan)
  • 1997 Researcher Award, National Annual Research Award (Executive Yuan)
  • 1996 Researcher Award, Annual Research Award (Department of Health)
  • 1991 National Certificate in Environmental Hygiene, National Senior Civil Service Examination (Examination Yuan)
  • 1991 National Certificate in Dietician Profession (Department of Health)
  • 1991 National Certificate in Nutrition, Professionals and Technologists Examination (Examination Yuan)
Year Paper Title
2025 Li IC, Chan YL, Lu WT, Chiang LH, Li TJ, Li TL, Chen CC*, Wu CJ*, Phellinus linteus Mycelia Extracts Show Potent Antiviral and Immunomodulatory Effects in H1N1 Influenza Virus Infected Mice, FOODS, vol. 14(23), 4047, 2025任職中研院著作;
2025 Selvaraj SP, Chang JC, Raja K, Zsu JT, Hazam PK, Lin WC, Huang JR*, Li TL*, Chen JY*, Novel self-assembled antimicrobial peptide Pardaxin hydrogel as a functional biomaterial for food packaging and preservation, CHEMICAL ENGINEERING JOURNAL, vol. 525, 170727, 2025具代表性; 任職中研院著作;
2025 Y. L. Chan*, Y. P. Chao, T. L. Li, K. W. Liao, Chitosan-based Oral DNA vaccine elicits mucosal immunity and reduces Helicobacter pylori colonization in mice, VACCINE, vol. 64, 127692, 2025任職中研院著作;
2025 Y. L. Chan, J. C. Liao, T. L. Li, C. J. Wu*, Y. H. Chiu*, Bifidobacterium lactis ameliorates AOM/DSS‑induced inflammation, dysbiosis, and colonic precancerous lesions, APPLIED MICROBIAL AND CELL PHYSIOLOGY, vol. 109 (69), 1-15, 2025任職中研院著作;
2025 H. T. Huang, C. T. Chiou, Y. C. Lin, L. J. Zhang, C. H. Chao, P. J. Sung, J. J. Chen, T. L. Li, I. W. Lo*, C. C. Liaw*, Potential Anti-H1N1 Schtriterpenoids from Kadsura japonica L. Vines, PHYTOCHEMISTRY, vol. 240, 114632, 2025任職中研院著作;
2025 H. T. Huanga, C. T. Chioua, Y. C. Lin, L. J. Zhang, C. H. Chao, P. J. Sung, J. J. Chen, T. L. Li, I. W. Lo*, C. C. Liaw*, Potential Anti-H1N1 Schtriterpenoids from Kadsura japonica L. Vines, PHYTOCHEMISTRY, 2025
2025 Y. L. Chan, J. C. Liao, T. L. Li, C. J. Wu*, Y. H. Chiu*, Bifidobacterium lactis ameliorates AOM/DSS‑induced inflammation, dysbiosis, and colonic precancerous lesions, APPLIED MICROBIAL AND CELL PHYSIOLOGY, vol. 109 (69), 1-15, 2025任職中研院著作;
2024 S. P. Selvaraj, K. H. Lin, W. C. Lin, M. F. You, T. L. Li*, J. Y Chen*, Rejuvenation of Meropenem by Conjugation with Tilapia Piscidin-4 Peptide Targeting NDM-1 Escherichia coli, ACS OMEGA, vol. 28;9(27):29756-29764, 2024具代表性; 任職中研院著作;
2024 H. T. Huang, I. W. Lo, Y. C. Lin, G. Y. Liao, Y. S. Lin, L. J. Zhang, T. L. Li, C. C. Liaw*, Y. H. Kuo*, Kaguacidine A: a novel spirohydantoin-containing cucurbitane glycoside from vines of Momordica charantia L., NATURAL PRODUCT RESEARCH, vol. 38 (13), 2179-2186, 2024任職中研院著作;
2023 H. T. Huang, I. W. Lo, Y. C. Lin, G. Y. Liao, Y. S. Lin, L. J. Zhang, T. L. Li, C. Ching Liaw*, Y. H. Kuo*, Kaguacidine A: a novel spirohydantoin-containing cucurbitane glycoside from vines of Momordica charantia, NATURAL PRODUCT RESEARCH, vol. 38(13):2179-2186, 2023任職中研院著作;
2023 Y. L. Wang, C. Y. Chang, N. S. Hsu, I. W. Lo, K. H. Lin, C. L. Chen, C. F. Chang, Z. C. Wang, Y. Ogasawara, T. Dairi, C. Maruyama, Y. Hamano*, T. L. Li*, N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry, NATURE COMMUNICATIONS, vol. 14:2528, 1-14, 2023具代表性; 任職中研院著作;
2023 S. S. Chang, H. T. Huang, W. C. Wei, I. W. Lo, Y. C. Lin, C. H. Chao, G. Y. Liao, Y. C. Shen, J. J. Chen, T. L. Li, L. T. Lin, C. J. Tai, Y. H. Kuo, C. C. Liaw*, Anti-inflammatory Effect of Euphane-and Tirucallane-type Triterpenes Isolated from Traditional Herb Euphorbia neriifolia L, FRONTIERS IN CHEMISTRY, vol. 11, 1-13, 10.3389/fchem.2023.1, 2023任職中研院著作;
2023 S. H. Liu, H. T. Huang, I. W. Lo, Y. C. Lin, G. Y. Liao, C. H. Chao, H. C. Huang, F. R. Chang, T. L. Li, Y. C. Shen, C. C. Liao*, Potential natural product 3,4-seco-schitriterpenoids from Kadsura japonica L. as anti-neuroinflammatory agents, BIOORGANIC CHEMISTRY, vol. 141, 106843, 2023任職中研院著作;
2022 M. H. Chen, Y. S. Li, N. S. Hsu, K. H. Lin, Y. L. Wang, Z. C. Wang, C. F. Chang, J. P. Lin, C. Y. Chang, T. L. Li*, Structural and mechanistic bases for StnK3 and its mutants-mediated Lewis-acid-dependent epimerization and retro aldol reactions, ACS CATALYSIS, vol. 12, 1945-1956, 2022具代表性; 任職中研院著作;
2022 R. Rattinam, R. S. Basha, Y. L. Wang, Z. C. Wang, N. S. Hsu, K. H. Lin, S. Malek Zadeh, K. Adhikari, J. P. Lin, T. L. Li*, KasQ an epimerase primes the biosynthesis of aminoglycoside antibiotic kasugamycin and KasF/H acetyltransferases inactivate its activity, BIOMEDICINES, vol. 10(2), 212, 2022具代表性; 任職中研院著作;
2022 B. R. Chen, W. M. Li, T. L. Li, Y. L. Chan, C. J. Wu*, Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori, SCIENTIFIC REPORTS, vol. 12(1), 429, 2022任職中研院著作;
2022 Y. C. Pan, Y. L. Wang, S. I. Toh, N. S. Hsu, K. H. Lin, Z. Xu, S. C. Huang, T. K. Wu, T. L. Li, C. Y. Chang*, Dual-mechanism confers self-resistance to the antituberculosis antibiotic capreomycin, ACS CHEMICAL BIOLOGY, vol. 17(1), 138-146, 2022任職中研院著作;
2022 C. C. Liaw, I. W. Lo, Y. C. Lin, H. T. Huang, L. J. Zhang, P. C. Hsiao, T. L. Li, * Y. H. Kuo*, Four cucurbitane glycosides taimordisins A–D with novel furopyranone skeletons isolated from the fruits of Momordica charantia, FOOD CHEMISTRY: X, vol. 14, 100286, 2022具代表性; 任職中研院著作;
2022 S. M. Zadeh, M. H. Chen, Z. C. Wang, E. K. Astani, I. W. Lo, K. H. Lin, N. S. Hsu, K. Adhikari, S. Y. Lyu, H. Y. Tsai, Y. Terasawa, M. Yabe, K. Yamamoto, S. Ichikawa, T. L. Li*, β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin, COMMUNICATIONS CHEMISTRY, vol. 5, 87, 1-16, 2022具代表性; 任職中研院著作;
2022 E. Astani, S. M. Zadeh, N. S. Hsu, K. H. Lin, S. Sardari, T. L. Li*, Intermolecular Interactions of Nucleoside Antibiotic Tunicamycin with On-Target MraYcb-TUN and Off-Target DPAGT1-TUN in the Active Sites Delineated by Quantum Mechanics/Molecular Mechanics Calculations, ACS OMEGA, vol. 7(37), 32970-32987, 2022具代表性; 任職中研院著作;
2022 Z. C. Wang, I. W. Lo, K. H. Lin, A. N. Cheng, S. M. Zadeh, Y. H. Huang, T. L. Li*, Genetic and biochemical characterization of halogenation and drug-transportation genes encoded in the albofungin biosynthetic gene cluster, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 88(17):e0080622, 1-20, 2022具代表性; 任職中研院著作;
2022 I. W. Lo, G. Y. Liao, J. C. Lee, C. I. Chang, Y. C. Wu, S. P. Liu, H. J. Su, C. I. Liu, C. Y. Kuo, Z.Y. Lin, T. L. Li*, Y. S. Lin*, C. C. Liaw*, Novel Aporphine- and Proaporphine-Clerodane Hybrids Identified from the Barks of Taiwanese Polyalthia Longifolia var. pendula with Strong Anti-DENV2 Activity, PHARMACEUTICS, vol. 15(10), 1218, 1-15, 2022具代表性; 任職中研院著作;
2022 H. T. Huang, I. W. Lo, G. Y. Liao, Y. C. Lin, Y. C. Shen, H. C. Huang, T. L. Li, K. T. Lee, Y. H. Kuo*, C. C. Liaw*, Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley, FRONTIERS IN CHEMISTRY, vol. 10:1003356, 1-13, 2022任職中研院著作;
2021 T. S. A. Wang*, R. Y. Wu, Y. Hong, Z. C. Wang, T. L. Li, J. J. Shie, C. C. Hsu, Labeling and characterization of phenol‐containing glycopeptides using chemoselective probes with isotope tags, CHEMBIOCHEM, vol. 22(14), 2415-2419, 2021任職中研院著作;
2021 B. R. Chen, K. T. Hsu, W. H. Hsu, B. H. Lee, T. L. Li, Y. L. Chan, C. J. Wu*, Immunomodulation and mechanisms of fucoidan from Cladosiphon okamuranus ameliorates atopic dermatitis symptoms, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 189, 537-543, 2021任職中研院著作;
2021 B. R. Chen, K. T. Hsu, T. L. Li, Y. L. Chan, C. J. Wu*, Topical application of fucoidan derived from Cladosiphon okamuranus alleviates atopic dermatitis symptoms through immunomodulation, INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 101, 108362, 2021任職中研院著作;
2020 K. H. Lin, S. Y. Lyu, H. W. Yeh, Y. S. Li, N. S. Hsu, C. M. Huang, Y. L. Wang, H. W. Shih, Z. C. Wang, C. J. Wu, T. L. Li*, Structural and chemical trapping of short-lived flavin-oxide intermediates reveals substrate-directed reaction multiplicity, PROTEIN SCIENCE, vol. 29, 1655-1666, 2020具代表性; 任職中研院著作;
2020 K. Adhikari, I. W. Lo, C. L. Chen, Y. L. Wang, K. H. Lin, S. Malek Zadeh, R. Rattinam, Y. S. Li, C. J. Wu, T. L. Li*, Chemoenzymatic synthesis and biological evaluation for bioactive molecules derived from bacterial benzoyl coenzyme A ligase and plant type III polyketide synthase, BIOMOLECULES, vol. 10(5), 738, 2020具代表性; 任職中研院著作;
2020 S. Malek Zadeh, E. Astani, Z. C. Wang, K. Adhikari, R. Rattinam, T. L. Li*, Theoretical study of intermolecular interactions between critical residues of membrane protein MraYAA and Promising Antibiotic Muraymycin D2, ACS OMEGA, vol. 5(36), 22739–22749, 2020具代表性; 任職中研院著作;
2020 Y. M. Liu, T. H. Wu, Y. H. Chiu, H. Wang, T. L. Li, S. Hsia, Y. L. Chan*, C. J. Wu*, Positive effects of preventive nutrition supplement on anticancer radiotherapy in lung cancer bearing mice, CANCERS, vol. 12(9), 2445, 2020任職中研院著作;
2019 C. M. Huang, S. Y. Lyu, K. H. Lin, C. L. Chen, M. H. Chen, H. W. Shih, N. H. Hsu, I. W. Lo, Y. L. Wang, Y. S. Li, C. J. Wu, T. L. Li*, Teicoplanin reprogrammed with the N-Acyl-glucosamine pharmacophore at the penultimate residue of aglycone acquires broad-spectrum antimicrobial activities effectively killing gram-positive and -negative pathogens, ACS INFECTIOUS DISEASES, vol. 5(3), 430-442, 2019具代表性; 任職中研院著作;
2019 H. W. Yeh, K. H. Lin, S. Y. Lyu, Y. S. Li, C. M. Huang, Y. L. Wang, H. W. Shih, N. S. Hsu, C. J. Wu, T. L. Li*, Biochemical and structural explorations for alpha-hydroxyacid oxidases reveal a 4-electron oxidative decarboxylation reaction, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, vol. 75(Pt 8), 733–742, 2019具代表性; 任職中研院著作;
2019 S. Y. Lyu, K. H. Lin, H. W. Yeh, Y. S. Li, C. M. Huang, Y. L. Wang, H. W. Shih, N. S. Hsu, C. J. Wu, T. L. Li*, The flavin mononucleotide cofactor in α-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate oxidation level, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, vol. 75(10), 918-929, 2019具代表性; 任職中研院著作;
2019 Y. M. Liu, Y. L. Chan, T. H. Wu, T. L. Li, S. Hsia, Y. H. Chiu*, C. J. Wu*, Antitumor, inhibition of metastasis and radiosensitizing effects of total nutrition formula on Lewis tumor-bearing mice, NUTRIENTS, vol. 11(8), 1944, 2019任職中研院著作;
2019 T. H. Huang, T. H. Wu, Y. H. Guo, T. L. Li, Y. L. Chan, C. J. Wu*, The concurrent treatment of Scutellaria baicalensis Georgi enhances the therapeutic efficacy of cisplatin but also attenuates chemotherapy-induced cachexia and acute kidney injury, JOURNAL OF ETHNOPHARMACOLOGY, vol. 243, 112075, 2019任職中研院著作;
2019 T. H. Wu, K. Y. Yeh, C. H. Wang, H. Wang, T. L. Li, Y. L. Chan, C. J. Wu*, The combination of Astragalus membranaceus and Angelica sinensis inhibits lung cancer and cachexia through its immunomodulatory function, JOURNAL OF ONCOLOGY, vol. 2019, 9206951, 2019任職中研院著作;
2018 N. S. Hsu, Y. L. Wang, K. H. Lin, C. F. Chang, S. Y. Lyu, L. J. Hsu, Y. C. Liu, C. Y. Chang, C. J. Wu, T. L. Li*, The mesomeric effect of thiazolium on non-Kekule diradicals in Pichia stipitis transketolase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 57(7), 1802-1807, 2018具代表性; 任職中研院著作;
2018 N. S. Hsu, Y. L. Wang, K. H. Lin, C. F. Chang, S. C. Ke, S. Y. Lyu, L. J. Hsu, Y. S. Li, S. C. Chen, K. C. Wang, T. L. Li*, Evidence of diradicals involved in the yeast transketolase catalyzed keto-transferring reactions, CHEMBIOCHEM, vol. 19(22), 2395-2402, 2018具代表性; 任職中研院著作;
2017 Y. W. Chen, C. H. Lee, Y. L. Wang, T. L. Li, H. C. Chang*, Nanodiamonds as nucleating agents for protein crystallization, LANGMUIR, vol. 33(26), 6521-6527, 2017任職中研院著作;
2016 H. J. Chai, C. J. Wu, S. H. Yang, T. L. Li, P. B. Sun*, Peptides from hydrolysate of lantern fish (Benthosema pterotum) proved neuroprotective in vitro and in vivo, JOURNAL OF FUNCTIONAL FOODS, vol. 24, 438-449, 2016任職中研院著作;
2016 L. J. Hsu, N. S. Hsu, Y. L. Wang, C. J. Wu, T. L. Li*, Structural and biochemical interrogation on transketolase from Pichia stipitis for new functionality, PROTEIN ENGINEERING DESIGN & SELECTION, vol. 29(11), 513-522, 2016具代表性; 任職中研院著作;
2015 H. Wang, T. L. Li, S. Hsia, I. L. Su, Y. L. Chan*, C. J. Wu*, Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium, ONCOTARGET, vol. 6(10), 7758-7773, 2015任職中研院著作;
2015 T. H. Huang, Y. H. Chiu, Y. L. Chan, Y. H. Chiu, H. Wang, K. C. Huang, T. L. Li, K. H. Hsu*, C. J. Wu*, Prophylactic administration of fucoidan represses cancer metastasis by inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in Lewis tumor-bearing mice, MARINE DRUGS, vol. 13, 1882-1900, 2015任職中研院著作;
2015 Y. C. Liu, Y. S. Li, S. Y. Lyu, L. J. Hsu, Y. H. Chen, Y. T. Huang, H. C. Chan, C. J. Huang, G. H. Chen, C. C. Chou, M. D. Tsai, T. L. Li*, Addendum: Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds, NATURE CHEMICAL BIOLOGY, vol. 11(5), 361-361, 2015任職中研院著作;
2015 T. H. Huang, Y. H. Chiu, Y. L. Chan, H. Wang, T. L. Li, Y. Chu, C. Y. Liu, C. T. Yang, T. Y. Lee, J. S. You, K. H. Hsu, C. J. Wu*, Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice, ONCOTARGET, vol. 6(28), 25741-25754, 2015任職中研院著作;
2014 C. Y. Chang, S. Y. Lyu, Y. C. Liu, N. S. Hsu, C. C. Wu, C. F. Tang, K. H. Lin, J. Y. Ho, C. J. Wu, M. D. Tsai, T. L. Li*, Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 53(7), 1943-1948, 2014具代表性; 任職中研院著作;
2014 K. C. Wang, S. Y. Lyu, Y. C. Liu, C. Y. Chang, C. J. Wu, T. L. Li*, Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple-reaction complexes, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, vol. 70(5), 1401-1410, 2014具代表性; 任職中研院著作;
2014 X. W. Zou, Y. C. Liu, N. S. Hsu, C. J. Huang, S. Y. Lyu, H. C. Chan, C. Y. Chang, H. W. Yeh, K. H. Lin, C. J. Wu, M. D. Tsai, T. L. Li*, Structure and mechanism of a non-heme iron-SAM dependent C-methyltransferase and its engineering to hydratase and O-methyltransferase, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, vol. 70(6), 1549-1560, 2014具代表性; 任職中研院著作;
2014 S. Y. Lyu, Y. C. Liu, C. Y. Chang, C. J. Huang, Y. H. Chiu, C. M. Huang, N. S. Hsu, K. H. Lin, C. J. Wu, M. D. Tsai, T. L. Li*, Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics effectively killing vancomycin-resistant Enterococcus, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136(31), 10989-10995, 2014具代表性; 任職中研院著作;
2013 H. Wang, Y. L. Chan, T. L. Li, B. A. Bauer, S. Hsia, C. H. Wang, J. S. Huang, H. M. Wang, K. Y. Yeh, T. H. Huang, C. J. Wu*, Reduction of splenic immunosuppressive cells and enhancement of anti-tumor immunity by synergy of fish oil and selenium yeast, PLOS ONE, vol. 8(1), e52912, 2013任職中研院著作;
2013 C. J. Chai, Y. L. Chan, T. L. Li, Y. K. Tsai, C. H. Wu, C. Y. Shiaua, C. J. Wu*, Evaluation of lanternfish (Benthosema pterotum) hydrolysates as antioxidants against hydrogen peroxide induced oxidative injury, FOOD RESEARCH INTERNATIONAL, vol. 54(2), 1409-1418, 2013任職中研院著作;
2012 Y. H. Chiu, Y. L. Chan, L. W. Tsai, T. L. Li, C. J. Wu*, Prevention of human enterovirus 71 infection by carrageenan, ANTIVIRAL RESEARCH, vol. 95, 128-134, 2012任職中研院著作;
2012 Y. H. Chiu, Y. L. Chan, T. L. Li, C. J. Wu*, Inhibition of Japanese encephalitis virus infection by the sulfated polysaccharide extracts from Ulva lactuca, MARINE BIOTECHNOLOGY, vol. 14, 468-478, 2012任職中研院著作;
2012 H. Wang, Y. L. Chan, T. L. Li, C. J. Wu*, Improving cachectic symptoms and immune strength of tumor-bearing mice in chemotherapy by a combination of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang, EUROPEAN JOURNAL OF CANCER, vol. 48, 1074-1084, 2012任職中研院著作;
2012 H. J. Chai, Y. L. Chan, T. L. Li, C. H. Wu, Y. C. Chen, C. Y. Shiau, C. J. Wu*, Composition characterization of Myctophids (Benthosema pterotum): antioxidation and safety evaluations for Myctophids protein hydrolysates, FOOD RESEARCH INTERNATIONAL, vol. 46, 118-126, 2012任職中研院著作;
2012 S. H. Chen, D. R. Hwang, G. H. Chen, N. S. Hsu, Y. T. Wu, T. L. Li*, C. H. Wong*, Engineering transaldolase in Pichia stipitis to improve bioethanol production, ACS CHEMICAL BIOLOGY, vol. 7(3), 481-486, 2012具代表性; 任職中研院著作;
2012 T. L. Li*, Y. C. Liu, S. Y. Lyu, Combining biocatalysis and chemoselective chemistries for glycopeptide antibiotics modification, CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 16, 170-178, 2012具代表性; 任職中研院著作;
2012 H. C. Wu, Y. S. Li, Y. C. Liu, S. Y. Lyu, C. J. Wu, T. L. Li*, Chain elongation and cyclization in type III PKS DpgA, CHEMBIOCHEM, vol. 13(6), 862-871, 2012具代表性; 任職中研院著作;
2012 T. L. Lin, F. L. Yang, A. S. Yang, H. P. Peng, T. L. Li, M. D. Tsai, S. H. Wu, J. T. Wang*, Amino acid substitutions of MagA in Klebsiella pneumoniae affect the biosynthesis of the capsular polysaccharide, PLOS ONE, vol. 7(10), e46783, 2012任職中研院著作;
2011 H. C. Chan, Y. T. Huang, S. Y. Lyu, C. J. Huang, Y. S. Li, Y. C. Liu, C. C. Chou, M. D. Tsai, T. L. Li*, Regioselective deacetylation based on teicoplanin-complexed Orf2* crystal structures, MOLECULAR OMICS (MOLECULAR BIOSYSTEMS), vol. 7(4), 1224-1231, 2011具代表性; 任職中研院著作;
2011 C. J. Wu, H. Wang, Y. L. Chan, T. L. Li, Passive immune-protection of small abalone against Vibrio alginolyticus infection by anti-Vibrio IgY-encapsulated feed, FISH & SHELLFISH IMMUNOLOGY, vol. 30, 1042-1048, 2011任職中研院著作;
2011 Y. C. Liu, Y. S. Li, S. Y. Lyu, L. J. Hsu, Y. H. Chen, Y. T. Huang, H. C. Chan, C. J. Huang, G. H. Chen, C. C. Chou, M. D. Tsai, T. L. Li*, Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds, NATURE CHEMICAL BIOLOGY, vol. 7, 304-309, 2011具代表性; 任職中研院著作;
2011 H. Wang, Y. J. Lai, Y. L. Chan, T. L. Li, C. J. Wu*, Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia, CANCER LETTERS, vol. 305(1):40-49, 2011任職中研院著作;
2011 J. Y. Ho, T. L. Lin, A. Lee, A. N. Cheng, C. Y. Li, M. C. Chen, S. H. Wu, J. T. Wang*, T. L. Li*, M. D. Tsai*, Functions of some capsular polysaccharide biosynthetic genes in Klebsiella pneumoniae NTUH K-2044, PLOS ONE, vol. 6(7), e21664, 2011具代表性; 任職中研院著作;
2010 H. J. Chai, J. H. Li, H. N. Huang, T. L. Li, Y. L. Chan, C. Y. Shiau, C. J. Wu*, Effects of sizes and conformations of fish scale collagen peptides (FSCPs) on facial skin qualities and transdermal penetration efficiency, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, vol. 2010, 757301, 2010任職中研院著作;
2009 T. L. Li*, D. Spiteller, J. B. Spencer, Identification of a pentaketide stilbene produced by a type III polyketide synthase from Pinus sylvestris and characterisation of free coenzyme A intermediates, CHEMBIOCHEM, vol. 10, 896-901, 2009具代表性; 任職中研院著作;
2009 J. Y. Cheng, H. N. Huang, W. C. Tseng, T. L. Li, Y. L. Chan, K. C. Cheng, C. J. Wu*, Transcutaneous immunization by lipoplex-patch based DNA vaccines is effective vaccination against Japanese encephalitis virus infection, JOURNAL OF CONTROLLED RELEASE, vol. 135, 242-249, 2009任職中研院著作;
2009 H. N. Huang, T. L. Li, Y. L. Chan, C. L. Chen, C. J. Wu*, Transdermal immunization with low-pressure-gene-gun mediated chitosan-based DNA vaccines against Japanese encephalitis virus, BIOMATERIALS, vol. 30(30), 6017-6025, 2009任職中研院著作;
2009 Y. T. Huang, S. Y. Lyu, P. H. Chuang, N. S. Hsu, Y. S. Li, H. C. Chan, C. J. Huang, Y. C. Liu, C. J. Wu, W. B. Yang, T. L. Li*, In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-b-methylphenylalanine in glycopeptide antibiotic mannopeptimycin, CHEMBIOCHEM, vol. 10, 2480-2487, 2009具代表性; 任職中研院著作;
2007 Y. S. Li, J. Y. Ho, C. C. Huang, S. Y. Lyu, C. Y. Lee, Y. T. Huang, C. J. Wu, H. C. Chan, C. J. Huang, N. S. Hsu, M. D. Tsai, T. L. Li*, A unique flavin mononucleotide-linked primary alcohol oxidase for glycopeptide A40926 maturation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, 13384-13385, 2007具代表性; 任職中研院著作;
2006 F. Huang, S. F. Haydock, D. Spiteller, T. Mironenko, T. L. Li, P. F. Leadlay, D. O'Hagan, J. B. Spencer*, The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A., CELL CHEMICAL BIOLOGY (CHEMISTRY & BIOLOGY), vol. 13(5), 475-484, 2006任職中研院著作;
2006 J. Y. Ho, Y. T. Huang, C. J. Wu, Y. S. Li, M. D. Tsai, T. L. Li*, Glycopeptide Biosynthesis: Dbv21/Orf2* from dbv/tcp Gene Clusters Are N-Ac-Glm Teicoplanin Pseudoaglycone Deacetylases and Orf15 from cep Gene Cluster Is a Glc-1-P Thymidyltransferase, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128(42), 13694-13695, 2006具代表性; 任職中研院著作;
2006 C. J. Wu*, T. L. Li, H. W. Huang, Y. L. Chan, M. H. Tao, Development of an effective Japanese encephalitis virus-specific DNA vaccine, MICROBES AND INFECTION, vol. 8, 2578-2586, 2006任職中研院著作;
2004 T. L. Li, F. Huang, S. F. Haydock*, T. Mironenko, P. F. Leadlay, J. B. Spencer*, Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase, CELL CHEMICAL BIOLOGY (CHEMISTRY & BIOLOGY), vol. 11(1), 107-119, 2004具代表性;
2002 T. L. Li*, Y. J. Chung-Wang, Y. C. Shih, Determination and confirmation of chloramphenicol residues in swine muscle and liver, JOURNAL OF FOOD SCIENCE, vol. 67(1), 21-28, 2002具代表性;
2001 W. C. Lee, T. L. Li*, P. C. Chang, S. S. Chou, High performance liquid chromatographic determination of maleic hydrazide residue in potatoes, JOURNAL OF FOOD AND DRUG ANALYSIS, vol. 9(3), 167-172, 2001
2001 T. L. Li, W. C. Lee*, P. C. Chang, S. S. Chou, High performance chromatographic determination of asulam residue in agricultural products, JOURNAL OF FOOD AND DRUG ANALYSIS, vol. 9 (1), 40-44, 2001
2001 T. L. Li, O. W. Choroba, E. H. Charles, A. M. Sandercock, D. H. Williams, J. B. Spencer*, Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics, CHEMICAL COMMUNICATIONS, vol. -18, 1752-1753, 2001具代表性;
2001 T. L. Li, O. W. Choroba, H. Hong, D. H. Williams, J. B. Spencer*, Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine, CHEMICAL COMMUNICATIONS, vol. 20, 2156-2157, 2001具代表性;
2000 T. L. Li, J. M. King, Y. B. Min*, Quenching mechanisms and kinetics of carotenoids in riboflavin photosensitized singlet oxygen oxidation of vitamin D-2, JOURNAL OF FOOD BIOCHEMISTRY, vol. 24 (6), 477-492, 2000具代表性;
1998 W. C. Lee, T. L. Li*, W. J. Cheng, P. C. Chang, S. S. Chou, Survey of nicotine and tar yields of domestic and imported cigarettes, JOURNAL OF FOOD AND DRUG ANALYSIS, vol. 6 (4), 691-701, 1998具代表性;
1998 T. L. Li*, D. B. Min*, Stability and photochemistry of vitamin D-2 in model system, JOURNAL OF FOOD SCIENCE, vol. 63 (3), 413-417, 1998具代表性;
1998 D. B. Min*, T. L. Li, H. O. Lee, Effects of processing steps on the contents of minor compounds and oxidation of soybean oil, ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 434, 161-180, 1998

Li TL Research highlight2023
N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry


Li TL Research highlight
 Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds

  1. Overcoming resistance (The Scientist)
  2. Dbv29 translation (SciBX) 
  3. Building a better germ-killer (A-IMBN) 
  4. 抗生素興亡史 (科學人第112期2011年6月號) 
  5. 李宗璘博士研究團隊以調整酵素方式成功增強現有抗生素藥效 (中央研究院 院新聞稿) 
  6. 巧手調整酵素,李宗璘實驗室以綠化學解除抗藥性窘境 (中央研究院基因體研究中心 新聞) 
  7. 醣胜肽類抗生素生合成酵素之探討 (中央研究院 週報第1125期 知識天地) 
  8. 功能基因體研究群發現關鍵酵素,可解決抗生素失效困境 (中央研究院基因體研究中心 新聞)
  9. 轉酮酶解密 發現前所未見的雙自由基中間體 (中央研究院基因體研究中心 新聞)
  10. 大自然為師 解鎖酵素StnK3翻轉生物合成路徑 (中央研究院基因體研究中心 新聞)
  11. 首揭酵素利用蛋白質與受質間氮氧硫鍵橋化學–氨基糖苷類抗生素逆轉勝 (中央研究院基因體研究中心 新聞)