具代表性研究發表

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年度 論文名稱
2006 A. Brik, S. Ficht, C.-H. Wong, Strategies for the Preparation of Homogenous Glycoproteins, CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 10(6):638-644., 2006
2006 M.F.Cheng, H.M.Yu, B.W.Ko, Y.Chang, T.I. Ho, Y.M.Tsai.and J.M.Fang, Practical synthesis of potential endothelin receptor antagonists of 1,4-Benzodiazepine-2,5-dione derivatives bearing substituent at the C3-, N1-, and N4-postions, ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 4, 510-518, 2006
2006 Sawa M, Hsu TL, Itoh T, Sugiyama M, Hanson SR, Vogt PK, Wong CH, Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo., Proceedings of the National Academy of Sciences of the United States of America, vol. 103(33), 12371-12376, 2006
2006 Chang CF, Chou HT, Lin YJ, Lee SJ, Chuang JL, Chuang DT, Huang TH, Structure of the subunit binding domain and dynamics of the di-domain region from the core of human branched chain alpha-ketoacid dehydrogenase complex., The Journal of biological chemistry, vol. 281(38), 28345-53, 2006
2006 K. P. Wu, J. M. Chang, J. B. Chen, (C. F. Chang, W. J. Wu, T. H. Huang, T. Y. Sung, W. L. Hsu, RIBRA - An Error-Tolerant Algorithm for the NMR Backbone Assignment Problem, J Comput Biol, vol. 13, 229-244, 2006
2006 C. F. Chang)*, F. K. Shi, Y. Y. Wu, Introduction of Recent Advance in NMR Technology and Application, Instrument Today, vol. 27, 61-67, 2006
2006 K. W. Hung, Y. C. Lin, C. C. Cheng, P. J. Fang, (C. F. Chang, S. F. Tasi, T. H. Huang, Resonance assignments of a CoA binding protein from Klebsiella pneumoniae, J Biomol NMR, vol. 36 Suppl 1, 74, 2006
2006 Chen CJ, (Yang HI, Su J, Jen CL, You SL, Lu SN, Huang GT, Iloeje UH, Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level., JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 295(1), 65-73, 2006
2006 Iloeje UH, (Yang HI, Su J, Jen CL, You SL, Chen CJ, Predicting cirrhosis risk based on the level of circulating hepatitis B viral load., GASTROENTEROLOGY, vol. 130(3), 678-686, 2006
2006 S.-T. Tsai, C.-W. Chen, L.-C. Huang, M.-C. Huang, C.-H. Chen, Y.-S. Wang, Simultaneous mass analysis of positive and negative ions using a dual-polarity time-of-flight mass spectrometer, Analytical Chemistry, vol. 78 (22), 7729-7734., 2006
2006 K.I Lin*, Y.Y. Kao, H.K. Kuo, W.B. Yang, A Chou, H.H. Lin, A.L. Yu, C.H.Wong, Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor blimp-1, J. Biol. Chem, vol. 281, 24111-24123, 2006
2006 F. Huang, S. F. Haydock, D. Spiteller, T. Mironenko, T. L. Li, P. F. Leadlay, D. O'Hagan, J. B. Spencer*, The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A., CELL CHEMICAL BIOLOGY (CHEMISTRY & BIOLOGY), vol. 13(5), 475-484, 2006
2006 J. Y. Ho, Y. T. Huang, C. J. Wu, Y. S. Li, M. D. Tsai, T. L. Li*, Glycopeptide Biosynthesis: Dbv21/Orf2* from dbv/tcp Gene Clusters Are N-Ac-Glm Teicoplanin Pseudoaglycone Deacetylases and Orf15 from cep Gene Cluster Is a Glc-1-P Thymidyltransferase, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128(42), 13694-13695, 2006
2006 C. J. Wu*, T. L. Li, H. W. Huang, Y. L. Chan, M. H. Tao, Development of an effective Japanese encephalitis virus-specific DNA vaccine, MICROBES AND INFECTION, vol. 8, 2578-2586, 2006
2006 Chiou SH, Yang YP, Lin JC, Hsu CH, Jhang HC, Yang YT, Lee CH, Ho LL, Hsu WM, Ku HH, Chen SJ, Chen SS, Chang MD, Wu CW*, (Juan LJ)*, The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression., Journal of immunology (Baltimore, Md. : 1950), vol. 177(9), 6199-206, 2006
2006 F. C. Chen, T. J. Chuang*, The effects of multiple features of alternatively spliced exons on the Ka/Ks ratio test, BMC Bioinformatics, vol. 7, 259, 2006
2006 F. C. Chen, C. J. Chen, J. Y. Ho, T. J. Chuang*, Identification and evolutionary analysis of novel exons and alternative splicing events using cross-species EST-to-genome comparisons in human, mouse and rat, BMC Bioinformatics, vol. 7, 136, 2006
2006 F. C. Chen, S. S. Wang, C. J. Chen, W. H. Li, T. J. Chuang*, Alternatively and Constitutively Spliced Exons Are Subject to Different Evolutionary Forces, Mol Biol Evol, vol. 23, 675-682 (impact factor: 10.353; ranking: 14/290: BIOCHEMISTRY & MOLECULAR BIOLOGY), 2006
2006 L. C. Hwang, C. H. Bai, C. J. Chen, Prevalence of obesity and metabolic syndrome in Taiwan, J Formos Med Assoc, vol. 105, 626-635, 2006
2006 Y. C. Chien, C. F. Jan, H. S. Kuo, C. J. Chen, Nationwide hepatitis B vaccination program in Taiwan: Effectiveness in 20 years after it was launched, Epidemiol Rev, vol. 28, 126-135, 2006
2005 Jun Li, Ying-Chih Chang*, Preparation of End-Grafted Polymer Brushes by Nitroxide-Mediated Free Radical Polymerization of Vaporized Vinyl Monomers, LANGMUIR, vol. 21, 9562-9567, 2005
2005 L. R. Chen, Y. C. Wang, Y. W. Lin, S. Y. Chou, S. F. Chen, L. T. Liu, C. J. Kuo, T. S. Chen, S. H. Juang, Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors, Bioorg Med Chem Lett, vol. 15, 3058-3062, 2005
2005 J. J. Shie, J. M. Fang, T.H. Kuo, C. J. Kuo, P. H. Liang, H. J. Huang, J.T. Jan, Y. S. Cheng, C. H. Wong, Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, 5240-5252, 2005
2005 Shie, J. J., Fang, J. M., Kuo, C. J., Kuo, T. H., Liang, P. H., Huang, H. J., Yang, W. B., Lin, C. H., Chen, J. L., Wu, Y. T., Wong, C. H., Discovery of Potent Anilide Inhibitors against the Severe Acute Respiratory Syndrome 3CL Protease., J Med Chem, vol. 48(13), 4469-4473, 2005
2005 Chun-Ping Lu, Yi-Ning Lai, S.-H. Wu, Wei-Man Wang, Jean-Yin Chen, Lee-Chiang Lo, Design of a Mechanism-Based Probe for Neuraminidase to Capture Influenza Viruses, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 44, 6888-6892, 2005
2005 An-Tai Wu, Yi-Ping Yu, Wei Zou, S.-H. Wu, 9-O-Sulfation on α-NeuAc-(2-8)-NeuAc and inter-residue lactonization, CARBOHYDRATE RESEARCH, vol. 340, 1219-1223, 2005
2005 Chen AY, Shih SJ, Garriques LN, Rothenberg ML, (Hsiao M, Curran DP, Silatecan DB-67 is a novel DNA topoisomerase I-targeted radiation sensitizer, Mol Cancer Ther, vol. 4, 317-324. Cite 10, 2005
2005 C. Y. Wu, A. Brik, S. K. Wang, Y. H. Chen, C. H. Wong, Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ, Chembiochem, vol. 6, 2176-2180, 2005
2005 Brik, A., Wu, C. Y., Best, M. D., Wong, C. H., Tetrabutylammonium fluoride-assisted rapid N(9)-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ., Bioorganic & medicinal chemistry, vol. 13(15), 4622-4626, 2005
2005 G. T. Fan, Y. S. Pan. K. C. Lu, Y. P. Cheng, W. C. Lin, S. Lin, S. H. Lin, C. H. Wong, J. M. Fang, C. C. Lin Wong, C. H., Fang, J. M., C. C. Lin, Synthesis of alpha-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes., Tetrahedron, vol. 61, 1855-1862, 2005