化學生物學研究領域 2022


Chen, Yun-Ru Ruby

  • Jin-Lin Wu and Yun-Ru Chen*, 2022, “Signal peptide stabilizes folding and inhibits misfolding of serum amyloid A”, PROTEIN SCIENCE, 31(12), e4485. (SCIE)
  • Ming-Che Lee‡, Yi-Hung Liao‡, Shih-Hui Chen, and Yun-Ru Chen*., 2022, “Amyloid-β E22K Fibril in Familial Alzheimer’s Disease is More Thermo-stable and Susceptible to Seeding.”, IUBMB LIFE, 74(8), 739-747. (SCIE)
  • Wan-Chin Chiang§, Yu-Sheng Fang§, Yuh-Shen Lye, Tzu-Yu Wong, Kiruthika Ganesan, Shih-Chieh Chou, Yun-Ru Chen*, 2022, “Hyperphosphorylation-mimetic TDP-43 Drives Amyloid Formation and Possesses Neuronal Toxicity at the Oligomeric Stage”, ACS Chemical Neuroscience, 37, 1,, 2599-2612. (SCIE)
  • Jin-Lin Wu, Tung-Hung Su, Pei-Jer Chen, and Yun-Ru Chen*, 2022, “Acute‑phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level”, Scientific Reports, 12, 5799. (SCIE)
  • Yuh Shen Lye and Yun-Ru Chen*, 2022, “TAR DNA-binding protein 43 oligomers in physiology and pathology”, IUBMB LIFE, 2022, 1-18. (SCIE)

Cheng, Wei-Chieh

  • Tseng YY, Liou JM, Cheng WC, Hsu JT, Hsu TL, Wu MS, Wong CH, 2022, “Combating multidrug-resistant Helicobacter pylori with moenomycin A in combination with clarithromycin or metronidazole.”, Frontiers in chemistry, 10, 897578. (SCIE)
  • Chen Wei-An, Chen Yu-Hsin, Hsieh Chiao-Yun, Hung Pi-Fang, Chen Chiao-Wen, Chen Chien-Hung, Lin Jung-Lee, Cheng Ting-Jen R., Hsu Tsui-Ling, Wu Ying-Ta, Shen Chia-Ning, Cheng Wei-Chieh, 2022, “Harnessing natural-product-inspired combinatorial chemistry and computation-guided synthesis to develop <i>N</i>-glycan modulators as anticancer agents”, Chemical Science, 13, 6233-6243. (SCIE)
  • Guo CW, Chen KT, You TY, Lin CC, Cheng WC, 2022, “Synthesis and Evaluation of Diverse N-Substituted Disaccharide Dipeptides for Human NOD2 Stimulation Activity.”, Chemistry, an Asian journal, 17(4), e202101169.
  • Chen WA, Li HY, Sayyad A, Huang CY, Cheng WC, 2022, “Synthesis of Nitrone-derived Pyrrolidine Scaffolds and Their Combinatorial Libraries to Develop Selective alpha-l-Rhamnosidase Inhibitors.”, Chemistry, an Asian journal, 17(14), e202200172.
  • Lee Hua-Yun, Chiang Po-Yu, Wu Hsi-Ju, Wang Ting-Yi, Yang Tzu-Ching, Cheng Wei-Chieh, Lo Lee-Chiang, Liao Wei-Ssu, 2022, “Versatile Azido-Functionalized Carbon Dots for Cancer Cell Imaging”, ACS Applied Nano Materials, 5(9), 12374-12379. (SCIE)

Hung, Shang-Cheng

  • Lu Tsung-Han, Chiang Nai-Jung, Tsai Yi-Cheng, Gopinathan Priya, Huang Chien-Jui, Chang Jui-Lin, Tu Hsiu-Chi, Shan Yan-Shen, Hung Shang-Cheng, Lee Gwo-Bin, 2022, “An integrated microfluidic system for cholangiocarcinoma diagnosis from bile by using specific affinity probes”, Sensors and Actuators B: Chemical, 373, 132724.
  • Teng KC, Tseng KY, Tzeng ZH, Hung SC, 2022, “A concise synthesis of L-gulose and its C-6 derivatives.”, Bioorganic & Medicinal Chemistry, 73, 117029. (SCIE)
  • Byung-sun Jeon, Teng-Yi Huang, Mark W. Ruszczycky, Sei-hyun Choi, Namho Kim, Joseph Livy Franklin, Shang-Cheng Hung*, Hung-wen Liu*, 2022, “Byproduct formation during the biosynthesis of spinosyn A and evidence for an enzymatic interplay to prevent its formation”, TETRAHEDRON, 103, 132569. (SCIE)
  • Tseng KY, Tzeng ZH, Cheng TR, Liang PH, Hung SC, 2022, “Design and Synthesis of 1-O- and 6\'-C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 Inhibitors.”, Frontiers in Chemistry, 10, 947475. (SCIE)
  • Wang Chih-Hung, Chang Jia-Ru, Hung Shang-Cheng, Dou Horng-Yunn, Lee Gwo-Bin, 2022, “Rapid molecular diagnosis of live Mycobacterium tuberculosis on an integrated microfluidic system”, Sensors and Actuators B: Chemical, 12(1), 10790.
  • Liew CY, Hsu HC, Nguan HS, Huang YC, Zhong YQ, Hung SC, Ni CK, 2022, “The Good, the Bad, and the Ugly Memories of Carbohydrate Fragments in Collision-Induced Dissociation.”, Journal of the American Society for Mass Spectrometry, 33(10), 1891-1903. (SCIE)
  • Weng WC, Liao HE, Huang SP, Tsai ST, Hsu HC, Liew CY, Gannedi V, Hung SC, Ni CK, 2022, “Unusual free oligosaccharides in human bovine and caprine milk.”, Scientific Reports, 12(1), 10790. (SCIE)

Li, Tsung-Lin

  • H. T. Huang, I. W. Lo, G. Y. Liao, Y. C. Lin, Y. C. Shen, H. C. Huang, T. L. Li, K. T. Lee, Y. H. Kuo*, C. C. Liaw*, 2022, “Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley”, FRONTIERS IN CHEMISTRY, 10:1003356, 1-13. (SCIE)
  • I. W. Lo, G. Y. Liao, J. C. Lee, C. I. Chang, Y. C. Wu, S. P. Liu, H. J. Su, C. I. Liu, C. Y. Kuo, Z.Y. Lin, T. L. Li*, Y. S. Lin*, C. C. Liaw*, 2022, “Novel Aporphine- and Proaporphine-Clerodane Hybrids Identified from the Barks of Taiwanese Polyalthia Longifolia var. pendula with Strong Anti-DENV2 Activity”, PHARMACEUTICS, 15(10), 1218, 1-15. (SCIE)
  • Z. C. Wang, I. W. Lo, K. H. Lin, A. N. Cheng, S. M. Zadeh, Y. H. Huang, T. L. Li*, 2022, “Genetic and biochemical characterization of halogenation and drug-transportation genes encoded in the albofungin biosynthetic gene cluster”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 88(17):e0080622, 1-20. (SCIE)
  • E. Astani, S. M. Zadeh, N. S. Hsu, K. H. Lin, S. Sardari, T. L. Li*, 2022, “Intermolecular Interactions of Nucleoside Antibiotic Tunicamycin with On-Target MraYcb-TUN and Off-Target DPAGT1-TUN in the Active Sites Delineated by Quantum Mechanics/Molecular Mechanics Calculations”, ACS OMEGA, 7(37), 32970-32987. (SCIE)
  • 李宗璘,2022,〈生物技術的工具〉,楊盛行,林世斌編,《新編食品生物技術 2nd》,頁2-1~2-44,台中:華格那。
  • S. M. Zadeh, M. H. Chen, Z. C. Wang, E. K. Astani, I. W. Lo, K. H. Lin, N. S. Hsu, K. Adhikari, S. Y. Lyu, H. Y. Tsai, Y. Terasawa, M. Yabe, K. Yamamoto, S. Ichikawa, T. L. Li*, 2022, “β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin”, COMMUNICATIONS CHEMISTRY, 5, 87, 1-16. (SCIE)
  • C. C. Liaw, I. W. Lo, Y. C. Lin, H. T. Huang, L. J. Zhang, P. C. Hsiao, T. L. Li,* Y. H. Kuo*, 2022, “Four cucurbitane glycosides taimordisins A–D with novel furopyranone skeletons isolated from the fruits of Momordica charantia”, FOOD CHEMISTRY: X, 14, 100286. (SCIE)
  • Y. C. Pan, Y. L. Wang, S. I. Toh, N. S. Hsu, K. H. Lin, Z. Xu, S. C. Huang, T. K. Wu, T. L. Li, C. Y. Chang*, 2022, “Dual-mechanism confers self-resistance to the antituberculosis antibiotic capreomycin”, ACS CHEMICAL BIOLOGY, 17(1), 138-146. (SCIE)
  • B. R. Chen, W. M. Li, T. L. Li , Y. L. Chan, C. J. Wu*, 2022, “Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori”, SCIENTIFIC REPORTS, 12(1), 429. (SCIE)
  • R. Rattinam, R. S. Basha, Y. L. Wang, Z. C. Wang, N. S. Hsu, K. H. Lin, S. Malek Zadeh, K. Adhikari, J. P. Lin, T. L. Li*, 2022, “KasQ an epimerase primes the biosynthesis of aminoglycoside antibiotic kasugamycin and KasF/H acetyltransferases inactivate its activity”, BIOMEDICINES, 10(2), 212. (SCIE)
  • M. H. Chen, Y. S. Li, N. S. Hsu, K. H. Lin, Y. L. Wang, Z. C. Wang, C. F. Chang, J. P. Lin, C. Y. Chang, T. L. Li*, 2022, “Structural and mechanistic bases for StnK3 and its mutants-mediated Lewis-acid-dependent epimerization and retro aldol reactions”, ACS CATALYSIS, 12, 1945-1956. (SCIE)

Ma, Che Alex

  • T Yong, KK Chang, YS Wang and C Ma*, 2022, “Active humoral response reverts tumorigenicity through disruption of key signaling pathway”, Vaccines, 10, 163. (SCIE)
  • Daniell H, Nair SK, Guan H, Guo Y, Kulchar RJ, Torres MDT, Shahed-Al-Mahmud M, Wakade G, Liu YM, Marques AD, Graham-Wooten J, Zhou W, Wang P, Molugu SK, de Araujo WR, de la Fuente-Nunez C, Ma C, Short WR, Tebas P, Margulies KB, Bushman FD, Mante FK, Ricciardi RP, Collman RG, Wolff MS, 2022, “Debulking different Corona (SARS-CoV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmission.”, Biomaterials, 288, 121671. (SCIE)
  • Wu CY, Cheng CW, Kung CC, Liao KS, Jan JT, Ma C, Wong CH*, 2022, “Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine.”, Proceedings of the National Academy of Sciences of the United States of America, 119(9), e2119995119. (SCIE)
  • Lee WH, Chen X, Liu IJ, Lee JH, Hu CM, Wu HC, Wang SK, Lee WH, Ma C*, 2022, “Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation”, Cell Reports, 41(4), 111555. (SCIE)
  • KYA Huang, D Zhou, TK Tan, C Chen, HME Duyvesteyn, Y Zhao, HM Ginn, L Qin, P Rijal, L Schimanski, R Donat, A Harding, J Gilbert-Jaramillo, W James, JA Tree, K Buttigieg, M Carroll, S Charlton, CE Lien, MY Lin, CP Chen, SH Cheng, X Chen, TY Lin, EE Fry, J Ren, C Ma, AR Townsend, DI Stuart, 2022, “Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2”, Theranostics, 12, 1-17. (SCIE)
  • HY Huang, HY Liao, X Chen, SW Wang, CW Cheng, M Shahed-Al-Mahmud, YM Liu, A Mohapatra, TH Chen, JM Lo, YM Wu, HH Ma, YH Chang, HY Tsai, YC Chou, YP Hsueh, CY Tsai, PY Huang, SY Chang, TL Chao, HC Kao, YM Tsai, YH Chen, CY Wu, JT Jan, TJR Cheng, KI Lin*, C Ma* and CH Wong*, 2022, “Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models”, Science Translational Medicine, 14, eabm0899. (SCIE)

Wong, Chi-Huey

  • Y.-Y. Tseng, J.-M. Liou, W.-C. Cheng, J.-T. Hsu, T.-L. Hsu, M.-S. Wu, C.-H. Wong, 2022, “Combating multidrug-resistant Helicobacter pylori with moenomycin A in combination with clarithromycin or metronidazole.”, Frontiers in chemistry, 10, 897578. (SCIE)
  • K. Uchimura, K. Nishitsuji, L.-T. Chiu, T. Ohgita, H. Saito, F. Allain, V. Gannedi, C.-H. Wong, S.-C. Hung, 2022, “Design and Synthesis of 6-O-Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid beta Aggregation.”, Chembiochem : a European journal of chemical biology, Epub ahead of print, e202200191. (SCIE)
  • S. S. Shivatare, V. S. Shivatare and C.-H. Wong, 2022, “Glycoconjugates: Synthesis, Functional Studies, and Therapeutic Developments.”, Chemical reviews, 122(20), 15603-15671. (SCIE)
  • C.-Y. Wu, C.-W. Cheng, C.-C. Kung, K.-S. Liao, J.-T. Jan, C. Ma, C.-H. Wong*, 2022, “Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine.”, Proceedings of the National Academy of Sciences of the United States of America, 119(9), e2119995119. (SCIE)
  • C.-Y. Chen, Y.-W. Lin, S.-W. Wang, Y.-C. Lin, Y.-Y. Cheng, C.-T. Ren, C.-H. Wong, and C.-Y. Wu, 2022, “Synthesis of Azido-Globo H Analogs for Immunogenicity Evaluation.”, ACS central science, 8(1), 77-85. (SCIE)
  • H.-Y. Huang, H.-Y. Liao, X. Chen, C.-W. Cheng, S.-W. Wang, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, H.-H. Ma, Y.-H. Chang, C.-Y. Tsai, P.-Y. Huang, S.-Y. Chang, T.-L. Chao, H.-C. Kao, Y.-M. Tsai, Y.-H. Chen, C.-Y. Chen, K.-C. Lee, C.-Y. Wu, J.-T. Jan, T.-J. R. Cheng, K.-I. Lin*, C. Ma*, and C.-H. Wong*, 2022, “Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models.”, Science translational medicine, 14(639), eabm0899. (SCIE)