翁啟惠博士
姓名 翁啟惠博士
現任 合聘特聘研究員 (與美國加州Scripps研究院合聘)
所屬單位

Ph.D. in Chemistry, MIT, 1979-1982
名片
研究方向/領域

研究方向/領域

Chemical Biology and Drug Discovery

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Current interest is centered on the development of discovery tools for understanding the role of biological glycosylation in cancer progression, bacterial and viral infection, neurodegenerative disorder and immune response. Programmable one-pot synthesis as well as chemo-enzymatic synthesis of oligosaccharides and homogeneous glycoproteins, and design of glycan microarrays and glycosylation probes are among the tools being developed for the study of cell-surface glycoconjugates. The ultimate goal of our research is to identify novel glycan targets for therapeutic development, including the AI-assisted development of carbohydrate-based vaccines, homogeneous antibodies with optimized effector functions, and inhibitors of key enzymes involved in the biosynthesis of glycan targets.

這是一張圖片

我們的研究工作主要著重於化學生物及新藥研發。從瞭解致病基因的功能及機制去設計並合成分子來進一步研究其與標的物的作用,進而研發出新的檢測方法及新 藥。目前重點放在瞭解醣分子在細胞表面所扮演的角色,醣蛋白合成方法的發展,醣晶片的設計與應用,及酵素抑制劑的設計與合成。希望將來能發展新的藥物以供 抗癌、抗病毒與抗細菌的研究。

經歷
  • 2019-present Scripps Family Chair Professor, Department of Chemistry, The Scripps Research Institute, La Jolla, California
  • 2006-2016 President, Academia Sinica, Taipei, Taiwan
  • 2003-2006 Director, The Genomics Research Center, Academia Sinica, Taipei, Taiwan
  • 2003-present Distinguished Professor, Genomics Research Center, Academia Sinica, Taipei, Taiwan
  • 1991-1999 Head, Frontier Research Program on Glycotechnology, Institute of Physical and Chemical Research (RIKEN), Japan
  • 1996-2006 Member, The Skaggs Institute for Chemical Biology, The Scripps Research Institute
  • 1989-2006 Professor and Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute
  • 1983-1989 Assistant Professor through Professor of Chemistry, Texas A&M University
  • 1982-1983 Postdoctoral Fellow, Harvard University
榮譽
  • 2025 Bio Asia Award
  • 2022 Tetrahedron Prize for Creativity in Organic Synthesis
  • 2021 Welch Award in Chemistry
  • 2015 The Royal Society of Chemistry Robert Robinson Award, UK
  • 2014 Elected Fellow of the U.S. National Academy of Inventors
  • 2014 The Wolf Prize in Chemistry
  • 2012 Nikkei Asia Prize for Science, Technology and Innovation
  • 2012 The American Chemical Society Arthur C. Cope Award
  • 2012 The American Chemical Society Arthur C. Cope Award
  • 2010 Elected Associate Member of the European Molecular Biology Organization (EMBO)
  • 1993-2010 Editor-in-Chief, Bioorganic & Medicinal Chemistry
  • 2008 The F. A. Cotton Medal for Excellence in Chemical Research
  • 2005 American Chemical Society Award for Creative Work in Synthetic Organic Chemistry
  • 2002 Elected Member of the National Academy of Sciences, USA
  • 2000 Presidential Green Chemistry Award, USA
  • 1999 The International Enzyme Engineering Award
  • 1999 American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry
  • 1998 American Chemical Society Harrison Howe Award in Chemistry
  • 1996 Elected Member of the American Academy of Arts and Sciences
  • 1994 Elected Member of Academia Sinica, Taipei
  • 1994 The IUPAC International Carbohydrate Award
  • 1986 Presidential Young Investigator in Chemistry
  • 1985 Searle Scholar Award in Biomedical Sciences
年度 論文名稱
2025 Chuang PK, Chung C, Liao KS, (Wong CH)*, Improving the efficacy of anti-SSEA4 antibody in pancreatic cancer immunotherapy with glyco-optimization and immune checkpoint blockade., Proceedings of the National Academy of Sciences of the United States of America, vol. 122(38), e2517415122, 2025任職中研院著作;
2025 J. M. Lo, C.-C. Kung, T.-J., C.-H. Wong, C. Ma, Structure-Based Mechanism and Specificity of Human Galactosyltransferase β3GalT5, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 147, 10875-10885, 2025具代表性; 任職中研院著作;
2025 C.-C. Kung, J. Lo, K.-S. Liao, C.-Y. Wu, L.-C. Cheng, C. Chung, T.-L. Hsu, C. Ma, C.-H. Wong, Expression of Human β3GalT5-1 in Insect Cells as Active Glycoforms for the Efficient Synthesis of Cancer-Associated Globo-Series Glycans, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 147, 10864-10874, 2025具代表性; 任職中研院著作;
2025 R. Li, P. Chen, Y.-F. Zeng, T.-H. Tseng, V. Gannedi, L. Krasnova, C.-H. Wong, Expedient Assembly of Multiantennary N-Glycans from Common N-Glycan Cores with Orthogonal Protection for the Profiling of Glycan-Binding Proteins., Journal of the American Chemical Society, vol. 147(15), 12937-12948, 2025具代表性; 任職中研院著作;
2025 K.-S. Liao, Y. Zhou, C. Chung, C.-C. Kung, C.-T. Ren, C.-Y. Wu, Y.-W. Lou, P.-K. Chuang, B. Imre, Y.S.Y. Hsieh, C.-H. Wong, Chemical and Enzymatic Synthesis of DisialylGb5 and Other Sialosides for Glycan Array Assembly and Evaluation of Siglec-Mediated Immune Checkpoint Inhibition., Molecules (Basel, Switzerland), vol. 30(11), 2264, 2025任職中研院著作;
2025 H.-W. Huang, Y.-F. Zeng, V. S. Shivatare, T.-H. Tseng, C.-H. Wong, Cell-based glycoengineering for production of homogeneous and specific glycoform enriched antibodies with improved effector functions, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 122 (8), e2423853122, 2025具代表性; 任職中研院著作;
2025 M. Usama, Y.-C. Hsu, M. Safaei, C.-Y. Chen, K.-H. Han, Y.-S. Ho, H. Yamaguchi, Y.-C. Li, M.-C. Hung, C.-H. Wong, C.-W. Lin, Antibody-drug conjugates targeting SSEA-4 inhibits growth and migration of SSEA-4 positive breast cancer cells., Cancer letters, vol. 611, 217453, 2025任職中研院著作;
2024 H.-H. Lin, C.-H. Wang, S.-H. Huang, S.-Y. Lin, T. Kato, K. Namba, N. Hosogi, C. song, K. Murata, C.-H. Yen, T.-L. Hsu, C.-H. Wong, Y.-M. Wu, I.-P. Tu, W.-H. Chang, Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 Å., Scientific reports, vol. 14(1), 14079, 2024任職中研院著作;
2024 C.-Y. Fan, S.-W. Wang, C. Chung, J.-Y. Chen, C.-Y. Chang, Y.-C. Chen, T.-L. Hsu, T.-R. Cheng, C.-H. Wong, Synthesis of a dendritic cell-targeted self-assembled polymeric nanoparticle for selective delivery of mRNA vaccines to elicit enhanced immune responses., Chemical science, vol. 15(29), 11626-11632, 2024具代表性; 任職中研院著作;
2024 N.-Y. Chen, C.-W. Lin, T.-Y. Lai, C.-Y. Wu, P.-C. Liao, T.-L. Hsu, C.-H. Wong, Increased expression of SSEA-4 on TKI-resistant non-small cell lung cancer with EGFR-T790M mutation., Proceedings of the National Academy of Sciences of the United States of America, vol. 121(5), e2313397121, 2024具代表性; 任職中研院著作;
2024 Chi-Huey Wong, Glycoengineering for a Universal COVID-19 Vaccine, Scientia, vol. Oct 30, 2024, e--pub, 2024任職中研院著作;
2024 M.-R. Kao, T.-H. Ma, H.-Y. Chou, S.-C. Chang, L.-C. Cheng, K.-S. Liao, J.-J. Shie, P.-J. Harris, C.-H. Wong, Y. S.-Y. Hsieh, A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies., ACS chemical biology, vol. 19(7), 1515-1524, 2024任職中研院著作;
2024 K.-S. Liao, C.-C. Kung, L.-C. Cheng, C. Chung, C.-H. Wong, Synthesis and Quantitative Analysis of Glycans Conjugated to Gold Nanoparticles, Helvetica Chimica Acta, vol. online only, e202300209, 2024任職中研院著作;
2023 V.-S. Shivatare, P.-K. Chuang, T.-H. Tseng, Y.-F. Zeng, H.-W. Huang, G. Veeranjaneyulu, H.-C. Wu, (C.-H. Wong*, Study on antibody Fc-glycosylation for optimal effector functions., Chemical communications (Cambridge, England), vol. 59, 5555-5558, 2023具代表性; 任職中研院著作;
2023 H.-W. Huang, C.-C. Chen, K.-I. Lin, T.-L. Hsu, C.-H. Wong, Single Site N-Glycosylation of B Cell Maturation Antigen (BCMA) Inhibits gamma-Secretase-Mediated Shedding and Improves Surface Retention and Cell Survival., ACS chemical biology, vol. 19, 153-161, 2023任職中研院著作;
2023 V. S. Shivatare, H.-W. Huang, T.-H. Tseng, P.-K. Chuang, Y.-F. Zeng, C.-H. Wong, Probing the Internalization and Efficacy of Antibody‐Drug Conjugate via Site‐Specific Fc‐Glycan Labelling of a Homogeneous Antibody Targeting SSEA‐4 Bearing Tumors, Israel Journal of Chemistry, vol. Online, ahead of print, 2023任職中研院著作;
2023 S.-W. Wang, Y.-A. Ko, C.-Y. Chen, K.-S. Liao, Y.-H. Chang, H.-Y. Lee, Y.-H. Yu, Y.-H. Lih, Y.-Y. Cheng, H.-H. Lin, T.-L. Hsu, C.-Y. Wu, K.-I. Lin, (C.-H. Wong, Mechanism of Antigen Presentation and Specificity of Antibody Cross-Reactivity Elicited by an Oligosaccharide-Conjugate Cancer Vaccine., Journal of the American Chemical Society, vol. 145(17), 9840-9849, 2023具代表性; 任職中研院著作;
2023 C.-W. Cheng, C.-Y. Wu, S.-W. Wang, J.-Y. Chen, C.-C. Kung, K.-S. Liao, C.-H. Wong, Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA)., Proceedings of the National Academy of Sciences of the United States of America, vol. 120(49), e2314392120, 2023具代表性; 任職中研院著作;
2023 O. Chou, Y.-P. Juang, T.-L. Chao, S.-F. Tsai, P.-F. Chiu, C.-T. Chiou, K.-C. Tsai, S.-Y. Chang, P.-H. Liang, C.-H. Wong, Isolation of Anti-SARS-CoV-2 Natural Products Extracted from Mentha canadensis and the Semi-synthesis of Antiviral Derivatives, Journal of natural products, vol. 86(6), 1428-1436, 2023任職中研院著作;
2023 Y. Zhou, K.-S. Liao, T.-Y. Chen, Y. SY Hsieh, C.-H. Wong, Effective Organotin-Mediated Regioselective Functionalization of Unprotected Carbohydrates., The Journal of organic chemistry, vol. 88(11), 7141-7151, 2023任職中研院著作;
2023 Z.-R. Li, R. Li, L. Pasternack, P. Chen, C.-H. Wong, Chemical Synthesis of a Keto Sugar Nucleotide, The Journal of Organic Chemistry, vol. 88(11), 7580-7585, 2023任職中研院著作;
2023 C.-C. Chen, H.-W. Huang, B.-R. Chen, C.-H. Wong, Quantitative Mass Spectrometric Analysis of Hepatocellular Carcinoma Biomarker Alpha-Fetoprotein, RSC Chemical Biology, vol. published online ahead of print, published online ahead of print, 2023任職中研院著作;
2022 H.-Y. Huang, H.-Y. Liao, X. Chen, C.-W. Cheng, S.-W. Wang, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, H.-H. Ma, Y.-H. Chang, C.-Y. Tsai, P.-Y. Huang, S.-Y. Chang, T.-L. Chao, H.-C. Kao, Y.-M. Tsai, Y.-H. Chen, C.-Y. Chen, K.-C. Lee, C.-Y. Wu, J.-T. Jan, T.-J. R. Cheng, K.-I. Lin*, C. Ma*, C.-H. Wong*, Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models., Science translational medicine, vol. 14(639), eabm0899, 2022具代表性; 任職中研院著作;
2022 C.-Y. Chen, Y.-W. Lin, S.-W. Wang, Y.-C. Lin, Y.-Y. Cheng, C.-T. Ren, (C.-H. Wong, C.-Y. Wu, Synthesis of Azido-Globo H Analogs for Immunogenicity Evaluation., ACS central science, vol. 8(1), 77-85, 2022任職中研院著作;
2022 C.-Y. Wu, C.-W. Cheng, C.-C. Kung, K.-S. Liao, J.-T. Jan, C. Ma, (C.-H. Wong*, Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine., Proceedings of the National Academy of Sciences of the United States of America, vol. 119(9), e2119995119, 2022任職中研院著作;
2022 S. S. Shivatare, V. S. Shivatare, C.-H. Wong, Glycoconjugates: Synthesis, Functional Studies, and Therapeutic Developments., Chemical reviews, vol. 122(20), 15603-15671, 2022任職中研院著作;
2022 K. Uchimura, K. Nishitsuji, L.-T. Chiu, T. Ohgita, H. Saito, F. Allain, V. Gannedi, (C.-H. Wong, S.-C. Hung, Design and Synthesis of 6-O-Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid beta Aggregation., Chembiochem : a European journal of chemical biology, vol. Epub ahead of print, e202200191, 2022任職中研院著作;
2022 Y.-Y. Tseng, J.-M. Liou, W.-C. Cheng, J.-T. Hsu, T.-L. Hsu, M.-S. Wu, C.-H. Wong, Combating multidrug-resistant Helicobacter pylori with moenomycin A in combination with clarithromycin or metronidazole., Frontiers in chemistry, vol. 10, 897578, 2022任職中研院著作;
2021 V. Gannedi, B. Villuri, S. Reddy, C.-C. Ku, C.-H. Wong, S.-C. Hung, Practical Remdesivir Synthesis through One-Pot Organocatalyzed Asymmetric (S)-P-Phosphoramidation., The Journal of organic chemistry, vol. 86(7), 4977–4985, 2021任職中研院著作;
2021 S. S. Shivatare, T.-J. Chen, Y.-Y. Cheng, V. S. Shivatare, T.-I. Tsai, H.-Y. Chaung, C.-Y. Wu, C.-H. Wong, Immunogenicity Evaluation of N-Glycans Recognized by HIV Broadly Neutralizing Antibodies., ACS chemical biology, vol. 16(10), 2016-2025, 2021任職中研院著作;
2021 J.-T. Jan, T.-J. R. Cheng, Y.-P. Juang, H.-H. Ma, Y.-T. Wu, W.-B. Yang, C.-W. Cheng, X. Chen, T.-H. Chou, J.-J. Shie, W.-C. Cheng, R.-J. Chein, S.-S. Mao, P.-H. Liang, C. Ma, S.-C. Hung, C.-H. Wong, Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection., Proceedings of the National Academy of Sciences of the United States of America, vol. 118(5), e2021579118, 2021任職中研院著作;
2021 C.-W. Lin, Y.-J. Wang, T.-Y. Lai, T.-L. Hsu, S.-Y. Han, H.-C. Wu, C.-N. Shen, V. Dang, M.-W. Chen, L.-B. Chen, C.-H. Wong, Homogeneous antibody and CAR-T cells with improved effector functions targeting SSEA-4 glycan on pancreatic cancer., Proceedings of the National Academy of Sciences of the United States of America, vol. 118(50), e-e2114774118, 2021任職中研院著作;
2021 R.-H. Lee, Y.-J. Wang, T.-Y. La, T.-L. Hsu, P.-K. Chuang, C.-H. Wong, Combined Effect of Anti-SSEA4 and Anti-Globo H Antibodies on Breast Cancer Cells., ACS chemical biology, vol. 16(8), 1526-1537, 2021任職中研院著作;
2021 C.-W. Chang, M.-H. Lin, C.-K. Chan, K.-Y. Su, C.-H. Wu, W.-C. Lo, S. Lam, Y.-T. Cheng, P.-H. Liao, C.-H. Wong, C.-C. Wang, Automated Quantification of Hydroxyl Reactivities: Prediction of Glycosylation Reactions., Angewandte Chemie (International ed. in English), vol. DOI: 10.1002/anie.202013909, 2021任職中研院著作;
2021 Y.-A. Ko, Y.-H. Yu, Y.-F. Wu, Y.-C. Tseng, C.-L. Chen, K.-S. Goh, H.-Y. Liao, T.-H. Chen, T.-J. R. Cheng, A.-S. Yang, C.-H. Wong, C. Ma, K.-I. Lin, A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells., PLoS pathogens, vol. 17(8), e1009724, 2021任職中研院著作;
2020 C.-F. Huang, W.-H. Chang, T.-K. Lee, Y. Joti, Y. Nishino, T. Kimura, A. Suzuki, Y. Bessho, T.-T. Lee, M.-C. Chen, S.-M. Yang, Y. Hwu, S.-H. Huang, P.-N. Lee, P. Chen, Y.-C. Tseng, C. Ma, T.-L. Hsu, C.-H. Wong, K. Tono, T. Ishikawa, K. Liang, XFEL coherent diffraction imaging for weakly scattering particles using heterodyne interference, AIP Advances, vol. 10(5), 055219, 2020任職中研院著作;
2020 L.-T. Chiu, N. Sabbavarapu, W.-C. Lin, C.-Y. Fang, C.-C. Wu, T.-J. Cheng, C.-H. Wong, S.-C. Hung, Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1, Journal of the American Chemical Society, vol. 142(11), 5282-5292, 2020任職中研院著作;
2020 S. Shivatare, C.-H. Wong, Synthetic Carbohydrate Chemistry and Translational Medicine., The Journal of organic chemistry, vol. 85(24), 15780-15800, 2020任職中研院著作;
2020 S. Pawar, L. Hsu, T. N. Reddy, M. Ravinder, C.-T. Ren, Y.-W. Lin, Y.-Y. Cheng, T.-W. Lin, T.-L. Hsu, S.-K. Wang, C.-H. Wong, C.-Y. Wu, Synthesis of Asymmetric N-Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation, ACS Chemical Biology, vol. 15(9), 2382-2394, 2020任職中研院著作;
2020 C.-Y. Lin, H.-Y. Wu, P.-S. Wu, Y.-L. Hsu, T.-J. Cheng, J.-H. Liu, R.-J. Huang, T. H. Hsiao, C.-J. Wang, P.-F. Hung, A. Lan, Y.-J. Chen, S.-H. Pan, R.-J. Chein, C.-H. Wong, P.-C. Yang, Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein, Journal of Medicinal Chemistry, vol. 63(6), 3172-3187, 2020任職中研院著作;
2020 C.-W. Cheng, C.-Y. Wu, W.-L. Hsu, C.-H. Wong, Programmable One-Pot Synthesis of Oligosaccharides, Biochemistry, vol. 59(34), 3078-3088, 2020任職中研院著作;
2020 S. Dey, H.-J. Lo, C.-H. Wong, Programmable One-Pot Synthesis of Heparin Pentasaccharide Fondaparinux, Organic Letters, vol. 22(12), 4638-4642, 2020任職中研院著作;
2020 E. A. Wang, W.-Y. Chen, C.-H. Wong, Multiple Growth Factor Targeting by Engineered Insulin-like Growth Factor Binding Protein-3 Augments EGF Receptor Tyrosine Kinase Inhibitor Efficacy, Scientific Reports, vol. 10(1), 2735, 2020任職中研院著作;
2020 C.-Y. Wu, H.-Y. Chuang, C.-H. Wong, Influenza virus neuraminidase regulates host CD8(+) T-cell response in mice., Communications biology, vol. 3(1), 748, 2020任職中研院著作;
2020 W.-F. Wang, M.-Y. Jade Lu, T.-J. R. Cheng, Y.-C. Tang, Y.-C. Teng, T.-Y. Hwa, Y.-H. Chen, M.-Y. Li, M.-H. Wu, P.-C. Chuang, R. Jou, C.-H. Wong, W.-H. Li, Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome, Genome Biology and Evolution, vol. 12(2), 3890-3905, 2020具代表性; 任職中研院著作;
2020 J. Woodring, S.-H. Lu, L. Krasnova, S.-C. Wang, J.-B. Chen, C.-C. Chou, Y.-C. Huang, T.-J. Cheng, Y.-T. Wu, Y.-H. Chen, J.-M. Fang, M.-D. Tsai, C.-H. Wong, Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein, Journal of Medicinal Chemistry, vol. 63(1), 205-215, 2020任職中研院著作;
2020 Y.-H. Chang, J.-C. Wu, H.-M. Yu, H.-T. Hsu, Y.-T. Wu, A. L.-T. Yu, C.-D. T. Yu, C.-H. Wong, Design and synthesis of glyco-peptides as anti-cancer agents targeting thrombin-protease activated receptor-1 interaction, Chemical Communications, vol. 56(43), 5827-5830, 2020任職中研院著作;
2020 H.-Y. Liao, S.-C. Wang, Y.-A. Koa, K.-I. Lin, C. Ma, T.-J. R. Cheng, C.-H. Wong, Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes, Proceedings of the National Academy of Sciences, vol. 117(30), 17757-17763, 2020具代表性; 任職中研院著作;
2020 Y.-M. Liu, M. Shahed-Al-Mahmud, X. Chen, T.-H. Chen, K.-S. Liao, J. M. Lo, Y.-M Wu., M.-C. Ho, C.-Y. Wu, C.-H. Wong, J.-T. Jan, C. Ma, A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2, Cell Reports, vol. 32(6), 108016, 2020任職中研院著作;
2019 X. Chen, C.-H. Wong, C. Ma, Targeting the Bacterial Transglycosylase: Antibiotic Development from a Structural Perspective, ACS Infectious Diseases, vol. 5(9), 1493-1504, 2019任職中研院著作;
2019 M.-R. Huang, Y.-L. Hsu, T.-C. Lin, T.-J. Cheng, L.-W. Li, W.-W. Tseng, Y.-S. Chou, J.-H. Liu, S.-H. Pan, J.-M. Fang, C.-H. Wong, Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer, European Journal of Medicinal Chemistry, vol. 181, 111551, 2019任職中研院著作;
2019 C.-H. Wong, L. Krasnova, Highlights in chemical glycobiology, Israel Journal of Chemistry, vol. 59, 18-22, 2019任職中研院著作;
2019 M.-S. Lin, T.-M. Hong, T.-H. Chou, S.-C. Yang, M.-C. Chung, C.-W. Weng, M.-L. Tsai, T.-R. Cheng, J.-J.-W., T.-C. Lee, C.-H. Wong, R.-J. Chein, P.-C. Yang, Hierarchical and Programmable One-Pot Oligosaccharide Synthesis, Journal of Visualized Experiments, vol. 151, e59987, 2019任職中研院著作;
2019 S. Dey, H.-J. Lo, C.-H. Wong, An Efficient Modular One-Pot Synthesis of Heparin-Based Anticoagulant Idraparinux, Journal of the American Chemical Society, vol. 141(26), 10309-10314, 2019任職中研院著作;
2019 M.-S. Lin, T.-M. Hong, T.-H. Chou, S.-C. Yang, M.-C. Chung, C.-W. Weng, M.-L. Tsai, T.-R. Cheng, J.-J.-W., T.-C. Lee, C.-H. Wong, R.-J. Chein, P.-C. Yang, 4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin, European Journal of Medicinal Chemistry, vol. 181, 111584, 2019任職中研院著作;
2019 S.-C. Wang, H.-Y. Liao, J.-Y. Zhang, T.-J. R. Cheng, C.-H. Wong, Development of a universal influenza vaccine using hemagglutinin stem protein produced from Pichia pastoris, VIROLOGY, vol. 526, 125-137, 2019任職中研院著作;
2019 P.-K. Chuang, M. Hsiao, T.-L. Hsu, C.-F. Chang, C.-Y. Wu, B.-R. Chen, H.-W. Huang, K.-S. Liao, C.-C. Chen, C.-L. Chen, S.-M. Yang, C. W. Kuo, P. Chen, P.-T. Chiu, I.-J. Chen, J.-S. Lai, C.-D. T. Yu, C.-H. Wong, Signaling pathway of globo-series glycosphingolipids and beta1,3-galactosyltransferase V (beta3GalT5) in breast cancer., Proceedings of the National Academy of Sciences of the United States of America, vol. 116 (9), 3518-3523, 2019任職中研院著作;
2019 L. Krasnova, C.-H. Wong, Oligosaccharide Synthesis and Translational Innovation., Journal of the American Chemical Society, vol. 141(9), 3735-3754, 2019具代表性; 任職中研院著作;
2019 Y.-C. Tseng, C.-Y. Wu, M.-L. Liu, T.-H. Chen, W.-L. Chiang, Y.-H. Yu, J.-T. Jan, K.-I. Lin, C.-H. Wong, C. Ma, Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections., Proceedings of the National Academy of Sciences of the United States of America, vol. 116(10), 4200-4205, 2019具代表性; 任職中研院著作;
2019 H.-J. Lo, L. Krasnova, S. Dey, T. Cheng, H. Liu, T.-I. Tsai, K. B. Wu, C.-Y. Wu, C.-H. Wong, Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing alpha2,6-Linked 3F(ax)-Neu5Ac., Journal of the American Chemical Society, vol. 141(16), 6484-6488, 2019具代表性; 任職中研院著作;
2018 V. S. Shivatare, S. S. Shivatare, C.-C. Lee, C.-H. Liang, K.-S. Liao, Y.-Y. Cheng, G. Saidachary, C.-Y. Wu, N.-H. Lin, P. D. Kwong, D. Burton, C.-Y. Wu, C.-H. Wong, Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies., Journal of the American Chemical Society, vol. 140(15), 5202-5210, 2018任職中研院著作;
2018 X. Wang, L. Krasnova, K. B. Wu, W.-S. Wu, T.-J. Cheng, C.-H. Wong, Towards new antibiotics targeting bacterial transglycosylase: Synthesis of a Lipid II analog as stable transition-state mimic inhibitor., Bioorganic & Medicinal Chemistry Letters, vol. 28(16 SI), 2708-2712, 2018任職中研院著作;
2018 S. Dey, S. O. Bajaj, T.-I. Tsai, H.-J. Lo, K. Wu, C.-H. Wong, Synthesis of Modular Building Blocks using Glycosyl Phosphate Donors for the Construction of Asymmetric N-Glycans, TETRAHEDRON, vol. 74(41), 6003-6011, 2018任職中研院著作;
2018 S. Dey, C.-H. Wong, Programmable one-pot synthesis of heparin pentasaccharides enabling access to regiodefined sulfate derivatives, Chemical Science, vol. 9(32), 6685-6691, 2018任職中研院著作;
2018 P.-W. Lo, J.-J. Shie, C.-H. Chen, C.-Y. Wu, T.-L. Hsu, C.-H. Wong, O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2, Proceedings of the National Academy of Sciences of the United States of America, vol. 115 (28), 7302-7307, 2018任職中研院著作;
2018 C.-W. Cheng, Y. Zhou, W.-H. Pan, S. Dey, C.-Y. Wu, W.-L. Hsu, C.-H. Wong, Hierarchical and programmable one-pot automated synthesis of oligosaccharides, Nature Communications, vol. 9, 5202, 2018任職中研院著作;
2018 C.-P. Liu, T.-I Tsai, T. Cheng, V. S. Shivatare, C.-Y. Wu, C.-Y. Wu, C.-H. Wong, Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation., Proceedings of the National Academy of Sciences of the United States of America, vol. 115(4), 720-725, 2018任職中研院著作;
2018 C.-F. Huang, K. S. Liang, T.-L. Hsu, T.-T. Lee, Y.-Y. Chen, S.-M. Yang, H.-H. Chen, S.-H. Huang, W.-H. Chang, T.-K. Lee, P. Chen, K.-E. Peng, C.-C. Chen, C.-Z. Shi, Y.-F. Hu, G. Margaritondo, T. Ishikawa, C.-H. Wong, Y. Hwu, Free-electron-laser coherent diffraction images of individual drug-carrying liposome particles in solution., Nanoscale, vol. 10(6), 2820-2824, 2018任職中研院著作;
2018 S. S. Shivatare, L.-Y. Huang, Y.-F. Zeng, J.-Y. Liao, T.-H. You, S.-Y. Wang, T. Cheng, C.-W. Chiu, P. Chao, L.-T. Chen, T.-I. Tsai, C.-C. Huang, C.-Y. Wu, N.-H. Lin, C.-H. Wong, Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies, CHEMICAL COMMUNICATIONS, vol. 54(48), 6161-6164, 2018任職中研院著作;
2018 S. S. Shivatare, V. S. Shivatare, C.-Y. Wu, C.-H. Wong, Chemo-Enzymatic Synthesis of N-Glycans for Array Development and HIV Antibodies Profiling, Jove-Journal of Visualized Experiments, vol. 132, 2018任職中研院著作;
2018 W.-S. Wu, W.-C. Cheng, T.-R. Cheng, C.-H. Wong, Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase., Journal of the American Chemical Society, vol. 140 (8), 2752-2755, 2018任職中研院著作;
2018 T. Zhou, A. Zheng, U. Baxa, G.-Y. Chuang, I. S. Georgiev, R. Kong, S. O’Dell, S. Shahzad-ul-Hussan, C.-H. Shen, Y. Tsybovsky, R. T. Bailer, S. K. Gift, M. K. Louder, K. McKee, R. Rawi, C. H. Stevenson, G. B. E. Stewart-Jones, J. D. Taft, E. Waltari, Y. Yang, B. Zhang, S. S. Shivatare, V. S. Shivatare, C.-C. D. Lee, C.-Y. Wu, NISC Comparative Sequencing Program, J. C. Mullikin, C. A. Bewley, D. R. Burton, V. R. Polonis, L. Shapiro, C.-H. Wong, J. R. Mascola, P. D. Kwong, X. Wu, A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope., Immunity, vol. 48(3), 500-513.e6, 2018任職中研院著作;
2018 H.-W. Cheng, R.-J. Chein, T.-J. Cheng, P.-S. Wu, H.-Y. Wu, P.-F. Hung, C.-J. Wang, Y.-L. Hsu, J.-M. Wong, A. Yuan, C.-H. Wong, P.-C. Yang, S.-H. Pan, 2-anilino-4-amino-5-aroylthiazole-type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction., Cancer science, vol. 109(3), 832-842, 2018任職中研院著作;
2017 L.-Y. Huang, S.-C. Wang, T.-J. R. Cheng, C.-H. Wong, Undecaprenyl Phosphate Phosphatase Activity of Undecaprenol Kinase Regulates the Lipid Pool in Gram-Positive Bacteria., Biochemistry, vol. 56(40), 5417-5427, 2017任職中研院著作;
2017 T. H. Tseng, T.-W. Lin, C.-Y. Chen, C.-H. Chen, J.-L. Lin, T.-L. Hsu, C.-H. Wong, Substrate Preference and Interplay of Fucosyltransferase 8 and N-Acetylglucosaminyltransferases., Journal of the American Chemical Society, vol. 139(28), 9431-9434, 2017任職中研院著作;
2017 Y.-W. Huang, H.-I. Yang, Y.-T. Wu, T.-L. Hsu, T.-W. Lin, J. Kelly, C.-H. Wong, Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency., Journal of the American Chemical Society, vol. 139(37), 12947-12955, 2017任職中研院著作;
2017 R. Andrabi, C.-Y. Su, C.-H. Liang, S.-S. Shivatare, B. Briney, J. E. Voss, S. K. Nawazi, C.-Y. Wu, C.-H. Wong, D. R. Burton, Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development., Immunity, vol. 47(5), 1004, 2017任職中研院著作;
2017 C.-Y. Ting, Y.-W. Lin, C.-Y. Wu, C.-H. Wong, Design of Disaccharide Modules for a Programmable One-Pot Synthesis of Building Blocks with LacNAc Repeating Units for Asymmetric N-Glycans, Asian Journal of Organic Chemistry, vol. 6(12), 1800-1807, 2017任職中研院著作;
2017 A. M. Stax, J. Tuengel, E. Girardi, N. Kitano, L. L. Allan, J. I. Alvarez, V. Li, D. Zheng, W. J. Panenka, C.-H. Wong, S. van Calenbergh, D. M. Zajonc, P. van den Elzen, Autoreactivity to Sulfatide by Human Invariant NKT Cells., JOURNAL OF IMMUNOLOGY, vol. 199(1), 97-106, 2017任職中研院著作;
2017 C.-Y. Wu, C.-W. Lin, T.-L. Tsai, C.-C. D. Lee, H.-Y. Chuang, J.-B. Chen, M.-H. Tsai, B.-R. Chen, P.-W. Lo, C.-P. Liu, V. S. Shivatare, C.-H. Wong, Influenza A surface glycosylation and vaccine design., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 114(2), 280-285, 2017任職中研院著作;
2017 T.-I. Tsai, S.-T. Li, C.-P. Liu, K. Chen, S. S. Shivatare, C.-W. Lin, S.-F. Liao, C.-W. Lin, T.-L. Hsu, Y.-T. Wu, M.-H. Tsai, M-Y. Lai, N.-H. Lin, C.-Y. Wu, C.-H. Wong, An Effective Bacterial Fucosidase for Glycoprotein Remodeling, ACS Chemical Biology, vol. 12(1), 63-72, 2017任職中研院著作;
2017 J.-J. Shie, Y.-C. Liu, J.-C. Hsiao, J.-M. Fang, C.-H. Wong, A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells, CHEMICAL COMMUNICATIONS, vol. 53(9),1490-1493, 2017任職中研院著作;
2017 W. Yang, D. Punyadarsaniya, R. Lambertz, D. Lee, C.-H. Liang, D. Höper, S. Leist, A. Hernandez-Caceres, J. Stech, M. Beer, C.-Y. Wu, C.-H. Wong, K. Schughart, F. Meng, G. Herrler, Mutations during the Adaptation of H9N2 Avian Influenza Virus to the Respiratory Epithelium of Pigs Enhance Sialic Acid Binding Activity and Virulence in Mice, JOURNAL OF VIROLOGY, vol. 91(8), e02125-16, 2017任職中研院著作;
2017 C.-L. Chen, J.-C. Hsu, C.-W. Lin, C.-H. Wang, M.-H. Tsai, C.-Y. Wu, C.-H. Wong, C. Ma, Crystal structure of a homogeneous IgG-Fc glycoform with the N-glycan designed to maximize the antibody dependent cellular cytotoxicity, ACS Chemical Biology, vol. 12(5), 1335-1345, 2017任職中研院著作;
2017 Y. Kizuka, M. Nakano, Y. Yamaguchi, K. Nakajima, R. Oka, K. Sato, C.-T. Ren, T.-L. Hsu, C.-H. Wong, N. Taniguchi, An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3., Cell chemical biology, vol. 24(12), 1467-1478.e5, 2017任職中研院著作;
2016 L. Krasnova, C.-H. Wong, Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis, Annual Review of Biochemistry, vol. 85, 599-630, 2016任職中研院著作;
2016 G. B. E. Stewart-Jones, C. Soto, T. Lemmin, G.-Y. Chuang, A. Druz, R. Kong, P. V. Thomas, K. Wagh, T. Zhou, A.-J. Behrens, T. Bylund, C. W. Choi, J. R. Davison, I. S. Georgiev, M. G. Joyce, Y. D. Kwon, M. Pancera, J. Taft, Y. Yang, B. Zhang, S. S. Shivatare, V. S. Shivatare, C.-C. D. Lee, C.-Y. Wu, C. A. Bewley, D. R. Burton, W. C. Koff, M. Connors, M. Crispin, B. T. Korber, C.-H. Wong, J. R. Mascola, P. D. Kwong, Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G., Cell, vol. 165(4), 813-826, 2016任職中研院著作;
2016 C.-H. Hsu, S. Park, D. E. Mortenson, B. L. Foley, X. Wang, R. J. Woods, D. A. Case, E. T. Powers, C.-H. Wong, H. J. Dyson, J. W. Kelly, The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate., Journal of the American Chemical Society, vol. 138(24), 7636-7648, 2016任職中研院著作;
2016 S. K. C. Cheung, P.-K. Chuang, H.-W. Huang, W. W. Hwang-Verslues, C. H.-H. Cho, W.-B. Yang, C.-N. Shen, M. Hsiao, T.-L. Hsu, C.-F. Chang, C.-H. Wong, Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells., Proceedings of the National Academy of Sciences of the United States of America, vol. 113(4), 960-965, 2016任職中研院著作;
2016 T.-C. Kuo, L.-W. Li, S.-H. Pan, J.-M. Fang, J.-H. Liu, T.-R. Cheng, C.-J. Wang, P.-F. Hung, H.-Y. Chen, T.-M. Hong, Y.-L .Hsu, C.-H. Wong, P.-C. Yan, Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin., JOURNAL OF MEDICINAL CHEMISTRY, vol. 59(18), 8521-8534, 2016任職中研院著作;
2016 T.-N. Wu, K.-H. Lin, Y.-T. Wu, J.-R. Huang, J.-T. Hung, J.-C. Wu, C.-Y. Chen, K.-C. Chu, N.-H. Lin, A. L.Yu, C.-H. Wong, Phenyl Glycolipids with Different Glycosyl Groups Exhibit Marked Differences in Murine and Human iNKT Cell Activation., ACS chemical biology, vol. 11(12), 3431-3441, 2016任職中研院著作;
2016 P.-C. Wang, J.-M. Fang, K.-C. Tsai, S.-Y. Wang, W.-I. Huang, Y.-S. Cheng, R. C., C.-H. Wong, Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors., Journal of medicinal chemistry, vol. 59(11), 5297-5310, 2016任職中研院著作;
2016 S. S. Shivatare, S.-H. Chang, T.-I. Tsai, S. Y. Tseng, Y.-S. Lin, Y.-Y. Cheng, C.-T. Ren, S. Pawar, C.-S. Tsai, H.-W. Shi, Y.-F. Zeng, C.-H. Liang, P. D. Kwong, D. R. Burton, C.-Y. Wu, C.-H. Wong, Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies, Nature Chemistry, vol. 8 (4), 338-346, 2016任職中研院著作;
2016 Y. Kizuka, S. Funayama, H. Shogomori, M. Nakano, K. Nakajima, R. Oka, S. Kitazume, Y. Yamaguchi, M. Sano, H. Korekane, T.-L. Hsu, H.-Y. Lee, C.-H. Wong, N. Taniguchi, High-Sensitivity and Low-Toxicity Fucose Probe for Glycan Imaging and Biomarker Discovery., Cell Chemical Biology, vol. 23(7), 782-792, 2016任職中研院著作;
2016 S.-C. Yeh, P.-Y. Wang, Y.-W. Lou, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity., Proceedings of the National Academy of Sciences of the United States of America, vol. 113(20), 5592-5597, 2016任職中研院著作;
2016 L. Krasnova, C.-H. Wong, Exploring human glycosylation for better therapies., MOLECULAR ASPECTS OF MEDICINE, vol. S0098-2997, 2016任職中研院著作;
2016 D. T. MacLeod, N. M. Choi, B. Briney, F. Garces, L. S. Ver, E. Landais, B. Murrell, T. Wrin, W. Kilembe, C.-H. Liang, A. Ramos, C.-B. Bian, L. Wickramasinghe, L. Kong, K. Eren, C.-Y. Wu, C.-H. Wong, S. L. Kosakovsky Pond, I. A. Wilson, D. R. Burton, P. Poignard, Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch., Immunity, vol. 44(5), 1215-1226, 2016任職中研院著作;
2016 Y.-L. Lo, G.-G. Liou, C.-H. Lu, M. Hsiao, T.-L. Hsu, C.-H. Wong, Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex., PloS one, vol. 11(11), e0166474, 2016任職中研院著作;
2016 D. Sok, M. Pauthner, B. Briney, J.-H. Lee, K. L.Saye-Francisco, J. Hsueh, A. Ramos, K.-M. Le, M. Jones, J. G. Jardine, R. Bastidas, A. Sarkar, C.-H. Liang, S. S. Shivatare, C.-Y. Wu, W. R. Schief, C.-H. Wong, I. A. Wilson, A. B. Ward, J. Zhu, P. Poignard, D. R. Burton, A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans., Immunity, vol. 45(1), 31-45, 2016任職中研院著作;
2016 S. Y. Tseng, W.-H. Cho, J. Su, S.-H. Chang, D. Chiang, C.-Y. Wu, C.-N. Hsiao, C.-H. Wong, Preparation of Aluminum Oxide-Coated Glass Slides for Glycan Microarrays, ACS Omega, vol. 1(5), 773–783, 2016任職中研院著作;
2015 C.-C. Tsai, C.-R. Lin, H.-Y. Tsai, C.-J. Chen, W.-T. Li, H.-M. Yu, Y.-Y. Ke, W.-Y. Hsieh, C.-Y. Chang, Y.-T. Wu, S.-T. Chen, C.-H. Wong, The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling, The Journal of biological chemistry, vol. 290(19), 11935, 2015任職中研院著作;
2015 S. K. C. Cheung, P.-K. Chuang, H.-W. Huang, W. W. Hwang-Verslues, C. H.-H. Cho, W.-B. Yang, C.-N. Shen, M. Hsiao, T.-L. Hsu, C.-F. Chang, C.-H. Wong, Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells, Proceedings of the National Academy of Sciences of the United States of America, vol. 113(4), 960-965, 2015任職中研院著作;
2015 Y.-Y. Ke, C.-H. Tsai, H.-M. Yu, Y.-C. Jao, J.-M. Fang, C.-H. Wong, Latifolicinin A from a Fermented Soymilk Product and the Structure-Activity Relationship of Synthetic Analogues as Inhibitors of Breast Cancer Cell Growth, Journal of agricultural and food chemistry, vol. 63(44), 9715-9721, 2015任職中研院著作;
2015 Y.-L. Huang, F.-S. Pai, Y.-T. Tsou, H.-C. Mon, T.-L. Hsu, C.-Y. Wu, T.-Y. Chou, W.-B. Yang, C.-H. Chen, C.-H. Wong, S.-L. Hsieh, Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity, The Journal of biological chemistry, vol. 290(35), 21252-21263, 2015任職中研院著作;
2015 J.-T. Chen, K.-L. Ku, C.-H. Chen, M. Hsiao, C.-P. Chiang, T.-L. Hsu, M.-H. Chen, C.-H. Wong, Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response, Proceedings of the National Academy of Sciences of the United States of America, vol. 112(42), 13057-13062, 2015任職中研院著作;
2015 T.-W. Lin, H.-T. Chang, C.-H. Chen, C.-H. Chen, S.-W. Lin, T.-L. Hsu, C.-H. Wong, Galectin-3 Binding Protein and Galectin-1 Interaction in Breast Cancer Cell Aggregation and Metastasis, Journal of the American Chemical Society, vol. 137(30), 9685-9693, 2015任職中研院著作;
2015 H.-Y. Yen, Y.-C. Liu, N.-Y. Chen, C.-F. Tsai, Y.-T. Wang, Y.-J. Chen, T.-L. Hsu, P.-C.Yang, C.-H. Wong, Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition, Proceedings of the National Academy of Sciences of the United States of America, vol. 112(22), 6955-6960, 2015任職中研院著作;
2015 S. Danishefsky, Y.-K. Shue, M. Chang, C.-H. Wong, Development of Globo-H Cancer Vaccine, Accounts of Chemical Research, vol. 48 (3), 643-652, 2015任職中研院著作;
2015 X. Li, A. Kawamura, C. Andrews, J. Miller, D. Wu; M. Zhang, J. Huang, D. Oren, N. Padte, S. Porcelli, C.-H. Wong, S. Kappe, D. Ho, M. Tsuji, Co-localization of a CD1d-binding glycolipid with malaria vaccines in LN-resident DCs for a robust adjuvant effect, JOURNAL OF IMMUNOLOGY, vol. 195(6), 2710-2721, 2015任職中研院著作;
2015 C.-H. Wong, Chemistry in Taiwan and Academia Sinica, Angewandte Chemie-International Edition, vol. 54(46), 13472-13473, 2015任職中研院著作;
2015 C.-W. Lin, M.-H. Tsai, S.-T. Li, T.-I. Tsai, K.-C. Chu, Y.-C. Liu, M.-Y. Lai, C.-Y. Wu, Y.-C. Tseng, S. S. Shivatare, C.-H. Wang, P. Chao, S.-Y. Wang, H.-W. Shih, Y.-F. Zeng, T.-H. You, J.-Y. Liao, Y.-C. Tu, Y.-S. Lin, H.-Y. Chuang, C.-L. Chen, C.-S. Tsai, C.-C. Huang, N.-H. Lin, C. Ma, C.-Y. Wu, C.-H. Wong, A common glycan structure on immunoglobulin G for enhancement of effector functions, Proceedings of the National Academy of Sciences of the United States of America, vol. 112(34), 10611-10616, 2015任職中研院著作;
2014 J.-R. Chen, Y.-H. Yu, Y.-C. Tseng, W.-L. Chiang, M.-F. Chiang, Y.-A. Ko, Y.-K. Chiu, S.-H. Ma, C.-Y. Wu, J.-T. Jan, K.-I. Lin, C. Ma, C.-H. Wong, Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections, Proceedings of the National Academy of Sciences of the United States of America, vol. 111 (7), 2476-2481, 2014任職中研院著作;
2014 J. Lin, Y.-J. Chang, W.-B. Yang, A. L. Yu, C.-H. Wong, The Multifaceted Effects of Polysaccharides Isolated from Dendrobium huoshanense on Immune Functions with the Induction of Interleukin-1 Receptor Antagonist (IL-1ra) in Monocytes., PloS one, vol. 9(4), e94040, 2014任職中研院著作;
2014 C.-L. Chen, T.-C. Lin, S.-Y. Wang, J.-J. Shie, K.-C. Tsai, Y.-S. E. Cheng, J.-T. Jan, C.-J. Lin, J.-M. Fang, C.-H. Wong, Tamiphosphor Monoesters as Effective Anti-influenza Agents, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 81, 106-118, 2014任職中研院著作;
2014 Y.-W. Lou, P.-Y. Wang, S.-C. Yeh, P.-K. Chuang, S.-T. Li, C.-Y. Wu, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers, Proceedings of the National Academy of Sciences of the United States of America, vol. 111 (7), 2482-2487, 2014任職中研院著作;
2014 C.-Y. Wang, C.-Y. Wu, T.-J. Hung, C.-H. Wong, C.-H. Chen, Sequence-constructive SELEX: A new strategy for screening DNA aptamer binding to Globo H., Biochemical and biophysical research communications, vol. 452(3), 484-489, 2014任職中研院著作;
2014 P.-C. Chen, P.-K. Chuang, C.-H. Chen, J.-R. Chen, S.-W. Lin, C. Ma, T.-L. Hsu, C.-H. Wong, Role of N-linked glycans in the interactions of recombinant HCV envelope glycoproteins with cellular receptors., ACS chemical biology, vol. 9(7), 1437-1443, 2014任職中研院著作;
2014 J.-T. Hung, Y.-C. Tsai, W.-D. Lin, J.-T. Jan, K.-H. Lin, J.-R. Huang, J.-Y. Cheng, M.-W. Chen, C.-H. Wong, A. L. Yu, Potent adjuvant effects of novel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1 influenza virus., Antiviral research, vol. 107, 110-118, 2014任職中研院著作;
2014 B.-T. Hong, C.-L. Chen, Jim-Min Fang, Shi-Yun Wang, Wen-I Huang, Yih-Shyun E. Cheng, Chi-Huey Wong, Oseltamivir Hydroxamate and Acyl Sulfonamide Derivatives as Influenza Neuraminidase Inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22(23), 6647-6654, 2014任職中研院著作;
2014 C.-S. Chu, P.-W. Lo, Y.-H. Yeh, P.-H. Hsu, S.-H. Peng, Y.-C. Teng, M.-L. Kang, C.-H. Wong, L.-J. Juan, O-GlcNAcylation regulates EZH2 protein stability and function., Proceedings of the National Academy of Sciences of the United States of America, vol. 111(4), 1355-1360, 2014任職中研院著作;
2014 H.-Y. Lee, C.-Y. Chen, T.-I. Tsai, S.-T. Li, K.-H. Lin, Y.-Y. Cheng, C.-T. Ren, T.-J. Cheng, C.-Y. Wu, C.-H. Wong, Immunogenicity study of Globo H derivatives with modification at the reducing or non-reducing end of the tumor antigen, J. Am. Chem. Soc., vol. 136(48), 16844-16853, 2014任職中研院著作;
2014 C.-H. Hsu, M. Schelwies, S. Enck, L.-Y. Huang, S.-H. Huang, Y.-F. Chang, T.-J. Cheng, W.-C. Cheng, C.-H. Wong, Iminosugar C-Glycoside Analogues of alpha-d-GlcNAc-1-Phosphate: Synthesis and Bacterial Transglycosylase Inhibition., The Journal of organic chemistry, vol. 79(18), 8629-8637, 2014任職中研院著作;
2014 S.-C. Lin, W.-C. Liu, J.-T. Jan, C.-H. Wong, S.-C. Wu, Glycan Masking of Hemagglutinin for Adenovirus Vector and Recombinant Protein Immunizations Elicits Broadly Neutralizing Antibodies against H5N1 Avian Influenza Viruses, PLoS One, vol. 9(3), e92822, 2014任職中研院著作;
2014 L.-Y. Huang, S.-H. Huang, Y.-C. Chang, W.-C. Cheng, T.-J. R. Cheng, C.-H. Wong, Enzymatic Synthesis of Lipid II and Analogues., Angewandte Chemie-International Edition, vol. 53(31), 8060-8065, 2014任職中研院著作;
2014 Y.-Y. Tseng, J.-M. Liou, T.-L. Hsu, W.-C. Cheng, M.-S. Wu, C.-H. Wong, Development of bacterial transglycosylase inhibitors as new antibiotics: Moenomycin A treatment for drug-resistant Helicobacter pylori., Bioorganic & medicinal chemistry letters, vol. 24(11), 2412-2414, 2014任職中研院著作;
2014 J.-M. Fang, Y.-S. Chen, H.-M. Yu, J.-J. Shie, T.-J. R. Cheng, C.-Y. Wu, C.-H. Wong, Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity., Bioorganic & medicinal chemistry, vol. 22(5), 1766-1772, 2014任職中研院著作;
2014 A.-K. Sauer, C.-H. Liang, J. Stech, B. Peeters, P. Quéré, C. Schwegmann-Wessels, C.-Y. Wu, C.-H. Wong, G. Herrler, Characterization of the sialic Acid binding activity of influenza a viruses using soluble variants of the h7 and h9 hemagglutinins., PloS one, vol. 9(2), e89529, 2014任職中研院著作;
2014 E. Falkowska, A. Ramos, K. J. Doores, J. H. Lee, C. Blattner, A. Ramirez, R. Derking, M. J. van Gils, C.-H. Liang, R. Mcbride, S. S. Shivatare, C.-Y. Wu, P.-Y. Chan-Hui, Y. Liu, T. Feizi, M. B. Zwick, W. C. Koff, M. S. Seaman, K. Swiderek, J. P. Moore, J. C. Paulson, C.-H. Wong, A. B. Ward, I. A. Wilson, R. W. Sanders, P. Poignard, D. R. Burton, Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers., Immunity, vol. 40(5), 657-668, 2014任職中研院著作;
2014 J.-J. Shie, Y.-C. Liu, Y.−M. Lee, C. Lim, J.-M. Fang, C.-H. Wong, An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation, Journal of the American Chemical Society, vol. 136 (28), 9953-9961, 2014任職中研院著作;
2014 J -R. Huang, Y.-C. Tsia, Y.-J. Chang, J.-C. Wu, J.-T. Hung, K.-H. Lin, C.-H. Wong, Alice L. Yu, alpha-Galactosylceramide but Not Phenyl-Glycolipids Induced NKT Cell Anergy and IL-33-Mediated Myeloid-Derived Suppressor Cell Accumulation via Upregulation of egr2/3., Journal of immunology, vol. 192(4), 1972-1981, 2014任職中研院著作;
2013 T.-L. Hsu, G. Lin, A. Koizumi, K. Brehm, N. Hada, P.-K.Chuang, C.-H. Wong, S.-L. Hsieh, A. Diaz, The surface carbohydrates of the Echinococcus granulosus larva interact selectively with the rodent Kupffer cell receptor., Molecular and biochemical parasitology, vol. 192(1-2), 55-9, 2013任職中研院著作;
2013 C.-C.Tsai, C.-R. Lin, H.-Y. Tsai, C.-J. Chen, W.-T. Li, H.-M.Yu, Y.-Y. Ke, W.-Y. Hsieh, C.-Y. Chang, C.-Y. Wu, S.-T. Chen, C.-H. Wong, The Immunologically Active Oligosaccharides Isolated from Wheatgrass Modulate Monocytes via Toll-like Receptor-2 Signaling., The Journal of biological chemistry, vol. 288(24), 17689-17697, 2013任職中研院著作;
2013 C.-H. Wang, S.-T. Li, T.-L. Lin, Y.-Y. Cheng, T.-H. Sun, J.-T. Wang, T.-J. Cheng, K.-K. Mong, C.-H. Wong, C.-Y. Wu, Synthesis of Neisseria meningitidis Serogroup W135 Capsular Oligosaccharides for Immunogenicity Comparison and Vaccine Development., ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 52(35), 9157-9161, 2013任職中研院著作;
2013 H.-Y.Chuang, C.-T. Ren, C.-A. Chao, C.-Y. Wu, S. Shivatare; T.-J. R. Cheng, C.-Y. Wu, C.-H. Wong, Synthesis and Vaccine Evaluation of the Tumor-Associated Carbohydrate Antigen RM2 from Prostate Cancer., Journal of the American Chemical Society, vol. 135(30), 11140-11150, 2013任職中研院著作;
2013 K. Ohara, C.-C. Lin, P.-J. Yang, W.-T. Hung, W.-B. Yang, T.-J. Cheng, J.-M. Fang, C.-H. Wong, Synthesis and Bioactivity of beta-(1-->4)-Linked Oligomannoses and Partially Acetylated Derivatives., The Journal of organic chemistry, vol. 78(13), 6390-6411, 2013任職中研院著作;
2013 W. Chen, S. Enck, J. Price, D. Powers, E. Powers, C.-H. Wong, H. J. Dyson, J. Kelly, Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins., Journal of the American Chemical Society, vol. 135(26), 9877-9884, 2013任職中研院著作;
2013 K.-T. Chen, Y.-C. Kuan, W.-C. Fu, H.-W. Shih, P.-H. Liang, T.-J. R. Cheng, C.-H. Wong, W.-C. Cheng, Rapid Preparation of Mycobacterium N-Glycolyl Lipid I and Lipid II Derivatives via a Biocatalytic Approach, Chemistry a European Journal, vol. 19(3), 834-838, 2013任職中研院著作;
2013 S.-H. Huang, W.-S. Wu, L.-Y., Huang, W.-F., Huang, W.-C., Fu, ; S.-T. Yang, P.-T. Chen, J.-M. Fang, W.-C. Cheng, T.-J. Cheng, C.-H. Wong, New continuous fluorometric assay for bacterial transglycosylase using forster resonance energy transfer., Journal of the American Chemical Society, vol. 135(45), 17078-17089, 2013任職中研院著作;
2013 R. Bryk, N. Arango, C. Maksymiuk, A. Balakrishnan, Y.-T. Wu, C.-H. Wong, T. Masquelin, P. Hipskind, C. D. Lima, C. Nathan, Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase, BIOCHEMISTRY, vol. 52(51), 9375-9384, 2013任職中研院著作;
2013 T.-C. Hung, C.-W. Lin, T.-L. Hsu, C.-Y. Wu, C.-H. Wong, Investigation of SSEA-4 binding protein in breast cancer cells., Journal of the American Chemical Society, vol. 135(16), 5934-5937, 2013任職中研院著作;
2013 S.-F. Liao, C.-H. Liang, M.-Y. Ho, T.-L. Hsu, T.-I. Tsai, Y. S.-Y. Hsieh, S.-T. Li, Y.-Y. Cheng, S.-M. Tsao, T.-Y. Lin, Z.-Y. Lin, W.-B. Yang, C.-T. Ren, K.-I. Lin, K.-K. Khoo, C.-H. Lin, H.-Y. Hsu, C.-Y. Wu, C.-H. Wong, Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies against tumor-associated Globo H-series epitopes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, 13809-13814, 2013任職中研院著作;
2013 C.-Y. Chen, Y.-H. Jan, Y.-H. Juan, C.-J. Yang, M.-S. Huang, C.-J. Yu, P.-C. Yang, M. Hsiao, T.-L. Hsu, C.-H. Wong, Fucosyltransferase 8 as a Functional Regulator of Non-Small Cell Lung Cancer, Proceedings of the National Academy of Sciences of the United States of America, vol. 110 (2), 630-635, 2013任職中研院著作;
2013 S. Shivatare, S.-H.Chang, T.-I. Tsai, C.-T. Ren, H.-Y. Chuang, L. Hsu, C.-W. Lin, S.-T. Li, C.-Y. Wu, C.-H. Wong, Efficient Convergent Synthesis of Bi-, Tri-, and Tetra-antennary Complex Type N-Glycans and Their HIV-1 Antigenicity., Journal of the American Chemical Society, vol. 135(41), 15382-15391, 2013任職中研院著作;
2013 T.-I. Tsai, H.-Y. Lee, S.-H. Chang, C.-H. Wang, Y.-C. Tu, Y.-C. Lin, D.-R. Hwang, C.-Y. Wu, C.-H. Wong, Effective sugar nucleotide regeneration for the large-scale enzymatic synthesis of Globo H and SSEA4., Journal of the American Chemical Society, vol. 135(39), 14831-14839, 2013任職中研院著作;
2013 S.-C. Lin, J.-T. Jan, B. Dionne, M. Butler, M.-H. Huang, C.-Y. Wu, C.-H. Wong, S.-C. Wu, Different Immunity Elicited by Recombinant H5N1 Hemagglutinin Proteins Containing Pauci-Mannose, High-Mannose, or Complex Type N-Glycans., PloS one, vol. 8(6), e66719, 2013任職中研院著作;
2013 C.-Y. Yang, J.-B. Chen, T.-F. Tsai, Y.-C. Tsai, C.-Y. Tsai, P.-H. Liang, T.-L. Hsu, C.-Y. Wu, M. G. Netea, C.-H. Wong, S.-L. Hsieh, CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver., PloS one, vol. 8(6), e65070, 2013任職中研院著作;
2013 T.-J. R. Cheng, S.-Y. Wang, W.-H. Wen, C.-Y. Su, M. Lin, W.-I. Huang, M.-T. Liu, H.-S. Wu, N-S. Wang, C.-K. Cheng, C.-L. Chen, C.-T. Ren, C.-Y. Wu, J.-M. Fang, Y.-S. E. Cheng, C.-H. Wong, Chemical probes for drug resistance assessment by binding competition (RABC) oseltamivir susceptibility evaluation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 52(1), 366-370, 2013任職中研院著作;
2013 Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu, C.-H. Wong, Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer, Proceedings of the National Academy of Sciences of the United States of America, vol. 110 (7), 2517-2522, 2013任職中研院著作;
2013 H.-W. Huang, C.-H. Chen, C.-H. Lin, C.-H. Wong, K.-I. Lin, B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention., Proceedings of the National Academy of Sciences of the United States of America, vol. 110(27), 10928-10933, 2013任職中研院著作;
2013 N. Padte, M. B. Carrera, C. A. McManus, B. Grasperge, A. Gettie, J. Coelho-dos-Reis, X. Li, N. Levenkova, D. Wu, J. T. Bruder, M. Sedegah, N. Petterson, T. Richie, C.-H. Wong, D. D. Ho, S. Vasan, M. Tsuji, A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+ T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates., PloS one, vol. 8(10), e78407, 2013任職中研院著作;
2013 C.-S. Tsai, H.-Y. Yen, M.-I. Lin, T.-I. Tsai, S.-Y. Wang, W.-I. Huang, T.-L. Hsu, Y.-S. E. Cheng, J.-M. Fang, C.-H. Wong, A Cell Permeable Probe for Identification and Imaging of Sialidases, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110(7), 2466-2471, 2013任職中研院著作;
2013 E. Al-Shareffi, J.-L. Chaubard, C. Leonhard-Melief, C.-H. Wong, R. S. Haltiwanger, 6-Alkynyl Fucose is a bioorthogonal analogue for O-fucosylation of Epidermal Growth Factor-like repeats and Thrombospondin Type-1 repeats by Protein O-Fucosyltransferases 1 and 2., Glycobiology, vol. 23(2), 188-198, 2013任職中研院著作;
2013 K. J. Doores, M. Huber, K. M. Le, S.-K. Wang, C. Doyle-Cooper, A. Cooper, R. Pantophlet, C.-H. Wong, D. Nemazee, D. R. Burton, 2G12-expressing B cell lines inform HIV carbohydrate vaccine design strategies, Journal of Virology, vol. 87(4),2234-2241, 2013任職中研院著作;
2012 S.-C. Hung, M. Zulueta, S.-Y. Lin, Y.-T. Lin, C.-J. Huang, C.-C. Wang, C.-C. Ku, Z.-H. Shi, C.-L. Chyan, D. Irene, L.-H. Lim, T.-I. Tsai, Y.-P. Hu, S. Arco, C.-H. Wong, α-Glycosylation by D-Glucosamine-Derived Donors: Synthesis of Heparosan and Heparin Analogs that Interact with Mycobacterial Heparin-Binding Hemagglutinin, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134 (21), 8988-8995, 2012任職中研院著作;
2012 M.-H. Hsieh, J.-T. Hung, Y.-W. Liw, Y.-J. Lu, C.-H. Wong, A. L. Yu, P.-H. Liang, Synthesis and evaluation of acyl-chain- and galactose-6''-modified analogues of alpha-GalCer for NKT cell activation., Chembiochem, vol. 13(11), 1689-1697, 2012任職中研院著作;
2012 J. L. Price, E. K. Culyba, W. Chen, A. N. Murray, S. R. Hanson, C.-H. Wong, E. T. Powers, J. W. Kelly, N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability., Biopolymers, vol. 98(3), 195-211, 2012任職中研院著作;
2012 J. Lenger, M. Schröder, E. C. Ennemann, B. Müller, C.-H. Wong, T. Noll, T. Dierks, S. R. Hanson, N. Sewald, Evaluation of Sulfatase-Directed Quinone Methide Traps for Proteomics, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20(2), 622-627, 2012任職中研院著作;
2012 K.-C. Liu, J.-M. Fang, J.-T. Jan, T.-J. R. Cheng, S.-Y. Wang, Y.-S. E. Cheng, K.-C. Tsai, A.-S. Yang, C.-H. Wong, Enhanced Anti-influenza Agents Conjugated with Anti-inflammatory Activity., Journal of medicinal chemistry, vol. 55(19), 8493-8501, 2012任職中研院著作;
2012 S.-H. Chen, D.-R. Hwang, G.-H. Chen, N.-S. Hsu, Y.-T. Wu, T.-L. Li, C.-H. Wong, Engineering Transaldolase in Pichia stipitis to Improve Bioethanol Production, ACS CHEMICAL BIOLOGY, vol. 7(3), 481-486, 2012任職中研院著作;
2012 H.-W. Shih, Y.-F. Chang, W.-J. Li, F.-C. Meng, C.-Y. Huang, C. Ma, T.-J. R. Cheng, C.-H. Wong, W.-C. Cheng, Effect of the peptide moiety of lipid II on bacterial transglycosylase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 51(40), 10123-10126, 2012任職中研院著作;
2012 T.-J. R. Cheng, S. Weinheimer, E. B. Tarbet, J.-T. Jan, Y.-S. E. Cheng, J.-J. Shie, C.-L. Chen, C.-A. Chen, W.-C. Hsieh, P.-W. Huang, W.-H. Lin, S.-Y. Wang, J.-M. Fang, O. Y.-P. Hu, C.-H. Wong, Development of Oseltamivir Phosphonate Congeners as Anti-influenza Agents., Journal of medicinal chemistry, vol. 55(20), 8657-8670, 2012任職中研院著作;
2012 C.-Y. Huang, H.-W. Shih, L-Y. Lin, Y.-W. Tien, T.-J. R. Cheng, W.-C. Cheng, C.-H. Wong, C. Ma, Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis, Proceedings of the National Academy of Sciences of the United States of America, vol. 109 (7), 6496-6501, 2012任職中研院著作;
2012 Y. Hsu, X.-A. Lu, M. Zulueta, C.-M. Tsai, K.-I. Lin, S.-C. Hung, C.-H. Wong, Acyl and Silyl Group Effects in Reactivity-based One-pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4 , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134(10), 4549-4552, 2012任職中研院著作;
2011 C.-H. Hsu, S.-C. Hung, C.-Y. Wu, C.-H. Wong, Toward Automated Oligosaccharide Synthesis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 50 (50), 11872-11923, 2011任職中研院著作;
2011 F.-C. Meng, K.-T. Chen, L.-Y. Huang, H.-W. Shih, H.-H. Chang, F.-Y. Nien, P.-H. Liang, T.-J. Cheng, C.-H. Wong, W.-C. Cheng, Total Synthesis of Polyprenyl N-Glycolyl Lipid II as a Mycobacterial Transglycosylase Substrate, ORGANIC LETTERS, vol. 13(19), 5306-5309, 2011任職中研院著作;
2011 R. T. Lee, T.-L. Hsu, S. K. Huang, S.-L. Hsieh, C.-H. Wong, Y. C. Lee, Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities, GLYCOBIOLOGY, vol. 21(4), 512-520, 2011任職中研院著作;
2011 C.-F. Chang, J.-F. Pan, C.-N. Lin, C.-H. Wong, C.-H. Lin, Rapid Characterization of Sugar-Binding Specificity by In-Solution Proximity Binding with Photosensitizers, GLYCOBIOLOGY, vol. 21(7), 895-902, 2011任職中研院著作;
2011 E. K. Culyba, J. L. Price, S. R. Hanson, A. Dhar, C.‐H. Wong, M. Gruebele, E. T. Powers, J. W. Kelly, Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns, Science, vol. 331(6017), 571-575, 2011任職中研院著作;
2011 C.-Y. Wu, C.-H. Wong, Programmable one-pot glycosylation, Topics in Current Chemistry, vol. 301, 223-252, 2011任職中研院著作;
2011 C.-Y. Chou, T.-P. Ko, K.-J. Wu, K.-F. Huang, C.-H. Lin, C.-H. Wong, A. H.-J. Wang, Modulation of Substrate Specificities of D-Sialic Acid Aldolase through Single Mutations of Val-251., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286(16), 14057-14064, 2011任職中研院著作;
2011 Y. Kinjo, P. Illarionov, J. L. Vela, B. Pei, E. Girardi, X. Li, Y. Li, M. Imamura, Y. Kaneko, Y. Miyazaki, P. Rogers, S. Dahesh, S. Uchiyama, A. Khurana, K. Kawahara, H. Yesilkaya, P. W. Andrew, C.-H. Wong, K. Kawakami, V. Nizet, G. S. Besra, M. Tsuji, D. M. Zajonc, M. Kronenberg, Invariant NKT cells recognize glycolipids from pathogenic Gram-positive bacteria, NATURE IMMUNOLOGY, vol. 12(10), 966-974, 2011任職中研院著作;
2011 D. Punyadarsaniya, C.-H. Liang, C. Winter, H. Petersen, S. Rautenschlein, I. Hennig-Pauka, C. Schwegmann-Wessels, C.-Y. Wu, C.-H. Wong, G. Herrler, Infection of differentiated porcine airway epithelial cells by influenza virus: differential susceptibility to infection by porcine and avian viruses, PLoS One, vol. 6(12), e28429, 2011任職中研院著作;
2011 J.-W. Hsu, H.-C. Huang, S.-T. Chen, C.-H. Wong, H.-F. Juan, Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia THP-1 cells via caspase and p53 activation, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 1-13, 2011任職中研院著作;
2011 C.-H. Liang, S.-K. Wang, C.-W. Lin, C.-C. Wang, C.-H. Wong, C.-Y. Wu, Effects of neighboring glycans on antibody-carbohydrate interaction, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 50(7), 1608-1612, 2011任職中研院著作;
2011 Y.-F. Shen, Y.-H. Chen, S.-Y. Chu, M.-I. Lin, H.-T. Hsu, P.-Y. Wu, C.-J. Wu, H.-W. Liu, F.-Y. Lin, G. Lin, P.-H. Hsu, A.-S. Yang, Y.-S. E. Cheng, Y.-T. Wu, C.-H. Wong, M.-D. Tsai, E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors, Proceedings of the National Academy of Sciences of the United States of America, vol. 108(40), 16515-16520, 2011任職中研院著作;
2011 C.-Y. Wu, C.-H. Wong, Chemistry and glycobiology, CHEMICAL COMMUNICATIONS, vol. 47(22), 6201-6207, 2011任職中研院著作;
2011 M. W. Chen, H.-Y. Liao, T.-J. R. Cheng, C.-T. Ren, C.-Y. Wu, Y. Huang, D. D. Ho, C.-H. Wong, Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 108(9), 3510-3515, 2011任職中研院著作;
2011 T.-N. Wu, K.-H. Lin, Y.-J. Chang, J.-R. Huang, J.-Y. Cheng, A. L. Yu, C.-H. Wong, Avidity of CD1d-ligand-receptor ternary complex contributes to Th1 polarization and anticancer efficacy, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 108(42), 17275-17280, 2011任職中研院著作;
2011 J.-J. Shie, J.-M. Fang, P.-T. Lai, W.-H. Wen, S.-Y. Wang, Y.-S. Cheng, K.-C. Tsai, A.-S. Yang, C.-H. Wong, A Practical Synthesis of Zanamivir Phosphonate Congeners with Potent Anti-influenza Activity, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133(44), 17959-17965, 2011任職中研院著作;
2011 R. Pejchal, K.J. Doores, L.M. Walker, R. Khayat, P.-S. Huang, S.-K. Wang, R.L. Stanfield, J.P. Julien, A. Ramos, M. Crispin, R. Depetris, U. Katpally, A. Marozsan, A. Cupo, S. Maloveste, Y. Liu, R. McBride, Y. Ito, R.W. Sanders, C. Ogohara, J.C. Paulson, T. Feizi, C.N. Scanlan, C.-H. Wong, J.P. Moore, W.C. Olson, A.B. Ward, P. Poignard, W.R. Schief, D.R. Burton, I.A. Wilson, A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield, SCIENCE, vol. 334(6059), 1097-1103, 2011任職中研院著作;
2011 H.-W. Shih, K.-T. Chen, T.-J. Cheng, C.-H. Wong, W.-C. Cheng, A New Synthetic Approach toward Bacterial Transglycosylase Substrates, Lipid II and Lipid IV, ORGANIC LETTERS, vol. 13(17), 4600-4603, 2011任職中研院著作;
2011 B.-L. Tsai, J.-L. Han, C.-T. Ren, C.-Y. Wu, C.-H. Wong, Programmable One-Pot Synthesis of Tumor-Associated Carbohydrate Antigens Lewis X Dimer and KH-1 Epitopes, TETRAHEDRON LETTERS, vol. 52(17), 2132-2135, 2011任職中研院著作;
2011 J.-R. Chen, C. Ma, C.-H. Wong, Vaccine design of hemagglutinin glycoprotein against influenza, TRENDS IN BIOTECHNOLOGY, vol. 29(9), 426-434, 2011任職中研院著作;
2011 Y.-C. Liu, H.-Y. Yen, C.-Y. Chen, C.-H. Chen, P.-F. Cheng, Y.-H. Juan, C.-H. Chen, K.-H. Khoo, C.-J. Yu, P.-C. Yang, T.-L. Hsu, C.-H. Wong, Sialylation and Fucosylation of Epidermal Growth Factor Receptor Suppress its Dimerization and Activation in Lung Cancer Cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 108 (28), 11332-11337, 2011任職中研院著作;
2011 R. Schmaltz, S. R. Hanson, C.-H. Wong, Enzymes in the Synthesis of Glycoconjugates, CHEMICAL REVIEWS, vol. 111(7), 4259-4307, 2011任職中研院著作;
2011 K.-C. Liu, P.-S. Lee, S.-Y. Wang, Y.-S. E. Cheng, J.-M. Fang, C.-H. Wong, Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19(16), 4796-4802, 2011任職中研院著作;
2011 H.-L. Yen, C.-H. Liang, C.-Y. Wu, H. Forrest, A. Ferguson, K.T. Choy, J. Jones, D.D.Y. Wong, P.P.H. Cheung, C.-H. Hsu, O.T. Li, K.M. Yuen, R.W.Y. Chan, L.L.M. Poon, M.C.W. Chan, J. Nicholls, S. Krauss, C.-H. Wong, Y. Guan, R.G. Webster, R.J. Webby & J.S.M. Peiris, Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 108(34), 14264-14269, 2011任職中研院著作;
2011 K.-C. Chu, C.-T. Ren, C.-P. Lu, C.-H. Hsu, T.-H. Sun, T.-A. Chao, Y.-F. Lin, S.-H. Wu, C.-H. Wong, C.-Y. Wu, Efficient and Stereoselective Synthesis of α(2→9) Oligosialic Acids Up to Dodecamer, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 50(40), 9391-9395, 2011任職中研院著作;
2011 L. M. Walker, M. Huber, K. J. Doores, E. Falkowska, R. Pejchal, J.-P. Julien, S.-K. Wang, P.-Y. Chan-Hui, P. W. Hammond, O. A. Olsen, A. Ramos, P. Phung, T. Wrin, M. D. Simek, S. Fling, C.-H. Wong, S. Phogat, W. C. Koff, I. A. Wilson, D. R. Burton, P. Poignard, Broad neutralization coverage of HIV by multiple highly potent antibodies, NATURE, vol. 477(7365), 466-470, 2011任職中研院著作;
2010 C.-Y. Liu, C.-W. Guo, Y.-F. Chang, J.-T. Wang, H.-W. Shih, Y.-F. Hsu, C.-W. Chen, S.-K. Chen, Y.-C. Wang, T.-J. Cheng, C. Ma, C.-H. Wong, J.-M. Fang, W.-C. Cheng, Synthesis and evaluation of a new fluorescent transglycosylase substrate: lipid II-based molecule possessing a dansyl-C20 polyprenyl moiety., Organic letters, vol. 12(7), 1608-1611, 2010任職中研院著作;
2010 J.-J. Shie, C.-A. Chen, C.-C. Lin, A. F. Ku, T.-J. R. Cheng, J.-M. Fang, C.-H. Wong, Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities., Organic & biomolecular chemistry, vol. 8(19), 4451-4462, 2010任職中研院著作;
2010 K.-H. Lin, J.-J. Liang, W.-I. Huang, S.-Y. Lin-Chu, C.-Y. Su, Y.-L. Lee, J.-T. Jan, Y.-L. Lin, Y.-S. E. Cheng, C.-H. Wong, In vivo protection of bacterial and viral infections in murine models using a synthetic new {alpha}-GalCer analog., Antimicrobial agents and chemotherapy, vol. 54(10), 4129-4136, 2010任職中研院著作;
2010 C.-H. Hsu, K.-C. Chu, Y.-S. Lin, J.-L. Han, Y.-S. Peng, C.-T. Ren, C.-Y. Wu, C.-H. Wong, Highly alpha-selective sialyl phosphate donors for efficient preparation of natural sialosides., CHEMISTRY-A EUROPEAN JOURNAL, vol. 16(6), 1754-1760, 2010任職中研院著作;
2010 C.-Y. Su, T.-J. R. Cheng, M.-I. Lin, S.-Y. Wang, W.-I. Huang, S.-Y. Lin-Chua, Y.-H. Chen, C.-Y. Wu, M. M. C. Lai, W.-C. Cheng, Y.-T. Wu, M.-D. Tsai, Y.-S. E. Cheng, C.-H. Wong, High-throughput Identification of Compounds Targeting Influenza RNA-dependent RNA Polymerase Activity, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 107(45), 19151-1916, 2010任職中研院著作;
2010 T.-J. R. Cheng, Y.-T. Wu, S.-T. Yang, A. Loh, S.-K. Chen, Y.-H. Chen, W.-I. Huang, C.-H. Yuan, H.-W. Shih, Y.-S. E. Cheng, W.-C. Cheng, C.-H. Wong, High-Throughput Identification of Antibacterials against Methichillin-Resistant Staphylococcus Aureus (MRSA) and the Transglycosylase, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18(24), 8512-8529, 2010任職中研院著作;
2010 S.-H. Chang, J.-L. Han, Susan Y. Tseng, H.-Y. Lee, C.-W. Lin, Y.-C. Lin, W.-Y. Jeng, A. H.-J. Wang, C.-Y. Wu, C.-H. Wong, Glycan Array on Aluminum Oxide Coated Glass Slides Through Phosphonate Chemistry, Journal of the American Chemical Society, vol. 132 (38), 13371-13380, 2010任職中研院著作;
2010 W.-Y. Chen, W.-B. Yang, C.-H. Wong, D.T.-B. Shih, Effect of Reishi Polysaccharides on Human Stem/Progenitor Cells, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18(24), 8583-8591, 2010任職中研院著作;
2010 H.-Y. Liao, C.-H. Hsu, S.-C. Wang, C.-H. Liang, H.-Y. Yen, C.-Y. Su, J.-T. Jan, C.-T. Ren, T.-J. Cheng, C.-Y. Wu, C.-H. Wong, Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays, J. Am. Chem. Soc., vol. 132(42),14849-14856, 2010任職中研院著作;
2010 X. Li, D. Wu, M. Fujio, M. Imamura, S. Vasan, C.-H. Wong, D. D. Ho, M. Tsuji, Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant., Proceedings of the National Academy of Sciences of the United States of America, vol. 107(29), 13010-13015, 2010任職中研院著作;
2010 R. D. Astronomo, E. Kaltgrad, A. K. Udit, S.-K. Wang, R. Pantophlet, C.-Y. Huang, J. C. Paulson, C.-H. Wong, M.G. Finn, D. R. Burton, Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds., Chemistry & biology, vol. 17(4), 357-370, 2010任職中研院著作;
2010 H.-W. Shih, K.-T. Chen, S.-K. Chen, C.-Y. Huang, T.-J. Cheng, C. Ma, C.-H. Wong, W.-C. Cheng, Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors., Organic & biomolecular chemistry, vol. 8(11), 2586-2593, 2010任職中研院著作;
2010 J. C. Lewis, S. M. Mantovani, Y. Fu, C. D. Snow, R. S. Komor, C.-H. Wong, F. H. Arnold, Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates, CHEMBIOCHEM, vol. 11(18), 2502-2505, 2010任職中研院著作;
2010 W.-H. Wen, S.-Y. Wang, K.-C. Ysai, Y.-S. E. Cheng, A.-S. Yang, J.-M. Fang, C.-H. Wong, Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses., Bioorganic & medicinal chemistry, vol. 18(11), 4074-4084, 2010任職中研院著作;
2010 R. J. Payne, C.-H. Wong, Advances in Chemical Ligation Strategies for the Synthesis of Glycopeptides and Glycoproteins, CHEMICAL COMMUNICATIONS, vol. 46, 21-43, 2010任職中研院著作;
2010 C.-C. Chang, A. F. Ku, Y.-Y. Tseng, W.-B. Yang, J.-M. Fang, C.-H. Wong, 6,8-Di-C-glycosyl flavonoids from Dendrobium huoshanense., Journal of natural products, vol. 73(2), 229-232, 2010任職中研院著作;
2010 S. Otsuki, S. Hanson, S. Miyaki, S. Grogan, M. Kinoshita, H. Asahara, C.-H. Wong, M. Lotz, Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways., Proceedings of the National Academy of Sciences of the United States of America, vol. 107(22), 10202-10207, 2010任職中研院著作;
2010 C.-S. Tsai, P.-Y. Liu, H.-Y. Yen, T.-L. Hsu, C.-H. Wong, Development of trifunctional probes for glycoproteomic analysis., CHEMICAL COMMUNICATIONS, vol. 46(30), 5575-5577, 2010任職中研院著作;
2010 M. Schelwies, D. Brinson, Y.-H. Hong, M. K. Lotz, C.-H. Wong, S. R. Hanson, GlcN-6-sulfamate Heparan Analogs as Inhibitors of Endosulfatases, ChemBioChem, vol. 11(17), 2393-2397, 2010任職中研院著作;
2009 M.-H. Chuang, S.-H. Chiou, C.-H. Huang, W.-B. Yang, C.-H. Wong, The lifespan-promoting effect of acetic acid and Reishi polysaccharide, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17(22), 7831-7840, 2009任職中研院著作;
2009 S. R. Hanson, E. K. Culyba, T. L. Hsu, C.-H. Wong, J. W. Kelly, E. T. Powers, The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability, Proceedings of the National Academy of Sciences of the United States of America, vol. 106(9), 3131-3136, 2009任職中研院著作;
2009 W.-H. Wen, M. Lin, C.-Y. Su, S.-Y. Wang, Y.-S. E. Cheng, J.-M. Fang, C.-H. Wong, Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus., Journal of medicinal chemistry, vol. 52(15), 4903-4910, 2009任職中研院著作;
2009 A. Schiefner, M. Fujio, D. Wu, C.-H. Wong, I. A. Wilson, Structural Evaluation of Potent NKT Cell Agonists: Implications for Design of Novel Stimulatory Ligands, JOURNAL OF MOLECULAR BIOLOGY, vol. 394(1), 71-82, 2009任職中研院著作;
2009 C.-Y. Wu, P.-H. Liang, C.-H. Wong, New development of glycan arrays, ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 7(11), 2247-2254, 2009任職中研院著作;
2009 C.-H. Liang, C.-C. Wang, Y.-C. Lin, C.-H. Chen, C.-H. Wong, C.-Y. Wu, Iron Oxide/Gold Core/Shell Nanoparticles for Ultrasensitive Detection of Carbohydrate-Protein Interactions, ANALYTICAL BIOCHEMISTRY, vol. 81(18), 7750-7756, 2009任職中研院著作;
2009 S.-Y. Wang, C.-Y. Su, M. Lin, S.-Y. Huang, W.-I. Huang, C.-C. Wang, Y.-T. Wu, T.-J. R. Cheng, H.-M. Yu, C.-T. Ren, C.-Y. Wu, C.-H. Wong, Y.-S. E. Cheng, HA-pseudotyped retroviral vectors for influenza antagonist screening., Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening, vol. 14(3), 294-302, 2009任職中研院著作;
2009 C.-C. Wang, J.-R. Chen, Y.-C. Tseng, C.-H. Hsu, Y.-F. Hung, S.-W. Chen, C.-M. Chen, K.-H. Khoo, T.-J. Cheng, Y.-S. E. Cheng, J.-T. Jan, C.-Y. Wu, C. Ma, C.-H. Wong, Glycans on influenza hemagglutinin affect receptor binding and immune response, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 106(43), 18137-18142, 2009任職中研院著作;
2009 C.-H. Wong, Enzymes for Glycoprotein Synthesis, CHIMIA, vol. 63(6), 318-326, 2009任職中研院著作;
2009 M.-T. Sung, Y.-T. Lai, C.-Y. Huang, L.-Y. Chou, H.-W. Shih, W.-C. Cheng, C.-H. Wong, C. Ma, Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli., Proceedings of the National Academy of Sciences of the United States of America, vol. 106(22), 8824-8829, 2009任職中研院著作;
2009 Z. Hong, L. Liu, M. Sugiyama, Y. Fu, C.-H. Wong, Concise synthesis of iminocyclitols via Petasis-type aminocyclization., Journal of the American Chemical Society, vol. 131(24), 8352-8653, 2009任職中研院著作;
2009 J. C. Lewis, S. Bastian, C. S. Bennett, Y. Fu, Y. Mitsuda, M. M. Chen, W. A. Greenberg, C.-H. Wong, F. H. Arnold, Chemoenzymatic Elaboration of Monosaccharides Using Engineered Cytochrome P450BM3 Demethylases, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 106(39), 16550-16555, 2009任職中研院著作;
2009 L. Motiei, S. Rahimipour, D.A. Thayer, C.-H. Wong, M.R. Ghadiri, Antibacterial cyclic D,L-alpha-glycopeptides., CHEMICAL COMMUNICATIONS, vol. 7(25), 3693-3695, 2009任職中研院著作;
2009 T.-L. Hsu, S.-C. Cheng, W.-B. Yang, S.-W. Chin, S.-L. Hsieh, C.-H. Wong, Profiling Carbohydrate-Receptor Interaction with Recombinant Innate Immunity Receptor-Fc Fusion Proteins, JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284(50), 34479-34489, 2009任職中研院著作;
2008 S.-K. Wang, P.-H. Liang, R. Astronomo, T.-L. Hsu, S.-L. Hsieh, D. Burton, C.-H. Wong, Tagteting the carbohydrates on HIV-1: interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105(10), 3690-3695, 2008任職中研院著作;
2008 C. Bennett, S. Dean, R. Payne, S. Ficht, A. Brik, C.-H. Wong, Sugar-assisted Glycopeptide Ligation with Complex Oligosaccharides: Scope and Limitations, Journal of the American Chemical Society, vol. 130(36), 11945-11952, 2008任職中研院著作;
2008 Y. S.-Y. Hsieh, C. Chien, S. K.-S. Liao, S.-F. Liao, W.-T. Hung, W.-B. Yang, C.-C. Lin, T.-J. R. Cheng, C.-C. Chang, J.-M. Fang, C.-H. Wong, Structure and Bioactivity of the Polysaccharides in Medicinal Plant Dendrobium huoshanense, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 6054-6068, 2008任職中研院著作;
2008 S. Ficht, R. Payne, R. Guy, C.-H. Wong, Solid-Phase Synthesis of Peptide- and Glycopeptide Thioesters via Side Chain Anchoring Strategies, CHEMISTRY-A EUROPEAN JOURNAL, vol. 14(12), 3620-3629, 2008任職中研院著作;
2008 P.-H. Liang, M. Imamura, X. Li, D. Wu, M. Fujio, R. Guy, B.-C. Wu, M. Tsuji, C.-H. Wong, Quantitative Microarray Analysis of Intact Glycolipid-CD1d Interaction and Correlation with Cell-based Cytokine Production, J. Am. Chem. Soc, vol. 130(37), 12348-12354, 2008任職中研院著作;
2008 Tupin E, Benhnia MR, Kinjo Y, Patsey R, Lena CJ, Haller MC, Caimano MJ, Imamura M, Wong CH, Crotty S, Radolf JD, Sellati TJ, Kronenberg M, NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi., Proceedings of the National Academy of Sciences of the United States of America, vol. 105(50), 19863-19868, 2008任職中研院著作;
2008 E. Tupin, M. R.-E.-I. Benhnia, Y. Kinjo, R. Patsey, C. Lena, M. Haller, M. J. Caimano, M. Imamura, C.-H. Wong, S. Crotty, J. D. Radolf, T. J. Sellati, M. Kronenberg, NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105(50), 19863-19868, 2008任職中研院著作;
2008 Y. Kinjo, B. Pei, S. Bufali, R. Raju, S. K. Richardson, M. Imamura, M. Fujio, D. Wu, A. Khurana, K. Kawahara, C.-H. Wong, A. R. Howell, P. H. Seeberger, M. Kronenberg, Natural Sphingomonas Glycolipids Vary Greatly in their Ability to Activate Natural Killer T Cells, Chem. Biol, vol. 15(7), 654-664, 2008任職中研院著作;
2008 C.-S. Shi, G.-Y. Shi, S.-M. Hsiao, Y.-C. Kao, K.-L. Kuo, C.-Y. Ma, C.-H. Kuo, B.-I. Chang, C.-F. Chang, C.-H. Lin, C.-H. Wong, H.-L. Wu, Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response, Blood, vol. 112(9), 3661-3670, 2008任職中研院著作;
2008 C.-Y. Su, S.-Y. Wang, J.-J. Shie, K.-S. Jeng, N. J. Temperton, J.-M. Fang, C.-H. Wong, Y.-S.E. Cheng, In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses, ANTIVIRAL RESEARCH, vol. 79(3), 199-205, 2008任職中研院著作;
2008 D. Wu, M. Fujio, C.-H. Wong, Glycolipids as Immunostimulating Agents, Bioorganic & Medicinal Chemistry, vol. 16, 1073-1083, 2008任職中研院著作;
2008 C.-C. Wang, Y.-L. Huang, C.-T. Ren, C.-W. Lin, J.-T. Hung, J.-C. Yu, A. Yu, C.-Y. Wu, C.-H. Wong, Glycan Microarray of Globo H and Related Structures for Quantitative Analysis of Breast Cancer, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105(33), 11661-11666, 2008任職中研院著作;
2008 P-H. Liang, C.-Y. Wu, W. A. Greenberg, C.-H. Wong, Glycan Arrays: Perspectives in Biological and Medical Applications, CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 12(1), 86-92, 2008任職中研院著作;
2008 S. Y. Tseng, C. C. Wang, C.-W. Lin, C.-L. Chen, W.-Y. Yu, C.-H. Chen, C.-Y. Wu, C.-H. Wong, Glycan Arrays on Aluminum Coated Glass Slides, CHEMISTRY-AN ASIAN JOURNAL, vol. 3(8), 1395-1405, 2008任職中研院著作;
2008 Chen ML, Adak AK, Yeh NC, Yang WB, Chuang YJ, Wong CH, Hwang KC, Hwu JR, Hsieh SL, Lin CC, Fabrication of an oriented Fc-fused lectin microarray through boronate formation., ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 47(45), 8627-8630, 2008任職中研院著作;
2008 M.-L. Chen, A.K. Adak, N.-C. Yeh, W.-B. Yang, Y.-J. Chuang, C.-H. Wong, K.-C. Hwang, J.-R.R. Hwu, S.-L. Hsieh, C.-C. Lin, Fabrication of an Oriented Fc-Fused Lectin Microarray through Boronate Formation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 47(45), 8627-8630, 2008任職中研院著作;
2008 W.-W. Chang, C. H. Lee, P. Lee, J. Lin, C.-W. Hsu, J.-T. Hung, J.-J. Lin, J.-C. Yu, L. Shao, J. Yu, C.-H. Wong, A. Yu, Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 & 2 in Globo H synthesis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105(33), 11667-11672, 2008任職中研院著作;
2008 T.-J. R. Cheng, M.-D. Sung, H.-Y. Liao, Y.-F. Chang, C.-W. Chen, C.-Y. Huang, L.-Y. Chou, Y.-D. Wu, Y.-H. Chen, Y.-S. E. Cheng, C.-H. Wong, C. Ma, W-C Cheng, Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105(2), 431-436, 2008任職中研院著作;
2008 N.-Y. Hsu, S.Y. Tseng, C.-Y. Wu, C.-T. Ren, Y.-C. Lee, C.-H. Wong, C.-H. Chen, Desorption Ionization of Biomolecules on Metals, ANALYTICAL CHEMISTRY, vol. 80, 5203-5210, 2008任職中研院著作;
2008 Y.-M. Shao, W.-B. Yang, T.-H. Kuo, K.-C. Tsai, C.-H. Lin, A.-S. Yang, P.-H. Liang, C.-H. Wong, Design, Synthesis, and Evaluation of Trifluoromethyl Ketones as Inhibitors of SARS-CoV 3CL Protease, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 4652-4660, 2008任職中研院著作;
2008 R. Payne, S. Ficht, W. A. Greenberg, C.-H. Wong, Cysteine-Free Peptide and Glycopeptide Ligations by Direct Aminolysis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 47(23), 4411-4415, 2008任職中研院著作;
2008 S.-T. Chen, Y.-L. Lin, M.-T. Huang, M.-F. Wu, S.-C. Cheng, H.-Y. Lei, C.-K. Lee, T.-W. Chiou, C.-H. Wong, S.-L. Hsieh, CLEC5A is Critical for Dengue Virus-Induced Lethal Disease, Nature, vol. 453, 672-676, 2008任職中研院著作;
2008 T. R. Northen, J.-C. Lee, L. Hoang, J. Raymond, D.-R. Hwang, S.M. Yannone, C.-H. Wong, G. Siuzdak, A Nanostructure-Initiator Mass Spectrometry Based Enzyme Activity Assay, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105(10), 3678-3683, 2008任職中研院著作;
2008 R. D. Astronomo, H. K. Lee, C. N. Scanlan, R. Pantophlet, C. Y. Huang, I. A. Wilson, O. Blixt, R. A. Dwek, C.-H. Wong, D. R. Burton, A glycoconjugate antigen based on the recognition motif of a broadly-neutralising human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120, JOURNAL OF VIROLOGY, vol. 82, 6359-6368, 2008任職中研院著作;
2008 Giffin MJ, Heaslet H, Brik A, Lin YC, Cauvi G, Wong CH, McRee DE, Elder JH, Stout CD, Torbett BE, A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant., Journal of medicinal chemistry, vol. 51(20), 6263-6270, 2008任職中研院著作;
2008 M. J. Giffin, H. Heaslet, A. Brik, Y.-C. Lin, G. Cauvi, C.-H.Wong, D. E. McRee, J. H. Elder, C. D. Stout, B. E. Torbett, A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant, J. Med. Chem, vol. 51(20), 6263-6270, 2008任職中研院著作;
2008 M. W. Chen, T.-J. Cheng, Y. Huang, J.-T. Jan, S.H. Ma, A. Yu, C.-H. Wong, D. Ho, A Consensus-Hemagglutinin-Based DNA Vaccine that Protects Mice Against Divergent H5N1 Influenza Viruses, Proceedings of the national academy of sciences of the united states of america, vol. 105(36), 13538-13543, 2008任職中研院著作;
2008 J.-J. Shie, J.-M. Fang, C.-H. Wong, A Concise and Flexible Synthesis of the Potent Anti-Influenza Agents – Tamiflu and Tamiphosphor, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 47(31), 5788-5791, 2008任職中研院著作;
2007 M.-T. Wei, K.-F. Hua, J. Hsu, A. Karmenyan, K.-Y. Tseng, C.-H. Wong, H.-Y. Hsu, A. Chiou, The Interaction of Lipopolysaccharide with Membrane Receptors on Macrophages Pretreated with Extract of Reishi Polysaccharides Measured by Optical Tweezers, OPTICS EXPRESS, vol. 15(17), 11020-11032, 2007任職中研院著作;
2007 S. R. Hanson, T. L. Hsu, E. Weerapana, K. Kishikawa, G. M. Simon, B. F. Cravatt, C. H. Wong, Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes, J Am Chem Soc, vol. 129, 7266-7267, 2007任職中研院著作;
2007 Shie JJ, Fang JM, Wang SY, Tsai KC, Cheng YS, Yang AS, Hsiao SC, Su CY, Wong CH, Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity., Journal of the American Chemical Society, vol. 129(39), 11892-3, 2007任職中研院著作;
2007 J.-J. Shie, J.-M. Fang, S.-Y. Wang, K.-C. Tsai, Y.S.E. Cheng, A.-S. Yang, S.-C. Hsiao, C.Y. Su, C.-H. Wong, Synthesis of Tamiflu and its Phosphonate Congeners Possessing Potent Anti-Influenza Activity, J. Am. Chem. Soc, vol. 129(39), 11892-11893, 2007任職中研院著作;
2007 Y. Y. Yang, S. Ficht, A. Brik, C. H. Wong, Sugar-assisted ligation in glycoprotein synthesis, J Am Chem Soc, vol. 129, 7690-7701, 2007任職中研院著作;
2007 Brik A, Wong CH, Sugar-assisted ligation for the synthesis of glycopeptides., CHEMISTRY-A EUROPEAN JOURNAL, vol. 13(20), 5670-5675, 2007任職中研院著作;
2007 Y. M. Shao, W. B. Yang, H. P. Peng, M. F. Hsu, K. C. Tsai, T. H. Kuo, A. S. Yang, A. H. J. Wang, P. H. Liang, C. H. Lin, C. H. Wong, Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors, ChemBioChem, vol. 8(14), 1654-1657, 2007任職中研院著作;
2007 S. Ficht, R. J. Payne, A. Brik, C. H. Wong, Second Generation Sugar-Assisted Ligation: An Effective New Method for the Synthesis of Cysteine-Containing Glycopeptides, Angewandte chemie-international edition, vol. 46(31), 5975-5979, 2007任職中研院著作;
2007 S.M. Dean, W.A. Greenberg, C.-H. Wong, Recent Advances in Aldolase-catalyzed Asymmetric Synthesis, Advanced synthesis & catalysis, vol. 349, 1308-1320, 2007任職中研院著作;
2007 P. H. Liang, S. K. Wang, C. H. Wong, Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants, J Am Chem Soc, vol. 129(36), 11177-11184, 2007任職中研院著作;
2007 S. R. Hanson, W. A. Greenberg, C.-H. Wong, Probing Glycans with the Copper(I)-Catalyzed [3+2] Azide-Alkyne Cycloaddition, QSAR & Combinatorial Science, vol. 26, 1243-1252, 2007任職中研院著作;
2007 Y.-J. Chang, J.-R. Huang, Y.-C. Tsai, J.-T. Hung, D. Wu, M. Fujio, C.-H. Wong, A. L. Yu, Potent Immune-modulating and Anti-cancer Effects of NKT Cell Stimulatory Glycolipids, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 104(25), 10299-10304, 2007任職中研院著作;
2007 Casey CP, Wong CH, Partly cloudy with a chance of showers., ACS chemical biology, vol. 2(9), 573-6, 2007任職中研院著作;
2007 C. Casey, C.-H. Wong, Partly cloudy with a chance of showers, ACS Chem. Biol, vol. 2(9), 573-576, 2007任職中研院著作;
2007 Yu Z, Sawkar AR, Whalen LJ, Wong CH, Kelly JW, Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention., Journal of medicinal chemistry, vol. 50(1), 94-100, 2007任職中研院著作;
2007 Z. Yu, A.R. Sawkar, L.J. Whalen, C.-H. Wong, J.W. Kelly, Isofagomine- and 2,5-Anhydro-2,5-imino-D-glucitol-Based Glucocerebrosidase Pharmacological Chaperones for Gaucher Disease Intervention, J. Med. Chem, vol. 50, 94-100, 2007任職中研院著作;
2007 Sugiyama M, Hong Z, Greenberg WA, Wong CH, In vivo selection for the directed evolution of L-rhamnulose aldolase from L-rhamnulose-1-phosphate aldolase (RhaD)., Bioorganic & medicinal chemistry, vol. 15(17), 5905-5911, 2007任職中研院著作;
2007 M.-L. Michel, A.C. Keller, C. Paget, M. Fujio, F. Trottein, P.B. Savage, C.-H. Wong, E. Schneider, M. Dy, & M.C. Leite-de-Moraes, Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia, JOURNAL OF EXPERIMENTAL MEDICINE, vol. 204(5), 995-1001, 2007任職中研院著作;
2007 Michel ML, Keller AC, Paget C, Fujio M, Trottein F, Savage PB, Wong CH, Schneider E, Dy M, Leite-de-Moraes MC, Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia, Journal of experimental medicine, vol. 204(5), 995-1001, 2007任職中研院著作;
2007 Cheng KC, Huang HC, Chen JH, Hsu JW, Cheng HC, Ou CH, Yang WB, Chen ST, Wong CH, Juan HF, Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction., BMC genomics, vol. 8, 411, 2007任職中研院著作;
2007 K.-C. Cheng, H.-C. Huang, J.-H. Chen, J.-W. Hsu, H.-C. Cheng, C.-H. Ou, W.-B. Yang, S.-T. Chen, C.-H. Wong, H.-F. Juan, Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction, BMC Genomics, vol. 8(1), 411, 2007任職中研院著作;
2007 Hua KF, Hsu HY, Chao LK, Chen ST, Yang WB, Hsu J, Wong CH, Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression., Journal of cellular physiology, vol. 212(2), 537-550, 2007任職中研院著作;
2007 K.-F. Hua, H.-Y Hsu, L.K. Chao, S.-T. Chen, W.-B. Yang, J. Hsu, C.H. Wong, Ganoderma Lucidum Polysaccharides Enhance CD14 Endocytosis of LPS and Promote TLR4 Signal Transduction of Cytokine Expression, J. Cell. Physiol, vol. 212, 537-550, 2007任職中研院著作;
2007 R. J. Payne, S. Ficht, S. Tang, A. Brik, Y.-Y. Yang, D. A. Case, C.-H. Wong, Extended Sugar-Assisted Ligations: Development, Scope and Applications, J. Am. Chem. Soc, vol. 129(44), 13527-13536, 2007任職中研院著作;
2007 M. Sugiyama, Z. Hong, P.-H. Liang, L.J. Whalen, W.A. Greenberg, C.-H. Wong, D-Fructose-6-Phosphate Aldolase Catalyzed One-Pot Synthesis of Iminocyclitols, J. Am. Chem. Soc, vol. 129(47), 14811-14817, 2007任職中研院著作;
2007 Bennett CS, Wong CH, Chemoenzymatic approaches to glycoprotein synthesis., Chemical Society reviews, vol. 36(8), 1227-38, 2007任職中研院著作;
2007 Kaltgrad E, Sen Gupta S, Punna S, Huang CY, Chang A, Wong CH, Finn MG, Blixt O, Anti-carbohydrate antibodies elicited by polyvalent display on a viral scaffold., Chembiochem : a European journal of chemical biology, vol. 8(12), 1455-62, 2007任職中研院著作;
2007 E. Kaltgrad, S. Sen Gupta, S. Punna, C.-Y. Huang, A. Chang, C.-H. Wong, M.G. Finn, O. Blixt, Anti-Carbohydrate Antibodies Elicited by Polyvalent Display on a Viral Scaffold, CHEMBIOCHEM, vol. 8(12), 1455-1462, 2007任職中研院著作;
2007 Polat T, Wong CH, Anomeric reactivity-based one-pot synthesis of heparin-like oligosaccharides., Journal of the American Chemical Society, vol. 129(42), 12795-800, 2007任職中研院著作;
2007 T. Polat, C.-H. Wong, Anomeric Reactivity-Based One-Pot Synthesis of Heparin-like Oligosaccharides, J. Am. Chem. Soc, vol. 129(42), 12795-12800, 2007任職中研院著作;
2007 T. L. Hsu, S. R. Hanson, K. Kishikawa, S. K. Wang, M. Sawa, C. H. Wong, Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells, Proceedings of the National Academy of Sciences of the United States of America, vol. 104, 2614-2619, 2007任職中研院著作;
2006 D. A. Thayer, C.-H. Wong, Vancomycin analogues containing monosaccharides exhibit improved antibiotic activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy., CHEMISTRY-AN ASIAN JOURNAL, vol. 1(3), 445-452, 2006任職中研院著作;
2006 D. Thayer, C.-H. Wong, Vancomycin analogs with improved biological activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy, Chemistry-An Asian Journal, vol. 1, 445-452, 2006任職中研院著作;
2006 Hong Z, Liu L, Hsu CC, Wong CH, Three-step synthesis of sialic acids and derivatives., ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 45(44), 7417-21, 2006任職中研院著作;
2006 M. H. Chuang, M. S. Wu, W. L. Lo, J. T. Lin, C. H. Wong, S. H. Chiou, The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function, Proceedings of the national academy of sciences of the united states of america, vol. 103, 2552-2557, 2006任職中研院著作;
2006 S. Hanson, L. Whalen, C.-H. Wong, Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenol sulfate and phenol cyclic sulfamate motifs, Bioorganic & medicinal chemistry, vol. 14(24):8386-95, 2006任職中研院著作;
2006 Brik A, Ficht S, Yang YY, Bennett CS, Wong CH, Sugar-assisted ligation of N-linked glycopeptides with broad sequence tolerance at the ligation junction., Journal of the American Chemical Society, vol. 128(46), 15026-33, 2006任職中研院著作;
2006 A. Brik, S. Ficht, Y.-Y. Yang, C. Bennett, C.-H. Wong, Sugar-Assisted ligation (SAL) of N-linked Glycopeptides with Broad Sequence Tolerance at the Ligation Junction, J. Am. Chem. Soc, vol. 128(46), 15026-33, 2006任職中研院著作;
2006 Brik A, Yang YY, Ficht S, Wong CH, Sugar-assisted glycopeptide ligation., Journal of the American Chemical Society, vol. 128(17), 5626-7, 2006任職中研院著作;
2006 M. Fujio, D. Wu, R. Garcia-Navarro, D. D. Ho, M. Tsuji, C. H. Wong, Structure-Based Discovery of Glycolipids for CD1d-Mediated NKT Cell Activation: Tuning the Adjuvant versus Immunosuppression Activity, J Am Chem Soc, vol. 128, 9022-9023, 2006任職中研院著作;
2006 Brik A, Ficht S, Wong CH, Strategies for the preparation of homogenous glycoproteins., Current opinion in chemical biology, vol. 10(6), 638-44, 2006任職中研院著作;
2006 C. Y. Wu, K. Y. King, C. J. Kuo, P. H. Liang, Y. T. Wu, M. Y. Ho, C. L. Liao, J. M. Fang, C. H. Wong, Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease, Chem Biol, vol. 13, 261-268, 2006任職中研院著作;
2006 Y. S. Cheng, K. H. Lo, H. H. Hsu, Y. M. Shao, W. B. Yang, C. H. Lin, C. H. Wong, Screening for HIV protease inhibitors by protection against activity-mediated cytotoxicity in Escherichia coli, J Virol Methods, vol. 137(1), 82-87, 2006任職中研院著作;
2006 K.-I. Lin, Y.-Y. Kao, H.-K. Kuo, W.-B. Yang, A. Chou, H.-H. Lin, A. L.-T. Yu, C.-H. Wong, Reishi Polysaccharides Induce Immunoglobulin Production Through the TLR4/TLR2-mediated Induction of Transcription Factor Blimp-1, J. Biol. Chem., vol. 281(34):24111-123, 2006任職中研院著作;
2006 J. C. Lee, C. Y. Wu, J. V. Apon, G. Siuzdak, C. H. Wong, Reactivity-Based One-Pot Synthesis of the Tumor-Associated Antigen N3 Minor Octasaccharide for the Development of a Photocleavable DIOS-MS Sugar Array, Angewandte chemie-international edition, vol. 45, 2753-2757, 2006任職中研院著作;
2006 J. C. Lee, W. A. Greenberg, C. H. Wong, Programmable reactivity-based one-pot oligosaccharide synthesis, Nat Protoc, vol. 1, 3143-3152, 2006任職中研院著作;
2006 S.C. Cheng, W.B. Yang, S.W. Chin, C.C. Lin, C.-H. Lin, Y.J. Chen, P.C. Lin, M.F. Wu, C.-H. Wong, S.L. Hsieh, Profiling of Polysaccharide-receptor Interaction with Recombinant Innate Immunity Receptor-Fe Fusion Proteins, Glycobiology, vol. 16(11), 1131-1132, 2006任職中研院著作;
2006 P. H. Liang, W. C. Cheng, Y. L. Lee, H. P. Yu, Y. T. Wu, Y. L. Lin, C. H. Wong, Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis, Chembiochem, vol. 7, 165-173, 2006任職中研院著作;
2006 Y. Kinjo, E. Tupin, D. Wu, M. Fujio, R. Garcia-Navarro, M. R.E.I. Benhnia, D.M. Zajonc, G. Ben-Menachem, G.D. Ainge, G.F. Painter, A. Khurana, K. Hoebe, S.M. Behar, B. Beutler, I. A. Wilson, M. Tsuji, T.J. Sellati, C.-H. Wong, M. Kronenberg, NKT cells recognize diacylglycerol antigens from pathogenic bacteria, NATURE IMMUNOLOGY, vol. 7(9), 978-986, 2006任職中研院著作;
2006 Kinjo Y, Tupin E, Wu D, Fujio M, Garcia-Navarro R, Benhnia MR, Zajonc DM, Ben-Menachem G, Ainge GD, Painter GF, Khurana A, Hoebe K, Behar SM, Beutler B, Wilson IA, Tsuji M, Sellati TJ, Wong CH, Kronenberg M, Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria., Nature immunology, vol. 7(9), 978-86, 2006任職中研院著作;
2006 Huang KT, Wu BC, Lin CC, Luo SC, Chen C, Wong CH, Lin CC, Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide., Carbohydrate research, vol. 341(12), 2151-5, 2006任職中研院著作;
2006 K.-T. Huang, B.-C. Wu, C.-C. Lin, S.-C. Luo, C. Chen, C.-H. Wong, C.-C. Lin, Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide, CARBOHYDRATE RESEARCH, vol. 341(12), 2151-2155, 2006任職中研院著作;
2006 A. Brik, C.-Y. Wu, C.-H. Wong, Microtiter plate based chemistry and in situ screening: a useful approach for enzymatic inhibitor discovery, Org. Biomol. Chem., vol. 4:1446–14, 2006任職中研院著作;
2006 Sawa M, Hsu TL, Itoh T, Sugiyama M, Hanson SR, Vogt PK, Wong CH, Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo., Proceedings of the National Academy of Sciences of the United States of America, vol. 103 (33), 12371-12376, 2006任職中研院著作;
2006 Qiu H, Gabrielsen A, Agardh HE, Wan M, Wetterholm A, Wong CH, Hedin U, Swedenborg J, Hansson GK, Samuelsson B, Paulsson-Berne G, Haeggstrom JZ, Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability., Proceedings of the National Academy of Sciences of the United States of America, vol. 103(21), 8161-6, 2006任職中研院著作;
2006 H. Qiul, A. Gabrielsen, H.E. Agardh, M. Wan, A. Wetterholm, C.-H. Wong, U. Hedin, J. Swedenborg, G.K. Hansson, B. Samuelsson, G. Paulsson-Berne, J.Z. Haeggstrom, Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlate with symptoms of plaque instability, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103(21), 8161-8166, 2006任職中研院著作;
2006 Liang FS, Greenberg WA, Hammond JA, Hoffmann J, Head SR, Wong CH, Evaluation of RNA-binding specificity of aminoglycosides with DNA microarrays., Proceedings of the National Academy of Sciences of the United States of America, vol. 103(33), 12311-6, 2006任職中研院著作;
2006 F.-S. Liang, W. A. Greenberg, J. A. Hammond, J. Hoffmann, S. R. Head, C.-H. Wong, Evaluation of RNA Binding Specificity of Aminoglycosides with DNA Microarrays, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103(33), 12311-12316, 2006任職中研院著作;
2006 F. S. Liang, A. Brik, Y. C. Lin, J. H. Elder, C. H. Wong, Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates, Bioorganic & medicinal chemistry, vol. 14, 1058-1062, 2006任職中研院著作;
2006 L.J. Whalen, C-H. Wong, Enzymes in Organic Synthesis: Aldolase-mediated Synthesis of Iminocyclitols and Novel Heterocycles, Aldrichimica Acta, vol. 39(3), 63-71, 2006任職中研院著作;
2006 M.G. Sanna, S.-K. Wang, P.J. Gonzalez-Cabrera, A. Don, D. Marsolais, M.P. Matheu, S.H. Wei, I. Parker, E. Jo, W.-C. Cheng, M.D. Cahalan, C.-H. Wong, H. Rosen, Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo, Nature Chemical Biology, vol. 2(8):434-441, 2006任職中研院著作;
2006 D. Wu, D.M. Zajonc, M. Fujio, B.A. Sullivan, Y. Kinjo, M. Kronenberg, I.A. Wilson, C.-H. Wong, Design of NKT-cell activators: Structure and function of a microbial glycosphingolipid bound to mouse CD1d, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103(11), 3972-3977, 2006任職中研院著作;
2006 Wu D, Zajonc DM, Fujio M, Sullivan BA, Kinjo Y, Kronenberg M, Wilson IA, Wong CH, Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d., Proceedings of the National Academy of Sciences of the United States of America, vol. 103(11), 3972-7, 2006任職中研院著作;
2006 L. Liu, Z.-Y. Hong, C.-H. Wong, Convergent Glycopeptide Synthesis by Traceless Staudinger Ligation and Enzymatic Coupling, Chembiochem, vol. 7, 429-432, 2006任職中研院著作;
2006 M. Brigl, P. van den Elzen, X. Chen, J. H. Meyers, D. Wu, C. H. Wong, F. Reddington, P. A. Illarianov, G. S. Besra, M. B. Brenner, J. E. Gumperz, Conserved and Heterogeneous Lipid Antigen Specificities of CD1d-Restricted NKT Cell Receptors, J Immunol, vol. 176, 3625-3634, 2006任職中研院著作;
2006 Liu H, Wong CH, Characterization of a transglycosylase domain of Streptococcus pneumoniae PBP1b., Bioorganic & medicinal chemistry, vol. 14(21), 7187-95, 2006任職中研院著作;
2006 H. Liu, C.-H. Wong, Characterization of a transglycosylase domain of Streptococcus pneumoniae PBP1b, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, 7187-7195, 2006任職中研院著作;
2006 C. Y. Huang, D. A. Thayer, A. Y. Chang, M. D. Best, J. Hoffman, S. Head, C. H. Wong, Carbohydrate microarray for profiling the antibodies interacting with Globo H tumor antigen, Proceedings of the national academy of sciences of the united states of america, vol. 103, 15-20, 2006任職中研院著作;
2006 M. Sugiyama, L.J. Whalen, Z.-Y. Hong, W.A. Greenberg, C.-H. Wong, Borate as a Phosphate Ester Mimic in Aldolase-Catalyzed Reactions: Practical Syntheses of L-Fructose and L-Iminocyclitols, Advanced Synthesis and Catalysis, vol. 348, 2555-2559, 2006任職中研院著作;
2006 Lin YC, Brik A, de Parseval A, Tam K, Torbett BE, Wong CH, Elder JH, Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system., Journal of virology, vol. 80(16), 7832-43, 2006任職中研院著作;
2006 Y.-C. Lin, A. Brik, A. P., K. Tam, A. Parseval, B.E. Torbett, C.-H. Wong, J.H. Elder, Altered Gag Polyprotein Cleavage Specificity of Feline Immunodeficiency Virus/Human Immunodeficiency Virus Mutant Proteases as Demonstrated in a Cell-Based Expression System, JOURNAL OF VIROLOGY, vol. 80(16), 7832-7843, 2006任職中研院著作;
2006 H.-Y. Hsu, K.-F. Hua, Y.-C. Su, L.-C. Chu, H.-W. Chiu, C.-H. Wong, S.U-S. Yang, L. K. Chao, Alkali-soluble polysaccharides of Rhizoclonium riparium alga induces IL-1 gene expression via protein kinase signaling pathways, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 54, 3558-3565, 2006任職中研院著作;
2006 Hsu HY, Hua KF, Su YC, Chu LC, Su SC, Chiu HW, Wong CH, Chen ST, Shieh CW, Yang SS, Chen YM, Chao LK, Alkali-soluble polysaccharides of Rhizoclonium riparium alga induce IL-1 gene expression via protein kinase signaling pathways., Journal of agricultural and food chemistry, vol. 54(10), 3558-65, 2006任職中研院著作;
2006 L. Liu, C. S. Bennett, C. H. Wong, Advances in glycoprotein synthesis, Chemical communications, vol. 7, 21-33, 2006任職中研院著作;
2006 A. Brik, S. Ficht, C.-H. Wong, Strategies for the Preparation of Homogenous Glycoproteins, CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 10(6):638-644., 2006任職中研院著作;
2005 C. Y. Wu, A. Brik, S. K. Wang, Y. H. Chen, C. H. Wong, Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ, Chembiochem, vol. 6, 2176-2180, 2005任職中研院著作;
2005 Brik, A., Wu, C. Y., Best, M. D., Wong, C. H., Tetrabutylammonium fluoride-assisted rapid N(9)-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ., Bioorganic & medicinal chemistry, vol. 13(15), 4622-4626, 2005任職中研院著作;
2005 G. T. Fan, Y. S. Pan. K. C. Lu, Y. P. Cheng, W. C. Lin, S. Lin, S. H. Lin, C. H. Wong, J. M. Fang, C. C. Lin Wong, C. H., Fang, J. M., C. C. Lin, Synthesis of alpha-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes., Tetrahedron, vol. 61, 1855-1862, 2005任職中研院著作;
2005 G. T. Fan, Y. S. Pan. K. C. Lu, Y. P. Cheng, W. C. Lin, S. Lin, S. H. Lin, C. H. Wong, J. M. Fang, C. C. Lin, Synthesis of ?galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes, Tetrahedron, vol. 61, 1855-1862, 2005任職中研院著作;
2005 G. W. Xing, D. Wu, M. A. Poles, A. Horowitz, M. Tsuji, D. D. Ho, C. H. Wong, Synthesis and human NKT cell stimulating properties of 3-O-sulfo-alpha/beta-galactosylceramides, Bioorganic & medicinal chemistry, vol. 13, 2907-2916, 2005任職中研院著作;
2005 Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA, Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity., The Journal of experimental medicine, vol. 202(11), 1517-26, 2005任職中研院著作;
2005 S. H. Wei, H. Rosen, M. P. Matheu, M. G. Sanna, S. K. Wang, E. Jo, C. H. Wong, I. Parker, M. D. Cahalan, Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses, Nat Immunol, vol. 6, 1228-1235, 2005任職中研院著作;
2005 Y. Kinjo, D. Wu, G. Kim, G. W. Xing, M. A. Poles, D. D. Ho, M. Tsuji, K. Kawahara, C. H. Wong, M. Kronenberg, Recognition of bacterial glycosphingolipids by natural killer T cells, Nature, vol. 434, 520-525, 2005任職中研院著作;
2005 Sinchaikul, S., Pan, F. M., Cheng, C. W., Wong, C. H., Fang, J. M., Tseng, M. J., Chen, S. T., Protein microarray using alpha-amino acids as metal tags on chips., Bioorg Med Chem Lett, vol. 15(5), 1413-1416, 2005任職中研院著作;
2005 C. H. Wong, Protein glycosylation: new challenges and opportunities, J Org Chem, vol. 70, 4219-4225, 2005任職中研院著作;
2005 J. J. Shie, J. M. Fang, T. H. Kuo, C. J. Kuo, P. H. Liang, H. J. Huang, Y. T. Wu, J. T. Jan, Y. S.E. Cheng, C. H. Wong, Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters., Bioorganic & medicinal chemistry, vol. 13, 5240–5252, 2005任職中研院著作;
2005 M. M. Numa, L. V. Lee, C. C. Hsu, K. E. Bower, C. H. Wong, Identification of novel anthrax lethal factor inhibitors generated by combinatorial Pictet-Spengler reaction followed by screening in situ, Chembiochem, vol. 6, 1002-1006, 2005任職中研院著作;
2005 Sawkar AR, Adamski-Werner SL, Cheng WC, Wong CH, Beutler E, Zimmer KP, Kelly JW, Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles., Chemistry & biology, vol. 12(11), 1235-44, 2005任職中研院著作;
2005 A.R. Sawkar, S.L. Adamski-Werner, W.-C. Cheng, C.-H. Wong, E. Beutler, K.-P. Zimmer, J.W. Kelly, Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles, Chem. Biol, vol. 12(11), 1235–1244, 2005任職中研院著作;
2005 M. Fridman, V. Belakhov, L. V. Lee, F. S. Liang, C. H. Wong, T. Baasov, Dual effect of synthetic aminoglycosides: antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor, Angewandte chemie-international edition, vol. 44, 447-452, 2005任職中研院著作;
2005 D. A. Calarese, H. K. Lee, C. Y. Huang, M. D. Best, R. D. Astronomo, R. L. Stanfield, H. Katinger, D. R. Burton, C. H. Wong, I. A. Wilson, Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 13372–13377, 2005任職中研院著作;
2005 J. J. Shie, J. M. Fang, C. J. Kuo, T. H. Kuo, P. H. Liang, H. J. Huang, W. B. Yang, C. H. Lin, J. L. Chen, Y. T. Wu, C. H. Wong, Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease, J Med Chem, vol. 48, 4469-4473, 2005任職中研院著作;
2005 C.-C. Hsu, Y. Zhang, M. Wada, D. Franke, C.-H. Wong, Directed evolution of d-sialic acid aldolase l-3-deoxy-manno-2-octulosonic acid (l-KDO) aldolases, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 9122-9126, 2005任職中研院著作;
2005 C. C. Hsu, Y. Zhang, M. Wada, D. Franke, C. H. Wong, Directed evolution of D-sialic acid aldolase L-3-deoxy-manno-2-octulosonic acid (L-KDO) aldolases, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 9122–9126, 2005任職中研院著作;
2005 D. Wu, G. W. Xing, M. A. Poles, A. Horowitz, Y. Kinjo, B. Sullivan, V. Bodmer Narkevitch, O. Plettenburg, M. Kronenberg, M. Tsuji, D. D. Ho, C. H. Wong, Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 1351-1356, 2005任職中研院著作;
2005 Scanlan C, Calarese D, Lee HK, Blixt O, Wong CH, Wilson I, Burton D, Dwek R, Rudd P, Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design., Advances in experimental medicine and biology, vol. 564, 7-8, 2005任職中研院著作;
2005 T. J. Tolbert, D. Franke, C. H. Wong, A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as TEV protease cleavable fusion protein, Bioorganic & medicinal chemistry, vol. 13, 909-915, 2005任職中研院著作;
2005 H. N. Yu, D. A. Thayer, M. C. Galan, C. H. Wong, A general strategy toward S-linked glycopeptides, Angewandte chemie-international edition, vol. 44, 4596-4599, 2005任職中研院著作;
2005 A. Brik, J. Alexandratos, Y. C. Lin, J. H. Elder, A. J. Olson, A. Wlodawer, D. S. Goodsell, C. H. Wong, 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors, Chembiochem, vol. 6, 1167-1169, 2005任職中研院著作;
2004 F. S. Liang, S. K. Wang, T. Nakatani, C. H. Wong, Targeting RNAs with tobramycin analogues, Angewandte chemie-international edition, vol. 43, 6496-6500, 2004
2004 J. Liu, M.M.D. Numa, H. Liu, S. J. Huang, P. Sears, A. R. Shikhman, C. H. Wong, Synthesis and high-throughput screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis, J Org Chem, vol. 69, 6273-6283, 2004
2004 E. Chapman, M. D. Best, S. R. Hanson, C. H. Wong, Sulfotransferases: structure, mechanism, biological activity, inhibition, and synthetic utility, Angewandte chemie-international edition, vol. 43, 3526-3548, 2004
2004 S. R. Hanson, M. D. Best, C. H. Wong, Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility, Angewandte chemie-international edition, vol. 43, 5736-5763, 2004
2004 T. J. Tolbert, C. H. Wong, Subtilisin-catalyzed glycopeptide condensation, Methods Mol Biol, vol. 283, 267-280, 2004
2004 H. S. Chen, Y. F. Tsai, S. Lin, C. C. Lin, K. H. Khoo, C. H. Lin, C. H. Wong, Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides, Bioorganic & medicinal chemistry, vol. 12, 5595-5601, 2004任職中研院著作;
2004 C. Y. Wu, J. T. Jan, S. H. Ma, C. J. Kuo, H. F. Juan, Y. S. Cheng, H. H. Hsu, H. C. Huang, D. Wu, A. Brik, F. S. Liang, R. S. Liu, J. M. Fang, S. T. Chen, P. H. Liang, C. H. Wong, Small molecules targeting severe acute respiratory syndrome human coronavirus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, 10012-10017, 2004任職中研院著作;
2004 C.-Y. Wu, J.-T. Jan, H.-H. Ma, C.-J. Kuo, H.-F. Juan, Y.-S. E. Cheng, H.-H. Hsu, H.-C. Huang, D. Wu, A. Brik, F.-S. Liang, R.-S. Liu, J.-M. Fang, S.-T. Chen, P.-H. Liang, C.-H. Wong, Small molecules targeting severe acute respiratory syndrome (SARS) human coronavirus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, 10012-10017, 2004任職中研院著作;
2004 R. Xu, S. R. Hanson, Z. Zhang, Y. Y. Yang, P. G. Schultz, C. H. Wong, Site-specific incorporation of the mucin-type N-acetylgalactosamine-alpha-O-threonine into protein in Escherichia coli, J Am Chem Soc, vol. 126, 15654-15655, 2004
2004 J. Liu, C. C. Hsu, C. H. Wong, Sequential aldol condensation catalyzed by DERA mutant Ser238Asp and a formal total synthesis of atorvastatin, Tetrahedron Lett, vol. 45, 2439-2441, 2004
2004 P. T. Nyffeler, S. G. Duron, M. D. Burkart, S. P. Vincent, C. H. Wong, Selectflour : Mechanistic Insight and Application, Angewandte chemie-international edition, vol. 44, 192-214, 2004
2004 C. H. Chou, C. S. Wu, C. H. Chen, L. D. Lu, S. S. Kulkarni, C. H. Wong, S. C. Hung, Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues, Org Lett, vol. 6, 585-588, 2004任職中研院著作;
2004 H. K. Lee, C. N. Scanlan, C. Y. Huang, A. Y. Chang, D. A. Calarese, R. A. Dwek, P. M. Rudd, D. R. Burton, I. A. Wilson, C. H. Wong, Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody, Angewandte chemie-international edition, vol. 43, 1000-1003, 2004
2004 M. D. Best, A. Brik, E. Chapman, L. V. Lee, W. C. Cheng, C. H. Wong, Rapid Discovery of Potent Sulfotransferase Inhibitors by Diversity-Oriented Reaction in Microplates Followed by in situ Screening, Chembiochem, vol. 5, 811-819, 2004
2004 O. Blixt, S. Head, T. Mondala, C. Scanlan, M.E. Huflejt, R. Alvarez, M.C. Bryan, F. Fazio, D. Calarese, J. Stevens, N. Razi, I. van Die, D. Burton, I.A. Wilson, R. Cummings, N. Bovin, C.-H. Wong, J.C. Paulson, Printed covalent glycan array for ligand profiling of diverse glycan binding proteins, Proceedings of the National Academy of Sciences of the United States of America, vol. 101, 17033-17038, 2004任職中研院著作;
2004 C. M. Chien, J. L. Cheng, W. T. Chang, M. H. Tien, W. Y. Wu, Y. H. Chang, H. Y. Chang, J. F. Hsieh, C. H. Wong, S. T. Chen, Polysaccharides of Ganoderma lucidum Alter Cell Immunophenotypic Expression and Enhance CD56+ NK-Cell Cytotoxicity in Cord Blood, Bioorganic & medicinal chemistry, vol. 12, 5603-5609, 2004任職中研院著作;
2004 J. H. Chen, Y. W. Chang, C. W. Yao, T. S. Chiueh, S. C. Huang, K. Y. Chien, A. Chen, F. Y. Chang, C. H. Wong, Y. J. Chen, Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, 17039-17044, 2004任職中研院著作;
2004 H. N. Yu, J. Furukawa, T. Ikeda, C. H. Wong, Novel efficient routes to heparin monosaccharides and disaccharides achieved via regio- and stereoselective glycosidation, Org Lett, vol. 6, 723-726, 2004
2004 S. G. Duron, T. Polat, C. H. Wong, N-(phenylthio)-epsilon-caprolactam: a new promoter for the activation of thioglycosides, Org Lett, vol. 6, 839-841, 2004
2004 T. J. Cheng, A. Brik, C. H. Wong, C. C. Kan, Model system for high-throughput screening of novel human immunodeficiency virus protease inhibitos in Escherichia coli, Antimicrob Agents Chemother, vol. 48, 2437-2447, 2004
2004 H. Lin, D. A. Thayer, C. H. Wong, C. T. Walsh, Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase, Chem Biol, vol. 11, 1635-1642, 2004
2004 L. V. Lee, K. E. Bower, F. S. Liang, J. Shi, D. Wu, S. J. Sucheck, P. K. Vogt, C. H. Wong, Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides, J Am Chem Soc, vol. 126, 4774-4775, 2004
2004 V. P. Mocharla, B. Colasson, L. V. Lee, S. Romper, K. B. Sharpless, C. H. Wong, H. C. Kolb, In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrate II, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 44, 116–120, 2004
2004 M. C. Bryan, L. V. Lee, C. H. Wong, High-throughput identification of fucosyltransferase inhibitors using carbohydrate microarrays, Bioorg Med Chem Lett, vol. 14, 3185-3188, 2004
2004 C. W. Cheng, K. C. Lin, F. M. Pan, S. Sinchaikul, C. H. Wong, W. C. Su, C. H. Hsu, S. T. Chen, Facile synthesis of metal-chelating peptides on chip for protein array, Bioorg Med Chem Lett, vol. 14, 1987-1990, 2004
2004 H. Y. Hsu, K. F. Hua, C. C. Lin, C. H. Lin, C. H. Wong, Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways, J Immunol, vol. 173, 5989-5999, 2004任職中研院著作;
2004 C. H. Wong, Enzymatic synthesis of L-fucose and L-fucose analogs, US Patent, vol. #6,713,287, 2004
2004 C. F. Chang, C. W. Ho, C. Y. Wu, C. H. Wong, C. H. Lin, Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase, Chem Biol, vol. 11, 1301-1306, 2004任職中研院著作;
2004 D. Franke, C. C. Hsu, C. H. Wong, Directed evolution of aldolases, Methods Enzymol, vol. 388, 224-238, 2004
2004 F. Agnelli, S. J. Sucheck, K. A. Marby, D. Rabuka, S. L. Yao, P. S. Sears, F. S. Liang, C. H. Wong, Dimeric aminoglycosides as antibiotics, Angewandte chemie-international edition, vol. 43, 1562-1566, 2004
2004 P. T. Nyffeler, L. Eltepu, N. A. Boyle, C. H. Wong, A. Eschenmoser, R. A. Lerner, P. J. Wentworth, Dihydrogen trioxide (HOOOH) is generated during the thermal reaction between hydrogen peroxide and ozone, Angewandte chemie-international edition, vol. 43, 4656-4659, 2004
2004 M. P. Heck, S. P. Vincent, B. W. Murray, F. Bellamy, C. H. Wong, C. Mioskowski, Cyclic amidine sugars as transition-state analogue inhibitors of glycosidases: potent competitive inhibitors of mannosidases, J Am Chem Soc, vol. 126, 1971-1979, 2004
2004 M. C. Bryan, F. Fazio, H. K. Lee, C. Y. Huang, A. Chang, M. Best, D. A. Calarese, O. Blixt, J. C. Paulson, D. Burton, I. A. Wilson, C. H. Wong, Covalent display of oligosaccharide arrays in microtiter plates, J Am Chem Soc, vol. 126, 8640-8641, 2004
2004 T. J. Tolbert, C. H. Wong, Conjugation of glycopeptide thioesters to expressed protein fragments: semisynthesis of glycosylated interleukin-2, Methods Mol Biol, vol. 283, 255-266, 2004
2004 S. R. Hanson, M. D. Best, M. C. Bryan, C. H. Wong, Chemoenzymatic synthesis of oligosaccharides and glycoproteins, Trends Biochem Sci, vol. 29, 656-663, 2004
2004 T. J. Tolbert, C. H. Wong, Carbohydrate chains: enzymatic and chemical synthesis, Encyclopedia of Biological Chemistry, vol. 307-313, 2004
2004 F. Fazio, M. C. Bryan, H. K. Lee, A. Chang, C. H. Wong, Assembly of sugars on polystyrene plates: a new facile microarray fabrication technique, Tetrahedron Lett, vol. 45, 2689-2692, 2004
2004 A. Heine, J. G. Luz, C. H. Wong, I. A. Wilson, Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution, J Mol Biol, vol. 343, 1019-1034, 2004
2004 M. C. Bryan, C. H. Wong, Aminoglycoside array for the high-throughput analysis of small molecule-RNA interactions, Tetrahedron Lett, vol. 45, 3639-3642, 2004
2004 D. Klostermeier, P. Sears, C. H. Wong, D. P. Millar, J. R. Williamson, A three-fluorophore FRET assay for high-throughput screening of small-molecule inhibitors of ribosome assembly, Nucleic Acids Res, vol. 32, 2707-2715, 2004任職中研院著作;
2004 Z. Zhang, J. Gildersleeve, Y. Y. Yang, R. Xu, J. A. Loo, S. Uryu, C. H. Wong, P. G. Schultz, A new strategy for the synthesis of glycoproteins, Science, vol. 303, 371-373, 2004
2003 T. K. Mong, L. V. Lee, J. R. Brown, J. D. Esko, C. H. Wong, Synthesis of N-acetyllactosamine derivatives with variation in the aglycon moiety for the study of inhibition of sialyl Lewis x expression, Chembiochem, vol. 4, 835-840, 2003
2003 C. H. Wong, M. C. Bryan, P. T. Nyffeler, H. T. Liu, E. Chapman, Synthesis of carbohydrate-based antibiotics, Pure Appl Chem, vol. 75, 179-186, 2003
2003 C. H. Wong, F. S. Liang, Surface plasmon resonance study of RNA-aminoglycoside interactions, Methods in Enzymology, vol. 362, 340-353, 2003
2003 C. H. Wong, M. C. Bryan, Sugar arrays in microtiter plates, Methods in Enzymology, vol. 362, 218-225, 2003
2003 G. DeSantis, J. Liu, D. P. Clark, A. Heine, I. A. Wilson, C. H. Wong, Structure-based mutagenesis approaches toward expanding the substrate specificity of D-2-deoxyribose-5-phosphate aldolase, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 43-52, 2003
2003 F. Fazio, C. H. Wong, RuCl3-promoted amide formation from azides and thioacids, Tetrahedron Lett, vol. 44, 9083-9085, 2003
2003 T. K. Mong, H. K. Lee, S. G. Duron, C. H. Wong, Reactivity-based one-pot total synthesis of fucose GM1 oligosaccharide: a sialylated antigenic epitope of small-cell lung cancer, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, 797-802, 2003
2003 C. Y. Wu, C. F. Chang, J. S. Chen, C. H. Wong, C. H. Lin, Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 42, 4661-4664, 2003任職中研院著作;
2003 A. Brik, J. Muldoon, Y. C. Lin, J. H. Elder, D. S. Goodsell, A. J. Olson, V. V. Fokin, K. B. Sharpless, C. H. Wong, Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors, Chembiochem, vol. 4, 1246-1248, 2003任職中研院著作;
2003 C. H. Wong, Programmable one-pot oligosaccharide synthesis, US Patent, vol. #6,538,117, 2003
2003 D. Franke, T. Machajewski, C. C. Hsu, C. H. Wong, One-pot synthesis of L-Fructose using coupled multienzyme systems based on rhamnulose-1-phosphate aldolase, J Org Chem, vol. 68, 6828-6831, 2003
2003 C. H. Wong, New developments in biocatalysis, Adv Synth Catal, vol. 345, 651-651, 2003
2003 E. Chapman, M. C. Bryan, C. H. Wong, Mechanistic studies of beta-arylsulfotransferase IV, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, 910-915, 2003
2003 A. Brik, C. H. Wong, HIV-1 protease: mechanism and drug discovery, Org Biomol Chem, vol. 1, 5-14, 2003
2003 T. J. Tolbert, C. H. Wong, Glycoprotein synthesis, In: Yearbook of Science & Technology, vol. 159-162, 2003
2003 M. Wada, C. C. Hsu, D. Franke, M. Mitchell, A. Heine, I. Wilson, C. H. Wong, Directed evolution of N-acetylneuraminic acid aldolase to catalyze enantiomeric aldol reactions, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 2091-2098, 2003
2003 C. C. Mak, A. Brik, D. L. Lerner, J. H. Elder, G. M. Morris, A. J. Olson, C. H. Wong, Design and synthesis of broad-based mono- and bi- cyclic inhibitors of FIV and HIV proteases, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 2025-2040, 2003
2003 T. Feizi, F. Fazio, W. Chai, C. H. Wong, Carbohydrate microarrays - a new set of technologies at the frontiers of glycomics, CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 13, 637-645, 2003
2003 M. G. Silvestri, G. Desantis, M. Mitchell, C. H. Wong, Asymmetric aldol reactions using aldolases, In: Topics in Stereochemistry, Vol 23, vol. 23, 267-342, 2003
2003 H. Liu, T. K. Ritter, R. Sadamoto, P. S. Sears, M. Wu, C. H. Wong, Acceptor specificity and inhibition of the bacterial cell-wall glycosyltransferase MurG, Chembiochem, vol. 4, 603-609, 2003
2003 T. K. Ritter, K. K. Mong, H. Liu, T. Nakatani, C. H. Wong, A programmable one-pot oligosaccharide synthesis for diversifying the sugar domains of natural products: a case study of vancomycin, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 42, 4657-4660, 2003
2003 L. V. Lee, M. L. Mitchell, S. J. Huang, V. V. Fokin, K. B. Sharpless, C. H. Wong, A potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click chemistry, J Am Chem Soc, vol. 125, 9588-9589, 2003
2003 T. K. Mong, C. Y. Huang, C. H. Wong, A new reactivity-based one-pot synthesis of N-acetyllactosamine oligomers, J Org Chem, vol. 68, 2135-2142, 2003
2003 H. Liu, L. Wang, A. Brock, C. H. Wong, P. G. Schultz, A method for the generation of glycoprotein mimetics, J Am Chem Soc, vol. 125, 1702-1703, 2003
2002 P. T. Nyffeler, C. H. Liang, K. M. Koeller, C. H. Wong, The chemistry of amine-azide interconversion: catalytic diazotransfer and regioselective azide reduction, J Am Chem Soc, vol. 124, 10773-10778, 2002
2002 F. Fazio, M. C. Bryan, O. Blixt, J. C. Paulson, C. H. Wong, Synthesis of sugar arrays in microtiter plate, J Am Chem Soc, vol. 124, 14397-14402, 2002
2002 O. Plettenburg, V. Bodmer Narkevitch, C. H. Wong, Synthesis of alpha-galactosyl ceramide, a potent immunostimulatory agent, J Org Chem, vol. 67, 4559-4564, 2002
2002 M. L. Mitchell, F. Tian, L. V. Lee, C. H. Wong, Synthesis and evaluation of transition-state analogue inhibitors of alpha-1,3-fucosyltransferase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 41, 3041-3044, 2002
2002 M. L. Mitchell, L. V. Lee, C. H. Wong, Synthesis and evaluation of six-membered GDP-iminocyclitol, Tetrahedron Lett, vol. 43, 5691-5693, 2002
2002 Y. Y. Wang, K. H. Khoo, S. T. Chen, C. C. Lin, C. H. Wong, C. H. Lin, Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, 1057-1062, 2002
2002 J. J. Liu, G. DeSantis, C. H. Wong, Structure-based rationalization of aldolase-catalyzed asymmetric synthesis, CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, vol. 80, 643-645, 2002
2002 T. Kanemitsu, C. H. Wong, O. Kanie, Solid-phase synthesis of oligosaccharides and on-resin quantitative monitoring using gated decoupling (13)C NMR, J Am Chem Soc, vol. 124, 3591-3599, 2002
2002 J. Liu, C. H. Wong, Selectfluor(TM)-mediated allylstannation of aldehydes and imines, Tetrahedron Lett, vol. 43, 3915-3917, 2002
2002 M. C. Bryan, O. Plettenburg, P. Sears, D. Rabuka, S. Wacowich Sgarbi, C. H. Wong, Saccharide display on microtiter plates, Chem Biol, vol. 9, 713-720, 2002
2002 Z. Zhang, C. H. Wong, Regioselective benzoylation of sugars mediated by excessive Bu2SnO: observation of temperature promoted migration, Tetrahedron, vol. 58, 6513-6519, 2002
2002 K. K. Mong, C. H. Wong, Reactivity-based one-pot synthesis of a Lewis Y carbohydrate hapten: a colon-rectal cancer antigen determinant, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 41, 4087-4090, 2002
2002 O. Plettenburg, C. Mui, V. Bodmer Narkevitch, C. H. Wong, Rapid preparation of glycolipid libraries by cross metathesis, Adv Synth Catal, vol. 344, 622-626, 2002
2002 T. J. Tolbert, C. H. Wong, New methods for proteomic research: Preparation of proteins with N-terminal cysteines for labeling and conjugation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 41, 2171-2174, 2002
2002 C. H. Wong, Mannosyl transfer with regeneration of GDP-mannose, US Patent, vol. #6,485,930, 2002
2002 C. H. Wong, F. MorisVaras, Hydroxyazepanes as inhibitors of glycosidases and HIV protease, US Patent, vol. #6,462,193, 2002
2002 M. M. Thunnissen, B. Andersson, B. Samuelsson, C. H. Wong, J. Z. Haeggstrom, Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors, Faseb J, vol. 16, 1648-1650, 2002
2002 A. R. Sawkar, W. C. Cheng, E. Beutler, C. H. Wong, W. E. Balch, J. W. Kelly, Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 99, 15428-15433, 2002
2002 R. Sadamoto, K. Niikura, P. S. Sears, H. Liu, C. H. Wong, A. Suksomcheep, F. Tomita, K. Monde, S. Nishimura, Cell-wall engineering of living bacteria, J Am Chem Soc, vol. 124, 9018-9019, 2002
2002 C. T. Guo, X. L. Sun, O. Kanie, K. F. Shortridge, T. Suzuki, D. Miyamoto, K. I. Hidari, C. H. Wong, Y. Suzuki, An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses, Glycobiology, vol. 12, 183-190, 2002
2002 J. Liu, C. Y. Huang, C. H. Wong, An efficient method for the preparation of 2-hydroxy- and 2-aminoglycals from glycosyl sulfoxides, Tetrahedron Lett, vol. 43, 3447-3448, 2002
2002 J. Liu, C. H. Wong, An efficient method for the cleavage of p-methoxybenzylidene (PMP), tetrahydropyranyl (THP) and 1,3-dithiane protecting groups by Selectfluor(TM), Tetrahedron Lett, vol. 43, 4037-4039, 2002
2002 J. J. Liu, C. H. Wong, Aldolase-catalyzed asymmetric synthesis of novel pyranose synthons as a new entry to heterocycles and epothilones, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 41, 1404-1407, 2002
2002 Z. Y. Zhang, K. Niikura, X. F. Huang, C. H. Wong, A strategy for the one-pot synthesis of sialylated oligosaccharides, CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, vol. 80, 1051-1054, 2002
2002 A. Brik, Y. C. Lin, J. Elder, C. H. Wong, A quick diversity-oriented amide-forming reaction to optimize P-subsite residues of HIV protease inhibitors, Chem Biol, vol. 9, 891-896, 2002
2002 E. Chapman, S. Ding, P. G. Schultz, C. H. Wong, A potent and highly selective sulfotransferase inhibitor, J Am Chem Soc, vol. 124, 14524-14525, 2002
2002 E. Chapman, C. H. Wong, A pH sensitive colorometric assay for the high-throughput screening of enzyme inhibitors and substrates: a case study using kinases, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, 551-555, 2002
2001 B. Buhler, Y. C. Lin, G. Morris, A. J. Olson, C. H. Wong, D. D. Richman, J. H. Elder, B. E. Torbett, Viral evolution in response to the broad-based retroviral protease inhibitor TL-3, J Virol, vol. 75, 9502-9508, 2001
2001 P. Sears, C. H. Wong, Toward automated synthesis of oligosaccharides and glycoproteins, Science, vol. 291, 2344-2350, 2001
2001 C. S. Yu, K. Niikura, C. C. Lin, C. H. Wong, The Thioglycoside and Glycosyl Phosphite of 5-Azido Sialic Acid: Excellent Donors for the alpha-Glycosylation of Primary Hydroxy Groups This research was supported by Academia Sinica (Taipei) and the NIH (USA), ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 40, 2900-2903, 2001
2001 F. Burkhart, Z. Y. Zhang, S. Wacowich Sgarbi, C. H. Wong, Synthesis of the Globo H hexasaccharide using the programmable reactivity-based one-pot strategy ( This research was supported by the National Institutes of Health. F.B. thanks the Deutsche Forschungsgemeinschaft for a fellowship), ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 40, 1274-1277, 2001
2001 I. A. Kozlov, S. Mao, Y. Xu, X. Huang, L. Lee, P. S. Sears, C. Gao, A. R. Coyle, K. D. Janda, C. H. Wong, Synthesis of solid-supported mirror-image sugars: a novel method for selecting receptors for cellular-surface carbohydrates, Chembiochem, vol. 2, 741-746, 2001
2001 T. K. Ritter, C. H. Wong, Synthesis of N-acetylglucosamine thiazoline/lipid II hybrids, Tetrahedron Lett, vol. 42, 615-618, 2001
2001 V. D. Le, C. C. Mak, Y. C. Lin, J. H. Elder, C. H. Wong, Structure-activity studies of FIV and HIV protease inhibitors containing allophenylnorstatine, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, 1185-1195, 2001
2001 C. H. Wong, Y. Ichikawa, G. J. Shen, Production of fucosylated carbohydrates by enzymatic fucosylation; synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose, US Patent, vol. #6,319,695, 2001
2001 M. G. Silvestri, C. H. Wong, Opening of thiiranes: preparation of orthogonal protected 2-thioglyceraldehyde, J Org Chem, vol. 66, 910-914, 2001
2001 A. Heine, G. DeSantis, J. G. Luz, M. Mitchell, C. H. Wong, I. A. Wilson, Observation of covalent intermediates in an enzyme mechanism at atomic resolution, Science, vol. 294, 369-374, 2001
2001 M. Izumi, C. H. Wong, Microbial sialyltransferases for carbohydrate synthesis, TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, vol. 13, 345-360, 2001
2001 M. Izumi, G. J. Shen, S. Wacowich Sgarbi, T. Nakatani, O. Plettenburg, C. H. Wong, Microbial glycosyltransferases for carbohydrate synthesis: alpha-2,3-sialyltransferase from Neisseria gonorrheae, J Am Chem Soc, vol. 123, 10909-10918, 2001
2001 C. H. Wong, Inhibition of human fucosyltransferases with N-linked Lewis-x and LacNAc analogs, US Patent, vol. #6,232,450, 2001
2001 X. F. Huang, K. L. Witte, D. E. Bergbreiter, C. H. Wong, Homogenous enzymatic synthesis using a thermo-responsive water-soluble polymer support, Adv Synth Catal, vol. 343, 675-681, 2001
2001 J. Liu, A. R. Shikhman, M. K. Lotz, C. H. Wong, Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis, Chem Biol, vol. 8, 701-711, 2001
2001 K. M. Koeller, C. H. Wong, Enzymes for chemical synthesis, Nature, vol. 409, 232-240, 2001
2001 C. H. Wong, M. D. Burkart, Enzymatic sulfation of biomolecules, US Patent, vol. # 6,255,088, 2001
2001 C. H. Wong, Editorial commentary, Adv Synth Catal, vol. 343, 495-495, 2001
2001 C. C. Mak, V. D. Le, Y. C. Lin, J. H. Elder, C. H. Wong, Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3' residue, Bioorg Med Chem Lett, vol. 11, 219-222, 2001
2001 X. S. Ye, X. F. Huang, C. H. Wong, Conversion of the carboxy group of sialic acid donors to a protected hydroxymethyl group yields an efficient reagent for the synthesis of the unnatural beta-linkage, Chem Commun, vol. 11, 974-975, 2001
2001 C. Saotome, C. H. Wong, O. Kanie, Combinatorial library of five-membered iminocyclitol and the inhibitory activities against glyco-enzymes, Chem Biol, vol. 8, 1061-1070, 2001
2001 M. Mitchell, L. Qaio, C. H. Wong, Chemical-enzymatic synthesis of iminocyclitol phosphonic acids, Adv Synth Catal, vol. 343, 596-599, 2001
2001 T. K. Ritter, C. H. Wong, Carbohydrate-Based Antibiotics: A New Approach to Tackling the Problem of Resistance, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 40, 3508-3533, 2001
2001 H. Liu, R. Sadamoto, P. S. Sears, C. H. Wong, An efficient chemoenzymatic strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall precursors: UDP-N-acetylmuramyl-peptides, J Am Chem Soc, vol. 123, 9916-9917, 2001
2000 K. M. Koeller, M. E. B. Smith, C. H. Wong, Tyrosine sulfation on a PSGL-1 glycopeptide influences the reactivity of glycosyltransferases responsible for synthesis of the attached O-glycan, J Am Chem Soc, vol. 122, 742-743, 2000
2000 T. D. Machajewski, C. H. Wong, The Catalytic Asymmetric Aldol Reaction, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 39, 1352-1375, 2000
2000 K. M. Koeller, C. H. Wong, Synthesis of complex carbohydrates and glycoconjugates: enzyme-based and programmable one-pot strategies, Chem Rev, vol. 100, 4465-4494, 2000
2000 V. D. Le, C. H. Wong, Synthesis of 2-substituted polyhydroxytetrahydropyrimidines (N-hydroxy cyclic guanidino-sugars): transition-state mimics of enzymatic glycosidic cleavage, J Org Chem, vol. 65, 2399-2409, 2000
2000 K. Shibata, K. Hiruma, O. Kanie, C. H. Wong, Synthesis of 1,1-linked galactosyl mannosides carrying a thiazine ring as mimetics of sialyl Lewis X antigen: investigation of the effect of carboxyl group orientation on P-selectin inhibition, J Org Chem, vol. 65, 2393-2398, 2000
2000 C. Saotome, Y. Kanie, O. Kanie, C. H. Wong, Synthesis and enzymatic evaluation of five-membered iminocyclitols and a pseudodisaccharide, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, 2249-2261, 2000
2000 X. L. Sun, Y. Kanie, C. T. Guo, O. Kanie, Y. Suzuki, C. H. Wong, Syntheses of C-3-modified sialylglycosides as selective inhibitors of influenza hemagglutinin and neuraminidase, Eur J Org Chem, vol. 2643-2653, 2000
2000 M. Li, G. M. Morris, T. Lee, G. S. Laco, C. H. Wong, A. J. Olson, J. H. Elder, A. Wlodawer, A. Gustchina, Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease, Proteins, vol. 38, 29-40, 2000
2000 S. J. Sucheck, C. H. Wong, RNA as a target for small molecules, Curr Opin Chem Biol, vol. 4, 678-686, 2000
2000 O. Kanie, G. Grotenbreg, C. H. Wong, Removal of Benzyl Protecting Groups from Solid-Supported Compounds by Hydrogenolysis Using Palladium Nanoparticles, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 39, 4545-4547, 2000
2000 M. D. Burkart, M. Izumi, E. Chapman, C. H. Lin, C. H. Wong, Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides, J Org Chem, vol. 65, 5565-5574, 2000
2000 K. M. Koeller, C. H. Wong, Recycling of sugar nucleotides in enzymatic glycosylation, In: Carbohydrates in Chemistry and Biology, vol. 663-684, 2000
2000 T. L. Sheppard, C. H. Wong, G. F. Joyce, Nucleoglycoconjugates: design and synthesis of a new class of DNA-carbohydrate conjugates, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 39, 3660-3663, 2000
2000 C. H. Wong, M. Hendrix, P. Alper, S. Priestley, Nucleic acid binders having an hydroxyamine motif, US Patent, vol. #6,120,997, 2000
2000 C. H. Wong, Method for synthesizing 2-ketoaldonic acids, US Patent, vol. #6,080,563, 2000
2000 C. H. Wong, C. H. Lin, Ketoaldonic acids having formed stereogenic centers of R configuration: Methods and Compositions, US Patent, vol. #6,353,095, 2000
2000 T. J. Tolbert, C. H. Wong, Intein-mediated synthesis of proteins containing carbohydrates and other molecular probes, J Am Chem Soc, vol. 122, 5421-5428, 2000
2000 Z. Zhang, C. H. Wong, Glycosylation methods: use of phosphites, In: Carbohydrates in Chemistry and Biology, vol. 117-134, 2000
2000 K. D. Kreutter, C. H. Wong, Enzyme inhibitors, In: Stimulating Concepts in Chemistry, vol. 356-368, 2000
2000 K. M. Koeller, C. H. Wong, Emerging themes in medicinal glycoscience, Nat Biotechnol, vol. 18, 835-841, 2000
2000 T. Flessner, C. H. Wong, Efficient synthesis of triazoles from -arabinose and -fucose, Tetrahedron Lett, vol. 41, 7805-7808, 2000
2000 S. Fong, T. D. Machajewski, C. C. Mak, C. H. Wong, Directed evolution of D-2-keto-3-deoxy-6-phosphogluconate aldolase to new variants for the efficient synthesis of D- and L-sugars, Chem Biol, vol. 7, 873-883, 2000
2000 S. J. Sucheck, W. A. Greenberg, T. J. Tolbert, C. H. Wong, Design of Small Molecules That Recognize RNA: Development of Aminoglycosides as Potential Antitumor Agents That Target Oncogenic RNA Sequences, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 39, 1080-1084, 2000
2000 S. J. Sucheck, A. L. Wong, K. M. Koeller, D. D. Boehr, K. Draker, P. Sears, G. D. Wright, C. H. Wong, Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes, J Am Chem Soc, vol. 122, 5230-5231, 2000
2000 C. Y. Tsai, X. Huang, C. H. Wong, Design and synthesis of cyclic sialyl Lewis X mimetics: a remarkable enhancement of inhibition by pre-organizing all essential functional groups, Tetrahedron Lett, vol. 41, 9499-9503, 2000
2000 K. M. Koeller, C. H. Wong, Complex carbohydrate synthesis tools for glycobiologists: enzyme-based approach and programmable one-pot strategies, Glycobiology, vol. 10, 1157-1169, 2000
2000 K. M. Koeller, C. H. Wong, Chemoenzymatic synthesis of sialyl-trimeric-Lewis x, CHEMISTRY-A EUROPEAN JOURNAL, vol. 6, 1243-1251, 2000
2000 K. M. Koeller, M. E. Smith, C. H. Wong, Chemoenzymatic synthesis of PSGL-1 glycopeptides: sulfation on tyrosine affects glycosyltransferase-catalyzed synthesis of the O-glycan, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, 1017-1025, 2000
2000 A. Duffels, L. G. Green, R. Lenz, S. V. Ley, S. P. Vincent, C. H. Wong, Chemoenzymatic synthesis of L-galactosylated dimeric sialyl Lewis X structures employing alpha-1,3-fucosyltransferase V, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, 2519-2525, 2000
2000 K. M. Koeller, M. E. B. Smith, R. F. Huang, C. H. Wong, Chemoenzymatic synthesis of a PSGL-1 N-terminal glycopeptide containing tyrosine sulfate and alpha-O-linked sialyl Lewis X, J Am Chem Soc, vol. 122, 4241-4242, 2000
2000 V. Wittmann, A. K. Datta, K. M. Koeller, C. H. Wong, Chemoenzymatic synthesis and fluorescent visualization of cell-surface selectin-bound sialyl Lewis x derivatives, CHEMISTRY-A EUROPEAN JOURNAL, vol. 6, 162-171, 2000
2000 A. Romero, C. H. Wong, Chemo-enzymatic total synthesis of 3-epiaustraline, australine, and 7-epialexine, J Org Chem, vol. 65, 8264-8268, 2000
2000 M. D. Burkart, S. P. Vincent, A. Duffels, B. W. Murray, S. V. Ley, C. H. Wong, Chemo-enzymatic synthesis of fluorinated sugar nucleotide: useful mechanistic probes for glycosyltransferases, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, 1937-1946, 2000
2000 S. P. Vincent, A. Schleyer, C. H. Wong, Asymmetric Strecker synthesis of C-glycopeptide, J Org Chem, vol. 65, 4440-4443, 2000
2000 X. S. Ye, C. H. Wong, Anomeric reactivity-based one-pot oligosaccharide synthesis: a rapid route to oligosaccharide libraries, J Org Chem, vol. 65, 2410-2431, 2000
2000 Y. C. Lin, Z. Beck, T. Lee, V. D. Le, G. M. Morris, A. J. Olson, C. H. Wong, J. H. Elder, Alteration of substrate and inhibitor specificity of feline immunodeficiency virus protease, J Virol, vol. 74, 4710-4720, 2000
2000 M. Takayanagi, T. Flessner, C. H. Wong, A strategy for the solution-phase parallel synthesis of N-(pyrrolidinylmethyl)hydroxamic acids, J Org Chem, vol. 65, 3811-3815, 2000
1999 X. Zhang, P. B. Rosenthal, F. Formanowski, W. Fitz, C. H. Wong, H. Meier Ewert, J. J. Skehel, D. C. Wiley, X-ray crystallographic determination of the structure of the influenza C virus haemagglutinin-esterase-fusion glycoprotein, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, vol. 55, 945-961, 1999
1999 C. H. Wong, T. Kimura, Transglycosylation reactions employing a-galactosidase, US Patent, vol. #5,876,981, 1999
1999 P. Sears, K. Witte, C. H. Wong, The effect of counterion, water concentration, and stirring on the stability of subtilisin BPN ' in organic solvents, Journal of Molecular Catalysis B-Enzymatic, vol. 6, 297-304, 1999
1999 C. C. Lin, F. Moris-Varas, G. Weitz-Schmidt, C. H. Wong, Synthesis of sialyl Lewis x mimetics as selectin inhibitors by enzymatic aldol condensation reactions, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, 425-433, 1999
1999 D. Depre, A. Duffels, L. G. Green, R. Lenz, S. V. Ley, C. H. Wong, Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide, CHEMISTRY-A EUROPEAN JOURNAL, vol. 5, 3326-3340, 1999
1999 K. M. Koeller, C. H. Wong, Synthesis of biologically active glycopeptides, J Chin Chem Soc, vol. 46, 659-686, 1999
1999 H. Yuasa, H. Hashimoto, Y. Abe, T. Kajimoto, C. H. Wong, Studies on the unusual stability of cis-2,5-diethoxy-2,5-bis(hydroxymethyl)-1,4-dioxane, Tetrahedron, vol. 55, 2193-2204, 1999
1999 W. G. Wu, L. Pasternack, D. H. Huang, K. M. Koeller, C. C. Lin, O. Seitz, C. H. Wong, Structural study on O-glycopeptides: Glycosylation-induced conformational changes of O-GlcNAc, O-LacNAc, O-sialyl-LacNAc, and O-sialyl-lewis-X peptides of the mucin domain of MAdCAM-1, J Am Chem Soc, vol. 121, 2409-2417, 1999
1999 C. H. Wong, C. C. Lin, T. Kajimoto, Sialyl Lewis x mimetics incorporating fucopeptides, US Patent, vol. #5,962,660, 1999
1999 S. Takayama, S. J. Chung, Y. Igarashi, Y. Ichikawa, A. Sepp, R. I. Lechler, J. Wu, T. Hayashi, G. Siuzdak, C. H. Wong, Selective inhibition of beta-1,4- and alpha-1,3-galactosyltransferases: donor sugar-nucleotide based approach, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, 401-409, 1999
1999 G. Weitz Schmidt, K. W. Gong, C. H. Wong, Selectin/glycoconjugate binding assays for the identification and optimization of selectin antagonists, Anal Biochem, vol. 273, 81-88, 1999
1999 Z. Y. Zhang, I. R. Ollmann, X. S. Ye, R. Wischnat, T. Baasov, C. H. Wong, Programmable one-pot oligosaccharide synthesis, J Am Chem Soc, vol. 121, 734-753, 1999
1999 S. Mao, C. Gao, C. H. Lo, P. Wirsching, C. H. Wong, K. D. Janda, Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewisx and Lewisx, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 96, 6953-6958, 1999
1999 C. H. Wong, C. H. Lin, G. J. Shen, One-pot enzymatic sulfation process using 3?-phosphoadenosine-5?-phosphosulfate and recycled phosphorylated adenosine intermediates, US Patent, vol. #5,919,673, 1999
1999 C. H. Wong, Y. Ichikawa, Oligosaccharide enzyme substrates and inhibitors: Methods and composition, Canadian Patent, vol. #2,106,301, 1999
1999 C. H. Wong, Mimics of complex carbohydrates recognized by receptors, Accounts Chem Res, vol. 32, 376-385, 1999
1999 C. H. Wong, C. C. Lin, T. Woltering, Liposomic sialyl Lewis X mimetics, US Patent, vol. (Allowed), 1999
1999 R.A. Lerner, C. H. Wong, D. L. Boger, S. J. Henriksen, Inhibitors of oleamide hydrolase, US Patent, vol. #5,856,537, 1999
1999 T. Lee, J.H. Elder, C. H. Wong, HIV protease inhibitors with small P3 residues. Broad-based Protease Inhibitors Efficacious Against FIV, SIV, US Patent, vol. (Allowed), 1999
1999 C. H. Wong, D. Slee, K. Laslo, HIV protease inhibitors, US Patent, vol. (Allowed), 1999
1999 S. Hiranuma, O. Kanie, C. H. Wong, Formation of the 1,2,6-orthoester of mannose and its utilization in the glycosylation reaction, Tetrahedron Lett, vol. 40, 6423-6426, 1999
1999 G. J. Shen, A. K. Datta, M. Izumi, K. M. Koeller, C. H. Wong, Expression of alpha2,8/2,9-polysialyltransferase from Escherichia coli K92. Characterization of the enzyme and its reaction products, J Biol Chem, vol. 274, 35139-35146, 1999
1999 M. Hendrix, C. H. Wong, Enzymatic synthesis of carbohydrates, In: Bioorganic Chemistry: Carbohydrates, vol. 198-243, 1999
1999 M. D. Burkart, M. Izumi, C. H. Wong, Enzymatic Regeneration of 3'-Phosphoadenosine-5'-Phosphosulfate Using Aryl Sulfotransferase for the Preparative Enzymatic Synthesis of Sulfated Carbohydrates, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 38, 2747-2750, 1999
1999 C. H. Wong, S. Takayama, B. Orsat, W. Moree, Enantioselective enzymatic protection of amines, US Patent, vol. #5,981,267, 1999
1999 S. P. Vincent, M. D. Burkart, C. Y. Tsai, Z. Y. Zhang, C. H. Wong, Electrophilic fluorination-nucleophilic addition reaction mediated by Selectfluor: Mechanistic studies and new applications, J Org Chem, vol. 64, 5264-5279, 1999
1999 T. Y. Lee, V. D. Le, D. Y. Lim, Y. C. Lin, G. M. Morris, A. L. Wong, A. J. Olson, J. H. Elder, C. H. Wong, Development of a new type of protease inhibitors, efficacious against FIV and HIV variants, J Am Chem Soc, vol. 121, 1145-1155, 1999
1999 S. Takayama, S. T. Lee, S. C. Hung, C. H. Wong, Designing enzymatic resolution of amines, Chem Commun, vol. 2, 127-128, 1999
1999 C. M. Huwe, T. J. Woltering, J. Jiricek, G. Weitz-Schmidt, C. H. Wong, Design, synthesis and biological evaluation of aryl-substituted sialyl Lewis X mimetics prepared via cross-metathesis of C-fucopeptides, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, 773-788, 1999
1999 W. A. Greenberg, E. S. Priestley, P. S. Sears, P. B. Alper, C. Rosenbohm, M. Hendrix, S. C. Hung, C. H. Wong, Design and synthesis of new aminoglycoside antibiotics containing neamine as an optimal core structure: Correlation of antibiotic activity with in vitro inhibition of translation, J Am Chem Soc, vol. 121, 6527-6541, 1999
1999 C. H. Wong, Design and synthesis of carbohydrate mimetics: A new strategy for tackling the problem of carbohydrate-mediated biological recognition, J Chin Chem Soc, vol. 46, 271-281, 1999
1999 M. Famulok, E. L. Winnacker, C. H. Wong, Combinatorial Chemistry in Biology, Current Topics in Microbiology and Immunology, vol. 243, 1999
1999 T. D. Machajewski, C. H. Wong, Chemoenzymatic synthesis of key epothilone fragments, Synthesis, vol. Suppl 1, 1469-1472, 1999
1999 B. Cornils, W. A. Herrmann, R. Schlogl, C. H. Wong, Catalysis from A to Z-A Concise Encyclopedia, In: Wiley-VCH, Weinheim, Germany, 1999
1999 P. Sears, C. H. Wong, Carbohydrate Mimetics: A New Strategy for Tackling the Problem of Carbohydrate-Mediated Biological Recognition, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 38, 2300-2324, 1999
1999 R. D. Kidd, P. Sears, D. H. Huang, K. Witte, C. H. Wong, G. K. Farber, Breaking the low barrier hydrogen bond in a serine protease, Protein Sci, vol. 8, 410-417, 1999
1999 C. H. Wong, T. Sugai, G. J. Shen, Biologically pur culture of Aureobacterium barkeri: KDO-37-2, US Patent, vol. # 5,869,316, 1999
1999 M. D. Burkart, S. P. Vincent, C. H. Wong, An efficient synthesis of CMP-3-fluoroneuraminic acid, Chem Commun, vol. 16, 1525-1526, 1999
1999 M. Takebayashi, S. Hiranuma, Y. Kanie, T. Kajimoto, O. Kanie, C. H. Wong, A versatile synthetic strategy for the preparation and discovery of new iminocyclitols as inhibitors of glycosidases, J Org Chem, vol. 64, 5280-5291, 1999
1999 M. D. Burkart, C. H. Wong, A continuous assay for the spectrophotometric analysis of sulfotransferases using aryl sulfotransferase IV, Anal Biochem, vol. 274, 131-137, 1999
1998 C. H. Wong, H.J.M. Gijsen, Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives, US Patent, vol. #5,795,749, 1998
1998 R. Martin, K. L. Witte, C. H. Wong, The synthesis and enzymatic incorporation of sialic acid derivatives for use as tools to study the structure, activity, and inhibition of glycoproteins and other glycoconjugates, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, 1283-1292, 1998
1998 C. T. Guo, C. H. Wong, T. Kajimoto, T. Miura, Y. Ida, L. R. Juneja, M. J. Kim, H. Masuda, T. Suzuki, Y. Suzuki, Synthetic sialylphosphatidylethanolamine derivatives bind to human influenza A viruses and inhibit viral infection, GLYCOCONJUGATE JOURNAL, vol. 15, 1099-1108, 1998
1998 C. Y. Tsai, W. K. Park, G. Weitz-Schmidt, B. Ernst, C. H. Wong, Synthesis of sialyl Lewis X mimetics using the Ugi four-component reaction, Bioorg Med Chem Lett, vol. 8, 2333-2338, 1998
1998 K. Hiruma, O. Kanie, C. H. Wong, Synthesis of analogs of 1,1-linked galactosyl mannoside as mimetics of sialyl Lewis X tetrasaccharide, Tetrahedron, vol. 54, 15781-15792, 1998
1998 R. Wischnat, R. Martin, C. H. Wong, Synthesis of a new class of N-linked Lewis and LacNAc analogues as potential inhibitors of human fucosyltransferases: A general method for the incorporation of an iminocyclitol as a transition-state mimetic of the donor sugar to the acceptor, J Org Chem, vol. 63, 8361-8365, 1998
1998 C. H. Wong, S. Takayama, Synthesis of 9-0-acetyl N-acetyl-neuraminic acid oligosaccharides, US Patent, vol. #5,766,887, 1998
1998 T. Miura, T. Kajimoto, M. Jimbo, K. Yamagishi, J. C. Inokuchi, C. H. Wong, Synthesis and evaluation of morpholino- and pyrrolidinosphingolipids as inhibitors of glucosylceramide synthase, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, 1481-1489, 1998
1998 P. B. Rosenthal, X. Zhang, F. Formanowski, W. Fitz, C. H. Wong, H. Meier Ewert, J. J. Skehel, D. C. Wiley, Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus, Nature, vol. 396, 92-96, 1998
1998 C. H. Wong, M. Hendrix, E. S. Priestley, W. A. Greenberg, Specificity of aminoglycoside antibiotics for the A-site of the decoding region of ribosomal RNA, Chem Biol, vol. 5, 397-406, 1998
1998 K. Witte, O. Seitz, C. H. Wong, Solution- and solid-phase synthesis of N-protected glycopeptide esters of the benzyl type as substrates for subtilisin-catalyzed glycopeptide couplings, J Am Chem Soc, vol. 120, 1979-1989, 1998
1998 C. H. Wong, T. G. Marron, T. J. Woltering, G. WeitzSchmidt, Sialyl Lewis x mimetics incorporating mannopeptides, US Patent, vol. #5,837,862, 1998
1998 E. E. Simanek, G. J. McGarvey, J. A. Jablonowski, C. H. Wong, Selectin−Carbohydrate Interactions:  From Natural Ligands to Designed Mimics, Chem Rev, vol. 98, 833-862, 1998
1998 T. Kanemitsu, O. Kanie, C. H. Wong, Quantitative monitoring of solid-phase synthesis using gated decoupling C-13 NMR spectroscopy with a C-13-enriched protecting group and an internal standard in the synthesis of sialyl Lewis(X) tetrasaccharide, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 37, 3415-3418, 1998
1998 C. H. Wong, T. Hayashi, Process for preparing nucleoside inhibitors of glycosyltransferases, US Patent, vol. #5,770,407, 1998
1998 P. B. Alper, M. Hendrix, P. Sears, C. H. Wong, Probing the specificity of aminoglycoside ribosomal RNA interactions with designed synthetic analogs, J Am Chem Soc, vol. 120, 1965-1978, 1998
1998 J. H. Hogg, I. R. Ollmann, A. Wetterholm, M. B. Andberg, J. Haeggstrom, B. Samuelsson, C. H. Wong, Probing the activities and mechanisms of leukotriene A(4) hydrolase with synthetic inhibitors, CHEMISTRY-A EUROPEAN JOURNAL, vol. 4, 1698-1713, 1998
1998 T. F. J. Lampe, G. Weitz-Schmidt, C. H. Wong, Parallel Synthesis of Sialyl Lewis X Mimetics on a Solid Phase: Access to a Library of Fucopeptides, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 37, 1707-1711, 1998
1998 C. H. Wong, Method for synthesizing 2-ketoaldonic acids, US Patent, vol. #5,759,825, 1998
1998 P. Sears, C. H. Wong, Mechanism-based inhibition of carbohydrate-mediated biological recognitions, Chem Commun, vol. 11, 1161-1170, 1998
1998 V. Wittmann, S. Takayama, K. W. Gong, G. Weitz-Schmidt, C. H. Wong, Ligand recognition by E- and P-selectin: Chemoenzymatic synthesis and inhibitory activity of bivalent sialyl Lewis x derivatives and sialyl Lewis x carboxylic acids, J Org Chem, vol. 63, 5137-5143, 1998
1998 C. H. Wong, F. MorisVaras, C. C. Lin, Inhibitors of E-, P-, and L-selectin binding, US Patent, vol. #5,830,871, 1998
1998 E. E. Simanek, D. H. Huang, L. Pasternack, T. D. Machajewski, O. Seitz, D. S. Millar, H. J. Dyson, C. H. Wong, Glycosylation of threonine of the repeating unit of RNA polymerase II with beta-linked N-acetylglucosame leads to a turnlike structure, J Am Chem Soc, vol. 120, 11567-11575, 1998
1998 C. H. Wong, H. Kondo, Glycosylation of peptides using glycosyl phosphite reagents, US Patent, vol. #5,854,391, 1998
1998 P. Sears, C. H. Wong, Enzyme action in glycoprotein synthesis, Cell Mol Life Sci, vol. 54, 223-252, 1998
1998 V. P. Vassilev, E. E. Simanek, M. R. Wood, C. H. Wong, Enzymatic synthesis of a chiral gelator with remarkably low molecular weight, Chem Commun, vol. 17, 1865-1866, 1998
1998 Y. Kanie, A. Kirsch, O. Kanie, C. H. Wong, Enzymatic assay of galactosyltransferase by capillary electrophoresis, Anal Biochem, vol. 263, 240-245, 1998
1998 R. Wischnat, R. Martin, S. Takayama, C. H. Wong, Chemoenzymatic synthesis of iminocyclitol derivatives: a useful library strategy for the development of selective fucosyltransfer enzymes inhibitors, Bioorg Med Chem Lett, vol. 8, 3353-3358, 1998
1998 J. B. Jones, C. H. Wong, Biocatalysis and biotransformation exploiting nature's magic - Overview, Curr Opin Chem Biol, vol. 2, 67-69, 1998
1998 C. H. Wong, X. S. Ye, Z. Y. Zhang, Assembly of oligosaccharide libraries with a designed building block and an efficient orthogonal protection-deprotection strategy, J Am Chem Soc, vol. 120(28), 7137-7138, 1998
1998 T. Lee, G. S. Laco, B. E. Torbett, H. S. Fox, D. L. Lerner, J. H. Elder, C. H. Wong, Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 95, 939-944, 1998
1998 S. J. Chung, S. Takayama, C. H. Wong, Acceptor substrate-based selective inhibition of galactosyltransferases, Bioorg Med Chem Lett, vol. 8, 3359-3364, 1998
1998 K. Witte, J. Skolnick, C. H. Wong, A synthetic retrotransition (backward reading) sequence of the right-handed three-helix bundle domain (10-53) of protein A shows similarity in conformation as predicted by computation, J Am Chem Soc, vol. 120, 13042-13045, 1998
1998 H. Kamitakahara, T. Suzuki, N. Nishigori, Y. Suzuki, O. Kanie, C. H. Wong, A lysoganglioside poly-L-glutamic acid conjugate as a picomolar inhibitor of influenza hemagglutinin, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 37, 1524-1528, 1998
1998 C. H. Wong, M. Hendrix, D. D. Manning, C. Rosenbohm, W. A. Greenberg, A library approach to the discovery of small molecules that recognize RNA: Use of a 1,3-hydroxyamine motif as core, J Am Chem Soc, vol. 120, 8319-8327, 1998
1997 C. H. Lin, B. W. Murray, I. R. Ollmann, C. H. Wong, Why is CMP-ketodeoxyoctonate highly unstable?, Biochemistry, vol. 36, 780-785, 1997
1997 M. Kaneko, O. Kanie, T. Kajimoto, C. H. Wong, Toward a transition state analog inhibitor of N-acetylglucosaminyl transferase V, Bioorg Med Chem Lett, vol. 7, 2809-2812, 1997
1997 M. W. Cappi, W. J. Moree, L. Qiao, T. G. Marron, G. Weitz-Schmidt, C. H. Wong, Synthesis of novel 6-amido-6-deoxy-l-galactose derivatives as sialyl Lewis X mimetics, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 5, 283-296, 1997
1997 M. Koketsu, T. Nitoda, H. Sugino, L. R. Juneja, M. Kim, T. Yamamoto, N. Abe, T. Kajimoto, C. H. Wong, Synthesis of a novel sialic acid derivative (sialylphospholipid) as an antirotaviral agent, J Med Chem, vol. 40, 3332-3335, 1997
1997 C. H. Wong, F. MorisVara, S. C. Hung, T. G. Marron, C. C. Lin, K. W. Gong, G. WeitzSchmidt, Small molecules as structural and functional mimics of sialyl Lewis X tetrasaccharide in selectin inhibition: A remarkable enhancement of inhibition by additional negative charge and/or hydrophobic group, J Am Chem Soc, vol. 119, 8152-8158, 1997
1997 C. H. Wong, Sialyl Lewis x mimetics incorporating fucopeptides, US Patent, vol. #5,614,615, 1997
1997 C. H. Wong, T. Kajimoto, Sialyl Lewis X mimetics, US Patent, vol. #5,599,915, 1997
1997 C. C. Lin, C. H. Lin, C. H. Wong, Sialic acid aldolase-catalyzed condensation of pyruvate and N-substituted mannosamine: A useful method for the synthesis of N-substituted sialic acids, Tetrahedron Lett, vol. 38, 2649-2652, 1997
1997 J. Wu, S. Takayama, C. H. Wong, G. Siuzdak, Quantitative electrospray mass spectrometry for the rapid assay of enzyme inhibitors, Chem Biol, vol. 4, 653-657, 1997
1997 S. C. Hung, C. C. Lin, C. H. Wong, One-pot synthesis of 1-allyl- and 1-allenyl-6-O-acetyl-2,3,4-tri-O-benzyl-[alpha]-D-glycosides from methyl tetra-O-benzyl-[alpha]-D-glycosides, Tetrahedron Lett, vol. 38, 5419-5422, 1997
1997 C. H. Wong, T. Kajimoto, K.C. Liu, L. Chen, Omega-deoxy-azasugars, US Patent, vol. #5,596,005, 1997
1997 W. Fitz, C. H. Wong, Oligosaccharide synthesis by enzymatic glycosidation, In: Preparative Carbohydrate Chemistry, vol. 485-504, 1997
1997 C. H. Wong, Y. Ichikawa, G. J. Shen, Oligosaccharide enzyme substrates and inhibitors: methods and compositions, US Patent, vol. #5,593,887, 1997
1997 S. Takayama, G. J. McGarvey, C. H. Wong, Microbial aldolases and transketolases: new biocatalytic approaches to simple and complex sugars, Annu Rev Microbiol, vol. 51, 285-310, 1997
1997 B. W. Murray, V. Wittmann, M. D. Burkart, S. C. Hung, C. H. Wong, Mechanism of human alpha-1,3-fucosyltransferase V: glycosidic cleavage occurs prior to nucleophilic attack, Biochemistry, vol. 36, 823-831, 1997
1997 M. Hendrix, P. B. Alper, E. S. Priestley, C. H. Wong, Hydroxyamines as a new motif for the molecular recognition of phosphodiesters: Implications for aminoglycoside-RNA interactions, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 36, 95-98, 1997
1997 W. J. Moree, P. Sears, K. Kawashiro, K. Witte, C. H. Wong, Exploitation of subtilisin BPN' as catalyst for the synthesis of peptides containing noncoded amino acids, peptide mimetics and peptide conjugates, J Am Chem Soc, vol. 119, 3942-3947, 1997
1997 S. Takayama, G. J. McGarvey, C. H. Wong, Enzymes in organic synthesis: recent developments in aldol reactions and glycosylations, Chem Soc Rev, vol. 26, 407-415, 1997
1997 T. Kimura, V. P. Vassilev, G. J. Shen, C. H. Wong, Enzymatic synthesis of beta-hydroxy-alpha-amino acids based on recombinant D- and L-threonine aldolases, J Am Chem Soc, vol. 119, 11734-11742, 1997
1997 M. J. Kim, I. T. Lim, H. J. Kim, C. H. Wong, Enzymatic single aldol reactions of remote dialdehydes, Tetrahedron-Asymmetry, vol. 8, 1507-1509, 1997
1997 K. Witte, P. Sears, R. Martin, C. H. Wong, Enzymatic glycoprotein synthesis: Preparation of ribonuclease glycoforms via enzymatic glycopeptide condensation and glycosylation, J Am Chem Soc, vol. 119, 2114-2118, 1997
1997 M. Hendrix, E. S. Priestley, G. F. Joyce, C. H. Wong, Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance, J Am Chem Soc, vol. 119, 3641-3648, 1997
1997 T. Ikeda, T. Kajimoto, H. Kondo, C. H. Wong, Design and synthesis of an alpha-mannosyl terpenoid as selective inhibitor of P-selectin, Bioorg Med Chem Lett, vol. 7, 2485-2490, 1997
1997 O. Seitz, C. H. Wong, Chemoenzymatic solution- and solid-phase synthesis of O-glycopeptides of the mucin domain of MAdCAM-1. A general route to O-LacNAc, O-sialyl-LacNAc, and O-sialyl-Lewis-X peptides, J Am Chem Soc, vol. 119, 8766-8776, 1997
1997 S. Takayama, R. Martin, J. Y. Wu, K. Laslo, G. Siuzdak, C. H. Wong, Chemoenzymatic preparation of novel cyclic imine sugars and rapid biological activity evaluation using electrospray mass spectrometry and kinetic analysis, J Am Chem Soc, vol. 119, 8146-8151, 1997
1997 S. Takayama, C. H. Wong, Chemo-enzymatic approach to carbohydrate recognition, Curr Org Chem, vol. 1, 109-126, 1997
1997 G. J. McGarvey, C. H. Wong, Chemical, enzymatic and structural studies in molecular glycobiology, LIEBIGS ANNALEN DER CHEMIE, vol. 6, 1059-1074, 1997
1997 K. D. Janda, L. C. Lo, C. H. Lo, M. M. Sim, R. Wang, C. H. Wong, R. A. Lerner, Chemical selection for catalysis in combinatorial antibody libraries, Science, vol. 275, 945-948, 1997
1997 C. H. Wong, H. Kondo, Carbon Linked Glycosyl Compounds, US Patent, vol. #5,597,906, 1997
1997 R. Wang, D. H. Steensma, Y. Takaoka, J. W. Yun, T. Kajimoto, C. H. Wong, A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 5, 661-672, 1997
1997 M. D. Burkart, Z. Y. Zhang, S. C. Hung, C. H. Wong, A new method for the synthesis of fluoro-carbohydrates and glycosides using selectfluor, J Am Chem Soc, vol. 119, 11743-11746, 1997
1997 C. H. Wong, G. C. Look, A facile enzymatic synthesis of galactosyl-b-1,3-glycals, Australian Patent, vol. #672029, 1997
1997 T. Hayashi, B. W. Murray, R. Wang, C. H. Wong, A chemoenzymatic synthesis of UDP-(2-deoxy-2-fluoro)-galactose and evaluation of its interaction with galactosyltransferase, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 5, 497-500, 1997
1997 C. H. Wong, A chemo-enzymatic approach to the study of carbohydrate-based biological recognitions, Pure Appl Chem, vol. 69, 419-422, 1997
1997 V. Wittmann, C. H. Wong, 1H-Tetrazole as Catalyst in Phosphomorpholidate Coupling Reactions: Efficient Synthesis of GDP-Fucose, GDP-Mannose, and UDP-Galactose, J Org Chem, vol. 62, 2144-2147, 1997
1996 C. H. Wong, H. Kondo, Thio Linked Glycosyl Compounds, US Patent, vol. #5,514,784, 1996
1996 M. W. Cappi, W. J. Moree, L. Qiao, T. G. Marron, G. Weitz-Schmidt, C. H. Wong, The synthesis of novel 6-amino-6-deoxy-L-galactose glycopeptides as potent sialyl Lewis X mimetics, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 35, 2346-2347, 1996
1996 M. W. Cappi, W. J. Moree, L. Qiao, T. G. Marron, G. Weitz-Schmidt, C. H. Wong, The synthesis of novel 6-amido-6-deoxy-L-galactose derivatives as potent sialyl Lewis(x) mimetics, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 35, 2346-2348, 1996
1996 S. Takayama, P. O. Livingston, C. H. Wong, Synthesis of the melanoma-associated ganglioside 9-O-acetyl GD3 through regioselective enzymatic acetylation of GD3 using subtilisin, Tetrahedron Lett, vol. 37, 9271-9274, 1996
1996 R. Wang, C. H. Wong, Synthesis of sialyl Lewis X mimetics: Use of O-[alpha]-fucosyl-(1R, 2R)-2-aminocyclohexanol as core structure, Tetrahedron Lett, vol. 37, 5427-5430, 1996
1996 C. C. Lin, M. Shimazaki, M. P. Heck, S. Aoki, R. Wang, T. Kimura, H. Ritzen, S. Takayama, S. H. Wu, G. WeitzSchmidt, C. H. Wong, Synthesis of sialyl Lewis X mimetics and related structures using the glycosyl phosphite methodology and evaluation of E-selectin inhibition, J Am Chem Soc, vol. 118, 6826-6840, 1996
1996 S. Takayama, M. Shimazaki, L. Qiao, C. H. Wong, Synthesis of lactosamine derivatives using beta-D-galactosidase from Bacillus circulans, Bioorg Med Chem Lett, vol. 6, 1123-1126, 1996
1996 S. C. Hung, C. H. Wong, Synthesis of glycosyl chlorides with acid-labile protecting groups, Tetrahedron Lett, vol. 37, 4903-4906, 1996
1996 S. H. Wu, M. Shimazaki, C. C. Lin, L. Qiao, W. J. Moree, C. H. Wong, Synthesis of fucopeptides as sialyl Lewis X mimetics, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 35, 88-89, 1996
1996 X. H. Qian, F. MorisVaras, C. H. Wong, Synthesis of C-2-symmetrical polyhydroxyazepanes as inhibitors of glycosidases, Bioorg Med Chem Lett, vol. 6, 1117-1122, 1996
1996 W. Fitz, P. B. Rosenthal, C. H. Wong, Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 4, 1349-1353, 1996
1996 L. Qiao, B. W. Murray, M. Shimazaki, J. Schultz, C. H. Wong, Synergistic inhibition of human alpha-1,3-fucosyltransferase V, J Am Chem Soc, vol. 118, 7653-7662, 1996
1996 S. C. Hung, C. H. Wong, Samarium diiodide mediated coupling of glycosyl phosphates with carbon radical or anion acceptors - Synthesis of C-glycosides, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 35, 2671-2674, 1996
1996 H. J. Gijsen, L. Qiao, W. Fitz, C. H. Wong, Recent Advances in the Chemoenzymatic Synthesis of Carbohydrates and Carbohydrate Mimetics, Chem Rev, vol. 96, 443-474, 1996
1996 K. Hiruma, T. Kajimoto, G. WeitzSchmidt, I. Ollmann, C. H. Wong, Rational design and synthesis of a 1,1-linked disaccharide that is 5 times as active as sialyl Lewis X in binding to E-selectin, J Am Chem Soc, vol. 118, 9265-9270, 1996
1996 W. K. C. Park, M. Auer, H. Jaksche, C. H. Wong, Rapid combinatorial synthesis of aminoglycoside antibiotic mimetics: Use of a polyethylene glycol-linked amine and a neamine-derived aldehyde in multiple component condensation as a strategy for the discovery of new inhibitors of the HIV RNA Rev responsive element, J Am Chem Soc, vol. 118, 10150-10155, 1996
1996 C. H. Wong, Practical synthesis of oligosaccharides based on glycosyltransferases and glycosylphosphites, In: Modern Methods in Carbohydrate Synthesis, vol. 467-491, 1996
1996 C. De Luca, M. Lansing, F. Crescenzi, I. Martini, G. J. Shen, M. O'Regan, C. H. Wong, Overexpression, one-step purification and characterization of UDP-glucose dehydrogenase and UDP-N-acetylglucosamine pyrophosphorylase, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 4, 131-141, 1996
1996 C. H. Wong, Y. Ichikawa, Oligosaccharide enzyme substrates and inhibitors: Methods and composition, Australian Patent, vol. #668505, 1996
1996 C. H. Wong, N-Acetylgalactosaminyl or N-acetylglucosaminyl transfer using N-acetylglucosaminyl-1-phosphate or N-acetylgalactosaminyl-1-phosphate as precursor and glycosyl-nucleotide regeneration, US Patent, vol. # 5,516,665, 1996
1996 P. B. Alper, S. C. Hung, C. H. Wong, Metal catalyzed diazo transfer for the synthesis of azides from amines, Tetrahedron Lett, vol. 37, 6029-6032, 1996
1996 B. W. Murray, S. Takayama, J. Schultz, C. H. Wong, Mechanism and specificity of human alpha-1,3-fucosyltransferase V, Biochemistry, vol. 35, 11183-11195, 1996
1996 C. C. Lin, T. Kimura, S. H. Wu, G. WeitzSchmidt, C. H. Wong, Liposome-like fucopeptides as sialyl Lewis X mimetics, Bioorg Med Chem Lett, vol. 6, 2755-2760, 1996
1996 K. Shibata, K. Shingu, V. P. Vassiley, K. Nishide, T. Fujita, M. Node, T. Kajimoto, C. H. Wong, Kinetic and thermodynamic control of L-Threonine aldolase catalyzed reaction and its application to the synthesis of mycestericin D, Tetrahedron Lett, vol. 37, 2791-2794, 1996
1996 P. Sears, C. H. Wong, Intervention of carbohydrate recognition by proteins and nucleic acids, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 93, 12086-12093, 1996
1996 J. E. Patterson, I. R. Ollmann, B. F. Cravatt, D. L. Boger, C. H. Wong, R. A. Lerner, Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide, J Am Chem Soc, vol. 118, 5938-5945, 1996
1996 B. Orsat, P. B. Alper, W. Moree, C. P. Mak, C. H. Wong, Homocarbonates as substrates for the enantioselective enzymatic protection of amines, J Am Chem Soc, vol. 118, 712-713, 1996
1996 F. MorisVaras, X. H. Qian, C. H. Wong, Enzymatic/chemical synthesis and biological evaluation of seven-membered iminocyclitols, J Am Chem Soc, vol. 118, 7647-7652, 1996
1996 S. Takayama, W. J. Moree, C. H. Wong, Enzymatic resolution of amines and amino alcohols using pent-4-enoyl derivatives, Tetrahedron Lett, vol. 37, 6287-6290, 1996
1996 P. Sears, C. H. Wong, Engineering enzymes for bioorganic synthesis: Peptide bond formation, BIOTECHNOLOGY PROGRESS, vol. 12, 423-433, 1996
1996 C. H. Wong, Y. F. Wang, W. J. Hennen, Enantio- and regio-selective synthesis of organic compounds using enol esters as irreversible transacylation reagents, US Patent, vol. #5,585,252, 1996
1996 T. Uchiyama, T. J. Woltering, W. Wong, C. C. Lin, T. Kajimoto, M. Takebayashi, G. Weitz Schmidt, T. Asakura, M. Noda, C. H. Wong, Design and synthesis of C-linked fucosides as inhibitors of E-selectin, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 4, 1149-1165, 1996
1996 J. H. Jeong, B. W. Murray, S. Takayama, C. H. Wong, Cyclic guanidino-sugars with low pK(a) as transition-state analog inhibitors of glycosidases: Neutral instead of charged species are the active forms, J Am Chem Soc, vol. 118, 4227-4234, 1996
1996 C. H. Wong, Chemoenzymatic synthesis: Application to the study of carbohydrate recognition, ACTA CHEMICA SCANDINAVICA, vol. 50, 211-218, 1996
1996 X. Qian, F. Moris Varas, M. C. Fitzgerald, C. H. Wong, C2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 4, 2055-2069, 1996
1996 T. G. Marron, T. J. Woltering, G. Weitz-Schmidt, C. H. Wong, C-Mannose derivatives as potent mimics of sialyl Lewis X, Tetrahedron Lett, vol. 37, 9037-9040, 1996
1996 T. J. Woltering, G. Weitz-Schmidt, C. H. Wong, C-Fucopeptides as selectin antagonists: Attachment of lipid moieties enhances the activity, Tetrahedron Lett, vol. 37, 9033-9036, 1996
1996 C. H. Wong, R. L. Pederson, Y. F. Wang, Azido diacetal propane derivatives, US Patent, vol. #5,565,585, 1996
1996 C. H. Wong, J. R. Durrwachter, R. L. Pederson, Aldolase catalyzed stereoselective synthesis of arabinohexulose, xyloheptulose, threohexulose and xylohexulose, US Patent, vol. #5,576,426, 1996
1996 R. D. Kidd, H. P. Yennawar, P. Sears, C. H. Wong, G. K. Farber, A weak calcium binding site in subtilisin BPN' has a dramatic effect on protein stability, J Am Chem Soc, vol. 118, 1645-1650, 1996
1996 T. Kimura, S. Takayama, H. M. Huang, C. H. Wong, A practical method for the synthesis of N-acetyl-D-lactosamine derivatives by the tandem use of galactose oxidase and beta-galactosidase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 35, 2348-2350, 1996
1996 T. Kimura, S. Takayama, H. Huang, C. H. Wong, A practical method for the synthesis of N-acetyl-D-lactosamine derivatives by the tandem use of galactose oxidase and -galactosidase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 35, 2348-2349, 1996
1996 M. Hendrix, C. H. Wong, A chemoenzymatic approach to carbohydrate-mediated cell adhesion, Pure Appl Chem, vol. 68, 2081-2087, 1996
1996 M. Hendrix, C. H. Wong, A chemo-enzymatic approach to the study of carbohydrate recognition in biological systems, ENANTIOMER, vol. 1, 305-310, 1996
1996 C. H. Wong, W. J. Hennen, 2-Deoxyderivatives of N-acetylneuraminic acid and their preparation, US Patent, vol. #5,554,771, 1996
1995 T. Kajimoto, C. H. Wong, Transition-state analog inhibitors for N-acetylglucosaminyltransfer enzymes, RIKEN Review, vol. 8, 13-14, 1995
1995 C. H. Wong, Topochemistry and inhibition of carbohydrate-mediated cell adhesion, In: New Perspectives in Drug Design, vol. 35-50, 1995
1995 W. Yuan, C. H. Wong, B. Samuelsson, Tight-binding inhibitors of leukotriene A.sub.4 hydrolase, US Patent, vol. #5,455,271, 1995
1995 W. C. Chou, C. Fotsch, C. H. Wong, Synthesis of Nitrocyclitols Based on Enzymatic Aldol Reaction and Intramolecular Nitroaldol Reaction, J Org Chem, vol. 60, 2916-2917, 1995
1995 H. M. Huang, C. H. Wong, Synthesis of Biologically-Active Sialyl-Lewis-X Mimetics, J Org Chem, vol. 60, 3100-3106, 1995
1995 H. J. M. Gijsen, W. Chi Huey, Synthesis of a Cyclitol via a Tandem Enzymatic Aldol - Intramolecular Horner-Wadsworth-Emmons Reaction, Tetrahedron Lett, vol. 36, 7057-7060, 1995
1995 S. Hiranuma, T. Shimizu, T. Nakata, T. Kajimoto, W. Chi Huey, Synthesis and Inhibition Analysis of Five-Membered Homoazasugars from -Arabinofuranose via an S2 Reaction of the Chloromethylsulfonate, Tetrahedron Lett, vol. 36, 8247-8250, 1995
1995 C. H. Wong, L. Provencher, J. A. Porco, S. H. Jung, Y. F. Wang, L. R. Chen, R. Wang, D. H. Steensma, Synthesis and Evaluation of Homoazasugars as Glycosidase Inhibitors, J Org Chem, vol. 60, 1492-1501, 1995
1995 H. J. M. Gijsen, C. H. Wong, Sequential One-Pot Aldol Reactions Catalyzed by 2-Deoxyribose-5-Phosphate Aldolase and Fructose-1,6-Diphosphate Aldolase, J Am Chem Soc, vol. 117, 2947-2948, 1995
1995 H. J. M. Gijsen, C. H. Wong, Sequential 3-Substrate and 4-Substrate Aldol Reactions Catalyzed by Aldolases, J Am Chem Soc, vol. 117, 7585-7591, 1995
1995 D. H. Slee, K. L. Laslo, J. H. Elder, I. R. Ollmann, A. Gustchina, J. Kervinen, A. Zdanov, A. Wlodawer, C. H. Wong, Selectivity in the Inhibition of Hiv and Fiv Protease - Inhibitory and Mechanistic Studies of Pyrrolidine-Containing Alpha-Keto Amide and Hydroxyethylamine Core Structures, J Am Chem Soc, vol. 117, 11867-11878, 1995
1995 C. H. Wong, E. Garciajunceda, L. R. Chen, O. Blanco, H. J. M. Gijsen, D. H. Steensma, Recombinant 2-Deoxyribose-5-Phosphate Aldolase in Organic-Synthesis - Use of Sequential 2-Substrate and 3-Substrate Aldol Reactions, J Am Chem Soc, vol. 117, 3333-3339, 1995
1995 C. W. Bradshaw, C. H. Wong, G. J. Shen, Pseudomonas sp. ATCC 49794 PED alcohol dehydrogenase, US Patent, vol. #5,385,833, 1995
1995 T. Ikeda, T. Kajimoto, T. Nohara, J. e. Kinjo, C. H. Wong, Preparation of a neoglycolipid carrying the oligosaccharide component of saponin from Albizzia julibrissin, Tetrahedron Lett, vol. 36, 1509-1510, 1995
1995 A. Wetterholm, J. Z. Haeggstrom, B. Samuelsson, W. Yuan, B. Munoz, C. H. Wong, Potent and selective inhibitors of leukotriene A4 hydrolase: effects on purified enzyme and human polymorphonuclear leukocytes, J Pharmacol Exp Ther, vol. 275, 31-37, 1995
1995 T. Ikeda, T. Kajimoto, C. H. Wong, Oligosaccharides components in traditional Chinese medicines and the liposomes carrying oligosaccharides, RIKEN Review, vol. 8, 21-22, 1995
1995 C. H. Wong, Y. Ichikawa, Oligosaccharide enzyme substrates and inhibitors: Methods and composition, US Patent, vol. #5,461,143, 1995
1995 P. G. Wang, W. Fitz, C. H. Wong, Making Complex Carbohydrates Via Enzymatic Routes, CHEMTECH, vol. 25, 22-32, 1995
1995 S. A. Defrees, W. Kosch, W. Way, J. C. Paulson, S. Sabesan, R. L. Halcomb, D. H. Huang, Y. Ichikawa, C. H. Wong, Ligand Recognition by E-Selectin - Synthesis, Inhibitory Activity, and Conformational-Analysis of Bivalent Sialyl-Lewis-X Analogs, J Am Chem Soc, vol. 117, 66-79, 1995
1995 C. H. Wong, C. W. Bradshaw, Lactobacillus kefir alcohol dehydrogenase, US Patent, vol. #5,342,767, 1995
1995 V. P. Vassilev, T. Uchiyama, T. Kajimoto, C. H. Wong, L-threonine aldolase in organic synthesis: Preparation of novel [beta]-hydroxy-[alpha]-amino acids, Tetrahedron Lett, vol. 36, 4081-4084, 1995
1995 I. R. Ollmann, J. H. Hogg, B. Munoz, J. Z. Haeggstrom, B. Samuelsson, C. H. Wong, Investigation of the inhibition of leukotriene A4 hydrolase, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 3, 969-995, 1995
1995 C. H. Wong, Intervention of carbohydrate-mediated biological recognitions, RIKEN Review, vol. 8, 3月4日, 1995
1995 C. H. Wong, K.K.C. Liu, Fructosyl C-glycoside nucleoside analogs, US Patent, vol. #5,393,879, 1995
1995 I. Henderson, C. H. Wong, Formation of carbon-carbon bonds, In: Handbook of enzyme catalysis in organic synthesis, vol. 547-580, 1995
1995 J. M. Fang, C. H. Lin, C. W. Bradshaw, C. H. Wong, Enzymes in Organic-Synthesis - Oxidoreductions (Pg 967, 1995), JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, vol. 1781-1781, 1995
1995 J. M. Fang, C. H. Lin, C. W. Bradshaw, C. H. Wong, Enzymes in Organic-Synthesis - Oxidoreductions, JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, vol. 967-978, 1995
1995 C. H. Wong, R. L. Halcomb, Y. Ichikawa, T. Kajimoto, Enzymes in Organic-Synthesis - Application to the Problems of Carbohydrate-Recognition .2, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 34, 521-546, 1995
1995 C. H. Wong, R. L. Halcomb, Y. Ichikawa, T. Kajimoto, Enzymes in Organic-Synthesis - Application to the Problems of Carbohydrate-Recognition .1, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 34, 412-432, 1995
1995 M. Hendrix, C. H. Wong, Enzymes in organic synthesis: Application to the study of carbohydrate recognition, Proceedings of the Chiral '95 USA Symposium, vol. 27-34, 1995
1995 C. Deluca, M. Lansing, I. Martini, F. Crescenzi, G. J. Shen, M. Oregan, C. H. Wong, Enzymatic-Synthesis of Hyaluronic-Acid with Regeneration of Sugar Nucleotides, J Am Chem Soc, vol. 117, 5869-5870, 1995
1995 C. H. Lin, G. J. Shen, E. Garciajunceda, C. H. Wong, Enzymatic-Synthesis and Regeneration of 3'-Phosphoadenosine 5'-Phosphosulfate (Paps) for Regioselective Sulfation of Oligosaccharides, J Am Chem Soc, vol. 117, 8031-8032, 1995
1995 R. L. Halcomb, C. H. Wong, Enzymatic synthesis of glycoside bonds, In: Handbook of enzyme catalysis in organic synthesis, vol. 279-316, 1995
1995 C. H. Lin, M. Shimazaki, C. H. Wong, M. Koketsu, L. R. Juneja, M. Kim, Enzymatic synthesis of a sialyl Lewis X dimer from egg yolk as an inhibitor of E-selectin, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 3, 1625-1630, 1995
1995 C. H. Wong, G. C. Look, Enzymatic process for producing a galactosyl b-1,3-glycal disaccharide using b-galactosidase, US Patent, vol. #5,403,726, 1995
1995 C. H. Wong, Enzymatic and Chemoenzymatic Synthesis of Carbohydrates, Pure Appl Chem, vol. 67, 1609-1616, 1995
1995 S. Hiranuma, V. P. Vassilev, T. Kajimoto, C. H. Wong, Design of oligosaccharide mimetics with higher stability and simpler structures than parent oligosaccharides, RIKEN Review, vol. 8, 19-20, 1995
1995 T. Uchiyama, V. P. Vassilev, T. Kajimoto, W. C. Wong, H. M. Huang, C. C. Lin, C. H. Wong, Design and Synthesis of Sialyl-Lewis-X Mimetics, J Am Chem Soc, vol. 117, 5395-5396, 1995
1995 E. A. Stura, S. Ghosh, E. Garcia Junceda, L. Chen, C. H. Wong, I. A. Wilson, Crystallization and preliminary crystallographic data for class I deoxyribose-5-phosphate aldolase from Escherichia coli: an application of reverse screening, Proteins, vol. 22, 67-72, 1995
1995 T. Sugai, C. H. Lin, G. J. Shen, C. H. Wong, CMP-KDO synthetase: overproduction and application to the synthesis of CMP-KDO and analogs, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 3, 313-320, 1995
1995 E. Garcia Junceda, G. J. Shen, R. Alajarin, C. H. Wong, Cloning and overexpression of rhamnose isomerase and fucose isomerase, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 3, 1349-1355, 1995
1995 V. P. Vassilev, T. Kajimoto, C. H. Wong, Application of L-allo-threonine aldolase in the synthesis of glycoconjugate precursors, RIKEN Review, vol. 8, 25-26, 1995
1995 V. P. Vassilev, T. Uchiyama, T. Kajimoto, C. H. Wong, An efficient chemo-enzymatic synthesis of [alpha]-amino-[beta]-hydroxy-[gamma]-butyrolactone, Tetrahedron Lett, vol. 36, 5063-5064, 1995
1995 J. H. Hogg, I. R. Ollmann, J. Z. Haeggstrom, A. Wetterholm, B. Samuelsson, C. H. Wong, Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 3, 1405-1415, 1995
1995 W. Fitz, J. R. Schwark, C. H. Wong, Aldotetroses and C(3)-Modified Aldohexoses as Substrates for N-Acetylneuraminic Acid Aldolase - a Model for the Explanation of the Normal and the Inversed Stereoselectivity, J Org Chem, vol. 60, 3663-3670, 1995
1995 R. Alajarin, E. Garciajunceda, C. H. Wong, A Short Enzymatic-Synthesis of L-Glucose from Dihydroxyacetone Phosphate and L-Glyceraldehyde, J Org Chem, vol. 60, 4294-4295, 1995
1995 E. Garcia Junceda, G. J. Shen, T. Sugai, C. H. Wong, A new strategy for the cloning, overexpression and one step purification of three DHAP-dependent aldolases: rhamnulose-1-phosphate aldolase, fuculose-1-phosphate aldolase and tagatose-1,6-diphosphate aldolase, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 3, 945-953, 1995
1994 H. J. M. Gijsen, C. H. Wong, Unprecedented Asymmetric Aldol Reactions with 3 Aldehyde Substrates Catalyzed by 2-Deoxyribose-5-Phosphate Aldolase, J Am Chem Soc, vol. 116, 8422-8423, 1994
1994 Y. Ichikawa, C. H. Wong, Topochemistry and inhibition of selectin-mediated cell adhesion: Chemical-enzymatic synthesis of inhibitors related to E-selectin recognition, In: Complex Carbohydrates in Drug Research. The Alfred Benzon Symposium, vol. 36, 118-133, 1994
1994 H. Yuasa, T. Kajimoto, C. H. Wong, Synthesis of iminothiasugar as a potential transition-state analog inhibitor of glycosyltransfer reactions, Tetrahedron Lett, vol. 35, 8243-8246, 1994
1994 I. Henderson, K. B. Sharpless, C. H. Wong, Synthesis of Carbohydrates Via Tandem Use of the Osmium-Catalyzed Asymmetric Dihydroxylation and Enzyme-Catalyzed Aldol Addition-Reactions, J Am Chem Soc, vol. 116, 558-561, 1994
1994 C. H. Fotsch, C. H. Wong, Synthesis of a guanidino-sugar as a glycosyl cation mimic, Tetrahedron Lett, vol. 35, 3481-3484, 1994
1994 Y. Ichikawa, R. L. Halcomb, C. H. Wong, Sticky Solutions, Chemistry in Britain, vol. 30, 117-+, 1994
1994 R. L. Halcomb, H. M. Huang, C. H. Wong, Solution-Phase and Solid-Phase Synthesis of Inhibitors of Helicobacter-Pylori Attachment and E-Selectin-Mediated Leukocyte Adhesion, J Am Chem Soc, vol. 116, 11315-11322, 1994
1994 M. Schuster, P. Wang, J. C. Paulson, C. H. Wong, Solid-Phase Chemical-Enzymatic Synthesis of Glycopeptides and Oligosaccharides, J Am Chem Soc, vol. 116, 1135-1136, 1994
1994 Y. F. Wang, Y. Takaoka, C. H. Wong, Remarkable Stereoselectivity in the Inhibition of Alpha-Galactosidase from Coffee Bean by a New Polyhydroxypyrrolidine Inhibitor, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 33, 1242-1244, 1994
1994 Y. Ichikawa, R. Wang, C. H. Wong, Regeneration of sugar nucleotide for enzymatic oligosaccharide synthesis, Methods Enzymol, vol. 247, 107-127, 1994
1994 G. F. Herrmann, P. Wang, G. J. Shen, C. H. Wong, Recombinant Whole Cells as Catalysts for the Enzymatic-Synthesis of Oligosaccharides and Glycopeptides, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 33, 1241-1242, 1994
1994 C. H. Wong, M. Schuster, Process for solid-phase glycopeptide synthesis, US Patent, vol. #5,369,017, 1994
1994 C. H. Wong, T. Kajimoto, K.K.C. Liu, Lihren Chen, Process for forming Omega-deoxy-azasugars, US Patent, vol. #5,276,120, 1994
1994 G. F. Herrmann, P. Wang, G. J. Shen, E. Garciajunceda, S. H. Khan, K. L. Matta, C. H. Wong, Large-Scale Production of Recombinant Alpha-1,2-Mannosyltransferase from Escherichia-Coli for the Study of Acceptor Specificity and Use of the Recombinant Whole Cells in Synthesis, J Org Chem, vol. 59, 6356-6362, 1994
1994 J. L. Marquardt, E. D. Brown, W. S. Lane, T. M. Haley, Y. Ichikawa, C. H. Wong, C. T. Walsh, Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycin, Biochemistry, vol. 33, 10646-10651, 1994
1994 C. H. Wong, T. Sugai, G. J. Shen, KDO aldolase and condensation reactions employed therewith, US Patent, vol. #5,358,859, 1994
1994 H. Kondo, S. Aoki, Y. Ichikawa, R. L. Halcomb, H. Ritzen, C. H. Wong, Glycosyl Phosphites as Glycosylation Reagents - Scope and Mechanism, J Org Chem, vol. 59, 864-877, 1994
1994 S. Aoki, H. Kondo, C. H. Wong, Glycosyl phosphites as glycosylation reagents, Methods Enzymol, vol. 247, 193-211, 1994
1994 L. Provencher, D. H. Steensma, C. H. Wong, Five-membered ring azasugars as potent inhibitors of alpha-L-rhamnosidase (naringinase) from Penicillium decumbens, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 2, 1179-1188, 1994
1994 G. Siuzdak, Z. L. Zheng, J. Y. Rhamphal, Y. Ichikawa, K. C. Nicolaou, F. C. A. Gaeta, K. S. Chatman, C. H. Wong, Examination of the Sialyl-Lewis-X Calcium Complex by Electrospray Mass-Spectrometry, Bioorg Med Chem Lett, vol. 4, 2863-2866, 1994
1994 C. H. Wong, G. M. Whitesides, Enzymes in Synthetic Organic Chemistry, In: Pergamon Press, 1994
1994 J. M. Fang, C. H. Wong, Enzymes in Organic-Synthesis - Alteration of Reversible-Reactions to Irreversible-Processes, Synlett, vol. 393-402, 1994
1994 R. L. Halcomb, W. Fitz, C. H. Wong, Enzymatic-Synthesis of 7-Deoxy-N-Acetylneuraminic Acid and 7-O-Methyl-N-Acetylneuraminic Acid, Tetrahedron-Asymmetry, vol. 5, 2437-2442, 1994
1994 P. Sears, M. Schuster, P. Wang, K. Witte, C. H. Wong, Engineering Subtilisin for Peptide Coupling - Studies on the Effects of Counterions and Site-Specific Modifications on the Stability and Specificity of the Enzyme, J Am Chem Soc, vol. 116, 6521-6530, 1994
1994 W. Fitz, C. H. Wong, Combined Use of Subtilisin and N-Acetylneuraminic Acid Aldolase for the Synthesis of a Fluorescent Sialic-Acid, J Org Chem, vol. 59, 8279-8280, 1994
1994 C. H. Wong, F. Gaeta, Combined use of b-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one-pot synthesis of oligosaccharides, US Patent, vol. #5,374,541, 1994
1994 I. Henderson, E. Garcia Junceda, K. K. Liu, Y. L. Chen, G. J. Shen, C. H. Wong, Cloning, overexpression and isolation of the type II FDP aldolase from E. coli for specificity study and synthetic application, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 2, 837-843, 1994
1994 I. Henderson, K. Laslo, C. H. Wong, Chemoenzymatic synthesis of homoazasugars, Tetrahedron Lett, vol. 35, 359-362, 1994
1994 R. L. Halcomb, C. H. Wong, Asymmetric synthesis based on enzymes, In: Stereocontrolled Organic Synthesis, vol. 413, 1994
1994 S. H. Jung, J. H. Jeong, P. Miller, C. H. Wong, An Efficient Multigram-Scale Preparation of Dihydroxyacetone Phosphate, J Org Chem, vol. 59, 7182-7184, 1994
1994 B. Munoz, C. Z. Giam, C. H. Wong, Alpha-ketoamide Phe-Pro isostere as a new core structure for the inhibition of HIV protease, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 2, 1085-1090, 1994
1994 C. H. Wong, K.K.C. Liu, Aldolase enzyme process for making 5-azido-5-deoxy-hexulose-1-phosphate, US Patent, vol. #5,352,591, 1994
1994 W. C. Chou, L. H. Chen, J. M. Fang, C. H. Wong, A New Route to Deoxythiosugars Based on Aldolases, J Am Chem Soc, vol. 116, 6191-6194, 1994
1994 C. H. Wong, G. J. Shen, Y. Ichikawa, A method and composition for synthesizing sialylated glycosyl compounds, US Patent, vol. #5,278,299, 1994
1994 S. Hiranuma, Kajimoto, Tetsuya, C. H. Wong, A facile synthesis of 1-thiopentofuranoside, Tetrahedron Lett, vol. 35, 5257-5260, 1994
1993 T. Sugai, H. Ritzen, C. H. Wong, Towards the Chemoenzymatic Synthesis of Lipid-A, Tetrahedron-Asymmetry, vol. 4, 1051-1058, 1993
1993 P. Wang, M. Schuster, Y. F. Wang, C. H. Wong, Synthesis of Phospholipid Inhibitor Conjugates by Enzymatic Transphosphatidylation with Phospholipase-D, J Am Chem Soc, vol. 115, 10487-10491, 1993
1993 R. L. Halcomb, C. H. Wong, Synthesis of Oligosaccharides, Glycopeptides, and Glycolipids, CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 3, 694-700, 1993
1993 T. Sugai, G. J. Shen, Y. Ichikawa, C. H. Wong, Synthesis of 3-Deoxy-D-Manno-2-Octulosonic Acid (Kdo) and Its Analogs Based on Kdo Aldolase-Catalyzed Reactions, J Am Chem Soc, vol. 115, 413-421, 1993
1993 M. M. Sim, H. Kondo, C. H. Wong, Synthesis and Use of Glycosyl Phosphites - an Effective Route to Glycosyl Phosphates, Sugar Nucleotides, and Glycosides, J Am Chem Soc, vol. 115, 2260-2267, 1993
1993 Y. Ichikawa, G. C. Look, G. J. Shen, P. Sears, P. Wang, C. H. Wong, Recent development in enzymatic synthesis of oligosaccharides and glycopeptides, In: Carbohydrates and Carbohydrate Polymers, vol. 1月16日, 1993
1993 C. H. Wong, Y. Ichikawa, T. Kajimoto, K. K. C. Liu, G. J. Shen, C. H. Lin, Y. F. Wang, D. P. Dumas, Y. C. Lin, R. Wang, G. C. Look, Practical Synthesis of Carbohydrates Based on Aldolases and Glycosyl Transferases, Pure Appl Chem, vol. 65, 803-808, 1993
1993 M. Schuster, B. Munoz, W. Yuan, C. H. Wong, Papain catalyzed synthesis of peptide isosteres, Tetrahedron Lett, vol. 34, 1247-1250, 1993
1993 S. A. Defrees, F. C. A. Gaeta, Y. C. Lin, Y. Ichikawa, C. H. Wong, Ligand Recognition by E-Selectin - Analysis of Conformation and Activity of Synthetic Monomeric and Bivalent Sialyl Lewis-X Analogs, J Am Chem Soc, vol. 115, 7549-7550, 1993
1993 C. H. Wong, C. W. Bradshaw, Lactobacillus kefir alcohol dehydrogenase, US Patent, vol. #5,225,339, 1993
1993 Y. Takaoka, T. Kajimoto, C. H. Wong, Inhibition of N-Acetylglucosaminyltransfer Enzymes - Chemical-Enzymatic Synthesis of New 5-Membered Acetamido Azasugars, J Org Chem, vol. 58, 4809-4812, 1993
1993 G. Siuzdak, Y. Ichikawa, T. J. Caulfield, B. Munoz, C. H. Wong, K. C. Nicolaou, Evidence of Ca2+-Dependent Carbohydrate Association through Ion Spray Mass-Spectrometry, J Am Chem Soc, vol. 115, 2877-2881, 1993
1993 P. Wang, G. J. Shen, Y. F. Wang, Y. Ichikawa, C. H. Wong, Enzymes in Oligosaccharide Synthesis - Active-Domain Overproduction, Specificity Study, and Synthetic Use of an Alpha-1,2-Mannosyltransferase with Regeneration of Gdp-Man, J Org Chem, vol. 58, 3985-3990, 1993
1993 G. C. Look, C. H. Fotsch, C. H. Wong, Enzyme-Catalyzed Organic Synthesis: Practical Routes to Aza Sugars and Their Analogs for Use as Glycoprocessing Inhibitors, Accounts Chem Res, vol. 26, 182-190, 1993
1993 C. H. Wong, M. Schuster, P. Wang, P. Sears, Enzymatic-Synthesis of N-Linked and O-Linked Glycopeptides, J Am Chem Soc, vol. 115, 5893-5901, 1993
1993 W. Yuan, B. Munoz, C. H. Wong, J. Z. Haeggstrom, A. Wetterholm, B. Samuelsson, Development of selective tight-binding inhibitors of leukotriene A4 hydrolase, J Med Chem, vol. 36, 211-220, 1993
1993 C. H. Wong, Development of Enzymes for Chemoenzymatic Synthesis, Chimia, vol. 47, 127-132, 1993
1993 Yi Fong Wang, David Dumas P., C. H. Wong, Chemo-enzymatic synthesis of five-membered azasugars as inhibitors of fucosidase and fucosyltransferase: An issue regarding the stereochemistry discrimination at transition states, Tetrahedron Lett, vol. 34, 403-406, 1993
1993 T. Kajimoto, T. Sugai, C. H. Wong, Aldolase Catalyzed Reaction for Carbohydrate Synthesis, TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, vol. 5, 193-207, 1993
1993 G. F. Herrmann, Y. Ichikawa, C. Wandrey, F. C. A. Gaeta, J. C. Paulson, C. H. Wong, A new multi-enzyme system for a one-pot synthesis of sialyl oligosaccharides: Combined use of [beta]-galactosidase and [alpha](26)-sialyltransferase coupled with regeneration in situ of CMP-sialic acid, Tetrahedron Lett, vol. 34, 3091-3094, 1993
1993 G. C. Look, Y. Ichikawa, G. J. Shen, P. W. Cheng, C. H. Wong, A Combined Chemical and Enzymatic Strategy for the Construction of Carbohydrate-Containing Antigen Core Units, J Org Chem, vol. 58, 4326-4330, 1993
1993 C. H. Wong, K.K.C. Liu, 2-Methyl-5-hydroxylmethyl and 2,5-dimethyl-3,4-dihydroxypyrrolidines, US Patent, vol. #5,229,523, 1993
1993 C. H. Wong, W. J. Hennen, 2-Deoxy Derivatives of N-Acetyl Neuraminic Acid and Their Preparation, US Patent, vol. #5,239,091, 1993
1992 C. H. Lin, T. Sugai, R. L. Halcomb, Y. Ichikawa, C. H. Wong, Unusual Stereoselectivity in Sialic-Acid Aldolase-Catalyzed Aldol Condensations - Synthesis of Both Enantiomers of High-Carbon Monosaccharides, J Am Chem Soc, vol. 114, 10138-10145, 1992
1992 C. H. Wong, D. P. Dumas, Y. Ichikawa, K. Koseki, S. J. Danishefsky, B. W. Weston, J. B. Lowe, Specificity, Inhibition, and Synthetic Utility of a Recombinant Human Alpha-1,3-Fucosyl-Transferase, J Am Chem Soc, vol. 114, 7321-7322, 1992
1992 E. Fernholz, D. Schloeder, K. K. C. Liu, C. W. Bradshaw, H. M. Huang, K. Janda, R. A. Lerner, C. H. Wong, Specificity of Antibody-Catalyzed Transesterifications Using Enol Esters - a Comparison with Lipase Reactions, J Org Chem, vol. 57, 4756-4761, 1992
1992 S. J. Danishefsky, J. Gervay, J. M. Peterson, F. E. McDonald, K. Koseki, T. Oriyama, D. A. Griffith, C. H. Wong, D. P. Dumas, Remarkable Regioselectivity in the Chemical Glycosylation of Glycal Acceptors - a Concise Solution to the Synthesis of Sialyl-Lewis-X Glycal, J Am Chem Soc, vol. 114, 8329-8331, 1992
1992 C. H. Wong, R. Wang, Y. Ichikawa, Regeneration of Sugar Nucleotide for Enzymatic Oligosaccharide Synthesis - Use of Gal-1-Phosphate Uridyltransferase in the Regeneration of Udp-Galactose, Udp-2-Deoxygalactose, and Udp-Galactosamine, J Org Chem, vol. 57, 4343-4344, 1992
1992 K. K. C. Liu, R. L. Pederson, C. H. Wong, Rabbit muscle aldolase catalyzed preparation of 6-deoxy-6-chloro-D-fructose and 6-deoxy-6-chloro-L-sorbose from 3-chloro-2-hydroxypropanal and DHAP, In: Preparative Biotransformations, vol. 04:01.1, 1992
1992 J. L. C. Liu, G. J. Shen, Y. Ichikawa, J. F. Rutan, G. Zapata, W. F. Vann, C. H. Wong, Overproduction of Cmp-Sialic Acid Synthetase for Organic-Synthesis, J Am Chem Soc, vol. 114, 3901-3910, 1992
1992 W. Yuan, C. H. Wong, J. Z. Haeggstrom, A. Wetterholm, B. Samuelsson, Novel Tight-Binding Inhibitors of Leukotriene-a(4) Hydrolase, J Am Chem Soc, vol. 114, 6552-6553, 1992
1992 R. L. Pederson, C. H. Wong, Lipoprotein lipase catalyzed kinetic resolution of 2-acetoxy-3-azidopropanal diethyl acetal, In: Preparative Biotransformations, vol. 01:06.1, 1992
1992 C. W. Bradshaw, W. Hummel, C. H. Wong, Lactobacillus-Kefir Alcohol-Dehydrogenase - a Useful Catalyst for Synthesis, J Org Chem, vol. 57, 1532-1536, 1992
1992 C. H. Wong, l-Isomeric sugars having formed stereogenic centers of (R-configuration: Methods and compositions, US Patent, vol. #5,162,513, 1992
1992 C. H. Wong, J. R. Durrwachter, R. L. Pederson, Fructose-1,6-diphosphate Aldolase Catalyzed Stereoselective Synthesis of Sugars, US Patent, vol. #5,143,831, 1992
1992 C. H. Wong, K. K. C. Liu, T. Kajimoto, L. H. Chen, Z. Y. Zhong, D. P. Dumas, J. L. C. Liu, Y. Ichikawa, G. J. Shen, Enzymes for Carbohydrate and Peptide Syntheses, Pure Appl Chem, vol. 64, 1197-1202, 1992
1992 Y. Ichikawa, G. C. Look, C. H. Wong, Enzyme-catalyzed oligosaccharide synthesis, Anal Biochem, vol. 202, 215-238, 1992
1992 C. W. Bradshaw, J. J. Lalonde, C. H. Wong, Enzymatic synthesis of (R) and (S) 1-deuterohexanol, Appl Biochem Biotechnol, vol. 33, 15-24, 1992
1992 W. J. Hennen, H. M. Sweers, Y. F. Wang, C. H. Wong, Enzymatic regioselective hydrolysis of a peracetylated furanose derivative, In: Preparative Biotransformations, vol. 01:07.1, 1992
1992 K. K. C. Liu, C. H. Wong, Enzymatic Halohydration of Glycals, J Org Chem, vol. 57, 3748-3750, 1992
1992 C. H. Wong, Engineering enzymes for the synthesis of carbohydrates and peptides, In: Harnessing Biotechnology for the 21st Century. ACS Conference Proceedings Series, vol. 168-171, 1992
1992 C. H. Wong, Engineering enzymes for chemoenzymatic synthesis Part II: Modifying proteases for peptide synthesis, TIBTECH, vol. 10(110, 378-381, 1992
1992 C. H. Wong, Engineering enzymes for chemoenzymatic synthesis Part I: Practical routes to aza-sugars and complex carbohydrates, TIBTECH, vol. 10(10), 337-341, 1992
1992 C. H. Wong, Y. F. Wang, W. J. Hennen, Enantio- and Regioselective Synthesis of Organic Compounds Using Enol Esters as Irreversible Transacylation Reagents, US Patent, vol. #5,106,750, 1992
1992 Y. Ichikawa, M. M. Sim, C. H. Wong, Efficient Chemical Synthesis of Gdp-Fucose, J Org Chem, vol. 57, 2943-2946, 1992
1992 C. H. Wong, K. K. Liu, T. Kajimoto, L. Chen, Z. Zhong, Y. Ichikawa, G. J. Shen, Developing better enzymes for organic synthesis, Enzyme Engineering XI, Ann. N.Y. Acad. Sci, vol. 672, 343-351, 1992
1992 L. R. Chen, D. P. Dumas, C. H. Wong, Deoxyribose-5-Phosphate Aldolase as a Catalyst in Asymmetric Aldol Condensation, J Am Chem Soc, vol. 114, 741-748, 1992
1992 G. J. Shen, C. H. Wong, Construction of a diverse Fab expression library from autoimmunized mice based on an improved preparation of cloning arms from bacteriophage vectors: a new library with potential for screening of biocatalysts, Biocatalysis and Biotransformation, vol. 6, 101-114, 1992
1992 Y. C. Lin, C. W. Hummel, D. H. Huang, Y. Ichikawa, K. C. Nicolaou, C. H. Wong, Conformational Studies of Sialyl Lewis-X in Aqueous-Solution, J Am Chem Soc, vol. 114, 5452-5454, 1992
1992 G. J. Shen, J. L. C. Liu, C. H. Wong, Cloning and overexpression of a tagged CMP-N-acetylneuraminic acid synthetase from E. coli using a lambda phage system and application of the enzyme to the synthesis of CMP-N-acetylneuraminic acid, Biocatalysis and Biotransformation, vol. 6, 31-42, 1992
1992 H. Fu, H. Kondo, Y. Ichikawa, G. C. Look, C. H. Wong, Chloroperoxidase-Catalyzed Asymmetric-Synthesis - Enantioselective Reactions of Chiral Hydroperoxides with Sulfides and Bromohydration of Glycals, J Org Chem, vol. 57, 7265-7270, 1992
1992 C. H. Wong, Y. Ichikawa, T. Kajimoto, K. K. C. Liu, Y. C. Lin, G. C. Look, Chemical-enzymatic synthesis of carbohydrates, In: Microbial Reagents in Organic Synthesis. NATO ASI Series, vol. 381, 35-42, 1992
1992 Y. Ichikawa, Y. C. Lin, D. P. Dumas, G. J. Shen, E. Garciajunceda, M. A. Williams, R. Bayer, C. Ketcham, L. E. Walker, J. C. Paulson, C. H. Wong, Chemical-Enzymatic Synthesis and Conformational-Analysis of Sialyl Lewis-X and Derivatives, J Am Chem Soc, vol. 114, 9283-9298, 1992
1992 P.N. Bryan, M. Pantoliano, M.L. Rollence, C. H. Wong, Biosynthetic uses of thermostable proteases, US Patent, vol. #5,116,741, 1992
1992 H. Kondo, Y. Ichikawa, C. H. Wong, Beta-Sialyl Phosphite and Phosphoramidite - Synthesis and Application to the Chemoenzymatic Synthesis of Cmp-Sialic Acid and Sialyl Oligosaccharides, J Am Chem Soc, vol. 114, 8748-8750, 1992
1992 D. P. Dumas, T. Kajimoto, K. K. C. Liu, C. H. Wong, D. B. Berkowitz, S. J. Danishefsky, Azasugar and Glycal Inhibitors of Alpha-L-Fucosidase, Bioorg Med Chem Lett, vol. 2, 33-36, 1992
1992 C. W. Bradshaw, H. Fu, G. J. Shen, C. H. Wong, A Pseudomonas Sp Alcohol-Dehydrogenase with Broad Substrate-Specificity and Unusual Stereospecificity for Organic-Synthesis, J Org Chem, vol. 57, 1526-1532, 1992
1992 K. K. C. Liu, C. H. Wong, A New Strategy for the Synthesis of Nucleoside Analogs Based on Enzyme-Catalyzed Aldol Reactions, J Org Chem, vol. 57, 4789-4791, 1992
1992 G. C. Look, C. H. Wong, A facile enzymatic synthesis of gal[beta]1,3glucal: a key intermediate for the synthesis of Lea and sialyl Lea, Tetrahedron Lett, vol. 33, 4253-4256, 1992
1991 K. K. C. Liu, T. Kajimoto, L. R. Chen, Z. Y. Zhong, Y. Ichikawa, C. H. Wong, Use of Dihydroxyacetone Phosphate Dependent Aldolases in the Synthesis of Deoxyazasugars, J Org Chem, vol. 56, 6280-6289, 1991
1991 C. H. Wong, T. Krach, C. Gautheron Le Narvor, Y. Ichikawa, G. C. Look, F. Gaeta, D. Thompson, K. C. Nicolaou, Synthesis of novel disaccharides based on glycosyltransferases: [beta]1,4galactosyltransferase, Tetrahedron Lett, vol. 32, 4867-4870, 1991
1991 K. C. Nicolaou, C. W. Hummel, N. J. Bockovich, C. H. Wong, Stereocontrolled Synthesis of Sialyl Lex, the Oligosaccharide Binding Ligand to Elam-1 (Sialyl = N-Acetylneuramin), JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, vol. 13, 870-872, 1991
1991 H. Fu, M. Newcomb, C. H. Wong, Pseudomonas-Oleovorans Monooxygenase Catalyzed Asymmetric Epoxidation of Allyl Alcohol Derivatives and Hydroxylation of a Hypersensitive Radical Probe with the Radical Ring-Opening Rate Exceeding the Oxygen Rebound Rate, J Am Chem Soc, vol. 113, 5878-5880, 1991
1991 C. H. Wong, W. J. Hennen, Process for the enzymatic synthesis of nucleosides, US Patent, vol. #5,075,225, 1991
1991 W. Yuan, Z. Zhong, C. H. Wong, Probing the Inhibition of Leukotriene-A4 Hydrolase Based on Its Aminopeptidase Activity, Bioorg Med Chem Lett, vol. 1, 551-556, 1991
1991 C. H. Wong, Y. Ichikawa, T. Krach, C. Gautheronlenarvor, D. P. Dumas, G. C. Look, Probing the Acceptor Specificity of Beta-1,4-Galactosyltransferase for the Development of Enzymatic-Synthesis of Novel Oligosaccharides, J Am Chem Soc, vol. 113, 8137-8145, 1991
1991 T. Kajimoto, L. R. Chen, K. K. C. Liu, C. H. Wong, Palladium-Mediated Stereocontrolled Reductive Amination of Azido Sugars Prepared from Enzymatic Aldol Condensation - a General-Approach to the Synthesis of Deoxy Aza Sugars, J Am Chem Soc, vol. 113, 6678-6680, 1991
1991 C. F. Barbas, C. H. Wong, Overexpression and Substrate-Specificity Studies of Phosphodeoxyribomutase and Thymidine Phosphorylase, BIOORGANIC CHEMISTRY, vol. 19, 261-269, 1991
1991 C. H. Wong, K. T. Wang, New developments in enzymatic peptide synthesis, EXPERIENTIA, vol. 47, 1123-1129, 1991
1991 C. H. Wong, Microbial aldolases in carbohydrate synthesis, In: Enzymes in carbohydrate synthesis. American Chemical Society Symposium Series, vol. 466, 23-37, 1991
1991 F. Hong, G. C. Look, Z. Wei, E. N. Jacobsen, C. H. Wong, Mechanistic Study of a Synthetically Useful Monooxygenase Model Using the Hypersensitive Probe Trans-2-Phenyl-1-Vinylcyclopropane, J Org Chem, vol. 56, 6497-6500, 1991
1991 C. Gautheronlenarvor, C. H. Wong, Glycosyltransferase-Catalyzed Stereoselective Glycosidation of Monosaccharide-Based Glycosidase Inhibitors - a New Approach to the Synthesis of Sequence-Specific Glycosidase Inhibitors, J Chem Soc Chem Commun, vol. 1130-1131, 1991
1991 K. K. C. Liu, R. L. Pederson, C. H. Wong, Fructose 1,6-Diphosphate Aldolase-Catalyzed Stereoselective C-C Bond Formation, JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, vol. 2669-2673, 1991
1991 Y. Ichikawa, G. J. Shen, C. H. Wong, Enzyme-Catalyzed Synthesis of Sialyl Oligosaccharide with Insitu Regeneration of Cmp-Sialic Acid, J Am Chem Soc, vol. 113, 4698-4700, 1991
1991 C. W. Bradshaw, C. H. Wong, W. Hummel, M. R. Kula, Enzyme-Catalyzed Asymmetric-Synthesis of (S)-2-Amino-4-Phenylbutanoic Acid and (R)-2-Hydroxy-4-Phenylbutanoic Acid, BIOORGANIC CHEMISTRY, vol. 19, 29-39, 1991
1991 T. Kajimoto, K. K. C. Liu, R. L. Pederson, Z. Y. Zhong, Y. Ichikawa, J. A. Porco, C. H. Wong, Enzyme-Catalyzed Aldol Condensation for Asymmetric-Synthesis of Azasugars - Synthesis, Evaluation, and Modeling of Glycosidase Inhibitors, J Am Chem Soc, vol. 113, 6187-6196, 1991
1991 D. G. Drueckhammer, W. J. Hennen, R. L. Pederson, C. F. Barbas, C.M.G. III, T. Krach, C. H. Wong, Enzyme Catalysis in Synthetic Carbohydrate Chemistry, SYNTHESE, vol. 7, 499-525, 1991
1991 D. P. Dumas, Y. Ichikawa, C. H. Wong, J. B. Lowe, R. P. Nair, Enzymatic-Synthesis of Sialyl Lex and Derivatives Based on a Recombinant Fucosyl-Transferase, Bioorg Med Chem Lett, vol. 1, 425-428, 1991
1991 C. H. Wong, G. J. Shen, R. L. Pederson, Y. F. Wang, W. J. Hennen, Enzymatic catalysis in organic synthesis, Methods Enzymol, vol. 202, 591-620, 1991
1991 Z. Y. Zhong, J. L. C. Liu, L. M. Dinterman, M. A. J. Finkelman, W. T. Mueller, M. L. Rollence, M. Whitlow, C. H. Wong, Engineering Subtilisin for Reaction in Dimethylformamide, J Am Chem Soc, vol. 113, 683-684, 1991
1991 Z. Y. Zhong, C. H. Wong, Development of new enzymatic catalysts for peptide synthesis in aqueous and organic solvents, Biomed Biochim Acta, vol. 50, S9-14, 1991
1991 H. Fu, G. J. Shen, C. H. Wong, Asymmetric Epoxidation of Allyl Alcohol Derivatives by Omega-Hydroxylase from Pseudomonas-Oleovorans, Recueil Des Travaux Chimiques Des Pays-Bas-Journal of the Royal Netherlands Chemical Society, vol. 110, 167-170, 1991
1991 R. L. Pederson, J. Esker, C. H. Wong, An improved synthesis of dihydroxyacetone phosphate, Tetrahedron, vol. 47, 2643-2648, 1991
1991 C. H. Wong, Aldolases in synthesis of fluorosugars, In: Selective fluorination in organic and bioorganic chemistry. American Chemical Society Symposium Series, vol. 456, 156-162, 1991
1991 Z. Zhong, J. A. Bibbs, W. Yuan, C. H. Wong, Active-Site-Directed Modification of Subtilisin, J Am Chem Soc, vol. 113, 2259-2263, 1991
1991 C. W. Bradshaw, G. J. Shen, C. H. Wong, A New Alcohol-Dehydrogenase with Unique Stereospecificity from Pseudomonas Sp, BIOORGANIC CHEMISTRY, vol. 19, 398-417, 1991
1991 Y. Ichikawa, J. L. C. Liu, G. J. Shen, C. H. Wong, A Highly Efficient Multienzyme System for the One-Step Synthesis of a Sialyl Trisaccharide - Insitu Generation of Sialic-Acid and N-Acetyllactosamine Coupled with Regeneration of Udp-Glucose, Udp-Galactose, and Cmp-Sialic Acid, J Am Chem Soc, vol. 113, 6300-6302, 1991
1991 C. Gautheronlenarvor, Y. Ichikawa, C. H. Wong, A Complete Change of Stereoselectivity in Sialic-Acid Aldolase Reactions - a Novel Synthetic Route to the Kdo Type of 9-Carbon-L Sugars, J Am Chem Soc, vol. 113, 7816-7818, 1991
1990 K. K. Liu, K. Nozaki, C. H. Wong, Problems of acyl migration in lipase-catalyzed enantioselective transformation of meso-1,3-diol systems, BIOCATALYSIS, vol. 3, 169-177, 1990
1990 J. A. Bibbs, Z. Zhong, C. H. Wong, Modification of protease for peptide synthesis"", in Proceedings of symposium on materials synthesis utilizing biological processes, In: Materials Synthesis Utilizing Biological Processes, vol. 223-228, 1990
1990 S. H. Hsu, S. S. Wu, Wang, Yi Fong, C. H. Wong, Lipase-catalyzed irreversible transesterification using enol esters: XAD-8 immobilized lipoprotein lipase-catalyzed resolution of secondary alcohols, Tetrahedron Lett, vol. 31, 6403-6406, 1990
1990 K. A. Babiak, J. S. Ng, J. H. Dygos, C. L. Weyker, Y. F. Wang, C. H. Wong, Lipase-Catalyzed Irreversible Transesterification Using Enol Esters - Resolution of Prostaglandin Synthons 4-Hydroxy-2-Alkyl-2-Cyclopentenones and Inversion of the 4s Enantiomer to the 4r Enantiomer, J Org Chem, vol. 55, 3377-3381, 1990
1990 C. H. Wong, S. T. Chen, W. J. Hennen, J. A. Bibbs, Y. F. Wang, J. L. C. Liu, M. W. Pantoliano, M. Whitlow, P. N. Bryan, Enzymes in Organic-Synthesis - Use of Subtilisin and a Highly Stable Mutant Derived from Multiple Site-Specific Mutations, J Am Chem Soc, vol. 112, 945-953, 1990
1990 R. L. Pederson, K. K. C. Liu, J. F. Rutan, L. Chen, C. H. Wong, Enzymes in Organic-Synthesis - Synthesis of Highly Enantiomerically Pure 1,2-Epoxy Aldehydes, Epoxy Alcohols, Thiirane, Aziridine, and Glyceraldehyde-3-Phosphate, J Org Chem, vol. 55, 4897-4901, 1990
1990 C. H. Wong, Enzymes in organic synthesis, Chemtracts-Organic Chemistry, vol. 3, 91-111, 1990
1990 J. B. West, W. J. Hennen, J. L. Lalonde, J. A. Bibbs, Z. Y. Zhong, E. F. Meyer, C. H. Wong, Enzymes as Synthetic Catalysts - Mechanistic and Active-Site Considerations of Natural and Modified Chymotrypsin, J Am Chem Soc, vol. 112, 5313-5320, 1990
1990 C. H. Wong, Design and development of enzymatic organic synthesis, In: Chem. Aspects Enzyme Biotech, vol. 165-178, 1990
1990 C. F. Barbas, Y. F. Wang, C. H. Wong, Deoxyribose-5-Phosphate Aldolase as a Synthetic Catalyst, J Am Chem Soc, vol. 112, 2013-2014, 1990
1990 C. H. Wong, Aldolases in organic synthesis, BIOCATALYSIS, vol. 319, 1990
1990 G. J. Shen, Y. F. Wang, C. Bradshaw, C. H. Wong, A New Nad-Dependent Alcohol-Dehydrogenase with Opposite Facial Selectivity Useful for Asymmetric Reduction and Cofactor Regeneration, JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, vol. 677-679, 1990
1989 C. H. Vonderosten, A. J. Sinskey, C. F. Barbas, R. L. Pederson, Y. F. Wang, C. H. Wong, Use of a Recombinant Bacterial Fructose-1,6-Diphosphate Aldolase in Aldol Reactions - Preparative Syntheses of 1-Deoxynojirimycin, 1-Deoxymannojirimycin, 1,4-Dideoxy-1,4-Imino-D-Arabinitol, and Fagomine, J Am Chem Soc, vol. 111, 3924-3927, 1989
1989 S. T. Chen, C. H. Wong, Studies on Angiotensin-Converting Enzyme-Inhibitors - Protease Catalyzed Resolution of Aryl 3-Mercapto-2-Methylpropionic Ester, J Chin Chem Soc, vol. 36, 451-458, 1989
1989 D. G. Drueckhammer, J. R. Durrwachter, R. L. Pederson, D. C. Crans, L. Daniels, C. H. Wong, Reversible and Insitu Formation of Organic Arsenates and Vanadates as Organic Phosphate Mimics in Enzymatic-Reactions - Mechanistic Investigation of Aldol Reactions and Synthetic Applications, J Org Chem, vol. 54, 70-77, 1989
1989 C. H. von der Osten, C. F. Barbas, 3rd, C. H. Wong, A. J. Sinskey, Molecular cloning, nucleotide sequence and fine-structural analysis of the Corynebacterium glutamicum fda gene: structural comparison of C. glutamicum fructose-1,6-biphosphate aldolase to class I and class II aldolases, Mol Microbiol, vol. 3, 1625-1637, 1989
1989 Y. F. Wang, S. T. Chen, K. K. C. Liu, C. H. Wong, Lipase-catalyzed irreversible transesterification using enol esters: Resolution of cyanohydrins and syntheses of ethyl (R)-2-hydroxy-4-phenylbutyrate and (S)-propranolol, Tetrahedron Lett, vol. 30, 1917-1920, 1989
1989 C. H. Wong, Enzymes in organic synthesis: aldol reactions as a route to unusual sugars, In: Bioproducts and Bioprocesses, vol. 147-154, 1989
1989 C. H. Wong, Enzyme-catalyzed synthesis of carbohydrates, Trends in Synthetic Carbohydrate Chemistry, ACS Symposium Series, vol. 386, 317-335, 1989
1989 C. H. Wong, Enzymatic catalysts in organic synthesis, Science, vol. 244, 1145-1152, 1989
1989 R. L. Pederson, C. H. Wong, Enzymatic Aldol Condensation as a Route to Heterocycles - Synthesis of 1,4-Dideoxy-1,4-Imino-D-Arabinitol, Fagomine, 1-Deoxynojirimycin and 1-Deoxymannojirimycin, Heterocycles, vol. 28, 477-480, 1989
1989 Y. F. Wang, C. H. Wong, Enantioselective Syntheses of Platelet-Activating Factor and a Phospholipase-A2 Inhibitor from Chiral Synthons Prepared Enzymatically, J Chin Chem Soc, vol. 36, 463-468, 1989
1989 W. J. Hennen, C. H. Wong, A New Method for the Enzymatic-Synthesis of Nucleosides Using Purine Nucleoside Phosphorylase, J Org Chem, vol. 54, 4692-4695, 1989
1988 I. Barbas, Carlos F., C. H. Wong, One-pot tripeptide syntheses from three single amino acid derivatives catalyzed by papain, Tetrahedron Lett, vol. 29, 2907-2910, 1988
1988 J. B. West, J. Scholten, N. J. Stolowich, J. L. Hogg, A. I. Scott, C. H. Wong, Modification of Proteases to Esterases for Peptide-Synthesis - Methylchymotrypsin, J Am Chem Soc, vol. 110, 3709-3710, 1988
1988 Y. F. Wang, J. J. Lalonde, M. Momongan, D. E. Bergbreiter, C. H. Wong, Lipase-Catalyzed Irreversible Transesterifications Using Enol Esters as Acylating Reagents - Preparative Enantioselective and Regioselective Syntheses of Alcohols, Glycerol Derivatives, Sugars, and Organometallics, J Am Chem Soc, vol. 110, 7200-7205, 1988
1988 Y. F. Wang, C. H. Wong, Lipase-Catalyzed Irreversible Trans-Esterification for Preparative Synthesis of Chiral Glycerol Derivatives, J Org Chem, vol. 53, 3127-3129, 1988
1988 J. R. Durrwachter, C. H. Wong, Fructose 1,6-Diphosphate Aldolase Catalyzed Stereoselective Synthesis of C-Alkyl and N-Containing Sugars - Thermodynamically Controlled C-C Bond Formations, J Org Chem, vol. 53, 4175-4181, 1988
1988 M. J. Kim, W. J. Hennen, H. M. Sweers, C. H. Wong, Enzymes in Carbohydrate Synthesis - N-Acetylneuraminic Acid Aldolase Catalyzed-Reactions and Preparation of N-Acetyl-2-Deoxy-D-Neuraminic Acid-Derivatives, J Am Chem Soc, vol. 110, 6481-6486, 1988
1988 W. J. Hennen, H. M. Sweers, Y. F. Wang, C. H. Wong, Enzymes in Carbohydrate Synthesis - Lipase-Catalyzed Selective Acylation and Deacylation of Furanose and Pyranose Derivatives, J Org Chem, vol. 53, 4939-4945, 1988
1988 J. J. Lalonde, D. E. Bergbreiter, C. H. Wong, Enzymatic Kinetic Resolution of Alpha-Nitro Alpha-Methyl Carboxylic-Acids, J Org Chem, vol. 53, 2323-2327, 1988
1988 D. G. Drueckhammer, C. F. Barbas, K. Nozaki, C. H. Wong, C. Y. Wood, M. A. Ciufolini, Chemoenzymic Synthesis of Chiral Furan-Derivatives - Useful Building-Blocks for Optically-Active Structures, J Org Chem, vol. 53, 1607-1611, 1988
1988 C. H. Wong, D. G. Drueckhammer, H. M. Sweers, Chemoenzymatic synthesis of fluorosugars, ACS Symposium Series on Fluorocarbohydrates: Chemistry and Biochemistry, vol. 29-42, 1988
1988 C. F. Barbas, J. R. Matos, J. B. West, C. H. Wong, A Search for Peptide Ligase - Cosolvent-Mediated Conversion of Proteases to Esterases for Irreversible Synthesis of Peptides, J Am Chem Soc, vol. 110, 5162-5166, 1988
1988 R. L. Pederson, M. J. Kim, C. H. Wong, A combined chemical and enzymatic procedure for the synthesis of 1-deoxynojirimycin and 1-deoxymannojirimycin, Tetrahedron Lett, vol. 29, 4645-4648, 1988
1987 J. B. West, C. H. Wong, Use of nonproteases in peptide synthesis, Tetrahedron Lett, vol. 28, 1629-1632, 1987
1987 J. R. Matos, F. M. Raushel, C. H. Wong, S-adenosylmethionine: studies on chemical and enzymatic synthesis, BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, vol. 9, 39-52, 1987
1987 J. R. Matos, C. H. Wong, S-Adenosylmethionine - Stability and Stabilization, BIOORGANIC CHEMISTRY, vol. 15, 71-80, 1987
1987 C. F. Barbas, C. H. Wong, Papain Catalyzed Peptide-Synthesis - Control of Amidase Activity and the Introduction of Unusual Amino-Acids, JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, vol. 533-534, 1987
1987 J. R. Matos, J. B. West, C. H. Wong, Lipase Catalyzed Synthesis of Peptides - Preparation of a Penicillin-G Precursor and Other Peptides, BIOTECHNOLOGY LETTERS, vol. 9, 233-236, 1987
1987 D. C. Crans, R. J. Kazlauskas, B. L. Hirschbein, C. H. Wong, O. Abril, G. M. Whitesides, Enzymatic regeneration of adenosine 5'-triphosphate: acetyl phosphate, phosphoenolpyruvate, methoxycarbonyl phosphate, dihydroxyacetone phosphate, 5-phospho-alpha-D-ribosyl pyrophosphate, uridine-5'-diphosphoglucose, Methods Enzymol, vol. 136, 263-280, 1987
1987 D. G. Drueckhammer, S. K. Sadozai, C. H. Wong, S. M. Roberts, Biphasic One-Pot Synthesis of 2 Useful and Separable Compounds Using Nicotinamide Cofactor-Requiring Enzymes - Syntheses of (S)-4-Hydroxyhexanoate and Its Lactone, Enzyme Microb Technol, vol. 9, 564-570, 1987
1986 C. H. Wong, Nicotinamide cofactor-requiring enzymatic synthesis in organic solvent-water biphasic systems, Biocatalysis in Organic Media, vol. 197-208, 1986
1986 C. H. Wong, Enzyme-catalyzed synthesis of unusual carbohydrates and peptides, Proceeding of 5th International Symposium on Life Science: Prospects for Enzyme Technology, vol. 86-89, 1986
1986 J. B. West, C. H. Wong, Enzyme-Catalyzed Synthesis of Peptides Containing D-Amino Acids, JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, vol. 417-418, 1986
1986 H. M. Sweers, C. H. Wong, Enzyme-Catalyzed Regioselective Deacylation of Protected Sugars in Carbohydrate Synthesis, J Am Chem Soc, vol. 108, 6421-6422, 1986
1986 J. B. West, C. H. Wong, Enzyme-Catalyzed Irreversible Formation of Peptides Containing D-Amino Acids, J Org Chem, vol. 51, 2728-2735, 1986
1986 C. H. Wong, J. B. West, Enzymatic-Synthesis of Peptides Containing D-Amino Acids, FEDERATION PROCEEDINGS, vol. 45, 1789-1789, 1986
1986 J. R. Durrwachter, H. M. Sweers, K. Nozaki, C. H. Wong, Enzymatic aldol reaction/isomerization as a route to unusual sugars, Tetrahedron Lett, vol. 27, 1261-1264, 1986
1986 J. R. Durrwachter, D. G. Drueckhammer, K. Nozaki, H. M. Sweers, C. H. Wong, Enzymatic Aldol Condensation Isomerization as a Route to Unusual Sugar-Derivatives, J Am Chem Soc, vol. 108, 7812-7818, 1986
1986 S. T. Chen, K. T. Wang, C. H. Wong, Chirally Selective Hydrolysis of D,L-Amino Acid-Esters by Alkaline Protease, JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, vol. 1514-1516, 1986
1986 J. R. Matos, C. H. Wong, Biphasic One-Pot Synthesis of 2 Useful and Separable Compounds Using Cofactor-Requiring Enzymatic-Reactions - Glutamate-Dehydrogenase Catalyzed Synthesis of L-Alpha-Aminoadipate Coupled with Alcohol-Dehydrogenase Catalyzed Synthesis of a Chiral Lactone, J Org Chem, vol. 51, 2388-2389, 1986
1986 C. H. Wong, Aldolases as catalysts in organic synthesis, In: Enzymes as Catalysts in Organic Synthesis, vol. 199-216, 1986
1985 D. G. Drueckhammer, V. W. Riddle, C. H. Wong, Fmn Reductase Catalyzed Regeneration of Nad(P) for Use in Enzymatic-Synthesis, J Org Chem, vol. 50, 5387-5389, 1985
1985 C. H. Wong, Enzymes in organic synthesis: aldol condensation, Industrial Chemical News, vol. 6, 24-25, 1985
1985 G. M. Whitesides, C. H. Wong, Enzymes as Catalysts in Synthetic Organic Chemistry, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 24, 617-638, 1985
1985 R. L. Root, J. R. Durrwachter, C. H. Wong, Enzymatic-Synthesis of Unusual Sugars - Galactose-Oxidase Catalyzed Stereospecific Oxidation of Polyols, J Am Chem Soc, vol. 107, 2997-2999, 1985
1985 C. H. Wong, D. G. Drueckhammer, H. M. Sweers, Enzymatic Vs Fermentative Synthesis - Thermostable Glucose-Dehydrogenase Catalyzed Regeneration of Nad(P)H for Use in Enzymatic-Synthesis, J Am Chem Soc, vol. 107, 4028-4031, 1985
1985 C. H. Wong, D. G. Drueckhammer, Enzymatic synthesis of chiral hydroxy compounds using immobilized glucose dehydrogenase from Bacillus cereus for NAD(P)H regeneration, NATURE BIOTECHNOLOGY, vol. 3, 649-651, 1985
1985 J. R. Matos, M. B. Smith, C. H. Wong, Enantioselectivity of Alcohol Dehydrogenase-Catalyzed Oxidation of 1,2-Diols and Aminoalcohols, BIOORGANIC CHEMISTRY, vol. 13, 121-130, 1985
1985 C. H. Wong, J. R. Matos, Enantioselective Oxidation of 1,2-Diols to L-Alpha-Hydroxy Acids Using Coimmobilized Alcohol and Aldehyde Dehydrogenases as Catalysts, J Org Chem, vol. 50, 1992-1994, 1985
1985 D. G. Drueckhammer, C. H. Wong, Chemoenzymatic Syntheses of Fluoro Sugar Phosphates and Analogs, J Org Chem, vol. 50, 5912-5913, 1985
1984 G.M. Whitesides, P.F. Mazenod, C. H. Wong, Preparation of 6-Deoxy-d-Fructose and 6-deoxy-L-Sorbose, US Patent, vol. #4,440,854, 1984
1983 C. H. Wong, G. M. Whitesides, Synthesis of Sugars by Aldolase-Catalyzed Condensation-Reactions, J Org Chem, vol. 48, 3199-3205, 1983
1983 C. H. Wong, S. L. Haynie, G. M. Whitesides, Preparation of a Mixture of Nucleoside Triphosphates from Yeast Rna - Use in Enzymatic-Synthesis Requiring Nucleoside Triphosphate Regeneration and Conversion to Nucleoside Diphosphate Sugars, J Am Chem Soc, vol. 105, 115-117, 1983
1983 G. M. Whitesides, C. H. Wong, Enzymes as catalysts in organic synthesis, Aldrichimica Acta, vol. 16, 27-34, 1983
1983 C. H. Wong, G. M. Whitesides, Enzyme-Catalyzed Organic-Synthesis - Regeneration of Deuterated Nicotinamide Cofactors for Use in Large-Scale Enzymatic-Synthesis of Deuterated Substances, J Am Chem Soc, vol. 105, 5012-5014, 1983
1983 C. H. Wong, F. P. Mazenod, G. M. Whitesides, Chemical and Enzymatic Syntheses of 6-Deoxyhexoses - Conversion to 2,5-Dimethyl-4-Hydroxy-2,3-Dihydrofuran-3-One (Furaneol) and Analogs, J Org Chem, vol. 48, 3493-3497, 1983
1982 C. H. Wong, A. Pollak, S. D. McCurry, J. M. Sue, J. R. Knowles, G. M. Whitesides, Synthesis of ribulose 1,5-bisphosphate: routes from glucose 6-phosphate (via 6-phosphogluconate) and from adenosine monophosphate (via ribose 5-phosphate), Methods Enzymol, vol. 89 Pt D, 108-121, 1982
1982 C. H. Wong, Enzymes as catalysts in organic synthesis, Ph.D. Dissertation, Massachusetts Institute of Technology, 1982
1982 C. H. Wong, G. M. Whitesides, Enzyme-Catalyzed Transhydrogenation between Nicotinamide Cofactors and Its Application in Organic-Synthesis, J Am Chem Soc, vol. 104, 3542-3544, 1982
1982 C. H. Wong, S. L. Haynie, G. M. Whitesides, Enzyme-Catalyzed Synthesis of N-Acetyllactosamine with Insitu Regeneration of Uridine 5'-Diphosphate Glucose and Uridine 5'-Diphosphate Galactose, J Org Chem, vol. 47, 5416-5418, 1982
1982 C. H. Wong, G. M. Whitesides, Enzyme-Catalyzed Organic-Synthesis - Nad(P)H Cofactor Regeneration Using Ethanol Alcohol-Dehydrogenase Aldehyde Dehydrogenase and Methanol Alcohol-Dehydrogenase Aldehyde Dehydrogenase Formate Dehydrogenase, J Org Chem, vol. 47, 2816-2818, 1982
1982 G. M. Whitesides, C. M. Wong, A. Pollak, Asymmetric synthesis using cofactor-requiring enzymes, Asymmetric Reactions and Processes in Chemistry, vol. 185, 205-218, 1982
1981 C. H. Wong, J. Gordon, C. L. Cooney, G. M. Whitesides, Regeneration of Nad(P)H Using Glucose 6-Sulfate and Glucose-6-Phosphate-Dehydrogenase, J Org Chem, vol. 46, 4676-4679, 1981
1981 C. H. Wong, L. Daniels, W. H. Ormejohnson, G. M. Whitesides, Enzyme-Catalyzed Organic-Synthesis - Nad(P)H Regeneration Using Dihydrogen and the Hydrogenase from Methanobacterium-Thermoautotrophicum, J Am Chem Soc, vol. 103, 6227-6228, 1981
1981 C. H. Wong, G. M. Whitesides, Enzyme-Catalyzed Organic-Synthesis - Nad(P)H Cofactor Regeneration by Using Glucose-6-Phosphate and the Glucose-6-Phosphate-Dehydrogenase from Leuconostoc-Mesenteroides, J Am Chem Soc, vol. 103, 4890-4899, 1981
1981 R. Dicosimo, C. H. Wong, L. Daniels, G. M. Whitesides, Enzyme-Catalyzed Organic-Synthesis - Electrochemical Regeneration of Nad(P)H from Nad(P) Using Methyl Viologen and Flavoenzymes, J Org Chem, vol. 46, 4622-4623, 1981
1980 C. H. Wong, S. D. McCurry, G. M. Whitesides, Practical Enzymatic Syntheses of Ribulose 1,5-Bisphosphate and Ribose 5-Phosphate, J Am Chem Soc, vol. 102, 7938-7939, 1980
1979 C. H. Wong, Resolution of Rs-Mandelic Acid, J Chin Chem Soc, vol. 26, 75-78, 1979
1979 C. H. Wong, S. T. Chen, K. T. Wang, Enzymic synthesis of opioid peptides, BIOCHIMICA ET BIOPHYSICA ACTA, vol. 576, 247-249, 1979
1979 S. H. Chou, C. H. Wong, S. T. Chen, K. T. Wang, Enzymatic-Synthesis of Oligopeptide .2. Synthesis of Bis-(N-Protected Amino-Acid) Hydrazides by Papain, J Chin Chem Soc, vol. 26, 11-15, 1979
1978 C. H. Wong, S. W. Chen, C. L. Ho, K. T. Wang, Synthesis of cobra neurotoxin, Proc Natl Sci Council ROC, vol. 2, 149-153, 1978
1978 C. H. Wong, S. T. Chen, C. L. Ho, K. T. Wang, Synthesis of a fully active snake venom cardiotoxin by fragment condensation on solid polymer, BIOCHIMICA ET BIOPHYSICA ACTA, vol. 536, 376-389, 1978
1978 C. H. Wong, Y. H. Chen, M. C. Hung, K. T. Wang, C. L. Ho, T. B. Lo, Renaturation of a reduced Taiwan cobra cardiotoxin, BIOCHIMICA ET BIOPHYSICA ACTA, vol. 533, 105-111, 1978
1978 C. H. Wong, C. L. Ho, K. T. Wang, Purfication of synthetic cardiotoxin by affinity chromatography, JOURNAL OF CHROMATOGRAPHY, vol. 154, 13-23, 1978
1978 C. H. Wong, M. F. Ho, K. T. Wang, Preparation of Optically Pure N-Tert-Butyloxycarbonyl-O-Benzyl-L-Serine and Its Antipode, J Org Chem, vol. 43, 3604-3604, 1978
1978 C. H. Wong, K. T. Wang, Mutual Resolution of Dl-Ephedrine and N-Benzyloxycarbonyl-Dl-Amino Acids, J Chin Chem Soc, vol. 25, 209-214, 1978
1978 C. H. Wong, K. T. Wang, Mutual resolution of (+/-)-ephedrine and Z-DL-amino acid induced by seeding chiral salt, Tetrahedron Lett, vol. 19, 3813-3816, 1978
1978 S. H. Chou, S. T. Chen, C. H. Wong, K. T. Wang, Enzymatic-Synthesis of Oligopeptide .1. Papain-Catalyzed Synthesis of Dipeptide, Tripeptide and Tetrapeptide, J Chin Chem Soc, vol. 25, 215-218, 1978
1978 C. H. Wong, K. T. Wang, Electrochemistry in Organic-Synthesis .1. Large-Scale Preparation of Cysteine from Cystine, J Chin Chem Soc, vol. 25, 149-151, 1978
1977 C. H. Wong, S. T. Chen, K. T. Wang, Resolution of Amino-Acids by Enzymes .1. Proteolytic-Enzyme Bromelain for Hydrolysis of L-Amino-Acid Methyl-Esters, J Chin Chem Soc, vol. 24, 129-133, 1977
1976 F. T. Kong, T. C. Lin, C. H. Wong, K. T. Wang, Synthesis of Taiwan Cobra Venom Cardiotoxin .2. Synthesis of Protected Hexapeptide, Sequence 44-49 and Protected Tripeptide, Sequence 50-52, J Chin Chem Soc, vol. 23, 155-164, 1976
翁啟惠實驗室