Yun-Ru (Ruby) Chen, Ph.D.
Name Yun-Ru (Ruby) Chen, Ph.D.
Incumbent Professor
所屬單位 Deputy Director

Exploring the complexities of protein misfolding and amyloid diseases, our research seeks to clarify the pathological mechanisms of neurodegenerative disorders. Utilizing biochemistry, biophysics, and molecular cell biology, we investigate amyloid aggregation, toxicity, and glycation, with a focus on Alzheimer's and Parkinson's.

Ph.D., Department of Molecular and Structural Biochemistry, North Carolina State University, USA, 1998-2003
B.S., Department of Agricultural Chemistry, National Taiwan University, Taiwan, 1992-1996
NCLscan:
研究方向/領域

RESEARCH INTERESTS

Protein Folding/Misfolding, Amyloids, and Neurodegenerative Diseases

My research focuses on understanding the mechanism of protein misfolding diseases, amyloidosis, by various techniques including biochemical, biophysical, molecular, and cellular methods. Our long-term goal is to elucidate the disease mechanisms of amyloidosis in the aspects of protein folding and structure, pathogenic protein interactions, and relate the results to the medical consequences. We further utilize the knowledge to develop novel diagnostic means and therapeutic modalities. Many ageing-related neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) belong to amyloidosis. Among them, AD is the most serious problem in the 21st century. Amyloidosis is caused by aggregation of misfolded proteins to form amyloid fibrils comprising specific cross-β structures. Amyloid oligomers that exist in several neurodegenerative diseases imply a common toxicity mechanism in different neurodegenerative diseases. Currently, we are working on three amyloid and amyloid-like proteins and their interacting partners in neurodegenerative diseases. They are amyloid-β (Aβ) peptide and tau protein, the major substance in senile plaques and neurofibrillary tangles of AD patients respectively, α-synuclein, the component of Lewy bodies in PD, and TDP-43, a novel inclusion found in a subtype of frontotemporal lobar dementia (FTLD-U), amyotrophic lateral sclerosis (ALS), and AD. We start from elucidating the mechanism of such aggregation and further developing the diagnostic method, antibodies, and small molecule inhibitors. Moreover, we study the structure, function, and interactions of the related glycan conjugates, precursor proteins, and modifiers. The major research interests are listed as follows:

  • Protein folding and misfolding of amyloids in neurodegenerative diseases.
  • Amyloid protein oligomerization and the toxicity mechanisms in neurodegenerative diseases.
  • Interactions of proteins, glycans, and lipids with the proteins involved in pathogenesis of the neurodegenerative diseases.
  • Drug screening, diagnostic, and therapeutic developments in neurodegenerative diseases.

Amyloid formation, a detrimental protein aggregation, is initiated by protein misfolding followed by self-association to ultimately form amyloid fibrils. The discovery of cytotoxic pre-fibrillar oligomers in many neurodegenerative diseases underscores the importance of understanding the folding, aggregation, and pathogenic mechanisms as well as developing diagnostic and therapeutic methods.

MissfoldingcsFolding
 

EDUCATION AND POSITIONS HELD

  • 2023-present Deputy Director, Genomics Research Center, Academia Sinica
  • 2022-present Adjunct Professor/ Adjunct Research Fellow, Biomedical Translation Research Center, Academia Sinica, Taiwan
  • 2022-2025 President, Asia Pacific Protein Association (APPA)
  • 2021-present Adjunct Professor, Dept. of Biochemical Science & Technology, National Taiwan University, Taiwan
  • 2021-present Professor, The Genomics Research Center, Academia Sinica
  • 2015-present Adjunct Associate Professor, Dept. of Biochemical Science & Technology, National Taiwan University, Taiwan
  • 2014-2021 Associate Professor, The Genomics Research Center, Academia Sinica
  • 2015-2019 The World Academy of Sciences (TWAS) Young Affiliate
  • 2014-2017 Council Member of Asia Pacific Protein Association (APPA)
  • 2007-2014 Assistant Professor, Genomics Research Center, Academia Sinica, Taiwan
  • 2006-2007 Postdoctoral Fellow, Genomics Research Center, Academia Sinica, Taiwan
  • 2004-2002 Postdoctoral Fellow, Dept. of Molecular Biology & Biochemistry, University of California, Irvine, USA

HONORS

  • 2024 The 21th National Innovation Improvement Award. “A novel conformation-dependent monoclonal antibody against ALS and related neurodegenerative diseases”
  • 2024 National Biotechnology Research Park Demo Day, The Investment Award.
  • 2023 Awarded by Boehringer Ingelheim’s BioMedicine Innovation Program
  • 2023 NBRP PITCH DAY Potential Team Award “A novel therapeutic monoclonal antibody against ALS and related neurodegenerative diseases”
  • 2023 Outstanding Award by Chung Hwa Rotary Education Foundation, 2022-2023.
  • 2023 Investigator Project Grant, Academia Sinica
  • 2022-2023 Chung Hwa Rotary Education Foundation Outstanding Award
  • 2022 The 19th National Innovation Award. “A novel conformation-dependent monoclonal antibody against ALS and related neurodegenerative diseases”
  • 2021 The 19th Y. Z. Hsu Scientific Paper Award, Far Eastern Y. Z. Hsu Science and Technology Memorial Foundation
  • 2019 National China Youth Corps Youth Medal, Taiwan
  • 2018 Selected work for Future Tech Exhibition “A novel potential therapeutic antibody to combat ALS and related neurodegenerative diseases”
  • 2018 The 14th Young Investigator Award, TienTe Lee Biomedical Foundation
  • 2017 Career Development Award, Academia Sinica
  • 2016 Young Chemists Award of the Chemical Society, Taipei
  • 2015 Ta-You Wu Memorial Award
  • 2015-2019 TWAS Young Affiliate, East & Southeast Asia and Pacific Region
  • 2015 The 13th Y.Z. Hsu Scientific Paper Award
  • 2015 Academia Sinica Research Award for Junior Research Investigators
  • 2015 Junior Faculty Award, the 12th International Conference on Alzheimer’s Disease and Parkinson’s Disease
  • 2014 Promising Women in Science Award, Wu Chieh Shiung Education Foundation
  • 2013 Young Investigator Award, Biophysical Society of R.O.C.
  • 2012 Taiwan Dementia Society, LiFu Medical Research Foundation Academic Award, Advisor of the 1st Price
  • 2012 The Taiwan Society for Biochemistry and Molecular Biology Traveling Fellowship
  • 2011 Taiwan Dementia Society, LiFu Medical Research Foundation Academic Award, Advisor of the 2nd Price
  • 2006-2007 Academia Sinica Postdoctoral Fellowship
Year Paper Title
2025 Ya-Ling Chiang, Yu-Jen Chang, (Yun-Ru Chen, Ing-Shouh Hwang*, Evidence Supporting Enrichment of Dissolved Air Gases near Hydrophobic Macromolecules in Aqueous Solutions, Langmuir, vol. 41(1), 285-291, 2025具代表性; 任職中研院著作;
2025 Gary Jen-Wei Chen§, Ming-Yun Chang§, Xin-Peng Lin, Debapriya Kundu, Yu-Jen Chang, Yun-Ru Chen)*, Tau destabilization in a familial deletion mutant K280 accelerates its fibrillization and enhances the seeding effect, JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 301(2), 108184, 2025具代表性; 任職中研院著作;
2025 Hsiang-Ting Lee, Han-Wen Chang, Yeh-Tung Lin, Shing- Jong Huang, Meng-Hsin Wu, Chang-Shun Tsai, Ling-Hsien Tu, Ming-Che Lee, (Yun-Ru Chen)*, Jerry C. C. Chan*, Oligomeric Protein Complexes formed by Beta Amyloid Peptides and Their Molecular Associates, CHEMISTRY-A EUROPEAN JOURNAL, 2025具代表性; 任職中研院著作;
2025 Chia-Yi Ho, Yu-Jen Chang, Chih-Wen Yang, Orion Shih, U-Ser Jeng, Wan-Chen Huang, Ing-Shouh Hwang, (Yun-Ru Chen)*, Membrane disruption properties of poly-glycine arginine dipeptide repeats affected by peptide repeats continuity and membrane composition, Journal of Molecular Biology, 2025具代表性; 任職中研院著作;
2024 Chang, Yu-Jen; Chien, Yi-Hsin; Chang, Chieh-Chun; Wang, Pei-Ning; (Chen, Yun-Ru)*; Chang, Yun-Chorng*, Detection of Femtomolar Amyloid-β Peptides for Early-Stage Identification of Alzheimer's Amyloid-β Aggregation with Functionalized Gold Nanoparticles, ACS Applied Materials & Interfaces, vol. 16, 3, 3819-3828, 2024具代表性; 任職中研院著作;
2024 Tien-Ying Tsai, Wei-Ting Jhang, Hung-Kai Hsu, Yi-Tsu Chan, Chi-Fon Chang, (Yun-Ru Chen)*, Amyloid Modifier SERF1a Accelerates Alzheimers Amyloid-β Fibrillization and Exacerbates the Cytotoxicity, ACS Chemical Neuroscience, vol. 15, 3, 479-490, 2024具代表性; 任職中研院著作;
2024 Yu-Jen Chang, Kai-Tai Lin, Orion Shih, Chi-Hua Yang, Ching-Yu Chuang, Ming-Han Fang, Wei-Bin Lai, Yi-Chung Lee, Hung-Chih Kuo, Shang-Cheng Hung, Chi-Kuang Yao, U-Ser Jeng, (Yun-Ru Chen)*, Sulfated disaccharide protects membrane and DNA damages from arginine-rich dipeptide repeats in ALS, SCIENCE ADVANCES, vol. 10, eadj0347, 2024具代表性; 任職中研院著作;
2024 Tien-Chang Lin‡, Orion Shih, b‡, Tien-Ying Tsai, Yi-Qi Yeh, Kuei-Fen Liao, Bradley W. Mansel, Ying-Jen Shiu, Chi-Fon Chang, An-Chung Su, (Yun-Ru Chen)*, U-Ser Jeng*, Binding structures of SERF1a with NT17-polyQ peptides of huntingtin exon 1 revealed by SECSWAXS, NMR and molecular simulation, IUCrJ, vol. 11(Pt 5), 849-858, 2024具代表性; 任職中研院著作;
2023 Tien-Wei Lin, Jung-Kai Chang, Yih-Ru Wu, Tsung-Hsien Sun, Yang-Yu Cheng, Chien-Tai Ren, Mei-Hung Pan, Jin-Lin Wu, Kuo-Hsuan Chang, Hwai-I Yang, Chiung-Mei Chen*, Chung-Yi Wu*, Yun-Ru Chen)*, Ganglioside-focused Glycan Array Reveals Abnormal Anti-GD1b Auto-antibody in Plasma of Preclinical Huntington’s Disease, MOLECULAR NEUROBIOLOGY, vol. 60(7), 3873-3882, 2023具代表性; 任職中研院著作;
2023 Tien-Ying Tsai§, Chun-Yu Chen§, Tien-Wei Lin, Tien-Chang Lin, Feng-Lan Chiu, Orion Shih, Ming-Yun Chang, Yu-Chun Lin, An-Chung Su, U-Ser Jeng, Hung-Chih Kuo, Chi-Fon Chang, Yun-Ru Chen)*, Amyloid Modifier SERF1a Interacts with PolyQ-expanded Huntingtin Exon 1 via Helical Interactions and Exacerbates PolyQ-induced Toxicity, Communications Biology, vol. 6, 767, 2023具代表性; 任職中研院著作;
2022 Yuh Shen Lye, Yun-Ru Chen)*, TAR DNA-binding protein 43 oligomers in physiology and pathology, IUBMB LIFE, vol. 2022, 1-18, 2022具代表性; 任職中研院著作;
2022 Jin-Lin Wu, Tung-Hung Su, Pei-Jer Chen, Yun-Ru Chen)*, Acute‑phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level, Scientific Reports, vol. 12, 5799, 2022具代表性; 任職中研院著作;
2022 Wan-Chin Chiang§, Yu-Sheng Fang§, Yuh-Shen Lye, Tzu-Yu Wong, Kiruthika Ganesan, Shih-Chieh Chou, (Yun-Ru Chen)*, Hyperphosphorylation-mimetic TDP-43 Drives Amyloid Formation and Possesses Neuronal Toxicity at the Oligomeric Stage, ACS Chemical Neuroscience, vol. 37, 1, 2599-2612, 2022具代表性; 任職中研院著作;
2022 Ming-Che Lee‡, Yi-Hung Liao‡, Shih-Hui Chen, Yun-Ru Chen)*., Amyloid-β E22K Fibril in Familial Alzheimer’s Disease is More Thermo-stable and Susceptible to Seeding., IUBMB LIFE, vol. 74(8), 739-747, 2022具代表性; 任職中研院著作;
2022 Jin-Lin Wu, Yun-Ru Chen)*, Signal peptide stabilizes folding and inhibits misfolding of serum amyloid A, PROTEIN SCIENCE, vol. 31(12), e4485, 2022具代表性; 任職中研院著作;
2021 Ya-Ling Chiang, Yu-Jen Chang, (Yun-Ru Chen)*, Ing-Shouh Hwang*, Effects of Dissolved Gases on Amyloid Fibril Morphology, LANGMUIR, vol. 37, 1, 516-523, 2021具代表性; 任職中研院著作;
2021 Vu, Katrin; Lee, Ming-Che; Blankenburg, Gerhard; Chang, Yu-Jen; Chu, Ming-Lee; Erbe, Andreas; Lesser-Rojas, Leonardo; (Chen, Yun-Ru); Chou, Chia-Fu*, Time-evolved SERS signatures of DEP-trapped Aβ and Zn2+Aβ peptides revealed by a sub-10 nm electrode nanogap, ANALYTICAL CHEMISTRY, vol. 93(49), 16320-16329, 2021具代表性; 任職中研院著作;
2020 Shih-Ling Huang, Lien-Szu Wu, Min Lee, Chin-Wen Chang, Wei-Cheng Cheng, Yu-Sheng Fang, (Yun-Ru Chen, Pei-Lin Cheng, Che-Kun James Shen*, A Robust TDP-43 Knock-In Mouse Model of ALS, Acta Neuropathologica Communications, vol. 8(1),3, 2020具代表性; 任職中研院著作;
2020 Phillip Smethurst, Emmanuel Risse, Giulia E. Tyzack, Jamie S. Mitchell, Doaa M. Taha, (Yun-Ru Chen, Jia Newcombe, John Collinge, Katie Sidle, Rickie Patani*, Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis, BRAIN, vol. 143(2), 430-440, 2020具代表性; 任職中研院著作;
2020 Yao-Hsiang Shih§, Ling-Hsien Tu§, Ting-Yu Chang, Kiruthika Ganesan, Wei-Wei Chang, Pao-Sheng Chang, Yu-Sheng Fang, Yeh-Tung Lin, Lee-Way Jin, Yun-Ru Chen)*, TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease, NATURE COMMUNICATIONS, vol. 11, 5950, 2020具代表性; 任職中研院著作;
2018 Ming-Che Lee, Wan-Cheng Yu, Yao-Hsiang Shih, Chun-Yu Chen, Zhong-Hong Guo, Shing-Jong Huang, Jerry C. C. Chan, Yun-Ru Chen)*, Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease, Scientific Reports, vol. 8, 4772, 2018具代表性; 任職中研院著作;
2018 Chia-Jung Kuo, Hsu-Cheng Chiang, Chi-Ang Tseng, Chin-Fu Chang, Rajesh Kumar Ulaganathan, Tzu-Ting Ling, Yu-Jen Chang, Chiao-Chen Chen, (Yun-Ru Chen, Yit-Tsong Chen*., A Lipid-Modified Graphene-Transistor Biosensor for Monitoring Amyloid-β Aggregation, ACS APPLIED MATERIALS & INTERFACES, vol. 10(15), 12311-12316, 2018具代表性; 任職中研院著作;
2018 Ling-Hsien Tu, Ning-Hsuan Tseng, Ya-Ru Tsai, Tien-Wei Lin, Yi-Wei Lo, Jien-Lin Charng, Hua-Ting Hsu, Yu-Sheng Chen, Rong-Jie Chen, Ying-Da Wu, Yi-Tsu Chan, Chang-Shi Chen, Jim-Min Fang, *, Yun-Ru Chen)*, Rationally Designed Divalent Caffeic Amide Inhibits Amyloid-β Fibrillization, Induce Fibril Dissociation, and Ameliorate Cytotoxicity, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 158, 393-404, 2018具代表性; 任職中研院著作;
2017 Lin TW, Chang CF, Chang YJ, Liao YH, Yu HM, (Chen YR)*., Alzheimer's amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity, PLOS ONE, vol. 12(3), e0174561, 2017具代表性; 任職中研院著作;
2016 Chia‑Wei Lee, Lan‑Ling Jang, Huei‑Jyuan Pan, (Yun‑Ru Chen, Chih‑Cheng Chen, Chau‑Hwang Lee*, Membrane roughness as a sensitive parameter reflecting the status of neuronal cells in response to chemical and nanoparticle treatments, Journal of Nanobiotechnology, vol. 14, 9, 2016具代表性; 任職中研院著作;
2016 Yu-Jen Chang, U-Ser Jeng, Ya-Ling Chiang, Ing-Shouh Hwang, Yun-Ru Chen)*, Glycine-Alanine Dipeptide Repeat from C9orf72 Hexanucleotide Expansions Forms Toxic Amyloids Possessing Cell-to-cell Transmission Property, Journal of Biological Chemistry, vol. 291(10), 4903-4911, 2016具代表性; 任職中研院著作;
2016 Yu-Jen Chang, Nguyen Hoang Linh, Hui-Ming Yu, Mai Suan Li*, Yun-Ru Chen)*, Alzheimer’s Amyloid-β Sequesters Caspase-3 in vitro via its C-terminal Tail., ACS Chemical Neuroscience, vol. 7(8), 1097-1106, 2016具代表性; 任職中研院著作;
2016 Nguyen Quoc Thai, Ning-Hsuan Tseng, Mui Thi Vu, Tin Trung Nguyen, Huynh Quang Linh, Chin-Kun Hu*, (Yun-Ru Chen)*, Mai Suan Li*, Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for Alzheimer’s disease: in silico and in vitro study, JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 30(8), 639-50, 2016具代表性; 任職中研院著作;
2016 Smethurst, Phillip*; Newcombe, Jia; Troakes, Claire;Simone, Roberto; Wadsworth, John; Hardy, John; (Chen, Yun-Ru); Patani, Rickie; Sidle, Katie, In vitro prion-like mechanisms of TDP-43 in ALS, NEUROBIOLOGY OF DISEASE, vol. 96, 236-247, 2016任職中研院著作;
2015 Patricia F. Kao, (Yun-Ru Chen, Xiao-Bo Liu, Charles DeCarli, William W. Seeley, Lee-Way Jin*, Detection of TDP-43 oligomers in frontotemporal lobar degeneration-TDP, ANNALS OF NEUROLOGY, vol. 78(2), 211-221, 2015具代表性; 任職中研院著作;
2015 Yi-Hung Liao, Yun-Ru Chen*, A novel method for expression and purification of authentic amyloid-β with and without 15N labels., PROTEIN EXPRESSION AND PURIFICATION, vol. 113, 63-71, 2015任職中研院著作;
2014 Huei-Jyuan Pan, Ruei-Lin Wang, Jian-Long Xiao, Yu-Jen Chang, Ji-Yen Cheng, (Yun-Ru Chen, Chau-Hwang Lee, Using optical profilometry to characterize cell membrane roughness influenced by Amyloid-beta 42 aggregates and electric fields, Journal of Biomedical Optics, vol. 19(1), 011009, 2014具代表性; 任職中研院著作;
2014 Yu-Jen Chang, (Yun-Ru Chen)*, The Co-existence of an Equal Amount of Alzheimer’s Amyloid-β 40 and 42 forms Structurally Stable and Toxic Oligomers through a Distinct Pathway, FEBS JOURNAL, vol. 281(11), 2674-2687, 2014具代表性; 任職中研院著作;
2014 Yu-Sheng Fang, Kuen-Jer Tsai, Yu-Jen Chang, Patricia Kao, Rima Woods, Pan-Hsien Kuo, Cheng-Chun Wu, Jhih-Ying Liao, Shih-Chieh Chou, Vinson Lin, Lee-Way Jin, Hanna S. Yuan, Irene H Cheng, Pang-Hsien Tu, Yun-Ru Chen)*, Full-Length TDP-43 Forms Toxic Amyloid Oligomers that are Present in Frontotemporal Lobar Dementia-TDP Patients., Nature Communications, vol. 5, 4824, 2014具代表性; 任職中研院著作;
2013 Winny Ariesandi, Chi-Fon Chang, Tseng-Erh Chen, Yun-Ru Chen*, Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization, PLoS One, vol. 8(1), e53487, 2013具代表性; 任職中研院著作;
2013 Yi-Ting Wang, Pan-Hsien Kuo, Chien-Hao Chiang, Jhe-Ruei Liang, (Yun-Ru Chen, Shuying Wang, James C. K. Shen, Hanna S. Yuan*., The truncated C-terminal RRM domain of TDP-43 plays a key role in forming proteinaceous aggregates., J Biol. Chem., vol. 288(13), 9049-9057, 2013具代表性; 任職中研院著作;
2013 3. Wei-Chieh Cheng*, Chen-Yi Weng, Wen-Yi Yun, Shang-Yu Chang, Yu-Chun Lin, Fuu-Jen Tsai, Fu-Yung Huang, (Yun-Ru Chen)., Rapid modifications of N-substitution in iminosugars: Development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease. , BIOORGANIC & MEDICINAL CHEMISTRY, vol. 1, 5021-5028, 2013任職中研院著作;
2013 Rong-Jie Chen, Wei-Wei Chang, Yu-Chun Lin, Pei-Lin Pheng, (Yun-Ru Chen)*, Alzheimer’s Amyloid-β Oligomers Rescue Cellular Prion Protein Induced Tau Reduction via Fyn Pathways, ACS Chemical Neuroscience, vol. 4(9), 1287-1296, 2013具代表性; 任職中研院著作;
2013 Man Hoang Viet, Chun-Yu Chen, Chin-Kun Hu, (Yun-Ru Chen)*, Mai Suan Li*., Discovery of Dihydrochalcone as potential lead for Alzheimer's disease: in silico and in vitro study, PLoS One, vol. 8(11), e79151, 2013具代表性; 任職中研院著作;
2012 Wei-Ting Chen, Chen-Jee Hong, Ya-Tzu Lin, Wen-Han Chang, He-Ting Huang, Jhih-Ying Liao, Chih-Ya Cheng, Hsiu-Chih Liu, (Yun-Ru Chen)*, Irene H Cheng *, Amyloid-beta (Abeta) D7H mutation increases oligomeric Abeta42 and alters properties of Abeta-zinc/copper assemblies , PLos One, vol. 7(4), e35807, 2012具代表性; 任職中研院著作;
2012 Yi-Hung Liao, Yu-Jen Chang, Yuji Yoshiike, Yun-Chorng Chang*, Yun-Ru Chen)*, Negatively charged gold nanoparticles inhibit Alzheimer's amyloid-beta fibrillization, induce fibril dissociation, and mitigate neurotoxicity, SMALL, vol. 8(23), 3631-3639, 2012具代表性; 任職中研院著作;
2011 Wei-Ting Chen, Yi-Hung Liao, Hui-Ming Yu, Irene H. Cheng, Yun-Ru Chen)*, Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+ on Amyloid-beta Stability, Oligomerization, and Aggregation: Amyloid-beta Destabilization Promotes Annular Protofibril Formation, Journal of Biological Chemistry, vol. 286(11), 9646-9656, 2011具代表性; 任職中研院著作;
2011 Chun-Lun Ni, Hoi-Ping Shi, Kuo-Ging Lin, Hui-Ming Yu, Yun-Ru Chen)*, Folding Stability of Amyloid-beta 40 Monomer is an Important Determinant of the Nucleation Phase in Fibrillization, Faseb Journal, vol. 25(4),1390-1401, 2011具代表性; 任職中研院著作;
2010 Ni-Shian Lin, John Ching-Hao Chao, Fang-Chieh Chou, Chi-Fon Chang, (Yun-Ru Chen, Yu-Jen Chang, Shing-Jong Huang, Wei-Hsiang Tseng, Jerry C. C. Chan, Molecular Structure of Amyloid Fibrils Formed by Residues 127 to 147 of the Human Prion Protein, Chemistry - A European Journal, vol. 16(18), 5492-5499, 2010具代表性; 任職中研院著作;
2008 Yuji Yoshiike, Ryoichi Minai, Yo Matsuo, (Yun-Ru Chen, Tetsuya Kimura, Akihiko Takashima*, Amyloid Oligomer Conformation in a Group of Natively Folded Proteins, PLos ONE., vol. 3(9), e3235, 2008具代表性; 任職中研院著作;
2006 Yun-Ru Chen, A. Clay Clark*, Substitutions of prolines examine their role in kinetic trap formation of the caspase recruitment domain (CARD) of RICK, Protein Science, vol. 15, 395-409, 2006具代表性;
2006 Yun-Ru Chen, Charles G. Glabe*, Distinct Early Folding and Aggregation Properties of Alzheimer Amyloid-b Peptide Aβ40 and Aβ42: Stable Trimer or Tetramer Formation by Ab42, J Biol. Chem, vol. 281, 24414-24422, 2006具代表性;
2004 Yun-Ru Chen, A. Clay Clark*, Kinetic traps in the folding/unfolding of procaspase-1 CARD Domain, Protein Science, vol. 13, 2196-2206, 2004具代表性;
2003 Yun-Ru Chen, A. Clay Clark*, Equilibrium and Kinetic Folding of the α-Helical Greek Key Protein Domain: Caspase Recruitment Domain (CARD) of RICK, Biochemistry, vol. 42, 6310-6320, 2003具代表性;
2001 C. Pop, (Y. R. Chen, B. Smith, K. Bose, B. Bobay, A. Tripathy, S. Franzen, A. C. Clark*, Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer, Biochemistry, vol. 40, 14224-14235, 2001具代表性;