Wei-Chieh Cheng, Ph.D.
Name Wei-Chieh Cheng, Ph.D.
Incumbent Professor
所屬單位

Ph.D., Chemistry, University of California, Davis CA, USA, 1997-2002
M.S., Chemistry National Tsing-Hua University Taiwan, 1993
B.S., Chemistry, National Cheng-Kung University Taiwan, 1991
 
NCLscan:
  •  wcheng@as.edu.tw
  •  02-27898760
研究方向/領域

RESEARCH INTERESTS

The major research efforts of this group are directed toward the development of new synthetic strategies for biologically interesting natural products and heterocyclics. To understand the relationships between small molecules and biological systems, combinatorial approaches are applied in our diverse molecule library synthesis (core diversity, substituent diversity, and configuration diversity) with the assistance of automated or semi-automated equipment.

  • Organic Chemistry and Chemical Biology
  • Development of new synthetic methodology
  • Natural product and natural product-like molecule synthesis
  • Synthesis of biologically interesting molecule libraries
  • Development of new high-throughput library synthesis
  • Combinatorial approach towards the synthesis of natural product-like or novel heterocyclic molecule libraries
  • Study of the cell wall transglycosylase as a potential antibacterial target
  • Lead discovery of cell wall synthesis enzymes in mycobacterium
  • Novel chemical probe synthesis and application
  • Synthesis of chemical chaperones towards lysosomal storage disease associated enzymes
  • Synthesis of novel five- and six-membered iminosugars
EDUCATION AND POSITIONS HELD
  • 2023-present Professor, Genomics Research Center, Academia Sinica, Taiwan
  • 2010-2023 Associate Professor, Genomics Research Center, Academia Sinica, Taiwan
  • 2004-2010 Assistant Professor, Genomics Research Center, Academia Sinica, Taiwan
  • 2002-2004 Postdoctoral Fellow, the Scripps Research Institute, USA
HONORS
  • 2007 The distinguished lectureship award (Natural products synthesis), the CSJ (Chemical Society of Japan) Asian International Symposium, Japan
  • 2002-2004 Skaggs Postdoctoral Fellowship
Year Paper Title
2025 Hu CM, Tien SC, Lo YC, Huang CH, Ko YL, Wu DN, Lee JH, Wu YT, Yu HM, Lin KG, Zong-You L, (Cheng WC*, Innovative cyclic peptide disrupts IL-17RB-MLK4 interaction for targeted pancreatic cancer therapy., Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol. 184, 117892, 2025任職中研院著作;
2025 Hong MX, Wang BW, Lo LH, Jayalath GED, Lin WT, Yang YL, Tseng SP, Chen YH, Tsai WC, (Cheng WC, Liaw CC*, Pseudopeptides of Marine Vibrio spp. from Taiwan and Their Combined Treatment Effects with Commercial Antibiotics., Planta medica, vol. 91(6-07), 371-381, 2025任職中研院著作;
2025 Li HY*, Perez SJLP, Chang HL, Lo HH, Yang CN*, (Cheng WC)*, Design and synthesis of polyhydroxylated azabicyclo[3.3.1]nonane as selective lysosomal alpha-glucosidase stabilizers enhancing cellular uptake., Bioorganic Chemistry, vol. 165, 108994, 2025任職中研院著作;
2024 Li HY, Lin HY, Chang SK, Chiu YT, Hou CC, Ko TP, Huang KF, Niu DM, (Cheng WC*, Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase., JACS Au, vol. 4(3), 908-918, 2024任職中研院著作;
2024 Li HY, Chen WA, Lin HY, Tsai CW, Chiu YT, Yun WY, Lee NC, Chien YH, Hwu WL, Cheng WC, A practical synthesis of nitrone-derived C5a-functionalized isofagomines as protein stabilizers to treat Gaucher disease., Communications chemistry, vol. 7(1), 91, 2024任職中研院著作;
2023 Li Huang-Yi, Lee Ni-Chung, Chiu Yu-Ting, Chang Yu-Wen, Lin Chu-Chung, Chou Cheng-Li, Chien Yin-Hsiu, Hwu Wuh-Liang, Cheng Wei-Chieh, Harnessing polyhydroxylated pyrrolidines as a stabilizer of acid alpha-glucosidase (GAA) to enhance the efficacy of enzyme replacement therapy in Pompe disease, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 78, 117129, 2023具代表性; 任職中研院著作;
2023 Lin Hung-Yi, Chang Shih-Ying, Teng Hsuan-Hsuan, Wu Hsi-Ju, Li Huang-Yi, Cheng Chia-Chun, Chuang Chih-Kuang, Lin Hsiang-Yu, Lin Shuan-Pei, Cheng Wei-Chieh, Discovery of small-molecule protein stabilizers toward exogenous alpha-l-iduronidase to reduce the accumulated heparan sulfate in mucopolysaccharidosis type I cells, European Journal of Medicinal Chemistry, vol. 247, 115005, 2023具代表性; 任職中研院著作;
2022 Lee Hua-Yun, Chiang Po-Yu, Wu Hsi-Ju, Wang Ting-Yi, Yang Tzu-Ching, Cheng Wei-Chieh, Lo Lee-Chiang, Liao Wei-Ssu, Versatile Azido-Functionalized Carbon Dots for Cancer Cell Imaging, ACS Applied Nano Materials, vol. 5(9), 12374-12379, 2022任職中研院著作;
2022 Chen WA, Li HY, Sayyad A, Huang CY, Cheng WC, Synthesis of Nitrone-derived Pyrrolidine Scaffolds and Their Combinatorial Libraries to Develop Selective alpha-l-Rhamnosidase Inhibitors., Chemistry, an Asian journal, vol. 17(14), e202200172, 2022任職中研院著作;
2022 Guo CW, Chen KT, You TY, Lin CC, Cheng WC, Synthesis and Evaluation of Diverse N-Substituted Disaccharide Dipeptides for Human NOD2 Stimulation Activity., Chemistry, an Asian journal, vol. 17(4), e202101169, 2022任職中研院著作;
2022 Chen Wei-An, Chen Yu-Hsin, Hsieh Chiao-Yun, Hung Pi-Fang, Chen Chiao-Wen, Chen Chien-Hung, Lin Jung-Lee, Cheng Ting-Jen R., Hsu Tsui-Ling, Wu Ying-Ta, Shen Chia-Ning, Cheng Wei-Chieh, Harnessing natural-product-inspired combinatorial chemistry and computation-guided synthesis to develop N-glycan modulators as anticancer agents, Chemical Science, vol. 13, 6233-6243, 2022具代表性; 任職中研院著作;
2022 Tseng YY, Liou JM, Cheng WC, Hsu JT, Hsu TL, Wu MS, Wong CH, Combating multidrug-resistant Helicobacter pylori with moenomycin A in combination with clarithromycin or metronidazole., Frontiers in chemistry, vol. 10, 897578, 2022任職中研院著作;
2021 Jan JT, Cheng TR, Juang YP, Ma HH, Wu YT, Yang WB, Cheng CW, Chen X, Chou TH, Shie JJ, (Cheng WC, Chein RJ, Mao SS, Liang PH, Ma C, Hung SC, Wong CH, Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection., Proceedings of the National Academy of Sciences of the United States of America, vol. 118 (5), e2021579118, 2021任職中研院著作;
2021 Hsieh PY, Meng FC, Guo CW, Hu KH, Shih YL, Cheng WC, Harnessing Fluorescent Moenomycin A Antibiotics for Bacterial Cell Wall Imaging Studies., Chembiochem : a European journal of chemical biology, vol. 22(24), 3462-3468, 2021任職中研院著作;
2020 Cheng WC, Liu WJ, Hu KH, Tan YL, Lin YT, Chen WA, Lo LC, Rapid Synthesis of a Natural Product-Inspired Uridine Containing Library., ACS combinatorial science, vol. 22(11), 600-607, 2020任職中研院著作;
2020 Cheng Wei‐Chieh, You Ting‐Yun, Teo Zhen‐Zhuo, Sayyad Ashik A., Maharana Jitendra, Guo Chih‐Wei, Liang Pi‐Hui, Lin Chung‐Shun, Meng Fan‐Chun, Further Insights on Structural Modifications of Muramyl Dipeptides to Study the Human NOD2 Stimulating Activity, Chemistry – An Asian Journal, vol. 15(22), 3836-3844, 2020任職中研院著作;
2019 Chen Wei‐An, Sayyad Ashik, Chen Chiao‐Wen, Chen Yu‐Hsin, Cheng Ting‐Jen R., Cheng Wei‐Chieh, Divergent Synthesis of Bicyclic Iminosugars: Preparation of (−)‐Swainsonine‐Based Alkaloids and Their Inhibition Study towards α ‐Human Mannosidases, Asian Journal of Organic Chemistry, vol. 8(12), 2233-2242, 2019任職中研院著作;
2018 Li HY, Lee JD, Chen CW, Sun YC, Cheng WC, Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines., European journal of medicinal chemistry, vol. 144, 626-634, 2018任職中研院著作;
2018 Wu WS, Cheng WC, Cheng TR, Wong CH, Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase., Journal of the American Chemical Society, vol. 140(8), 2752-2755, 2018任職中研院著作;
2018 Cheng WC, Lin CK, Li HY, Chang YC, Lu SJ, Chen YS, Chang SY, A combinatorial approach towards the synthesis of non-hydrolysable triazole-iduronic acid hybrid inhibitors of human alpha-l-iduronidase: discovery of enzyme stabilizers for the potential treatment of MPSI., CHEMICAL COMMUNICATIONS, vol. 54(21), 2647-2650, 2018任職中研院著作;
2017 Cheng WC, Wang JH, Yun WY, Li HY, Hu JM, Rapid preparation of (3R,4S,5R) polyhydroxylated pyrrolidine-based libraries to discover a pharmacological chaperone for treatment of Fabry disease., European journal of medicinal chemistry, vol. 126, 1-6, 2017具代表性; 任職中研院著作;
2017 Chen KT, Lin CK, Guo CW, Chang YF, Hu CM, Lin HH, Lai Y, Cheng TR, Cheng WC, Effect of the lipid II sugar moiety on bacterial transglycosylase: the 4-hydroxy epimer of lipid II is a TGase inhibitor., CHEMICAL COMMUNICATIONS, vol. 53(4), 771-774, 2017任職中研院著作;
2016 Chen KT, Chen PT, Lin CK, Huang LY, Hu CM, Chang YF, Hsu HT, Cheng TJ, Wu YT, Cheng WC, Structural Investigation of Park's Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors., Scientific reports, vol. 6, 31579, 2016具代表性; 任職中研院著作;
2016 Lin CK, Hou CC, Guo YY, Cheng WC, Design and Synthesis of Orthogonally Protected d- and l-beta-Hydroxyenduracididines from d-lyxono-1,4-Lactone., Organic letters, vol. 18(20), 5216-5219, 2016具代表性; 任職中研院著作;
2016 Cheng WC, Wang JH, Li HY, Lu SJ, Hu JM, Yun WY, Chiu CH, Yang WB, Chien YH, Hwu WL, Bioevaluation of sixteen ADMDP stereoisomers toward alpha-galactosidase A: Development of a new pharmacological chaperone for the treatment of Fabry disease and potential enhancement of enzyme replacement therapy efficiency., European journal of medicinal chemistry, vol. 123, 14-20, 2016具代表性; 任職中研院著作;
2016 Lin CK, Yun WY, Lin LT, Cheng WC, A concise approach to the synthesis of the unique N-mannosyl d-beta-hydroxyenduracididine moiety in the mannopeptimycin series of natural products., Organic & biomolecular chemistry, vol. 14(17), 4054-4060, 2016任職中研院著作;
2015 Lin CK, Cheng LW, Li HY, Yun WY, Cheng WC, Synthesis of novel polyhydroxylated pyrrolidine-triazole/-isoxazole hybrid molecules., Organic & biomolecular chemistry, vol. 13(7), 2100-2107, 2015任職中研院著作;
2015 Chen KT, Huang DY, Chiu CH, Lin WW, Liang PH, Cheng WC, Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity., Chemistry-A European Journal, vol. 21(34), 11984-11988, 2015具代表性; 任職中研院著作;
2015 Lin CK, Chen KT, Hu CM, Yun WY, Cheng WC, Synthesis of 1-C-Glycoside-Linked Lipid II Analogues Toward Bacterial Transglycosylase Inhibition., Chemistry-A European Journal, vol. 21(20), 7511-7519, 2015任職中研院著作;
2015 Cheng WC, Guo CW, Lin CK, Jiang YR, Synthesis and Inhibition Study of Bicyclic Iminosugar-​Based Alkaloids, Scaffolds, and Libraries towards Glucosidase, Israel Journal of Chemistry, vol. 55(3-4), 403-411, 2015具代表性; 任職中研院著作;
2015 Chen PT, Lin CK, Tsai CJ, Huang DY, Nien FY, Lin WW, Cheng WC, Expeditious Synthesis of Enantiopure, Orthogonally Protected Bis-alpha-Amino Acids (OPBAAs) and their Use in a Study of Nod1 Stimulation., Chemistry-An Asian Journal, vol. 10(2), 474-482, 2015具代表性; 任職中研院著作;
2015 Zuegg J, Muldoon C, Adamson G, McKeveney D, Le Thanh G, Premraj R, Becker B, Cheng M, Elliott AG, Huang JX, Butler MS, Bajaj M, Seifert J, Singh L, Galley NF, Roper DI, Lloyd AJ, Dowson CG, Cheng TJ, Cheng WC, Demon D, Meyer E, Meutermans W, Cooper MA, Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity., Nature communications, vol. 6, 7719, 2015任職中研院著作;
2014 Hsu CH, Schelwies M, Enck S, Huang LY, Huang SH, Chang YF, Cheng TJ, Cheng WC, Wong CH, Iminosugar C-Glycoside Analogues of alpha-d-GlcNAc-1-Phosphate: Synthesis and Bacterial Transglycosylase Inhibition., The Journal of organic chemistry, vol. 79(18), 8629-8637, 2014任職中研院著作;
2014 Huang LY, Huang SH, Chang YC, Cheng WC, Cheng TJ, Wong CH, Enzymatic Synthesis of Lipid II and Analogues., Angewandte Chemie-International Edition, vol. 53(31), 8060-8065, 2014任職中研院著作;
2014 Tseng YY, Liou JM, Hsu TL, Cheng WC, Wu MS, Wong CH, Development of bacterial transglycosylase inhibitors as new antibiotics: moenomycin A treatment for drug-resistant Helicobacter pylori., Bioorganic & medicinal chemistry letters, vol. 24(11), 2412-2414, 2014任職中研院著作;
2013 Pan YW, Guo CW, Tu HY, Tsai CW, Cheng WC, Solid-Phase Synthesis of Diverse Spiroisoxazolinodiketopiperazines., ACS combinatorial science, vol. 15(8), 425-434, 2013任職中研院著作;
2013 Chen KT, Kuan YC, Fu WC, Liang PH, Cheng TJ, Wong CH, Cheng WC, Rapid preparation of mycobacterium N-glycolyl Lipid I and Lipid II derivatives: a biocatalytic approach., Chemistry-a European Journal, vol. 19(3), 834-838, 2013具代表性; 任職中研院著作;
2013 Cheng WC, Weng CY, Yun WY, Chang SY, Lin YC, Tsai FJ, Huang FY, Chen YR, Rapid modifications of N-substitution in iminosugars: development of new beta-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease., Bioorganic & medicinal chemistry, vol. 21(17), 5021-5028, 2013具代表性; 任職中研院著作;
2013 Huang SH, Wu WS, Huang LY, Huang WF, Fu WC, Chen PT, Fang JM, Cheng WC, Cheng TJ, Wong CH, New continuous fluorometric assay for bacterial transglycosylase using Forster resonance energy transfer., Journal of the American Chemical Society, vol. 135(45), 17078-17089, 2013任職中研院著作;
2013 Cheng TJ, Chan TH, Tsou EL, Chang SY, Yun WY, Yang PJ, Wu YT, Cheng WC, From Natural Product-Inspired Pyrrolidine Scaffolds to the Development of New Human Golgi alpha-Mannosidase II Inhibitors., Chemistry-An Asian Journal, vol. 8(11), 2600-2604, 2013具代表性; 任職中研院著作;
2012 Hsu YC, Chen NC, Chen PC, Wang CC, Cheng WC, Wu HN, Identification of a small-molecule inhibitor of dengue virus using a replicon system., Archives of virology, vol. 157(4), 681-688, 2012任職中研院著作;
2012 Shih HW, Chang YF, Li WJ, Meng FC, Huang CY, Ma C, Cheng TJ, Wong CH, Cheng WC, Effect of the Peptide Moiety of Lipid II on Bacterial Transglycosylase., Angewandte Chemie-International Edition, vol. 51(40), 10123-10126, 2012具代表性; 任職中研院著作;
2012 Huang CY, Shih HW, Lin LY, Tien YW, Cheng TJ, Cheng WC, Wong CH, Ma C, Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism., Proceedings of the National Academy of Sciences of the United States of America, vol. 109(17), 6496-6501, 2012具代表性; 任職中研院著作;
2012 Hao-Wei Shih, Kuo-Ting Chen, Wei-Chieh Cheng*, One-pot synthesis of phosphate diesters and phosphonate monoesters via a combination of microwave-CCl3CN-pyridine coupling conditions, Tetrahedron Lett., vol. 53(2), 243-246, 2012任職中研院著作;
2011 Meng FC, Chen KT, Huang LY, Shih HW, Chang HH, Nien FY, Liang PH, Cheng TJ, Wong CH, Cheng WC, Total Synthesis of Polyprenyl N-Glycolyl Lipid II as a Mycobacterial Transglycosylase Substrate., Org. Lett., vol. 13(19), 5306-5309, 2011具代表性; 任職中研院著作;
2011 Chang YF, Guo CW, Chan TH, Pan YW, Tsou EL, Cheng WC, Parallel synthesis of natural product-like polyhydroxylated pyrrolidine and piperidine alkaloids., Molecular diversity, vol. 15(1), 203-214, 2011具代表性; 任職中研院著作;
2011 Shih HW, Chen KT, Cheng TJ, Wong CH, Cheng WC, A New Synthetic Approach toward Bacterial Transglycosylase Substrates, Lipid II and Lipid IV., Org. Lett., vol. 13(17), 4600-4603, 2011具代表性; 任職中研院著作;
2010 Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Cheng WC, Wu YT, Tsai MD, Cheng YS, Wong CH, High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity., Proceedings of the National Academy of Sciences of the United States of America, vol. 107(45), 19151-19156, 2010任職中研院著作;
2010 Cheng TJ, Wu YT, Yang ST, Lo KH, Chen SK, Chen YH, Huang WI, Yuan CH, Guo CW, Huang LY, Chen KT, Shih HW, Cheng YS, Cheng WC, Wong CH, High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase., Bioorganic & medicinal chemistry, vol. 18(24), 8512-8529, 2010任職中研院著作;
2010 Shih HW, Chen KT, Chen SK, Huang CY, Cheng TJ, Ma C, Wong CH, Cheng WC, Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors., Organic & biomolecular chemistry, vol. 8(11), 2586-2593, 2010具代表性; 任職中研院著作;
2010 Chen-Yu Liu, Chih-Wei Guo, Yi-Fan Chang, Jen-Tsung Wang, Hao-Wei Shih, Yu-Fang Hsu, Chia-Wei Chen, Shao-Kang Chen, Yen-Chih Wang, Ting-Jen R. Cheng, Che Ma, Chi-Huey Wong, Jim-Min Fang*, Wei-Chieh Cheng)*, Synthesis and Evaluation of a New Fluorescent Transglycosylase Substrate: Lipid II-Based Molecule Possessing a Dansyl-C20 Polyprenyl Moiety, Org. Lett., vol. 12(7), 1608-1611., 2010具代表性; 任職中研院著作;
2010 Tin-Hao Chan, Yi-Fan Chang, Jung-Jung Hsu, Wei-Chieh Cheng, Straightforward Synthesis of Diverse 1-Deoxyazapyranosides via Stereocontrolled Nucleophilic Additons to Six-Membered Cyclic Nitrones, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2010(59), 5555-5559, 2010具代表性; 任職中研院著作;
2009 Shih, Hao-Wei, Guo, Chih-Wei, Lo, Kien-Hock, Huang, Min-Yang, Cheng, Wei-Chieh*, Solution-Phase Parallel Synthesis of Novel Spirooxazolinoisoxazolines, Journal of Combinatorial Chemistry, vol. 11(2), 281-287, 2009具代表性; 任職中研院著作;
2009 Tsou, En-Lun, Yeh, Yao-Ting, Liang, Pi-Hui, Cheng, Wei-Chieh*, A convenient approach toward the synthesis of enantiopure isomers of DMDP and ADMDP, Tetrahedron, vol. 65(1), 93-100, 2009具代表性; 任職中研院著作;
2009 Sung, M. T. Lai, Y. T. Huang, C. Y. Chou, L. Y. Shih, H. W. Cheng, W. C. Wong, C. H. Ma, C., Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 106(22), 8824-8829, 2009具代表性; 任職中研院著作;
2008 Chang, Yi-Fan, Jiang, Yi-Rui, Cheng, Wei-Chieh*, Traceless sulfone linker cleavage triggered by ozonolysis: solid-phase synthesis of diverse alpha -beta -unsaturated carbonyl compounds, Tetrahedron Lett., vol. 49(3), 543-547., 2008具代表性; 任職中研院著作;
2008 Tsou EL, Chen SY, Yang MH, Wang SC, Cheng TR, Cheng WC, Synthesis and biological evaluation of a 2-aryl polyhydroxylated pyrrolidine alkaloid-based library., Bioorganic & medicinal chemistry, vol. 16(24), 10198-204, 2008具代表性; 任職中研院著作;
2008 Huang, Chih-Ming, Liu, Rai-Shung, Wu, Tian-Shung, Cheng, Wei-Chieh*, Structural establishment of polygalatenosides A and B by total synthesis, Tetrahedron Lett., vol. 49(18), 2895-2898, 2008任職中研院著作;
2008 Shih, Hao-Wei, Cheng, Wei-Chieh*, Solution-phase parallel synthesis of highly diverse spiroisoxazolinohydantoins, Tetrahedron Lett., vol. 49(6), 1008-1011, 2008任職中研院著作;
2008 Chang, Yi-Fan, Liu, Chen-Yu, Guo, Chih-Wei, Wang, Yen-Chih, Fang, Jim-Min, Cheng, Wei-Chieh*, Solid-Phase Organic Synthesis of Polyisoprenoid Alcohols with Traceless Sulfone Linker, J. Org. Chem., vol. 73(18), 7197-7203, 2008具代表性; 任職中研院著作;
2008 Cheng TJ, Sung MT, Liao HY, Chang YF, Chen CW, Huang CY, Chou LY, Wu YD, Chen YH, Cheng YS, Wong CH, Ma C, Cheng WC, Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105(2), 431-6, 2008具代表性; 任職中研院著作;