Shang-Cheng Hung, Ph.D.
Name Shang-Cheng Hung, Ph.D.
Incumbent Distinguished Professor
所屬單位

Ph.D., Chemistry, National Tsing Hua University, 1992
NCLscan:
研究方向/領域

RESEARCH INTERESTS

Carbohydrate Synthesis, Glycotechnology, and Glycobiology

The research in Dr. Hung’s group aims on the development of novel methodologies for the synthesis of biologically potent oligosaccharides, glycolipids, and glycoproteins via a combination of regioselective one-pot protection and stereoselective one-pot glycosylation. The major interests include five topics:

  • Discovery of new technologies for carbohydrate synthesis
  • Preparation of cell-surfaced carbohydrates (heparin/heparan sulfate, GPI anchors) and mycobacterial cell envelope components
  • Development of heparin-related microarrays, dendrimers, and nanoparticles
  • Study of heparin-protein interaction
  • Investigation of carbohydrate-based anti-tuberculosis vaccines

Hung lab
Regioselective One-pot Protection of Carbohydrates
EDUCATION AND POSITIONS HELD
  • 2016-2018 Acting Division Director of Biotechnology Incubation Center, Genomics Research Center, Academia Sinica
  • 2022-2016 Director, Genomics Research Center, Academia Sinica
  • 2012-present Distinguished Professor, Genomics Research Center, Academia Sinica
  • 2010-present Adjunct Professor, Department of Applied Chemistry, National Chiao Tung University
  • 2009-2012 Professor, Genomics Research Center, Academia Sinica
  • 2007-2009 Distinguished Professor, Department of Chemistry, National Tsing Hua University
  • 2006-2007 Professor, Department of Chemistry, National Tsing Hua University
  • 2005-2006 Associate Professor, Department of Chemistry, National Tsing Hua University
  • 2002-2005 Associate Research Fellow, Institute of Chemistry, Academia Sinica
  • 1998-2002 Assistant Research Fellow, Institute of Chemistry, Academia Sinica
  • 1995-1998 Postdoctoral Fellow, The Scripps Research Institute
  • 1994-1995 Postdoctoral Fellow, University of California at Berkeley
HONORS
  • 2024 Academician, Academia Sinica
  • 2021 Future Tech Award, Ministry of Science and Technology
  • 2021 Academic Summit Program Award, Ministry of Science and Technology (2nd time)
  • 2017 Excellent Research Project of Future Tech Exhibition, Ministry of Science and Technology
  • 2017 Outstanding Merit Award, Wang Ming-Ning Memorial Foundation
  • 2016 13th National Innovation Award (Academic Research Category), Institute for Biotechnology and Medicine Industry
  • 2016 Academic Award, The Chinese Chemical Society at Taipei (CSLT)
  • 2016 Academic Summit Program Award, Ministry of Science and Technology
  • 2015 Technique Transfer Award, Ministry of Science and Technology
  • 2014 Investigator Award, Academia Sinica (2nd time)
  • 2014 David Ginsburg Memorial Lectureship, Technion-Israel Institute of Technology, Haifa, Israel
  • 2014 21st Research Grant Award, Mizutani Foundation for Glycoscience, Japan
  • 2013 Ho Chin Tui Outstanding Research Award, Ho Chin Tui Foundation
  • 2012 Outstanding Research Award, Ministry of Science and Technology (3rd time)
  • 2012 56th Academic Award, Ministry of Education, Taiwan
  • 2011 7th Outstanding Biomedical Technology Award, Tien-Te Lee Biomedical Foundation
  • 2010 Outstanding Scholar Chair, Foundation for the Advancement of Outstanding Scholarship (FAOS)
  • 2010 17th Teco Award, Teco Technology Foundation
  • 2009-2011 Distinguished Research Award, National Science Council
  • 2009 Best Annual Article Award, The Chinese Chemical Society
  • 2009 Academic Publication Award, Chung-Shan Academic and Cultural Foundation
  • 2008 Distinguished Teaching Award, National Tsing Hua University
  • 2008 Yu-Ziang Hsu Scientific Paper Award, Far Eastern Y. Z. Hsu Science and Technology Memorial Foundation
  • 2006 Letcureship Award, International Conference on Cutting-Edge Organic Chemistry in Asia
  • 2005 Outstanding Youth Medal, China Youth Corps
  • 2004 Distinguished Research Award, National Science Council
  • 2003 Mr. Tayou Wu Memorial Award, National Science Council
  • 2003 Travel Grant Award for Young Chemists, IUPAC
  • 2003 Outstanding Young Scholar Award, Tsing-Hua Fundation of Chemistry Technology
  • 2002 Outstanding Young Investigator Award, The Chinese Chemical Society
  • 2002 Young Scholar Research Publication Award, Academia Sinica
  • 1994 Postdoctoral Fellowship, Educational Ministry
-C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 Inhibitors., Frontiers in Chemistry, vol. 10, 947475, 2022任職中研院著作;
Year Paper Title
2025 Lin JS, Tzeng ZH, Dumalaog JS, (Hung SC)*, A streamlined synthetic approach to the truncated linear trisaccharide fragment of QS-21., Frontiers in Chemistry, vol. 13, 1650302, 2025任職中研院著作;
2025 Wei-Chien Weng, Hung-En Liao, Cheng-Hsiu Chang, (Shang-Cheng Hung, Kai Du, Zhijay Tu, Chun-Hung Lin, Chi-Kung Ni*, Unusual Free Trisaccharides in Caprine Colostrum Discovered by Logically Derived Sequence Tandem Mass Spectrometry, SCIENTIFIC REPORTS, vol. 15, 1586, 2025任職中研院著作;
2025 Ahmed Atito, Jasper S. Dumalaog, Kuei-Yao Tseng, Yen-Ju Ting, Medel Manuel L. Zulueta, (Shang-Cheng Hung*, Molecular Iodine-Mediated β-Glycosylation of Thiomannosides with 1,6-Anhydrosugars, ORGANIC LETTERS, vol. 27, 2450-2455, 2025具代表性; 任職中研院著作;
2025 Yi-Cheng Tsai, Chien-Jui Huang, Jui-Lin Chang, Nai-Jung Chiang, Yu-Shan Huang, Anandaraju Bandaru, (Shang-Cheng Hung*, Yan-Shen Shan*, Gwo-Bin Lee*, Application of CAPTURE Assay for Early Diagnosis and Prognosis in Bile and Blood of Cholangiocarcinoma, JCO PRECISION ONCOLOGY, vol. 9, e2400728, 2025任職中研院著作;
2025 Libor Hejduk, Norbert Müller, Adriana Rathner, Ján Štěrba, (Shang-Cheng Hung, Chia-Lin Chyan, Ryan O. M. Rego*, Martin Strnad*, Navigating Infection by Pathogenic Spirochetes: The Host-Bacteria Interface at the Atomic Level, PROTEIN SCIENCE, vol. 34, e70185, 2025任職中研院著作;
2025 Junpei Shimabukuro, Ci-Hua Shen, Tsung-Kai Hsueh, Ting-Wen Chen, Yin-Chen Tseng, Veeranjaneyulu Gannedi, Jasper S. Dumalaog, Cheng-Hsiu Chang, * Ting-Jen Rachel Cheng, * Chung-Shan Yu, * (Shang-Cheng Hung*, Streamlined Synthesis and Immunomodulatory Effects of Ulvan Oligosaccharides from Marine Green Algae, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025具代表性; 任職中研院著作;
2024 Chang YJ, Lin KT, Shih O, Yang CH, Chuang CY, Fang MH, Lai WB, Lee YC, Kuo HC, (Hung SC, Yao CK, Jeng US, (Chen YR, Sulfated disaccharide protects membrane and DNA damages from arginine-rich dipeptide repeats in ALS., Science advances, vol. 10(8), eadj0347, 2024任職中研院著作;
2024 Chang JL, Huang CJ, Tsai YC, Chiang NJ, Huang YS, (Hung SC)*, Shan YS*, Lee GB*, An integrated microfluidic system for automatic detection of cholangiocarcinoma cells from bile., Lab on a chip, vol. 24(2), 375-382, 2024任職中研院著作;
2023 Nguan HS, Tsai ST, Liew CY, Reddy NS, (Hung SC, Ni CK*, The collision-induced dissociation mechanism of sodiated Hex-HexNAc disaccharides., Physical chemistry chemical physics : PCCP, vol. 25(33), 22179-22194, 2023任職中研院著作;
2022 Weng WC, Liao HE, Huang SP, Tsai ST, Hsu HC, Liew CY, Gannedi V, Hung SC, Ni CK, Unusual free oligosaccharides in human bovine and caprine milk., Scientific Reports, vol. 12(1), 10790, 2022任職中研院著作;
2022 Liew CY, Hsu HC, Nguan HS, Huang YC, Zhong YQ, Hung SC, Ni CK, The Good, the Bad, and the Ugly Memories of Carbohydrate Fragments in Collision-Induced Dissociation., Journal of the American Society for Mass Spectrometry, vol. 33(10), 1891-1903, 2022任職中研院著作;
2022 Wang Chih-Hung, Chang Jia-Ru, Hung Shang-Cheng, Dou Horng-Yunn, Lee Gwo-Bin, Rapid molecular diagnosis of live Mycobacterium tuberculosis on an integrated microfluidic system, Sensors and Actuators B: Chemical, vol. 12(1), 10790, 2022任職中研院著作;
2022 Tseng KY, Tzeng ZH, Cheng TR, Liang PH, Hung SC, Design and Synthesis of 1-O- and 6
2022 Byung-sun Jeon, Teng-Yi Huang, Mark W. Ruszczycky, Sei-hyun Choi, Namho Kim, Joseph Livy Franklin, (Shang-Cheng Hung*, Hung-wen Liu*, Byproduct formation during the biosynthesis of spinosyn A and evidence for an enzymatic interplay to prevent its formation, TETRAHEDRON, vol. 103, 132569, 2022具代表性; 任職中研院著作;
2022 Teng KC, Tseng KY, Tzeng ZH, Hung SC, A concise synthesis of L-gulose and its C-6 derivatives., Bioorganic & Medicinal Chemistry, vol. 73, 117029, 2022任職中研院著作;
2022 Lu Tsung-Han, Chiang Nai-Jung, Tsai Yi-Cheng, Gopinathan Priya, Huang Chien-Jui, Chang Jui-Lin, Tu Hsiu-Chi, Shan Yan-Shen, Hung Shang-Cheng, Lee Gwo-Bin, An integrated microfluidic system for cholangiocarcinoma diagnosis from bile by using specific affinity probes, Sensors and Actuators B: Chemical, vol. 373, 132724, 2022任職中研院著作;
2022 Uchimura K, Nishitsuji K, Chiu LT, Ohgita T, Saito H, Allain F, Gannedi V, Wong CH, Hung SC, Design and Synthesis of 6-O-Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid beta Aggregation., Chembiochem : a European journal of chemical biology, vol. 23(15), e202200191, 2022任職中研院著作;
2021 Gannedi V, Villuri BK, Reddy SN, Ku CC, Wong CH*, (Hung SC*, Practical Remdesivir Synthesis through One-Pot Organocatalyzed Asymmetric (S)-P-Phosphoramidation., The Journal of Organic Chemistry, vol. 86(7), 4977-4985, 2021具代表性; 任職中研院著作;
2021 Jan JT, Cheng TR, Juang YP, Ma HH, Wu YT, Yang WB, Cheng CW, Chen X, Chou TH, Shie JJ, Cheng WC, Chein RJ, Mao SS, Liang PH, Ma C*, (Hung SC*, Wong CH*, Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection., Proceedings of the National Academy of Sciences of the United States of America, vol. 118(5), 2021具代表性; 任職中研院著作;
2021 Priya Gopinathan, Tsung-Han Lua, Nai-Jung Chiang, Chien-Jui Huang, Hsui-Chi Tu, (Shang-Cheng Hung, Yan-Shen Shan*, Gwo-Bin Lee*, Exfoliated tumor cells in bile as a promising indicator of disease status in cholangiocarcinoma, SENSORS AND ACTUATORS B-CHEMICAL, vol. 346, 130526, 2021任職中研院著作;
2020 Chiu LT, Sabbavarapu NM, Lin WC, Fan CY, Wu CC, Cheng TR, Wong CH*, (Hung SC*, Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1., Journal of the American Chemical Society, vol. 142(11), 5282-5292, 2020具代表性; 任職中研院著作;
2020 Yeh CJ, Zulueta MML, Li YK, (Hung SC*, Synthesis of hyaluronic acid oligosaccharides with a GlcNAc-GlcA repeating pattern and their binding affinity with CD44., Organic & biomolecular chemistry, vol. 18(28), 5370-5387, 2020任職中研院著作;
2020 Lin TS, Hsieh CH, Kuo C, Juang YP, Hsieh YSY, Chiang H, (Hung SC, Jiang CC, Liang PH, Sulfation pattern of chondroitin sulfate in human osteoarthritis cartilages reveals a lower level of chondroitin-4-sulfate., Carbohydrate polymers, vol. 229, 115496, 2020任職中研院著作;
2020 Gopinathan P, Chiang NJ, Bandaru A, Sinha A, Huang WY, (Hung SC*, Shan YS, Lee GB, Exploring Circulating Tumor Cells in Cholangiocarcinoma Using a Novel Glycosaminoglycan Probe on a Microfluidic Platform., Advanced healthcare materials, vol. 9(10), e1901875, 2020任職中研院著作;
2020 Farabi K, Manabe Y, Ichikawa H, Miyake S, Tsutsui M, Kabayama K, Yamaji T, Tanaka K, (Hung SC, Fukase K, Concise and Reliable Syntheses of Glycodendrimers via Self-Activating Click Chemistry: A Robust Strategy for Mimicking Multivalent Glycan-Pathogen Interactions., The Journal of organic chemistry, vol. 85(24), 16014-16023, 2020任職中研院著作;
2020 Gopinathan Priya, Chiang Nai-Jung, Wang Chih-Hung, Sinha Anirban, Tsai Yi-Cheng, Tu Hsiu-Chi, (Hung Shang-Cheng, Hsu Pang-Hung, Shan Yan-Shen, Lee Gwo-Bin, Aptamer probed isolation of circulating tumor cells in cholangiocarcinoma patients, SENSORS AND ACTUATORS B-CHEMICAL, vol. 322, 128569, 2020任職中研院著作;
2019 Kameyama, H.; Uchimura, K.; Yamashita, T.; Kuwabara, K.; Mizuguchi, M.; (Hung, S.-C.); Okuhira, K.; Masuda, T.; Kosugi, T.; Ohgita, T.; Saito, H.; Ando Y.; Nishitsuji, K.*, The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity, Am. J. Pathol, vol. 189, 308-319, 2019任職中研院著作;
2019 Yeh, C.-J.; Ku, C.-C.; Lin, W.-C.; Fan, C.-Y.; Medel Manuel L. Zulueta, M. M. L.; Manabe, Y.; Fukase, K.; Li, Y.-K.; (Hung, S.-C.*, Single-Step Per-O-Sulfonation of Sugar Oligomers with Concomitant 1,6-Anhydro Bridge Formation for Binding Fibroblast Growth Factors, CHEMBIOCHEM, vol. 20, 237-240, 2019具代表性; 任職中研院著作;
2019 Lin, Y.-C.; Ko, Y.-C.; (Hung, S.-C.); Lee, J.-H.; Lin, Y.-T.; Tsai, J.-Y.; Kung, P.-H.; Tsai, M.-C.; Chen, Y.-F.; Wu, C.-C.*, Selective Inhibition of PAR4-mediated Platelet Activation by a Synthetic Nonanticoagulant, Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 39, 694-703, 2019任職中研院著作;
2019 Sakamoto K, Ozaki T, Ko YC, Tsai CF, Gong Y, Morozumi M, Ishikawa Y, Uchimura K, Nadanaka S, Kitagawa H, Zulueta MML, Bandaru A, Tamura JI, (Hung SC, Kadomatsu K, Glycan sulfation patterns define autophagy flux at axon tip via PTPRsigma-cortactin axis., Nature Chemical Biology, vol. 15(7), 699-709, 2019具代表性; 任職中研院著作;
2019 Sianturi J, Manabe Y, Li HS, Chiu LT, Chang TC, Tokunaga K, Kabayama K, Tanemura M, Takamatsu S, Miyoshi E, (Hung SC, Fukase K, Development of α-Gal-Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies., Angewandte Chemie (International ed. in English), vol. 58(14), 4526-4530, 2019任職中研院著作;
2019 Shen, K. M.; Sabbavarapu, N. M.; Fu, C.-Y.; Jan, J.-T.; Wang, J.-R.; (Hung, S.-C.*); Lee, G.-B.*, An Integrated Microfluidic System for Rapid Detection and Multiple Subtyping of Influenza A Viruses by Using Glycan-Coated Magnetic Beads and RT-PCR, Lab Chip, vol. 19, 1277-1286, 2019任職中研院著作;
2018 Zulueta, M. M. L.*; Chyan, C.-L.; (Hung, S.-C.*, Structural Analysis of Synthetic Heparan Sulfate Oligosaccharides with Fibroblast Growth Factors and Heparin-Binding Hemagglutinin, Curr. Opin. Struct. Biol., vol. 50, 126-133, 2018具代表性; 任職中研院著作;
2018 Wang, C.-C.*; Sabbavarapu, N. M.; Podilapu, A. R.; Liao, P.-H.; (Hung, S.-C.*, One-Pot Protection, Glycosylation and Protection-Glycosylation Strategies of Carbohydrates, Chem. Rev., vol. 118, 8025-8104, 2018具代表性; 任職中研院著作;
2017 Padiyar, L. T.; Zulueta, M. M. L.; Sabbavarapu, N. M.; (Hung, S.-C.*, Yb(OTf)3-Catalyzed Desymmetrization of myo-Inositol-1,3,5-Orthoformate and Its Application in the Synthesis of Chiral Inositol Phosphates, J. Org. Chem, vol. 82, 11418-11430, 2017具代表性; 任職中研院著作;
2017 Tsai, C.-T.; Zulueta, M. M. L.; (Hung, S.-C.*, Synthetic Heparin and Heparan Sulfate: Probes in Defining Biological Functions, Curr. Opin. Chem. Biol., vol. 21, 152-159, 2017具代表性; 任職中研院著作;
2017 Huang, T.-Y.; Irene, D.; Ku, C.-C.; Zulueta, M. M. L.; Tai, T.-J.; Lain, S.-H.; Cheng, C.-P.; Tsai, P.-X.; Lin, S.-Y.; Chen, Z.-G.; Hsiao, C.-D.; Chyan, C.-L.*; (Hung, S.-C.*, Structure of the Complex between a Heparan Sulfate Octasaccharide and Mycobacterial Heparin-Binding Hemagglutinin, Angew. Chem. Int. Ed, vol. 56, 4192-4196, 2017具代表性; 任職中研院著作;
2017 Ho, K.-M.; Zulueta, M. M. L.; (Hung, S.-C.*, Stereoselective One-pot Synthesis of Polypropionates, Nat. Commun, vol. 8, 679, 2017具代表性; 任職中研院著作;
2017 Hughes, A. J.; Meneghetti, M. C. Z.; Huang, T.-Y.; (Hung, S.-C.); Elli, S.; Guerrini, M.; Rudd, T. R.; Lima, M. A.*; Yates, E. A.*, Investigating the Relationship between Temperature, Conformation and Calcium Binding in Heparin Model Oligosaccharides, Carbohydr. Res, vol. 438, 58-64, 2017任職中研院著作;
2017 Zheng RB, Jegouzo SAF, Joe M, Bai Y, Tran HA, Shen K, Saupe J, Xia L, Ahmed MF, Liu YH, Patil PS, Tripathi A, (Hung SC, Taylor ME, Lowary TL, Drickamer K, Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans., ACS chemical biology, vol. 12(12), 2990-3002, 2017任職中研院著作;
2017 Prados-Rosales, R.*; Carreño L.; Weinrick, B.; Lowary, T.; Baena, A.; Joe, M.; Bai, Y.; Kalscheuer, R.; Batista-Gonzalez, A.; Saavedra, N.; Chen, T.; Blanc, C.; (Hung, S.-C.); Tripathi, A.; Xu, J.; Glatman-Freedman, A.; Jacobs, W.; Chan, J.; Porcelli, S.; Achkar, J.; Casadevall, A., Enhanced Control of Mycobacterium tuberculosis Extrapulmonary Dissemination in Mice by an Arabinomannan-Protein Conjugate Vaccine, PLOS PATHOGENS, vol. 13, e1006250, 2017任職中研院著作;
2016 Ho, G.-M.; Huang, C.-J., Li, E. Y.-T.*, Hsu, S.-K.; Wu, T.; Zulueta, M. M. L.; Wu, K. P.-C.; (Hung, S.-C.*, Unconventional exo-Selectivity in Thermal Normal-Electron-Demand Diels–Alder Reactions, Sci. Rep, vol. 6, 35147, 2016具代表性; 任職中研院著作;
2016 Liang, W. G.; Huang, T.-Y.; Zulueta, M. M. L.; (Hung, S.-C.*); Tang, W.-J.*, Structural Basis for Oligomerization and Glycosaminoglycan-Binding of CCL5 and CCL3, Proc. Natl. Acad. Sci. USA, vol. 113, 5000-5005, 2016具代表性; 任職中研院著作;
2016 Stewart, K. L.; Hughes, E.; Yates, E. A.; Huang, T.-Y.; Lima, M. A.; Rudd, T. R.; Guerrini, M.; (Hung, S.-C.*); Radford, S. E.*; Middleton, D. A.*, Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils, J. Am. Chem. Soc., vol. 138, 8328-8331, 2016具代表性; 任職中研院著作;
2015 Patil PS; Cheng TJR; Zulueta MM; Yang ST; Lico LS; (Hung SC.*, Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity., Nat Commun., vol. 6, 7239, 2015具代表性; 任職中研院著作;
2015 Medel Manuel L. Zulueta*, Donala Janreddy, Shang-Cheng Hung*, One-Pot Methods for the Protection and Assembly of Sugars, ISRAEL JOURNAL OF CHEMISTRY, vol. 55(3), 347-359, 2015具代表性; 任職中研院著作;
2015 Kuwabara K; Nishitsuji K; Uchimura K; (Hung SC); Mizuguchi M; Nakajima H; Mikawa S; Kobayashi N; Saito H; Sakashita N., Cellular interaction and cytotoxicity of the Iowa mutation of apolipoprotein A-I (ApoA-IIowa) amyloid mediated by sulfate moieties of heparan sulfate., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 290, 24210-24221, 2015具代表性; 任職中研院著作;
2014 Huang, T.-Y.; Zulueta, M. M. L.; (Hung, S.-C., Regioselective One-pot Protection, Protection-Glycosylation and Protection- Glycosylation-Glycosylation of Carbohydrates: A Case Study with D-Glucose, Organic & Biomolecular Chemistry, vol. 12(2), 376-382, 2014具代表性; 任職中研院著作;
2014 Patil, P. S.; Zulueta, M. M. L.; (Hung, S.-C., Synthesis of Phosphatidylinositol Mannosides, Journal of the Chinese Chemical Society, vol. 61, 151-162, 2014具代表性; 任職中研院著作;
2014 Hsu Y; Ma HH; Lico LS; Jan JT; Fukase K; Uchinashi Y; Zulueta MM; (Hung SC.*, One-pot synthesis of N-acetyl- and N-glycolylneuraminic acid capped trisaccharides and evaluation of their influenza A(H1N1) inhibition., ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 53, 2413-2416, 2014具代表性; 任職中研院著作;
2014 Li YC; Ho IH; Ku CC; Zhong YQ; Hu YP; Chen ZG; Chen CY; Lin WC; Zulueta MM; (Hung SC*); Lin MG; Wang CC; (Hsiao CD*, Interactions That Influence the Binding of Synthetic Heparan Sulfate Based Disaccharides to Fibroblast Growth Factor-2, ACS Chem Biol., vol. 9, 1912-1717, 2014具代表性; 任職中研院著作;
2014 Chang CH; Lico LS; Huang TY; Lin SY; Chang CL; Arco SD; (Hung SC.*, Synthesis of the heparin-based anticoagulant drug Fondaparinux., ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 53, 9876-9879, 2014具代表性; 任職中研院著作;
2014 Ko YC; Tsai CF; Wang CC*; Dhurandhare VM; Hu PL; Su TY; Lico LS; Zulueta MM; (Hung SC*, Microwave-assisted one-pot synthesis of 1,6-anhydrosugars and orthogonally protected thioglycosides., J Am Chem Soc., vol. 136, 14425-14431, 2014具代表性; 任職中研院著作;
2013 Zulueta, M. M. L.; Lin, S.-Y.; Hu, Y.-P.; Hung, S.-C., Synthetic Heparin and Heparan Sulfate Oligosaccharides and their Protein Interactions, Current Opinion in Chemical Biology, vol. 17(6), 1023-1029, 2013具代表性; 任職中研院著作;
2013 Woolfson, D. N.; Hung, S.-C., Synthetic Biomolecules, Current Opinion in Chemical Biology, vol. 17(6), 925-928, 2013具代表性; 任職中研院著作;
2013 Zulueta, M. M. L.; Zhong, Y.-Q.; Hung, S.-C., Synthesis of Rare L-Hexoses and Their Related Biomolecules, Chemical Communications, vol. 49(32), 3275-3287, 2013具代表性; 任職中研院著作;
2013 Lu, F.-C.; Lico, L. S.; Hung, S.-C., Synthesis of Fluorogenic Substrate for α-L-Iduronidase, ARKIVOC, vol. 2013(2), 13-21, 2013具代表性; 任職中研院著作;
2013 Patil, P. S.; Lee, C.-C.; Huang, Y.-W.; Zulueta, M. M. L.; Hung, S.-C., Regioselective and Stereoselective Benzylidene Installation and One-pot Protection of D-mannose, Organic & Biomolecular Chemistry, vol. 11(16), 2605-2612, 2013具代表性; 任職中研院著作;
2013 Zulueta, M. M. L.; Lin, S.-Y.; Hung, S.-C., Chemical Synthesis of Oligosaccharides Based on Heparin and Heparan Sulfate, Trends in Glycoscience and Glycotechnology, vol. 25, 141-158, 2013具代表性; 任職中研院著作;
2012 Hung, S.-C.; Lu, X.-A.; Lee, J.-C.; Fang, S.-L.; Fan, T.-C.; Chang, M. D.-T.; Zulueta, M. M. L.; Chiu, L.-T., Synthesis of Heparin Oligosaccharides and Their Interaction with Eosinophil-Derived Neurotoxin, Org. Biomol. Chem., vol. 10, 760-772, 2012具代表性; 任職中研院著作;
2012 Hsu, C.-Y.; Lee, I-C.; Lico, L. S.; Uang, B.-J.; Hung, S.-C., Synthesis of a Furanosyl-pyranone Derivative Related to the Tri-O-heterocyclic Core of Herbicidins, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol. 59, 421-425, 2012具代表性; 任職中研院著作;
2012 Luo, S.-Y.; Tripathi, A.; Zulueta, M. M. L.; Hung, S.-C., 2-Allylphenyl Glycosides as Glycosyl Donors for Sugar Coupling, Carbohydrate Research, vol. 352, 197-201, 2012具代表性; 任職中研院著作;
2012 Hsu, Y.; Lu, X.-A.; Zulueta, M. M. L.; Tsai, C.-M.; Lin, K.-I; Hung, S.-C.; Wong, C.-H., Acyl and Silyl Group Effects in Reactivity-based One-pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4, J. Am. Chem. Soc., vol. 134, 4549-4552, 2012具代表性; 任職中研院著作;
2012 Zulueta, M. M. L.; Lin, S.-Y.; Lin, Y.-T.; Huang, C.-J.; Wang, C.-C.; Ku, C.-C.; Shi, Z.; Chyan, C.-L.; Irene, D.; Lim, L.-H.; Tsai, T.-I; Hu, Y.-P.; Liu, J.-Y.; Chang, W.; Arco, S. D.; Wong, C.-H.; Hung, S.-C., α-Glycosylation by D-Glucosamine-Derived Donors: Synthesis of Heparosan and Heparin Analogs that Interact with Mycobacterial Heparin-Binding Hemagglutinin, J. Am. Chem. Soc., vol. 134(21), 8988-8995, 2012具代表性; 任職中研院著作;
2012 Hu, Y.-P.; Zhong, Y.-Q.; Chen, Z.-G.; Chen, C.-Y.; Shi, Z.; Zulueta, M. M. L.; Ku, C.-C.; Lee, P.-Y.; Wang, C.-C.; Hung, S.-C., Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar–Fibroblast Growth Factor-1 Interaction, J. Am. Chem. Soc., vol. 134(51), 20722-20727, 2012具代表性; 任職中研院著作;
2011 Wang, C.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C., Synthesis of Hemagglutinin-Binding Trisaccharides, Advances in Experimental Medicine and Biology, vol. 705, 691-726, 2011具代表性; 任職中研院著作;
2011 Hu, Y.-P.; Lin, S.-Y.; Huang, C.-Y.; Zulueta, M. M. L.; Liu, J.-Y.; Chang, W.; Hung, S.-C., Synthesis of 3-O-Sulfonated Cell-Surface Heparan Sulfate Octasaccharides that Inhibit Herpes Simplex Virus Type 1 Host-Cell Interaction, Nature Chemistry, vol. 3, 557–563, 2011具代表性; 任職中研院著作;
2011 Wang, C.-C.; Zulueta, M. M. L.; Hung, S.-C., Regioselective One-pot Protection and Protection-glycosylation of Carbohydrates, Chimia, vol. 65, 54-58, 2011具代表性; 任職中研院著作;
2011 Huang, T.-Y.; Zulueta, M. M. L.; Hung, S.-C., One-Pot Strategies for the Synthesis of the Tetrasaccharide Linkage Region of Proteoglycans, Org. Lett., vol. 13, 1506–1509, 2011具代表性; 任職中研院著作;
2011 Lee, I.-C.; Zulueta, M. M. L.; Shie, C.-R.; Arco, S. D.; Hung, S.-C., Deuterium-Isotope Study on the Regioselective Ring Opening of Benzylidene Acetals, Org. Biomol. Chem., vol. 9, 7655–7658, 2011具代表性; 任職中研院著作;
2011 Chung, C.-C.; Zulueta, M. M. L.; Padiyar, L. T.; Hung, S.-C., Desymmetrization of 2,4,5,6-Tetra-O-benzyl-D-myo-inositol for the Synthesis of Mycothiol, Org. Lett., vol. 13, 5496–5499, 2011具代表性; 任職中研院著作;
2011 Hsu, C.-H.; Hung, S.-C.; Wu, C.-Y.; Wong, C.-H., Toward Automatic Oligosaccharide Synthesis, Angewandte Chemie-International Edition, vol. 50(50), 11872-11923, 2011具代表性; 任職中研院著作;
2010 Hung, S.-C., Synthesis of Mycobacterial Cell Envelope Components, Natural Sciences Newsletter, vol. 22, 43-46, 2010具代表性; 任職中研院著作;
2010 Padiyar, L. T.; Wen, Y.-S.; Hung, S.-C., Metal Trifluromethanesulfonate-Catalyzed Regioselective Acylation of myo-Inositol Orthoformate, Chem. Commun., vol. 46, 5524-5526, 2010具代表性; 任職中研院著作;
2010 Patil, P. S.; Hung, S.-C., Synthesis of Mycobacterial Triacylated Phosphatidylinositol Dimannoside Containing an Acyl Lipid Chain at 3-O of Inositol, Org. Lett., vol. 12, 2618-2621, 2010具代表性; 任職中研院著作;
2010 Chang, K.-L.; Zulueta, M. M. L.; Lu, X.-A.; Zhong, Y.-Q.; Hung, S.-C., Regioselective One-pot Protection of D-Glucosamine, J. Org. Chem, vol. 75, 7424-7427, 2010具代表性; 任職中研院著作;
2009 Patil, P. S.; Hung, S.-C., Total Synthesis of Phosphatidylinositol Dimmanoside: A Cell-Envelope Component of Mycobacterium tuberculosis, Chemistry-A European Journal, vol. 15, 1091–1094, 2009具代表性;
2009 Chi, F.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C., Synthesis of Alginate Oligosaccharides Containing L-Guluronic Acids, Chemistry-An Asian Journal, vol. 4, 386–390, 2009具代表性;
2009 Shie, C.-R.; Tzeng, Z.-H.; Wang, C.-C.; Hung, S.-C., Metal Trifluoromethanesulfonate-Catalyzed Regioselective Reductive Ring Opening of Benzylidene Acetals, Journal of the Chinese Chemical Society, vol. 56, 510–523, 2009具代表性;
2008 Wang, C.-C.; Kulkarni, S. S.; Lee, J.-C.; Luo, S.-Y.; Hung, S.-C., Regioselective One-pot Protection of Glucose, Nat. Protoc, vol. 3, 97–113, 2008具代表性;
2008 Fan, T.-C.; Fang, S.-L.; Hwang, C.-S.; Hsu, C.-Y.; Lu, X.-A.; Hung, S.-C.; Lin, S.-C.; Chang, M. D.-T., Characterization of Molecular Interactions between Eosinophil Cationic Protein and Heparin, J. Biol. Chem., vol. 283, 25468–25474, 2008具代表性;
2008 Luo, S.-Y.; Jang, Y.-J.; Liu, J.-Y.; Chu, C.-S.; Liao, C.-C.; Hung, S.-C., Carbohydrates-Templated Asymmetric Diels-Alder Reactions of Masked ortho-Benzoquinones for the Synthesis of Chiral Bicyclo[2.2.2]oct-5-en-2-ones, Angewandte Chemie-International Edition, vol. 47, 8082–8085, 2008具代表性;
2007 Wang, C.-C.; Kulkarni, S. S.; Hung, S.-C., Regioselective One-pot Protection of Carbohydrates, Synform, vol. 3, A32–A34, 2007具代表性;
2007 Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Kulkarni, S. S.; Huang, Y.-W.; Lee, C.-C.; Chang, K.-L.; Hung, S.-C., Regioselective One-pot Protection of Carbohydrates, Nature, vol. 446, 896–899, 2007具代表性;
2006 Lu, L.-D.; Shie, C.-R.; Kulkarni, S. S.; Pan, G.-R.; Lu, X.-A.; Hung, S.-C., Synthesis of 48 Disaccharide Building Blocks for the Assembly of a Heparin and Heparan Sulfate Oligosaccharide Library, Org. Lett, vol. 8, 5995–5998, 2006具代表性;
2006 Luo, S.-Y.; Kulkarni, S. S.; Chou, C.-H.; Liao, W.-M.; Hung, S.-C., A Concise Synthesis of Tetrahydroxy-LCB, -Galactosyl Ceramide, and 1,4-Dideoxy-1,4-imino-L-ribitol via D-Allosamines as Key Building Blocks, J. Org. Chem., vol. 71, 1226–1229, 2006具代表性;
2006 Lee, J.-C.; Pan, G.-R.; Kulkarni, S. S.; Luo, S.-Y.; Liao, C.-C.; Hung, S.-C., 2-Allyloxyphenyl Glycoside as a New and Stable Type of Glycosyl Donors, Tetrahedron Lett., vol. 47, 1621–1624, 2006
2005 Kulkarni, S. S.; Liu, Y.-H.; Hung, S.-C., Neighboring Group Participation of 9-Anthracenylmethyl Group in Glycosylation: Preparation of Unusual C-Glycosides, J. Org. Chem., vol. 70, 2808–2811, 2005具代表性;
2005 Kulkarni, S. S.; Hung, S.-C., Metal Trifluoromethanesulfonates as Versatile Catalysts in Carbohydrate Synthesis, Lett. Org. Chem., vol. 2, 670–677, 2005
2005 Shie, C.-R.; Tzeng, Z.-H.; Kulkarni, S. S.; Uang, B.-J.; Hsu, C.-Y.; Hung, S.-C., Cu(OTf)2 as an Efficient and Dual-Purpose Catalyst in the Regioselective Reductive Ring Opening of Benzylidene Acetals, Angewandte Chemie-International Edition, vol. 44, 1665–1668, 2005具代表性;
2005 Chen, Y.-Y.; Luo, S.-Y.; Hung, S.-C.; Chan, S. I.; Tzou, D.-L. M., C-13 solid-state NMR chemical shift anisotropy analysis of the anomeric carbon in carbohydrates , Carbohydrate Research, vol. 340, 723-729, 2005
2004 Lee, C.-J.; Lu, X.-A.; Kulkarni, S. S.; Wen, Y.-S.; Hung, S.-C., Synthesis of Heparin Oligosaccharides, J. Am. Chem. Soc., vol. 126, 476–477, 2004具代表性; 任職中研院著作;
2004 Chou, C. H., Wu, C. S., Chen, C. H., Lu, L. D., Kulkarni, S. S., Wong, C. H., Hung, S. C., Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues., Org Lett, vol. 6(4), 585-588, 2004具代表性;
2004 Kulkarni, S. S.; Lee, J.-C.; Hung, S.-C., Recent Advances in the Applications of D- and L-1,6-Anhydropyranoses for the Synthesis of Oligosaccharides and Natural Products, Curr. Org. Chem., vol. 8, 475–509, 2004任職中研院著作;
2004 Lee, J.-C.; Chang, S.-W.; Liao, C.-C.; Chi, F.-C.; Chen, C.-S.; Wen, Y.-S.; Wang, C.-C.; Kulkarni, S. S.; Puranik, R.; Liu, Y.-H.; Hung, S.-C., From D-Glucose to Biologically Potent L-Hexoses: Synthesis of -L-Iduronidase Fluorogenic Detector and the Disaccharide Moieties of Bleomycin A2 and Heparan Sulfate, Chemistry-A European Journal, vol. 10, 399–415, 2004具代表性; 任職中研院著作;
2004 Kulkarni, S. S.; Chi, F.-C.; Hung, S.-C., Biologically Potent L-Hexoses and 6-Deoxy-L-hexoses: Their Syntheses and Applications, Journal of the Chinese Chemical Society, vol. 51, 1193–1200, 2004任職中研院著作;
2003 Lu, X.-A.; Chou, C.-H.; Wang, C.-C.; Hung, S.-C., Regioselective Esterification of Various D-Glucopyranosides: A Concise Synthesis of a Fully Protected Disaccharide Unit of Hyaluronic Acid, Synlett, vol. 9(S1), 1364-1366, 2003任職中研院著作;
2003 Tai, C.-A.; Kulkarni, S. S.; Hung, S.-C., Facile Cu(OTf)2-catalyzed Preparation of Per-O-acetylated Hexopyranoses with Stoichiometric Acetic Anhydride and Sequential One-pot Anomeric Substitution to Thioglycosides under Solvent-free Conditions, J. Org. Chem., vol. 68, 8719–8722, 2003具代表性; 任職中研院著作;
2003 Yang, W.-C.; Lu, X.-A.; Kulkarni, S. S.; Hung, S.-C., Cu(OTf)2-catalyzed Et3SiH-reductive Etherification of Various Carbonyl Compounds with Trimethylsilyl Ethers, Tetrahedron Lett., vol. 44, 7837–7840, 2003任職中研院著作;
2002 Luo, S.-Y.; Thopate, S. R.; Hsu, C.-Y.; Hung, S.-C., Synthesis of D-ribo-C18-Phytosphingosine from D-Glucosamine via the D-Allosamine Derivatives as Key Intermediates, Tetrahedron Lett., vol. 43, 4889–4892, 2002任職中研院著作;
2002 Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Fan, H.-F.; Pai, C.-L.; Yang, W.-C.; Lu, L.-D.; Hung, S.-C., Synthesis of Biologically Potent 12 Linked Disaccharide Derivatives via Regioselective One-pot Protection-glycosylation, Angewandte Chemie-International Edition, vol. 41, 2360–2362, 2002具代表性; 任職中研院著作;
2002 Lin, T.-S.; Chia, C.-M.; Hsiao, J.-C.; Chang, W.; Ku, C.-C.; Hung, S.-C.; Tzou, D.-L. M., Structural analysis of the extracellular domain of vaccinia virus envelope protein, A27L, by NMR and CD spectroscopy, J. Biol. Chem., vol. 277, 20949–20959, 2002具代表性; 任職中研院著作;
2002 Lee, J.-C.; Tai, C.-A.; Hung, S.-C., Sc(OTf)3-catalyzed Acetolysis of 1,6-Anhydro--hexopyranoses and Solvent-free Per-acetylation of Hexoses, Tetrahedron Lett., vol. 43, 851–855, 2002任職中研院著作;
2002 Wang, C.-C.; Luo, S.-Y.; Shie, C.-R.; Hung, S.-C., Metal Trifluoromethanesulfonate-Catalyzed Regioselective Borane-Reductive Ring Opening of Benzylidene Acetals: A Concise Synthesis of 1,4-Dideoxy-1,4-imino-L- xylitol, Org. Lett., vol. 4, 847–849, 2002具代表性; 任職中研院著作;
2002 Hung, S.-C.; Wen, Y.-F.; Chang, J.-W.; Liao, C.-C.; Uang, B.-J., A Highly Diastereoselective Synthesis of (1R)-(+)-Camphor Based Chiral Allenes and their Asymmetric Hydroboration-Oxidation Reactions, J. Org. Chem., vol. 67, 1308–1313, 2002具代表性; 任職中研院著作;
2001 Hung, S.-C.; Thopate, S. R.; Puranik, R., Synthesis of 6-Deoxy-L-idose and L-Acovenose from Diacetone -D-Glucose, Carbohydrate Research, vol. 331, 369–374, 2001任職中研院著作;
2001 Hung, S.-C.; Thopate, S.-R.; Wang, C.-C., Regioselective and Stereoselective Benzoylation of 2-N-Protected 4,6-O-Ketalized D-Glucosamines with 1-(Benzoyloxy)benzotriazole, Carbohydrate Research, vol. 330, 177–182, 2001任職中研院著作;
2001 Hung, S.-C.; Thopate, S. R.; Chi, F.-C.; Chang, S.-W.; Lee, J.-C.; Wang, C.-C.; Wen, Y.-S., 1,6-Anhydro--L-hexopyranoses as Potent Synthons in the Synthesis of the Disaccharide Units of Bleomycin A2 and Heparin, J. Am. Chem. Soc., vol. 123, 3153–3154, 2001具代表性; 任職中研院著作;
2001 Hung, S.-C.; Wang, C.-C.; Chang, S.-W.; Chen, C-S., 1,6-Anhydro-β-l-hexopyranoses as valuable building blocks toward the synthesis of l-gulosamine and l-altrose derivatives, Tetrahedron Lett., vol. 42, 1321–1324, 2001任職中研院著作;
2000 Hung, S.-C.; Puranik, R.; Chi, F.-C., Novel Synthesis of 1,2:3,5-Di-O-isopropylidene-L-idofuranoside and its Derivatives at C6, Tetrahedron Lett., vol. 41, 77–80, 2000任職中研院著作;
2000 Hung, S.-C.; Wang, C.-C.; Thopate, S. R., Efficient Synthesis of L-Altrose and L-Mannose, Tetrahedron Lett., vol. 41, 3119–3122, 2000任職中研院著作;
2000 Hung, S.-C.; Chen, C.-S., Efficient Synthesis of 1,2,3,4,6-Penta-O-acetyl-L-idopyranose, Journal of the Chinese Chemical Society, vol. 47, 1257–1262, 2000任職中研院著作;
IBMI Award516