Kuo-I Lin, Ph.D.
Name Kuo-I Lin, Ph.D.
Incumbent Distinguished Professor
所屬單位 Division Director of Medical Biology


B.S., Medical Technology, National Taiwan University, 1991
M.S., Medical Technology, National Taiwan University, 1993
Ph.D., Molecular Microbiology and Immunology, The Johns Hopkins University, 1998
NCLscan:
研究方向/領域

RESEARCH INTERESTS

Regulatory mechanisms in the immune system

Research work in Lin’s laboratory combines molecular biology and mouse gene knockout models to study the mechanisms of gene expression or post-translational modifications in the regulation of immune system development and functions. Dr. Lin’s group employs single B cell-screening platform to isolate pathogen-specific or cancer-associated monoclonal antibodies. Her group studies the mode of action of monoclonal antibodies in disease progression, as well as in the applications of disease therapy.

Her major research interests are listed as follows:

  • Gene regulatory circuits in the immune system, focusing on studying the mode of action of a master regulator of cellular differentiation, Blimp-1
  • Molecular mechanisms of tumorigenesis of plasma cells and mature B cells
  • Post-translational modification by glycosylation in B cells
  • Single B cell-screening platform and the effector functions of antibody

 

EDUCATION AND POSITIONS HELD
  • 2022-present Distinguished Professor, Genomics Research Center, Academia Sinica
  • 2016-present Adjunct Professor, Graduate Institute of Immunology, National Taiwan University, Taipei, Taiwan
  • 2014-present Division Director of Medical Biology, Genomics Research Center, Academia Sinica, Taipei, Taiwan
  • 2014-2022 Professor, Genomics Research Center, Academia Sinica, Taiwan
  • 2010-2016 Adjunct Associate Professor, Institute of Immunology, National Taiwan University, Taipei, Taiwan
  • 2009-2014 Associate Professor, Genomics Research Center, Academia Sinica, Taiwan
  • 2004-2009 Assistant Professor, Genomics Research Center, Academia Sinica, Taiwan
  • 2003-2004 Associate Research Scientist, Columbia University
  • 1998-2003 Postdoctoral Fellow, Columbia University
HONORS
  • 2024 Chiung-Lin Chen memorial award for translational medicine
  • 2019 Academia Sinica Significant Research Publications
  • 2019 Outstanding Research Achievement to National Health, Ming-Ning Wang Memorial Foundation
  • 2018 Academia Sinica Investigator Award
  • 2016 Academia Sinica Significant Research Publications
  • 2016 Outstanding Research Award, Ministry of Science and Technology, Taiwan
  • 2015 Chair in Biotechnology, Taiwan Bio-Development Foundation
  • 2014 Outstanding Research Award, The Chinese Society of Immunology, Taiwan
  • 2014 Young Scientist Research Award, Tien-Te Lee Biomedical Foundation, Taiwan
  • 2013 Academia Sinica Significant Research Publications
  • 2013 Oustanding Research Award, National Science Council, Taiwan
  • 2012 Academia Sinica Significant Research Publications
  • 2010 Academia Sinica Career Development Award
  • 2008 ASAIHL-Scopus Young Scientist Award
  • 2005 Li Foundation Heritage Prize
  • 1999-2002 The Leukemia and Lymphoma Society Fellowship
  • 1999 Phi Beta Kappa, The Johns Hopkins University
  • 1995 Betty Lee Hampil Honorary Fellowship, Molecular Microbiology and Immunology.The Johns Hopkins University
  • 1987-1991 National Taiwan University Presidential Award (top 5% student)
Year Paper Title
2026 Chou, T.-F., Chiu, H.-C., Gebreyesus, S., Chen, G.-F., Chen, Y.-J., Velasquez, A. R., (Lin, K.-I, Chen, Y.-J., Tu, H.-L., MiProChip: A Scalable Microfluidic Platform for Multiplexed Single-cell Proteomics via Isobaric Labeling, Analytical Chemistry, vol. 98(9):, 6874-6886, 2026具代表性; 任職中研院著作;
2025 Liu, P.-C., Huang, S.-Y., (Lin, K.-I, Hsieh, S.-L, Leu, C.-M., Suppression of NF-κB and downstream XBP1 by DcR3 contributes to a decrease in antibody secretion, JOURNAL OF IMMUNOLOGY, vol. 214, 72-84, 2025具代表性; 任職中研院著作;
2025 Enkhbayar, B., Lu, S.-C., Tsai, H.-Y., Liang, S.-Y., Wu, S.-J., (Lin, K.-I, Angata, T., Insights into the transcriptional regulation of CD22 in B cell chronic lymphocytic leukemia., Journal of Biological Chemistry, vol. 108386, 108386, 2025具代表性; 任職中研院著作;
2024 Huang, H.-W., Chen, C.-C, (Lin, K.-I, Hsu, T.-L, Wong, C.-H., Single site N-glycosylation of B cell maturation antigen (BCMA) inhibits gamma - secretase-mediated shedding and improves surface retention and cell survival., ACS CHEMICAL BIOLOGY, vol. 19(1), 153-161, 2024具代表性; 任職中研院著作;
2024 Huang, C.-H., Yang, T.-T., Lin, K.-I*)., Mechanisms and functions of SUMOylation in health and disease: a review focusing on immune cells, J Biomed Sci., vol. 31(1), 16, 2024具代表性; 任職中研院著作;
2024 Chou, S.-C., Yen, C.-T., Yang, Y.-L., Chen, S.-H., Wang, J.-D., Fan, M.-N., Chen, L.-F., Yu, I-S., Tsai, D.-Y., (Lin, K.-I, Tao, M.-H., Wu, J.-C., Lin, S.-W., Recapitulating the immune system of hemophilia A patients with inhibitors using immunodeficient mice, Thrombosis Research, vol. 235, 155-163, 2024具代表性; 任職中研院著作;
2024 Chang, Y.-H., Hsu, M.-F., Chen, W. N., Wu, M.-H., Kong, W.L.D., Lu, M.-Y. J., Huang, C.-H., Chang, F.-J., Chang, L.-Y., Tsai, H.-Y., Tung, C.-P., Yu, J.-H., K., Y., Chou, Y.-C., Bai, L.-Y., Chang. Y.-C., Chen, A.-Y., Chen, C.-C., Chen, Y.-H., Liao, C.-C., Chang, C.-S., Liang, J.-L., Lin, Y.-L., Angata, T., Hsu, S.-T. D*, Lin, K.-I)*, Functional and structural investigation of a broadly neutralizing SARS-CoV-2 antibody, JCI INSIGHT, vol. 9(10):, e179726, 2024具代表性; 任職中研院著作;
2024 Yang, Y.-C., Hsu, T.-H., Chen, C.-S., Yu, J.-H., (Lin, K.-I)*, Chen, Y.-J*., Enhanced proteomic coverage in tissue microenvironment by immune cell subtype library-assisted DIA-MS., Mol Cell Proteomics, vol. doi: 10.1016/j.mcpro.2024., 100792, 2024具代表性; 任職中研院著作;
2024 Lee, P.-J., Hung, C.-M., Yang, A.-J., Hou, C.-Y., Chou, H.-W., Chang, Y.-C., Chu, W.-C., Hung, W.-Y., Kuo, W.-C., Yang, C.-C., (Lin, K.-I, Chang, L.-C., Lee, K.-Y., Kuo, H.-P., Lu, K.-M., Lai, H.-C., Kuo, M.-L., Chen, W.-J., MS-20 enhances the gut microbiota-associated antitumor effects of 1 anti-PD1 antibody., GUT MICROBES, vol. 16(1), 2380061, 2024具代表性; 任職中研院著作;
2024 Hsu, T.-H., Chang, Y.-C., Lee, Y.-Y., Chen, C.-L., Hsiao, M., Lin, F.-R, Chen, L.-H., Lin, C.-H., Angata, T., Liu, F.-T., Lin, K.-I)*., B4GALT1-dependent galectin-8 binding with TGF-β receptor suppresses colorectal cancer progression and metastasis, Cell Death and Disease, vol. 15(9):, 654, 2024具代表性; 任職中研院著作;
2023 Wang, S.-W., Ko, Y.-A., Chen, C.-Y., Liao, K.-S., Chang, Y.-H., Lee, H.-Y., Yu, Y.-H., Lih, Y.-H., Cheng, Y.-Y., Lin, H.-H., Hsu, T.-L., Wu, C.-Y., (Lin, K.-I)*, Wong, C.-H.*, Mechanism of Antigen Presentation and Specificity of Antibody Cross-Reactivity Elicited by an Oligosaccharide-Conjugate Cancer Vaccine, Journal of the American Chemical Society, vol. 145(17), 9840-9849, 2023具代表性; 任職中研院著作;
2023 Yang, T.-T., Chiang, M.-F., Chang, C.-C., Yang, S.-Y., Huang, S.-W., Liao, N.-S., Shih, H.-M., Hsu, W., Lin, K.-I)*., SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis, Communications Biology, vol. 6(1), 629, 2023具代表性; 任職中研院著作;
2023 Liu, Z., Wang, J., Shi, Y., Yee, B. A., Terrey, M., Zhang, Q., Lee, J.-C., (Lin, K.-I, Wang, H.-J. A., Ackerman, S., Yeo, G. W., Cui, H., Yang, X. L., Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery, Nucleic Acids Research, vol. 51(19), 10768-10781, 2023具代表性; 任職中研院著作;
2022 Gebreyesus, S. T., Siyal, A. A., Kitata, R. B., Chen, S.-W., Enkhbayar, B., Angata, T., (Lin, K.-I, Chen, Y.-J., Tu., S.-L., Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry, NATURE COMMUNICATIONS, vol. 13(1), 37, 2022具代表性; 任職中研院著作;
2022 Huang, H.-Y., Liao, H.-Y., Chen, X., Wang, S.-W., Cheng, C.-W., Shahed-Al-Mahmud, M. Chen, T.-H., Lo, J. M., Liu, Y.-M., Wu, Y.-M., Ma, H.-H., Chang, Y.-H., Tsai, H.-Y., Chou, Y.-C., Hsieh, Y.-P., Tsai, C.-Y., Huang, P.-Y., Chang, S.-Y., Chao, T.-L., Kao, H.-C., Tsai, Y.-M., Chen, Y.-H., Wu, C.-Y., Jan, J.-T., Cheng, T.-J. R., (Lin, K.-I)*, Ma, C*., Wong, C.-H.*, Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models, Science Translational Medicine, vol. 14(639):, eabm0899, 2022具代表性; 任職中研院著作;
2022 Chang, L.-Y., Liang, S.-Y., Lu, S.-C., Tseng, H.-C., Tsai, H.-Y., Tang, C.-J., Sugata, M., Chen, Y.-J., Chen, Y. -J. Wu, S.-J., (Lin, K.-I, Khoo, K.-H., Angata, T., Molecular basis and role of Siglec-7 ligand expression on chronic lymphocytic leukemia B cells, Frontiers in Immunology, vol. 13, 840388, 2022具代表性; 任職中研院著作;
2022 Wu, J.-L., Wu, H.-Y., Wu, S.-J., Tsai, H.-Y., Weng, S.-H., Lin, K.-T., Lin, L.-I., Yao, C.-Y., Zamanova, M., Lee, Y.-Y., Angata, T., Tien, H.-F., Chen, Y.-J.*, Lin, K.-I*, Phosphoproteomics reveals the role of constitutive KAP1 phosphorylation by B-cell receptor signaling in chronic lymphocytic leukemia, Molecular Cancer Research, vol. https://doi.org/10.1158/1541-7786., MCR-21-0722, 2022具代表性; 任職中研院著作;
2021 Lee, W., Wang, L.-T., Yen, M.-L., Hsu, P.-J., Lee, Y.-W., Liu, K.-J., (Lin, K.-I, Su, Y.-W., Sytwu, H.-K., Yen, B. L., Resident vs. nonresident multipotent mesenchymal stromal cell interactions with B lymphocytes result in disparate outcomes, Stem Cells Transi Med, vol. 10(5), 711-724, 2021具代表性; 任職中研院著作;
2021 Lo, L.-W., Chang, C.-W., Chiang, M.-F., Lin, I-Y., Lin, K.-I)*, Marginal zone B cells assist with neutrophil accumulation to fight against systemic Staphylococcus aureus infection, FRONTIERS IN IMMUNOLOGY, vol. 12, 636818, 2021具代表性; 任職中研院著作;
2021 Ko, Y.-A., Yu, Y.-H., Wu, Y.-F., Tseng, Y.-C., Chen, C.-L., Goh, K.-S, Liao, H.-Y., Chen, T.-H., Cheng, R. T.-J., Yang, A.-S., Wong, C.-H., Ma, C., Lin, K.-I)*, A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells, PLOS PATHOGENS, vol. 17(8), e1009724, 2021具代表性; 任職中研院著作;
2021 Hsieh, W.-C., Lai, E.-Y., Liu, Y.-T., Wang, Y.-F., Tzeng, Y.-S., Cui, L, Lai, Y.-J., Huang, H.-C., Huang, J.-H., Ni, H.-C., Tsai, D.-Y., Liang, J.-J., Liao, C.-C., Jiang, L, Liu, M.-T., Wang, J.-T., Chang, S.-Y., Chen, C.-Y., Tsai, H.-C., Chang, Y.-M., Wernig, G., Li, C.-W., (Lin, K.-I, Lin, Y.-L., Tsai, H.-K., Huang, Y.-T., Chen, S.-Y, NK cell receptor and ligand composition influences the clearance of SARS-CoV-2, JOURNAL OF CLINICAL INVESTIGATION, vol. 131 (21), e146408, 2021具代表性; 任職中研院著作;
2020 Liu, C.-H., Chou, C.-T., Chen, C.-H., Chen, C.-H., Yang, S.-Y., Ko, Y.-A., Wu, Y.-T., Wang, C.-C., Liu, F.-C., Yue, C.-T., Hung, S.-C., Tzeng, I-S., Tsai, W.-C. *, Lin, K.-I)*, Aberrant distribution and function of plasmacytoid dendritic cells in patients with ankylosing spondylitis are associated with unfolded protein response, KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, vol. doi: 10.1002/kjm2.12184, 2020具代表性; 任職中研院著作;
2020 Chen, H.-Y., Wu, Y.-F., Chou, F.-C., Wu, Y.-H., Yeh, L.-T., (Lin, K.-I, Liu, F.-T., Sytwu, H.-K, Intracellular galectin-9 enhances proximal TCR signaling and potentiates autoimmune disease, JOURNAL OF IMMUNOLOGY, vol. 204(5):1158-1172, 2020具代表性; 任職中研院著作;
2020 Chang, Y.-H., Weng, C.-L, Lin, K.-I)*, O-GlcNAcylation and its role in the immune system., J Biomed Sci., vol. 27(1):57, 2020具代表性; 任職中研院著作;
2020 Liao, H.-Y., Wang, S.-C., Ko, Y.-A. (Lin, K.-I, Ma, C., Cheng, R. T.-J., Wong, C.-H., Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes, Proc Natl Acad Sci USA, vol. 117(30), 17757-17763, 2020具代表性; 任職中研院著作;
2019 Tseng, Y, -C., Wu, C.-Y., Liu, M.-L., Chen, T.-H., Chinag, W.-L., Yu, Y.-H., Jan, J.-T., (Lin, K.-I, Wong, C.-H., Ma, C., Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 116 (10) ,4200-4205, 2019具代表性; 任職中研院著作;
2019 Wang, Y.-H., Tsai, D.-Y., Ko, Y.-A., Yang, T.-T., Lin, I-Y., Hung, K.-H., Lin, K.-I)*, Blimp-1 contributes to the development and function of regulatory B cells, FRONTIERS IN IMMUNOLOGY, vol. 10:1909, 2019具代表性; 任職中研院著作;
2019 Tsai, D.-Y., Hung, K.-H., Chang, C.-W., Lin, K.-I)*, Regulatory Mechanisms of B cell responses and the implication in B cell-related diseases, JOURNAL OF BIOMEDICAL SCIENCE, vol. 26(1):64, 2019具代表性; 任職中研院著作;
2019 Liu, C.-H., Raj, S, Chen, C.-H., Hung, K.-H., Chou, C.-T., Chen, I.-Ho., Chien, J.-T., Lin, I-Y., Yang, S.-Y., Angata, T., Tsai, W.-C., Wei. J. C.-C., Tzeng, I-S., Hung, S.-C.*, Lin, K.-I)*, HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis, JOURNAL OF CLINICAL INVESTIGATION, vol. 129 (12), 5357-5373, 2019具代表性; 任職中研院著作;
2018 Hung, K.-H., Woo, Y. H., Lin, I-Y., Liu, C.-H., Wang, L.-C., Chen, H.-Y., Chiang, B.-L., Lin, K.-I)*, The KDM4A/KDM4C/NF-κB and WDR5 epigenetic cascade regulates the activation of B cells, NUCLEIC ACIDS RESEARCH, vol. 46(11), 5547-5560, 2018具代表性; 任職中研院著作;
2018 Tsai, M.-S., Chiang, M.-T., Tsai, D.-L., Yang, C.-W., Hou, H.-S., Li, Y.-R., Chang, P.-C., Lin, H.-H., Chen, H.-Y., Hwang, I.-S., Wei, P.-K., Hsu, C.-P., (Lin, K.-I, Liu, F.-T., Chau, L.-Y, Galectin-1 restricts vascular smooth muscle cell motility via modulating adhesion force and focal adhesion dynamics, Scientific Reports, vol. 8(1), 11497, 2018具代表性; 任職中研院著作;
2018 Ko, Y.-A., Chan, Y.-H., Liu, C.-H., Liang, J.-J., Chuang, T.-H., Hsueh, Y.-P., Lin, Y.-L., Lin, K.-I)*, Blimp-1-mediated pathway promotes Type I IFN production in plasmacytoid dendritic cells by targeting to Interleukin-1 receptor-associated kinase M, FRONTIERS IN IMMUNOLOGY, vol. 9, 1828, 2018具代表性; 任職中研院著作;
2017 Lai, C.-Y., Su, Y.-W., (Lin, K.-I, Hsu, L.-C., Chuang, T.-H., Natural modulators of endosomal Toll-like receptor-mediated psoriatic skin inflammation, Journal of Immunology Research, vol. 10.1155/2017, 7807313, 2017具代表性; 任職中研院著作;
2017 Wu, J.-L., Chiang, M.-F., Hsu, P.-H., Tsai, D.-Y., Hung, K.-H., Wang, Y.-H., Angata, T.*, Lin, K.-I)*, O-GlcNAcylation is required for B cell homeostasis and antibody responses, NATURE COMMUNICATIONS, vol. 8(1):1854, 2017具代表性; 任職中研院著作;
2016 Yu, Y.-H., Lin, K.-I)*, Factors that regulate the generation of antibody-secreting plasma cells., Advances in Immunology, vol. 131, 61-99, 2016具代表性; 任職中研院著作;
2016 Hung, K.-H., Su, S.-T., Chen, C.-Y., Hsu, P.-H., Huang, S.-Y., Wu, W.-J., Chen, M.M., Chen, H.-Y., Wu, P.-C., Lin, F.-R., Tsai, M.-D., Lin, K.-I)*, Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells, CELL DEATH AND DIFFERENTIATION, vol. 23, 1175-1184, 2016具代表性; 任職中研院著作;
2016 Wu, J.-L., Wu, H.-Y., Tsai, D.-Y., Chiang, M.-F., Chen, Y.-J., Gao, S., Lin, C.-C., Lin, C.-H., Khoo, K.-H., Chen, Y.-J.*, Lin, K.-I )*, Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells, Nature Communications, vol. 7, 12526, 2016具代表性; 任職中研院著作;
2016 Chien, C.-Y., Lee, H.-S. Lee, Cho, C.H.H., (Lin, K.-I, Tosh, D., Wu, R.-R., Mao, W.-Y., Shen, C.-N., Maternal Vitamin A deficiency during pregnancy affects vascularized islet development, Journal of Nutritional Biochemistry, vol. 36, 51-59, 2016具代表性; 任職中研院著作;
2016 Chen, T.-T., Tsai, M.-H., Kung, J.T., (Lin, K.-I, Decker, T., Lee, C.-K., STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria, Journal of Experimental Medicine, vol. 213, 3025-3039, 2016具代表性; 任職中研院著作;
2015 Tsai, C.-M., Lin, K.-I)*, Examination of the role of galectins in plasma cell differentiation, Methods in Molecular Biology, vol. 1207, 153-167, 2015具代表性; 任職中研院著作;
2015 Tsai, D.-Y., Hung, K.-H., Lin, I-Y., Su, S.-T., Wu, S.-Y., Chung, C.-H., Wang, T.-C., Li, W.-H., Shih, A. C.-C.*, Lin, K.-I)*, Uncovering miRNA regulatory hubs that modulate plasma cell differentiation, Scientific Reports, vol. 5, 17957, 2015具代表性; 任職中研院著作;
2014 Chen, J.-R., Yu, Y.-H., Tseng, Y.-C., Chiang, W.-L., Chiang, M.-F., Ko, Y.-A., Chiu, Y.-K., Ma, S.-H., Wu, C.-Y., Jan, J.-T., (Lin, K.-I)*, Ma, C.*, Wong, C.-H.*, Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against Influenza virus infections, Proceedings of the National Academy of Sciences of the United States of America, vol. 111(7), 2476-2481, 2014具代表性; 任職中研院著作;
2014 Lin, M.-H., Yeh, L.-T., Chen, S.-J., Chiou, H.-Y., Chu, C.-C., Yen, L. B., (Lin, K.-I, Chang, D.-M., Sytwu, H.-K., T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells, CLINICAL IMMUNOLOGY, vol. 151(2), 101-113, 2014具代表性; 任職中研院著作;
2014 Lin, I-Y., Chiu, F.-L., Yeang, C.-H., Chen, H.-F., Chuang, C.-Y., Yang, S.-Y., Hou, P.-S., Sintupisut, N., Ho, H.-N., Kuo, H.-C.*, Lin, K.-I)*, Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells, Stem Cell Reports, vol. 2(2), 189-204, 2014具代表性; 任職中研院著作;
2014 Huang, K.-Y.; Wu, H.-Y.; Chen, Y.-J.; Lu, C.-T.; Su, M.-G.; Hsieh, Y.-C.; Tsai, C.-M.; (Lin, K.-I); Huang, H.-D.; Lee, T.-Y., Chen, Y.-J, RegPhos 2.0: an updated resource to explore protein kinase-substrate phosphorylation networks in mammals., Database-The Journal of Biological Databases and Curation, vol. bau034, 2014具代表性; 任職中研院著作;
2014 Tsai, C.-M. Wu, H.-Y., Su, T.-H., Kuo, C.-W., Huang, H.-W., Chung, C.-H., Chen, C.-S., Khoo, K.-H., Chen, Y.-J.*, Lin, K.-I)*, Phosphoproteomic analyses reveal that galectin-1 augments the dynamics of B-cell receptor signaling, Journal of Proteomics, vol. 103, 241-253, 2014具代表性; 任職中研院著作;
2014 Chiu, Y.-K., Lin, I-Y., Su, S.-T., Wang, K.-H., Yang, S.-Y., Tsai, D.-Y., Hsieh, Y.-T., Lin, K.-I)*, Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation, JOURNAL OF IMMUNOLOGY, vol. 193(5), 2207-2217, 2014具代表性; 任職中研院著作;
2014 Kretzschmar, K., Cottle, D.L., Donati, G, Chiang, M.-F., Quist, S.R., Gollnick, H.P., Natsuga, K., Aoyagi, S., (Lin, K.-I, Watt, F. M., BLIMP1 does not define a sebaceous gland progenitor population but is required for epidermal homeostasis, Stem Cell Reports, vol. 3(4), 620-633, 2014具代表性; 任職中研院著作;
2013 Lin, M.-H., Chou, F.-F., Yeh, L.-T., Fu, S.-H., Chiou, H.-Y., (Lin, K.-I, Chang, D.-M., Sytwu H.-K., B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells, DIABETOLOGIA, vol. 56(1), 136-146, 2013具代表性; 任職中研院著作;
2013 Chiang, M.-F., Yang, S.-Y., Lin, I-Y., Hong, J.-B., Lin, S.-J., Ying, H.-Y., Chen, C.-M., Wu, S.-Y., Liu, F.-T., Lin, K.-I*, Inducible deletion of Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110(16), 6476-6481, 2013具代表性; 任職中研院著作;
2013 Wang, S.-H., Tsai, C.-M., (Lin, K.-I)*, Khoo, K.-H.*, Advanced mass spectrometry and chemical analyses reveal the presence of terminal disialyl motif on mouse B-cell glycoproteins, GLYCOBIOLOGY, vol. 23(6), 677-689, 2013具代表性; 任職中研院著作;
2013 Tu, Z., Hsieh, H.-W., Tsai, C.-M., Hsu, C.-W., Wang, S.-G., Wu, K.-J., (Lin, K.-I*, Lin, C.-H*, Synthesis and characterization of sulfated Gal-beta-1, 3/4-GlcNAc disaccharides via consecutive Protection/glycosylation steps, Chemistry-An Asian Journal, vol. 8 (7), 1536-1550, 2013具代表性; 任職中研院著作;
2013 Huang, H.-W., Chen, C.-H., Lin, C.-H., Wong, C.-H.*, Lin, K.-I*, B cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110(27), 10928-10933, 2013具代表性; 任職中研院著作;
2013 Liao, S.-F, Liang, C.-H., Ho, M.-Y., Hsu, T.-L., Tsai, T.-I, Hsieh, Y. S.-Y., Tsai, C.-M., Li, S.-T., Cheng, Y.-Y., Tsao, S.-M., Lin, T.-Y., Lin, Z.-Y., Yang, W.-B., Ren, C.-T., (Lin, K.-I, Khoo, K.-H., Lin, C.-H., Hsu, H.-Y., Wu, C.-Y., Wong, C.-H., Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110(34), 13809-13814, 2013具代表性; 任職中研院著作;
2012 Wu, Y.-H., Yang, C.-Y., Chien, W.-L., (Lin, K.-I, Lai, M.-Z., Removal of Syndecan-1 promotes TRAIL-induced apoptosis in myeloma cells., J. Immunol., vol. 188, 2914-2921, 2012具代表性; 任職中研院著作;
2012 Chuang, C.-Y., (Lin, K.-I, Hsiao, M., Stone, L., Chen, H.-F., Huang, Y.-H., Lin, S.-P., Ho, H.-N., and Kuo, H.-C., Meiotic competent human germ cell-like cells derived from human embryonic stem cells induced by BMP4/WNT3A signaling and OCT4/EpCAM selection., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 287, 14389-14401, 2012具代表性; 任職中研院著作;
2012 Hsu Y, Lu XA, Zulueta MM, Tsai CM, (Lin KI, Hung SC, Wong CH., Acyl and Silyl Group Effects in Reactivity-Based One-Pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc(4) and IV(2)Fuc-Lc(4), J Am Chem Soc., vol. 134(10), 4549-4552, 2012具代表性; 任職中研院著作;
2012 Ying, H.-Y., Su, S.-T., Hsu, P.-H., Chang, C.-C., Lin, I-Y., Tseng, Y.-H., Tsai, M.-D., Shih, H.-M., Lin, K.-I*, SUMOylation of Blimp-1 is critical for plasma cell differentiation, EMBO REPORTS, vol. 13, 631-637, 2012具代表性; 任職中研院著作;
2012 Lin, F.-R., Huang, S.-Y., Hung, K.- H., Su, S.-T., Chung, C.-H., Matsuazwa, A., Hsiao, M., Ichijo, H., Lin, K.-I)*, ASK1 promotes apoptosis of normal and malignant plasma cells, Blood, vol. 120(5), 1039-1047, 2012具代表性; 任職中研院著作;
2011 Tsai, C.-M., Guan, C.-H., Hsieh, H.-W, Hsu, T.-L., Tu, Z., Wu, K.-J., Lin, C.-H.*, Lin, K.-I*), Galectin-1 and galectin-8 have redundant roles in promoting plasma cell formation, JOURNAL OF IMMUNOLOGY, vol. 187(4),1643-1652, 2011具代表性; 任職中研院著作;
2009 Su, S.-T., Ying, H.-Y., Chiu, Y.-K., Lin, F.-R., Chen, M.-Y., Lin, K.-I)*, Involvement of LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation, MOLECULAR AND CELLULAR BIOLOGY, vol. 29 (6), 1421-1431, 2009具代表性; 任職中研院著作;
2009 Chan, Y.-H., Chiang, M.-F., Tsai, Y.-C., Su, S.-T., Chen M.-H., Hou, M.-S., Lin, K.-I)*, Absence of the transcriptional repressor Blimp-1 in hematopoietic lineages reveals its role in the conventional dendritic cell homeostatic development and function., Journal of Immunology, vol. 183 (11), 7039-7046, 2009具代表性; 任職中研院著作;
2008 Tsai, C.-M., Chiu, Y.-K., Hsu, T.-L., Lin, I-Y., Hsieh, S.-L., Lin, K.-I*, Galectin-1 promotes immunoglobulin production during plasma cell differentiation, Journal of Immunology, vol. 181, 4570-4579, 2008具代表性; 任職中研院著作;
2007 Lin, F.-R., Kuo, H.-K., Ying, H.-Y., Yang, F.-H., Lin, K.-I*), Induction of apoptosis in plasma cells by B lymphocyte-induced maturation protein-1 knockdown, CANCER RESEARCH, vol. 67(24), 11914-11923, 2007具代表性; 任職中研院著作;
2006 K.I Lin*, Y.Y. Kao, H.K. Kuo, W.B. Yang, A Chou, H.H. Lin, A.L. Yu, C.H.Wong, Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor blimp-1, J. Biol. Chem, vol. 281, 24111-24123, 2006具代表性; 任職中研院著作;
2005 M. Shapiro-Shelef, K. I. Lin, D. Savitsky, J. Liao, K. Calame, Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow, J Exp Med, vol. 202, 1471-1476, 2005具代表性;
2004 K. I. Lin, K. Calame, Introduction of genes into primary murine splenic B cells using retrovirus vectors, Methods Mol Biol, vol. 271, 139-148, 2004具代表性;
2004 K. Johnson, D. L. Pflugh, D. Yu, D. G. Hesslein, K. I. Lin, A. L. Bothwell, A. Thomas-Tikhonenko, D. G. Schatz, K. Calame, B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locusdepends on Pax5, Nat Immunol, vol. 5, 853-861, 2004具代表性;
2003 K. I. Lin, C. Tunyaplin, K. Calame, Transcriptional regulatory cascades controlling plasma cell differentiation, Immunol Rev, vol. 194, 19-28, 2003具代表性;
2003 K. L. Calame, K. I. Lin, C. Tunyaplin, Regulatory mechanisms that determine the development and function of plasma cells, Annu Rev Immunol, vol. 21, 205-230, 2003具代表性;
2003 M. Shapiro-Shelef, K. I. Lin, L. J. McHeyzer-Williams, J. Liao, M. G. McHeyzer-Williams, K. Calame, Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells, Immunity, vol. 19, 607-620, 2003具代表性;
2002 K. I. Lin, C. Angelin-Duclos, T. C. Kuo, K. Calame, Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells, Mol Cell Biol, vol. 22, 4771-4780, 2002具代表性;
2002 A. L. Shaffer#, K. I. Lin#, T. C. Kuo, X. Yu, E. M. Hurt, A. Rosenwald, J. M. Giltnane, L. Yang, H. Zhao, K. Calame, L. M. Staudt. #co-first authors, Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program, Immunity, vol. 17, 51-62, 2002具代表性;
2002 C. Angelin-Duclos, K. Johnson, J. Liao, K. I. Lin, K. Calame, An interfering form of Blimp-1 increases IgM secreting plasma cells and blocks maturation of peripheral B cells, Eur J Immunol, vol. 32, 3765-3775, 2002
2000 K. I. Lin, Y. Lin, K. Calame, Repression of c-myc is necessary but not sufficient for terminal differentiation of B lymphocytes in vitro, Mol Cell Biol, vol. 20, 8684-8695, 2000
2000 C. Angelin-Duclos, G. Cattoretti, K. I. Lin, K. Calame, Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo, J Immunol, vol. 165, 5462-5471, 2000
2000 J. F. Piskurich#, K. I. Lin#, Y. Lin, Y. Wang, J. P. Ting, K. Calame. #co-first authors, BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cells, Nat Immunol, vol. 1, 526-532, 2000具代表性;
1999 C. Angelin-Duclos, G. Cattoretti, D. H. Chang, K. I. Lin, Y. Lin, J. Yu, K. Calame, Role of B-lymphocyte-induced maturation protein-1 in terminal differentiation of B cells and other cell lineages, Cold Spring Harb Symp Quant Biol, vol. 64, 61-70, 1999
1999 K. Zaman, H. Ryu, D. Hall, K. O'Donovan, K. I. Lin, M. P. Miller, J. C. Marquis, J. M. Baraban, G. L. Semenza, R. R. Ratan, Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1) and erythropoietin, J Neurosci, vol. 19, 9821-9830, 1999
1999 K. I. Lin, P. Pasinelli, R. H. Brown, J. M. Hardwick, R. R. Ratan, Decreased intracellular superoxide levels activate Sindbis virus-induced apoptosis, J Biol Chem, vol. 274, 13650-13655, 1999
1998 K. I. Lin, J. A. DiDonato, A. Hoffmann, J. M. Hardwick, R. R. Ratan, Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis, J Cell Biol, vol. 141, 1479-1487, 1998
1998 F. Esch, K. I. Lin, A. Hills, K. Zaman, J. M. Baraban, S. Chatterjee, L. Rubin, D. E. Ash, R. R. Ratan, Purification of a multipotent antideath activity from bovine liver and its identification as arginase: nitric oxide-independent inhibition of neuronal apoptosis, J Neurosci, vol. 18, 4083-4095, 1998
1998 K. I. Lin, J. M. Baraban, R. R. Ratan, Inhibition versus induction of apoptosis by proteasome inhibitors depends on concentration, Cell Death Differ, vol. 5, 577-583, 1998
1998 K. I. Lin, N. Chattopadhyay, M. Bai, R. Alvarez, C. V. Dang, J. M. Baraban, E. M. Brown, R. R. Ratan, Elevated extracellular calcium can prevent apoptosis via the calcium-sensing receptor, Biochemical and Biophysical Research Communications, vol. 249, 325-331, 1998
1997 D. N. Irani, K. I. Lin, D. E. Griffin, Regulation of brain-derived T cells during acute central nervous system inflammation, J Immunol, vol. 158, 2318-2326, 1997
1996 D. N. Irani, K. I. Lin, D. E. Griffin, Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells, J Immunol, vol. 157, 4333-4340, 1996
1995 K. I. Lin, S. H. Lee, R. Narayanan, J. M. Baraban, J. M. Hardwick, R. R. Ratan, Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B, J Cell Biol, vol. 131, 1149-1161, 1995
1993 S. B. Lin, G. W. Chang, G. W. Teh, K. I. Lin, L. C. Au, A simple and rapid method for purification of oligodeoxyribonucleoside methylphosphonates, Biotechniques, vol. 14, 795-798, 1993
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