Chia-Ning Shen, Ph.D.
Name Chia-Ning Shen, Ph.D.
Incumbent Professor (On Secondment)
所屬單位

Ph.D., Developmental Biology Program, University of Bath, 2002
NCLscan:
研究方向/領域

RESEARCH INTERESTS

Dr. Chia-Ning Shen is currently a research fellow in the Genomics Research Center, Academia Sinica, Taiwan. Dr. Shen earned his PhD from Developmental Biology Program, Department of Biology and Biochemistry, University of Bath, United Kingdom in 2002. From 2002 to 2004, Dr. Shen worked as a research officer in the Centre for Regenerative Medicine in University of Bath. Dr. Shen came back to Taiwan and joined the Genomics Research Center of Academia Sinica in the summer of 2004. Dr. Shen's research interest primarily focuses on two fields, cancer stem cells and regenerative medicine. He currently focuses on investigating mechanisms involved in naturally occurring somatic cell reprogramming. Based dissecting the basis of cell differentiation and transdifferentiation, Dr. Shen aims to develop methodologies to trigger tissue regeneration and to identify the initial factors for neoplastic transformation in somatic cells. As of today, Dr. Shen has published over 90 articles in world-renowned journals which have been cited for more than 3300 times.

 

EDUCATION AND POSITIONS HELD
  • 2022-present Professor, Genomics Research Center, Academia Sinica
  • 2019-2022 Acting Chief Executive Officer, Innovation & Incubation Center, Biomedical Translation Research Center, Academia Sinica, Taiwan
  • 2018-2021 Acting Division Director of Biotechnology Incubation Center, Genomics Research Center, Academia Sinica
  • 2013-2019 Deputy Director and Associate Research Fellow, Genomics Research Center, Academia Sinica
  • 2012-2022 Associate Professor, Genomics Research Center, Academia Sinica
  • 2004-2012 Assistant Professor, Genomics Research Center, Academia Sinica
  • 2002-2004 Postdoctoral Fellow, Centre For Regenerative Medicine, University of Bath
HONORS
  • 2017 Keystone Symposia Best Poster Prize (Regenerative Biology and Applications)
  • 2014-2015 Rotary International Presidential Charity Award
  • 2012 Travel award of International Society of Stem Cell Research
  • 2010 Academia Sinica Significant Research Achievements
  • 2007 Travel award of Japan Society for the promotion of science for attending NPG Nature Asia-Pacific network meeting
  • 2002 Conference Scholarship of International Society of Differentiation
  • 2001 Conference Scholarship of British Society of Developmental Biology
  • 2001 Entrant of Santa Cruz Investigator Award
  • 2000 Conference Scholarship of British Society of Developmental Biology
  • 2000 Conference Scholarship of International Federation of Cell Biology
  • 1999-2002 ORS Award, Committee of Vice-chancellors and Principals of Universities of United Kingdom
Year Paper Title
2025 Li H, Chiang CL, Kwak KJ, Lee HL, Wang X, Romano G, Saviana M, Toft R, Cheng TS, Chang Y, Hsiang BD, Liu GW, Mo X, Ma Y, Pan J, Rima XY, Kim TN, Reategui E, (Shen CN, Chu YS, Croce C, Chang PM, Yeh YC, Carbone DP, Huang CF, Chiang CL, Nana-Sinkam P, Lee LJ, Extracellular Vesicular Delta-Like Ligand 3 and Subtype Transcription Factors for Small Cell Lung Cancer Diagnosis., Advanced Science, vol. doi: 10.1002/advs.202416711., Online ahead of prin, 2025具代表性; 任職中研院著作;
2025 Lee C.Y., T.C. Kuo, Y.H. Chou, S.J. Peng, F.T. Hsiao, M.H. Chung, L.W. Lo, (C.N. Shen, H.J. Chien, H.P. Chang, C. C. Chen, Y.M. Jeng, Y.W. Tien, S.C. Tang., 3D imaging resolves human pancreatic duct-β-cell clusters during cystic change, Diabetes, vol. 74(5), 734-748, 2025具代表性; 任職中研院著作;
2024 Huang, Y.K., W.C. Cheng, J.C. Yang, Y.C. Wu, H.H. Wu, T.T. Kuo, C.C. Lo, C.Y. Hsieh, S.C. Wong, C.H. Lu, (C.N. Shen, M.C. Hung, J.T. Lin, C.C. Yeh, Y.P. Sher., Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy, Nature Cancer, vol. 5(3), 400-419, 2024具代表性; 任職中研院著作;
2024 Panda SS, Lee CC, Geevimaan K, Chen KC, Yang SH, (Shen CN, HuangFu WC, Wu HC, Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression., Journal of biomedical science, vol. 31(1), 72, 2024具代表性; 任職中研院著作;
2024 Chang PS, Chen YC, Hua WK, Hsu JC, Tsai JC, Huang YW, Kao YH, Wu PH, Wang PN, Chang YF, Chang MC, Chang YC, Jian SL, Lai JS, Lai MT, Yang WC, (Shen CN, Wen KK, Wu SC, Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-TSCM cells using a Quantum pBac-based CAR-T engineering system., PloS one, vol. 19(8), e0309245, 2024具代表性; 任職中研院著作;
2023 Fu-Ting Hsiao, Hung-Jen Chien, Ya-Hsien Chou, Shih-Jung Peng, Mei-Hsin Chung, Tzu-Hui Huang, Li-Wen Lo, (Chia-Ning Shen, Hsiu-Pi Chang, Chih-Yuan Lee, Chien-Chia Chen, Yung-Ming Jeng, Yu-Wen Tien, Shiue-Cheng Tang*, Transparent tissue in solid state for solvent-free and antifade 3D imaging, Nature Communications, vol. 14(1), 3395, 2023具代表性; 任職中研院著作;
2023 WK Hua, JC Hsu, YC Chen, PS Chang, KLK Wen, PN Wang, WC Yang, (CN Shen, YS Yu, YC Chen, IC Cheng, SCY Wu, Quantum pBac: An effective, high-capacity piggyBac-based gene integration vector system for unlocking gene therapy potential, FASEB JOURNAL, vol. 37:, e23108, 2023具代表性; 任職中研院著作;
2023 Hu CM, Huang CC, Hsu MF, Chien HJ, Wu PJ, Chen YI, Jeng YM, Tang SC, Chung MH, (Shen CN, Chang MC, Chang YT, Tien YW, Lee WH, Oncogenic KRAS, Mucin 4, and Activin A-Mediated Fibroblast Activation Cooperate for Panin Initiation., Advanced Science, vol. 2023, e2301240, 2023具代表性; 任職中研院著作;
2022 Lo, S.M., S.H.Hwang, C.L. Liu, (C.N. Shen, W.H. Hong, W.C. Yang, M.H. Lee, C.R.Shen, Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis, Frontiers in Immunology, vol. 12, 736251, 2022具代表性; 任職中研院著作;
2022 Hsu, F. C., H.L. Lee, Y.J. Chen, Y.A. Shen, M.H. Wu, W.S. Huang, Y.C. Tsai, S.D. Yeh, C.C. Kuo, L.S. Lu, (C.N. Shen*, J.F. Chiou*, A Few-Shot Learning Approach Assists in the Prognosis Prediction of Magnetic Resonance-Guided Focused Ultrasound for the Local Control of Bone Metastatic Lesions, Cancers, vol. 12, 445, 2022任職中研院著作;
2022 W.A. Chen, Y.H. Chen, C.Y. Hsieh, P.F. Hung, C.W. Chen, C.H. Chen, J.L. Lin, T.J. R. Cheng, T.L. Hsu, Y.T. Wu, (C.N. Shen*, W.C. Cheng*., Harnessing Natural-Product-Inspired Combinatorial Chemistry and Computation-Guided Synthesis to Develop N-Glycan Modulators as Anticancer Agents., Chemical Science, vol. 13, 6233-6243, 2022具代表性; 任職中研院著作;
2022 Khamushavalli, G., Guo, J.Y., (C.N. Shen, J.K. Jiang, C.S.J. Fann, M.J. Hwang, J.W. Shui, H.T. Lin, M.J. Wang, H.C. Shih, A. F.Y. Li, S.C. Chang, S.H. Yang*, J.Y. Chen*., Patient-derived organoids serves as a platform for personalized chemotherapy in advanced colorectal cancer patients., Frontiers in Oncology, vol. 12, 883437, 2022具代表性; 任職中研院著作;
2022 C.W. Lee, C.C. Kuo, C.J. Liang, H.J. Pan, (C.N. Shen*, C.H. Lee*, Effects of the media conditioned by various macrophage subtypes derived from THP-1 cells on tunneling nanotube formation in pancreatic cancer cells, BMC Molecular and Cell Biology, vol. 23(1), 26, 2022具代表性; 任職中研院著作;
2021 Wu, H.H., L.H. Tsai, C.K. Huang, S.C. Huang, P.H. Hsu, M.Y. Chen, Y.I. Chen, C.M. Hu, (C.N.Shen, C.C. Lee, M.C. Chang, Y.T. Chang, Y.W. Tien, Y.M. Jeng, E. Lee, W.H. Lee*, Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer, Science Translational Medicine, vol. 13, eabc2823, 2021具代表性; 任職中研院著作;
2021 Hsu HJ, Tung CP, Yu CM, Chen CY, Chen HS, Huang YC, Tsai PH, Lin SI, Peng HP, Chiu YK, Tsou YL, Kuo WY, Jian JW, Hung FH, Hsieh CY, Hsiao M, Chuang SS, (Shen CN, Wang YA, Yang AS, Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody-drug conjugates from synthetic antibody libraries., Scientific reports, vol. 11(1), 15430, 2021具代表性; 任職中研院著作;
2021 Hsu, L.J., C.L. Liu, M.L.Kuo, (C.N. Shen, C.R.Shen*, An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells, Biomedicines, vol. 9, 1323, 2021具代表性; 任職中研院著作;
2021 C.W. Lin, Y.J. Wang, T.Y. Lai, T.L. Hsu, S.Y. Han, H.C. Wu, (C.N. Shen, V. Dang, M.W. Chen, L.B. Chen, C.H. Wong*, Homogeneous antibody and CAR-T cell with improved effector functions targeting SSEA-4 glycan on pancreatic cancer, Proceedings of The National Academy of Sciences of the United States of America, vol. 118(50), e2114774118, 2021具代表性; 任職中研院著作;
2020 J.N.Sudhaker, H.H Lu, H.Y. Chang, C.S. Suen, M.J.Hwang, S.Y. Wu, (C.N.Shen, Y.M. Chang, F.A. Li, F.T. Liu, J.W. Shue*, Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas, Nature Communications, vol. 11(1), 4286, 2020具代表性; 任職中研院著作;
2020 Huang, C.Y. L.H. Li, W.T. Hsu, Y.C. Cheng, M.W. Nicholson, C.L. Liu, C.Y. Ting, H.W. Ko, S.H. Hsu, C.H. Wen, Z. Yan, H.P. Huang, H.L. Su, P.M. Chiang, (C.N. Shen, H.F. Chen, B. L.J. Yen, H.E. Lu, S.M. Hwang, S.H. Chiou, H.N. Ho, J.Y. Wu, T. J. Kamp, J.C. Wu, P. C. H. Hsieh*, Copy Number Variant Hotspots in Han Taiwanese Population Induced Pluripotent Stem Cell Lines - Lessons from Establishing the Taiwan Human Disease iPSC Consortium Bank, Journal of Biomedical Science, vol. 27(1), 92, 2020具代表性; 任職中研院著作;
2020 E.P.F. Chu, C.H. Lin, C.H.H. Cho, I.F. Cheng, T.C. Kuo R.Y. Chen, C.N. Liao, J.C. Cheng, J.I.S. Tsai, P.C. Wang, S.J. Chang, (C.N. Shen*, Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity, Stem Cell Research, vol. 49, 102029, 2020具代表性; 任職中研院著作;
2020 Lee, H.L., J.F. Chiou, P.Y. Wang, L.S. Lu, (C.N. Shen, H.L. Hsu, T. Burnouf, L.L.Ting, P.C. Chou, C.L. Chung, K.L.Lee, H.S. Shiah, Y.L. Liu, Y.J.Chen*, Ex vivo expansion and drug sensitivity profiling of circulating tumor cells from patients with small cell lung cancer, Cancers, vol. 12(11), 3394, 2020任職中研院著作;
2020 Chu, E.P.F., C.H.H. Cho, W.J. Lee, I.T.Lee, I.F. Cheng, T.C. Kuo, R.Y. Chen, W.H.H. Sheu, (C.N. Shen*, Generation of three induced pluripotent stem cell lines from type 2 diabetic patients with ocular complications., Stem Cell Research, vol. 49, 102109, 2020具代表性; 任職中研院著作;
2019 Shen CN, Goh KS, Huang CR, Chiang TC, Lee CY, Jeng YM, Peng SJ, Chien HJ, Chung MH, Chou YH, Hsieh CC, Kulkarni S, Pasricha PJ, Tien YW, Tang SC, Lymphatic vessel remodeling and invasion in pancreatic cancer progression., EBioMedicine, vol. 47, 98-113, 2019具代表性; 任職中研院著作;
2019 Lee, H.L., J.T.Tsai, C.Y. Chen, Y.C. Lin, C.B. Ho, L.L.Ting, C.C. Kuo, I.C. Lai, C.Y. Lin, J.H.Tang, Y.M. Huang, W.Y. Kao, S.W. Cheng, (C.N. Shen*, S.W.Chen*, J.F. Chiou*, Effectiveness of stereotactic ablative radiotherapy in patients with advanced hepatocellular carcinoma unsuitable for transarterial chemoembolization, Therapeutic Advances in Medical Oncology, vol. 11, 1758835919889002, 2019具代表性; 任職中研院著作;
2018 S.C.Tang, (C.N. Shen*, P.Y. Lin, S.J. Peng, H.J. Chien, Y.H. Chou, C.E. Chamberlain, P.J. Pasricha., Pancreatic neuro-insular network in young mice revealed by 3D panoramic histology., Diabetologia, vol. 61(10), 158-167, 2018具代表性; 任職中研院著作;
2018 S.C.Tang, L. Baeyens, (C.N. Shen, S.J. Peng, H.J. Chien, D.W. Scheel, C.E. Chamberlain, M.S.German., Human pancreatic neuro-insular network in health and fatty infiltration., Diabetologia, vol. 61(1), 168-181, 2018具代表性; 任職中研院著作;
2018 T.L. Chen, Y.W. Lin, Y.B. Chen, J.J. Lin, T.L. Su, (C.N. Shen*, T.C. Lee*, A low-toxicity DNA-alkylating N-mustard-quinoline conjugate with preferential sequence specificity exerts potent antitumor activity against colorectal cancer, Neoplasia, vol. 20(2), 119-130, 2018具代表性; 任職中研院著作;
2018 Chuang, T.J., Chen, Y.J., Chen, C.Y., Mai, T.L., Wang, Y.D., Yeh, C.S., Yang, M.Y., Hsiao, Y.T., Chang, T.H., Kuo, H.C., Cho, H.H., (Shen, C.N., ) Kuo, H.C., Lu, M.Y., Chen, Y.H., Hsieh, S.C, Chiang, T.W., Integrative transcriptome sequencing reveals extensive alternative trans-splicing and cis-backsplicing in human cells, Nucleic Acids Research, vol. 46(7), 3671-3691, 2018具代表性; 任職中研院著作;
2017 Hsieh, C.C., I.M. Shyu, W.Y. Liao, T.H. Chen, S.E. Wang, P.C. Lu, P.Y. Lin, Y.B. Chen, W.Y. Mao, H.Y. Han, M. Hsiao, W.B. Yang, W.S. Li, Y.P. Sher, (C.N. Shen*, Elevation of beta-galactoside alpha 2,6-sialyltransferase 1 modulated in a fructose-responsive manner promotes pancreatic cancer metastasis, Oncotarget, vol. 8(5), 7691-7709, 2017具代表性; 任職中研院著作;
2017 Y.T. Lin, C.K. Wang, S.C. Yang, S.C. Hsu, H. Lin, F.P. Chang, T. C. Kuo, (C.N. Shen, M. Hsiao, P.M. Chiang, F. L. Lu, J. Lu, Elimination of undifferentiated human embryonic stem cells by cardiac glycosides, Scientific Reports, vol. 7(1), 5289, 2017具代表性; 任職中研院著作;
2017 C.L. Hsieh, C.M. Liu, H.A. Chen, S.T. Yang, K. Shigemura, K. Kitagawa, F. Yamamichi, M. Fujisawa, Y.R. Liu, W.H. Lee, K.C. Chen, (C.N. Shen, C.C. Lin, L. Chung, S.Y. Sung., Reactive oxygen species-mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression., Scientific Reports, vol. 7(1), 9065, 2017具代表性; 任職中研院著作;
2017 W.C. Yang, Y.S. Hwang, Y.Y. Chen, C.L. Liu, (C.N. Shen, W.H. Hong, S.M. Lo, C.R. Shen, Interleukin-4 supports the suppressive immune responses elicited by regulatory T cells, Frontiers in Immunology, vol. 8, 1508, 2017具代表性; 任職中研院著作;
2016 Cheung SK, Chuang PK, Huang HW, Hwang-Verslues WW, Cho CH, Yang WB, (Shen CN, Hsiao M, Hsu TL, Chang CF, Wong CH, Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells., Proceedings of the National Academy of Sciences of the United States of America, vol. 113(4), 960-965, 2016具代表性; 任職中研院著作;
2016 Chang HM, Huang WY, Lin SJ, Huang WC, Shen CR, Mao WY, (Shen CN*, ABCG2 deficiency in skin impairs re-epithelialization in cutaneous wound healing., Experimental dermatology, vol. 25(5), 355-361, 2016具代表性; 任職中研院著作;
2016 Lien HW, Yuan RY, Chou CM, Chen YC, Hung CC, Hu CH, Hwang SP, Hwang PP, (Shen CN, Chen CL, Cheng CH, Huang CJ, Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2alpha., Scientific reports, vol. 6, 28297, 2016具代表性; 任職中研院著作;
2016 Chien, C.Y., H.S. Lee*, Candy.H.H. Cho, K.I. Lin, D. Tosh, R.R. Wu, W.Y. Mao, (C.N. Shen*, Maternal Vitamin A deficiency during pregnancy affects vascularized islet development, Journal of Nutritional Biochemistry, vol. 36, 51-59, 2016具代表性; 任職中研院著作;
2016 Lin PY, Peng SJ, (Shen CN*, Pasricha PJ, Tang SC, PanIN-associated pericyte, glial, and islet remodeling in mice revealed by 3-D pancreatic duct lesion histology., American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 311(3), G412-G422, 2016具代表性; 任職中研院著作;
2016 Liu CM, Hsieh CL, (Shen CN, Lin CC, Shigemura K, Sung SY, Exosomes from the tumor microenvironment as reciprocal regulators that enhance prostate cancer progression., International journal of urology, vol. 23(9), 734-744, 2016具代表性; 任職中研院著作;
2016 Chien, C.Y., T.A. Yuan, Candy.H.H. Cho, F.P. Chang, W.Y. Mao, R.R. Wu, H.S. Lee*, (C.N. Shen*, All-trans retinoic acid ameliorates glycemic control in diabetic mice via modulating pancreatic islet production of vascular endothelial growth factor-A, Biochemical and Biophysical Research Communications, vol. 477(4), 874-880., 2016具代表性; 任職中研院著作;
2016 F.P. Chang, C.H. Cho, C.R. Shen, C.Y. Chien, L.W.Ting, H.S. Lee, (C.N. Shen*, PDGF Facilitates Direct Lineage Reprogramming of Hepatocytes to Functional ß-Like Cells Induced by Pdx1 and Ngn3, Cell transplantation, vol. 25(10), 1893-1909, 2016具代表性; 任職中研院著作;
2015 Liaw CC, Yang YL, Lin CK, Lee JC, Liao WY, (Shen CN, Sheu JH, Wu SH., New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression, Organic Letters, vol. 17(10), 2330-2333, 2015具代表性; 任職中研院著作;
2015 Chang JS, Su CY, Yu WH, Lee WJ, Liu YP, Lai TC, Jan YH, Yang YF, (Shen CN, Shew JY, Lu J, Yang CJ, Huang MS, Lu PJ, Lin YF, Kuo ML, Hua KT, Hsiao M, GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis., Oncotarget, vol. 6(34), 36278-36291, 2015具代表性; 任職中研院著作;
2015 Chen CY, Lee DS, Yan YT, (Shen CN, Hwang SM, Tone Lee S, Hsieh PC, Bcl3 Bridges LIF-STAT3 to Oct4 Signaling in the Maintenance of Naive Pluripotency., Stem cells, vol. 33(12), 3468-3480, 2015具代表性; 任職中研院著作;
2014 Yang YF, Jan YH, Liu YP, Yang CJ, Su CY, Chang YC, Lai TC, Chiou J, Tsai HY, Lu J, (Shen CN, Shew JY, Lu PJ, Lin YF, Huang MS, Hsiao M, Squalene synthase induces tumor necrosis factor receptor 1 enrichment in lipid rafts to promote lung cancer metastasis., American journal of respiratory and critical care medicine, vol. 190(6), 675-687, 2014具代表性; 任職中研院著作;
2014 CL Chen, LJ Wang, YT Yan, HW Hsu, HL Su, FP Chang, PCH Hsieh, SM Hwang, (CN Shen*, Cyclin D1 Acts as a Barrier to Pluripotent Reprogramming by Promoting Neural Progenitor Fate Commitment, FEBS Letters, vol. 588(21), 4008-4017, 2014具代表性; 任職中研院著作;
2014 Lee IC, Liu YC, Tsai HA, (Shen CN, Chang YC, Promoting the selection and maintenance of fetal liver stem/ progenitor cell colonies by layer-by-layer polypeptide tethered supported lipid bilayer., ACS applied materials & interfaces, vol. 6(23), 20654-20663, 2014具代表性; 任職中研院著作;
2013 Liu YP, Yang CJ, Huang MS, Yeh CT, Wu AT, Lee YC, Lai TC, Lee CH, Hsiao YW, Lu J, (Shen CN, Lu PJ, Hsiao M, Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling., Cancer Research, vol. 73(1), 406-416, 2013具代表性; 任職中研院著作;
2013 WY Liao, CC Liaw, YC Huang, HY Han, HW Hsu, SM Hwang, SC Kuo, CN Shen*, Cyclohexylmethyl flavonoids suppress propagation of breast cancer stem cells via downregulation of NANOG, Evidence-based Complementary and Alternative Medicine, vol. 2013, 170261, 2013具代表性; 任職中研院著作;
2013 Lin YH, Chang HM, Chang FP, Shen CR, Liu CL, Mao WY, Lin CC, Lee HS, (Shen CN*, Protoporphyrin IX accumulation disrupts mitochondrial dynamics and function in ABCG2-deficient hepatocytes., FEBS letters, vol. 587(19), 3202-3209, 2013具代表性; 任職中研院著作;
2013 Tsai HY, Yang YF, Wu AT, Yang CJ, Liu YP, Jan YH, Lee CH, Hsiao YW, Yeh CT, (Shen CN, Lu PJ, Huang MS, Hsiao M, Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78., Oncogene, vol. 32(41), 4921-4931, 2013具代表性; 任職中研院著作;
2012 Liao WY, (Shen CN, Lin LH, Yang YL, Han HY, Chen JW, Kuo SC, Wu SH, Liaw CC, Asperjinone, a Nor-Neolignan, and Terrein, a Suppressor of ABCG2-Expressing Breast Cancer Cells, from Thermophilic Aspergillus terreus., Journal of Natural Products, vol. 75(4), 630-635, 2012具代表性; 任職中研院著作;
2012 Chu CY, Chen CF, Rajendran RS, (Shen CN, Chen TH, Yen CC, Chuang CK, Lin DS, Hsiao CD, Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish., PloS One, vol. 7(5), e36474, 2012具代表性; 任職中研院著作;
2012 Wu YC, Ling TY, Lu SH, Kuo HC, Ho HN, Yeh SD, (Shen CN*, Huang YH*, Chemotherapeutic Sensitivity of Testicular Germ Cell Tumors Under Hypoxic Conditions Is Negatively Regulated by SENP1-Controlled Sumoylation of OCT4., Cancer Research, vol. 72(19), 4963-4973, 2012具代表性; 任職中研院著作;
2012 Tsai HA, (Shen CN, Chang YC, The Use of Surface Properties to Control the Growth and Differentiation of Mouse Fetal Liver Stem/Progenitor Cell Colonies., Biomacromolecules, vol. 13(11), 3483-3493, 2012具代表性; 任職中研院著作;
2012 Tsai ST, Tsou CC, Mao WY, Chang WC, Han HY, Hsu WL, Li CL, (Shen CN*, Chen CH*, Label-free quantitative proteomics of CD133-positive liver cancer stem cells., Proteome science, vol. 10(1), 69, 2012具代表性; 任職中研院著作;
2011 C.F.Chen, C.Y. Chu, T.H. Chen, S.J. Lee, (C.N. Shen*, C.D. Hsiao*, Establishment of a Transgenic Zebrafish Line for Superficial Skin Ablation and for Functionally Validation of Anti-Apoptotic Pathways in vivo, PLoS One, vol. 6(5), e20654, 2011具代表性; 任職中研院著作;
2011 Liaw CC, Liao WY, Chen CS, Jao SC, Wu YC, (Shen CN*, Wu SH*, The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins., Angewandte Chemie-International Edition, vol. 50(34), 7885-7891, 2011具代表性; 任職中研院著作;
2011 Liang YJ, Yang BC, Chen JM, Lin YH, Huang CL, Cheng YY, Hsu CY, Khoo KH, (Shen CN, Yu J, Changes in Glycosphingolipid Composition During Differentiation of Human Embryonic Stem Cells to Ectodermal or Endodermal Lineages., Stem Cells, vol. 29(12), 1995-2004, 2011具代表性; 任職中研院著作;
2010 Shen CN*, Tosh D, Transdifferentiation of pancreatic cells to hepatocytes, Methods in molecular biology, vol. 640, 273-280, 2010具代表性; 任職中研院著作;
2010 Tsai HA, Wu RR, Lee IC, Chang HY, (Shen CN*, Chang YC*, Selection, Enrichment, and Maintenance of Self-Renewal Liver Stem/Progenitor Cells Utilizing Polypeptide Polyelectrolyte Multilayer Films., Biomacromolecules, vol. 11, 994-1001, 2010具代表性; 任職中研院著作;
2010 Wu SY, Hsieh CC, Wu RR, Susanto J, Liu TT, Shen CR, Chen Y, Su CC, Chang FP, Chang HM, Tosh D, (Shen CN*, Differentiation of pancreatic acinar cells to hepatocytes requires an intermediate cell type., Gastroenterology, vol. 138, 2519-2530, 2010具代表性; 任職中研院著作;
2010 Al-Adsani A, Burke ZD, Eberhard D, Lawrence KL, (Shen CN, Rustgi AK, Sakaue H, Farrant JM, Tosh D, Dexamethasone Treatment Induces the Reprogramming of Pancreatic Acinar Cells to Hepatocytes and Ductal Cells., PLoS ONE, vol. 5(10), e13650, 2010具代表性; 任職中研院著作;
2009 Huang YH, Chin CC, Ho HN, Chou CK, (Shen CN, Kuo HC, Wu TJ, Wu YC, Hung YC, Chang CC, Ling TY, Pluripotency of mouse spermatogonial stem cells maintained by IGF-1- dependent pathway., FASEB Journal, vol. 23(7), 2076-2087, 2009具代表性; 任職中研院著作;
2009 Huang YC, Hwang TL, Chang CS, Yang YL, (Shen CN, Liao WY, Chen SC, Liaw CC, Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica., Journal of natural products, vol. 72(7), 1273-1278, 2009具代表性; 任職中研院著作;
2009 Yang YL, Liao WY, Liu WY, Liaw CC, (Shen CN, Huang ZY, Wu SH, Discovery of New Natural Products by Intact-Cell Mass Spectrometry and LC-SPE-NMR: Malbranpyrroles, Novel Polyketides from Thermophilic Fungus Malbranchea sulfurea., Chemistry-A European Journal, vol. 15(43), 11573-11580, 2009具代表性; 任職中研院著作;
2009 Yang CJ, Liu YK, Liu CL, (Shen CN, Kuo ML, Su CC, Tseng CP, Yen TC, Shen CR, Inhibition of Acidic Mammalian Chitinase by RNA Interference Suppresses OVA-sensitized Allergic Asthma., Human gene therapy, vol. 20(12),1597–1606, 2009具代表性; 任職中研院著作;
2008 I-S. Chen, S. P. Huang, N. H. Jang-Liaw, (C. N. Shen, J. H. Wu, Molecular evidence for genetic differentiation of the Opsariichthys bidens complex (Teleostei: Cyprinidae) in southern China around the South China Sea and the validity of Opsariichthys hainanensis, The Raffles Bulletin of Zoology, vol. Supplement No. 19, 215-223, 2008任職中研院著作;
2008 J. Susanto, Y. H. Lin, Y. N. Chen, C. R. Shen, Y. T. Yan, S. T. Tsai, C. H. Chen, C. N. Shen*, Porphyrin homeostasis maintained by ABCG2 regulates self-renewal of embryonic stem cells, PLoS ONE, vol. 3(12), e4023, 2008具代表性; 任職中研院著作;
2007 D. Tosh, (C.N. Shen, M.R. Alison, C.E. Sarraf, J.M.W. Slack, Copper deprivation in rats induces islet hyperplasia and hepatic metaplasia in the pancreas, Biology of the cell, vol. 99, 37-44, 2007具代表性;
2007 C.N. Shen, A. Petiot, C.Y. Chien, C. Dickson, J. M.W. Slack, D. Tosh, All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas, Differentiation, vol. 75, 62-74, 2007具代表性; 任職中研院著作;
2006 Z. D. Burke, (C. N. Shen, K. L. Ralphs, D. Tosh, Characterization of liver function in transdifferentiated hepatocytes, Journal of cellular physiology, vol. 206(1), 147-159, 2006具代表性;
2005 R.Y.L. Wang, (C. N. Shen, M. H. Lin, D. Tosh, C. H. Shih, Hepatocyte-like cells transdifferentiated from a pancreatic origin can support replication of hepatitis B virus, Journal of virology, vol. 79, 13116-13128, 2005具代表性;
2004 Z. D. Burke, (C. N. Shen, D. Tosh, Bile ducts as a source of pancreatic beta cells, Bioessays, vol. 26, 932-937, 2004
2004 C. N. Shen, J. K. Kurash, D. Tosh, Induction and regulation of acute phase proteins in transdifferentiated hepatocytes, Experimental cell research, vol. 292, 342-358, 2004具代表性;
2004 C. N. Shen, Z. D. Burke, D. Tosh, Transdifferentiation, metaplasia, and tissue regeneration, Organogenesis, vol. 1(2), 36-44, 2004具代表性;
2003 Shen CN, Horb ME, Slack JM, Tosh D, Transdifferentiation of pancreas to liver., Mechanisms of development, vol. 120(1), 107-16, 2003具代表性;
2003 C. N. Shen, J. R. Seckl, J. M. Slack, D. Tosh, Glucocorticoids suppress beta-cell development and induce hepatic metaplasia in embryonic pancreas, Biochemical journal, vol. 375, 41-50, 2003具代表性;
2003 M. E. Horb, (C. N. Shen, D. Tosh, J. M. Slack, Experimental conversion of liver to pancreas, Current biology, vol. 13, 105-115, 2003具代表性;
2002 C. N. Shen, J.M.W. Slack, D. Tosh, Regulation of epithelia morphogenesis in hepatic transdifferentiation of pancreas, Differentiation, vol. 70, 363, 2002
2002 D. Tosh, (C. N. Shen, J. M. Slack, Differentiated properties of hepatocytes induced from pancreatic cells, Hepatology, vol. 36, 534-543, 2002具代表性;
2002 D. Tosh, (C. N. Shen, J. M. Slack, Conversion of pancreatic cells to hepatocytes, Biochemical society transactions, vol. 30, 51-55, 2002
2000 C. N. Shen, J. M. Slack, D. Tosh, Molecular basis of transdifferentiation of pancreas to liver, Nature Cell Biology, vol. 2, 879-887, 2000具代表性;
2000 C. N. Shen, J.M.W. Slack, D. Tosh, Molecular basis of hepatic metaplasia of pancreas, Cell Biology international, vol. 24, 934, 2000

Dr. Shen had spared time to attend several training courses. For example, in 2008, he has completed the course program in legal studies in National Taiwan University. In 2012, he also attended the international training program of Multidisciplinary Management of Technology in National Cheng-Chi University. Aside from conducting research, Dr. Shen has also been responsible for coordinating academic activities and overseeing administrative work at the Genomics Research Center as the Deputy Director from 2013 to 2019. He has also served as Acting Division Director of Biotechnology Incubation Center in the Genomics Research Center for incubating biotechnology companies that licensed technologies from Academia Sinica. Dr. Shen was involved in the establishment of Taiwan Society for stem cell research (TSSCR) in 2005 aiming at providing opportunities for close interactions among stem cell researchers in Taiwan. Dr. Shen has been served as TSSCR president from 2017 to 2021. TSSCR cooperates with the government to implement relevant cell therapy legislation and policies, and jointly establish a cell therapy physician training course with Taiwan Association for Cell Therapy (TACT) and Formosa Association for Regenerative Medicine (FARM).Currently, Dr. Shen is a chief PI managing the core facilities for translational medicine at National Biotechnology Research Park. Dr. Shen joined Biomedical Translation Research Center in September 2019 as Acting CEO of BioHub Taiwan (Innovation & Incubation Center, Biomedical Translation Research Center) to aid to incubate biotech startups at National Biotechnology Research Park.

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