News
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A glycan that completes the journey of B cell
O-GlcNAcylation is a type of protein modification that is catalyzed by an enzyme called Ogt (O-GlcNAc transferase) and has been proved important during B cell activation by Lin’s group previously.
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DcR3 is the Main Cause of Endometriosis
Menstrual cramps is not an unfamiliar matter for half of the world population. Most women, if not have experienced it, would have known it from her female friends. Although there may be various reasons of a cramp, if the pain is caused Endometriosis, one should probably not just take a pain killer and wish it’ll go away someday.
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Breast Cancer Cells Empowered in Tumor-draining Lymph Nodes by Tregs
When breast cancer cells are found in the lymph nodes, it is considered an important prognostic predictor for patient survival. However, whether tumor-draining lymph nodes (TDLNs) take parts in the course of breast cancer metastasis has never been thoroughly looked at.
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Contradictory Diels-Alder Reactions and Stereoselective “One-pot” Synthesis of Building Blocks for Antibiotics
To date, antibiotics are still the most effective weapon for treatment of bacterial infec-tions in clinic. By looking into the molecular structures of antibiotics closely, most of them have a core structure that is referred to as “Polypropionates” or “Skipped Pol-yols” with multiple consecutive carbon chiral centers.
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Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting
Genomic imprinting, a parental allele-specific gene expression phenomenon, is caused by allelic DNA methylation of imprinting control regions (ICRs) [also known as differentially methylated regions (DMRs)] and plays an important role in development as defects in genomic imprinting often result in developmental defects.
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Predicting Pentapeptide Sequon to Ensure Protein Glycosylation
More than 50% of human proteins are glycosylated. The glycans linked to asparagine (N) are called N-linked glycans, which are important co-/post-translational modifications regulating structures and functions of glycoproteins, and closely related to the development of protein drugs.
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CLEC5A proved to be a key player that triggers NET formation (NETosis) after bacterial infections
Years of CLEC5A study has successfully proved its heavy involvement in inflammation of Dengue fever and Avian flu patients, and is the lethal factor in dengue hemorrhagic shock syndrome.
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The interplay of glycosyltransferases determines the structures of glycans, their function and disease state
More than 50% of human proteins are glycosylated, but we do not quite understand why proteins are glycosylated. Typical examples include: why is blood type determined by the sugars on red blood cells?
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CLEC5A Is What Dengue Fever and H5N1 Avian Flu Have In Common
Back in 2008, Dr. Edmond Hsieh had proved CLEC5A to be a key factor that causes severe inflammation in Dengue infections, his continual studies focusing on CLEC5A has revealed another connection to CLEC5A with cases of H5N1 Avian Flu virus infections.
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DcR3 Proved Promising in Reversing A-β Damages in Mouse
DcR3 is a protein molecule proved to be a potent immunomodulator that can enhance monocyte differentiation toward the M2 macrophages. Dr. Edmond Hsieh has successfully explored its functionalities in regards to the neuroinflammation.
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Microenvironmental Study Tells How Fatty Tissues Help Breast Cancer Growth
In the battle against cancers, more and more attention are shifted toward the surrounding environment, not just of the environment of the patients, but also the surrounding matters of the cancer cells within the patients.
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New PCR Method Enhances Minute cfDNA Sequencing and More
The study of Genomics has come a long way. We now know that DNA is the basic information-storage material for coding our genes. Aside from the forensic dramas that we watch on television, DNA studies play a major role in new therapeutics.
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Simplified Process to Make Anticoagulant Drug Wins the Hung’s Team the IBMI Award
Nature does wonders! Who would have thought that something within the intestines of pigs called heparin could be used to make drugs being used in modern operating rooms in all hospitals?
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Reaching Out – Another Step to Go Above and Beyond
The collaborative spirit is one of the key strengths in Genomics Research Center. When chemists, biologists, and engineers are mixed and matched, the synergy thereby created and re-created helps to pave the way toward solving critical human diseases.
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A Simple Sugar Makes the Life or Death Difference to an Activated B Cell
O -GlcNAc is a monosaccharide spotted inside cells that has caught attentions lately. Although a very basic unit of carbohydrate, it is a big deal when noted to have shown up in the event of phosphorylation in the cell.
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NIFK – What Causes Lung Cancer to Spread
After tissues are removed from cancer patients, pathologists’ role would start intensively giving patients a precise diagnosis and staging as the guide for cancer therapy. In some cancer types, the pathologist would use a biomarker named Ki-67 to tell how rapidly cancer cells divide and how vicious the tumor is. Tumors that produced more Ki-67 tend to grow faster and are more likely to link to poor disease outcome.
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Glycan Technology - A New Chapter for Making Antibodies
The Glycomics focused research team in Genomics Research Center led by President Wong of Academia Sinica has been working on various glycan related subjects and successfully patented their inventions.
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Antibody targeting IL-17B/RB proved effective for pancreatic cancer
Of all battles against cancer, when it comes to the therapeutics for pancreatic cancer, more than ever, it is too little and too late.
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