News
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Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome
Among many strategies in pursuit of new antibiotics for treating resistant bacterial infections, one important approach is to identify and exploit novel targets for the development of new inhibitors.
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Inducing PODXL overexpression breaks a new milestone in the efficiency of interspecies chimerism in 8-cell embryos
Considering factors such as human immune rejection, limited organ donations, and restrictions on their preservation methods, organ transplantation has been in a state of short supply globally.
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Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2
The COVID-19 pandemic seems to be fading away from our daily life, but the threat of a recurring circulation of new variants still haunts.
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The circles Part II: investigating causal relationship between genetic variants and circular RNA expression in autism
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental and heritable complex disorder characterized by limited social communication, restricted and ritualized interests, and repetitive behavior [Mendelian Inheritance in Man (MIM) 209850].
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MEX3A mediates p53 degradation to suppress ferroptosis and facilitate ovarian cancer tumorigenesis
Among gynecological cancers, ovarian cancer (OC) has received less attention compared to breast cancer and cervical cancer.
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New direction for the treatment of Pseudomonas aeruginosa infection combination of anti-CLEC5A monoclonal antibody with antibiotic
Pseudomonas aeruginosa is one of the most common pathogens for nosocomial infections worldwide.
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Role of hyperphosphorylation of TDP-43 in the neurodegenerative disease
A research team led by Dr. Yun-Ru (Ruby) Chen at Genomic Research Center, aims to study the misfolded proteins related to neurodegenerative diseases.
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Crystal structure of 17B receptor complexed with antibody D9 provides solution for guiding antibody humanization and affinity maturation
A research team led by Dr. Che Ma and Dr. Wen-Hwa Lee in the Genomics Research Center reported they solved complex structure of IL-17RB with D9, and this structure provides important paratope information to guide the design of antibody humanization and affinity maturation of D9.
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CLEC5A and TLR2 are critical in SARS-CoV-2 induced NET formation and lung inflammation
Coronavirus-induced disease 19 (COVID‑19) infects more than three hundred and sixty million patients worldwide, and people with severe symptoms frequently die of acute respiratory distress syndrome (ARDS).
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Chemists restructure an old natural product: Discovery a highly specific Golgi α-mannosidase inhibitor as a new anticancer agent
Glycoproteins play important roles in all kinds of biological events. Enzymes that were anticipated in modulation of N-glycosylation processes are regarded as a potential therapeutic target because of the key role they play in glycosylation processes. But some are undruggable because they belong to families of related enzymes that share the very similar active sites, and targeting them can lead to severe side effects.
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PDAC tumor cell-fibroblast interactions promote metastasis via Homophilic ATP1A1 Binding
Pancreatic ductal adenocarcinoma (PDAC) is responsible for more than 90% of pancreatic cancer cases, just 11% of PDAC patients live for at least five years after their diagnosis. It is seldom detected at its early stages when it's most curable.
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Excess sugar intake increases the risk of pancreatic tumorigenesis
About 1.02 billion hand-shaken drinks are sold every year in Taiwan, working out to over 30% of people consume at least one cup a day. Excess sugar's impact on obesity and diabetes is well known. Still, one area that may surprise many men is consuming sugar in excessive amounts may contribute to the in-creased risk of Pancreatic ductal adenocarcinoma (PDAC).
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The critical point to treatment from the inside out: hybrid inorganic/organic nanoparticles with exosomes for cancer treatment
Since James E. Rothman, Randy W. Schekman, and Thomas C. Sudhof won the Nobel Prize in 2013 for revealing intracellular vesicles’ transport regulation mechanism, such as exosomes, which initially believed the primary function was only exosomes that transport cellular waste.
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Learning from nature: StnK3 is the epimerase controlling β-methyl amino acid stereochemistry
Natural products are a significant source of structurally diverse bioactive compounds for pharmaceutical, cosmetic, and food applications. Bioactive compounds often carry desired biological activities, such as anti-inflammation, anticancer, analgesics, and pain killing.
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Mono-GlcNAc-decorated spike vaccine is highly effective against COVID-19 variants
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in more than 440 million confirmed cases and over 6 million deaths so far. Although there are COVID-19 vaccines available, viruses constantly change through mutations. Key questions remain about how quickly the variants can spread, their potential to evade immunity and how effective the vaccines are against the variants.
