Cover Stories
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Discovery Of Antibiotics to Tackle the Problem of Drug Resistance
In the battle of mankind vs. bacteria, the first round was won by mankind due to the discovery of Penicillin. Antibiotics thus became a seemingly almighty weapon to some medical warriors.
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Functional Genomics Team Developed Recipes to Generate Key Enzymes in Making Better Antibiotics
The emergence of multiple-drug resistant bacteria results in unmanageable bacterial infection in human beings has raised global concerns.
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Tamiphosphor: A new orally active enzyme inhibitor against human and bird flu viruses is developed
The SARS outbreak back in 2003 alerted the world enormously due to the pandemic effect has proved to be above boundaries and beyond existing medical awareness. A research team at the Genomics Research Center of Academia Sinica has been developing vaccines and small molecules as new drug candidates targeting threats of various viruses. Their newest breakthrough is a promising drug candidate that can fight against bird flu and human influenza.
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New Highly Sensitive Sugar Chips Developed
“Sugar Chips” has been one of the research interests in the lab of Dr. Chi-Huey Wong, President of Academia Sinica. The group has announced a new sugar chip method which is effective and convenient. With this new method, a single glass chip can clinically diagnoses specific diseases like cancer, bacterial, or virus infections in a very rapid manner.
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New Tools for Mapping the Glycoproteome
Protein glycosylation is an important posttranslational modification that has profound effects on the structure and function of proteins. More than 90% human proteins have carbohydrates attached to, called glycoproteins.
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A Touch of Sugar Boosts Anti-Cancer Immunity
α-GalCer, an abbreviation of α-GalactosylCeramide, which is a glycolipid that was reported to have the capability to boost the human immune system in fighting cancers back in 1995.
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Sweet Attention!
This may just be the start of it, as “Functional Glycomics” is an emerging field that attracts more and more attentions given the fact that what goes on during the glycosylation stage within a cell may very well be the key factors of many diseases.
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Powerful Sugar Probes and Sugar Chips for Tracking Protein Glycosylation
Studying the biological functions of proteins is now an important task in the post-genomic era. However, more than 80% of human proteins have sugars attached to and are called glycoproteins. The process of protein glycosylation is known to play a central role in mediating protein function in living organisms.
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A break through Mass Spectrometry device was released!
A break through Mass Spectrometry device was released to the public in the November Journal of ”Analytical Chemistry”. This innovative invention is the first of its kind capable of measuring positive and negative molecular ions simultaneously.
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