Selected Publications

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Year Paper Title
2005 A.R. Sawkar, S.L. Adamski-Werner, W.-C. Cheng, C.-H. Wong, E. Beutler, K.-P. Zimmer, J.W. Kelly, Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles, Chem. Biol, vol. 12(11), 1235–1244, 2005
2005 M. Fridman, V. Belakhov, L. V. Lee, F. S. Liang, C. H. Wong, T. Baasov, Dual effect of synthetic aminoglycosides: antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor, Angewandte chemie-international edition, vol. 44, 447-452, 2005
2005 D. A. Calarese, H. K. Lee, C. Y. Huang, M. D. Best, R. D. Astronomo, R. L. Stanfield, H. Katinger, D. R. Burton, C. H. Wong, I. A. Wilson, Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 13372–13377, 2005
2005 J. J. Shie, J. M. Fang, C. J. Kuo, T. H. Kuo, P. H. Liang, H. J. Huang, W. B. Yang, C. H. Lin, J. L. Chen, Y. T. Wu, C. H. Wong, Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease, J Med Chem, vol. 48, 4469-4473, 2005
2005 C.-C. Hsu, Y. Zhang, M. Wada, D. Franke, C.-H. Wong, Directed evolution of d-sialic acid aldolase l-3-deoxy-manno-2-octulosonic acid (l-KDO) aldolases, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 9122-9126, 2005
2005 C. C. Hsu, Y. Zhang, M. Wada, D. Franke, C. H. Wong, Directed evolution of D-sialic acid aldolase L-3-deoxy-manno-2-octulosonic acid (L-KDO) aldolases, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 9122–9126, 2005
2005 D. Wu, G. W. Xing, M. A. Poles, A. Horowitz, Y. Kinjo, B. Sullivan, V. Bodmer Narkevitch, O. Plettenburg, M. Kronenberg, M. Tsuji, D. D. Ho, C. H. Wong, Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, 1351-1356, 2005
2005 Scanlan C, Calarese D, Lee HK, Blixt O, Wong CH, Wilson I, Burton D, Dwek R, Rudd P, Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design., Advances in experimental medicine and biology, vol. 564, 7-8, 2005
2005 T. J. Tolbert, D. Franke, C. H. Wong, A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as TEV protease cleavable fusion protein, Bioorganic & medicinal chemistry, vol. 13, 909-915, 2005
2005 H. N. Yu, D. A. Thayer, M. C. Galan, C. H. Wong, A general strategy toward S-linked glycopeptides, Angewandte chemie-international edition, vol. 44, 4596-4599, 2005
2005 A. Brik, J. Alexandratos, Y. C. Lin, J. H. Elder, A. J. Olson, A. Wlodawer, D. S. Goodsell, C. H. Wong, 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors, Chembiochem, vol. 6, 1167-1169, 2005
2005 T.K.Tang, P.J. Mark, S.T. Chen, M.H. Hou, M.H. Hong, F.M. Pan, H.M.Yu, J.H. Chen, C.W.Yao, A.H.J.Wang, Biochemical and immunological studies of nucleocapsid proteins of severee acute respiratory syndrome and 229E human coronaviruses, Proteomics, vol. 5(4), 925-937, 2005
2005 S. C. Sue, (C. F. Chang, Y. T. Huang, C. Y. Chou, T. H. Huang, Challenges in NMR-based structural genomics, Physica A, vol. 350, 12-27, 2005
2005 Kouza, M., (Chang, C. F., Hayryan, S., Yu, T. H., Li, M. S., Huang, T. H., Hu, C. K., Folding of the Protein Domain hbSBD., Biophys J, vol. 89(5), 3353-3361, 2005
2005 Chang, C. K., Sue, S. C., Yu, T. H., Hsieh, C. M., Tsai, C. K., Chiang, Y. C., Lee, S. J., Hsiao, H. H., Wu, W. J., (Chang, C. F., Huang, T. H., The dimer interface of the SARS coronavirus nucleocapsid protein adapts a porcine respiratory and reproductive syndrome virus-like structure., FEBS Lett, vol. 579(25), 5663-5668, 2005
2005 Mahajan, A., Yuan, C., Pike, B. L., Heierhorst, J., (Chang, C. F., Tsai, M. D., FHA domain-ligand interactions: importance of integrating chemical and biological approaches., J Am Chem Soc, vol. 127(42), 14572-14573, 2005
2005 O. P. Charkin, N. M. Klimenko, T. P. Nguyen, D. O. Charkin, Y.-S. Wang, S.-C. Wei, H.-C. Chang, S. H. Lin, Theoretical study of fragmentation of heme and its ion with successive removal of carboxymethyl groups, Russian Journal of Inorganic Chemistry, vol. 50 (9), 1398-1407, 2005
2005 Lo YC, (Lin SC, Shaw JF, Liaw YC*, Substrate specificities of Escherichia coli thioesterase I/protease I/lysophospholipase L1 are governed by its switch loop movement., Biochemistry, vol. 44(6), 1971-1979, 2005
2005 Chen, F. C., Chuang, T. J.*, ESTviewer: a web interface for visualizing mouse, rat, cattle, pig and chicken conserved ESTs in human genes and human alternatively spliced variants., Bioinformatics, vol. 21(10), 2510-2513, 2005
2004 Hao.-Ping Chen, Fang-Ciao Hsui, Li-Ying Lin, S.-H. Wu, Coexpression, purification and characterization of the E and S subunits of coenzyme B12 and B6 dependent Clostridium sticklandii D-ornithine aminomutase in Escherichia coli, European Journal of Biochemistry, vol. 271, 4293-4297, 2004
2004 H. S. Chen, Y. F. Tsai, S. Lin, C. C. Lin, K. H. Khoo, C. H. Lin, C. H. Wong, Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides, Bioorganic & medicinal chemistry, vol. 12, 5595-5601, 2004
2004 C. Y. Wu, J. T. Jan, S. H. Ma, C. J. Kuo, H. F. Juan, Y. S. Cheng, H. H. Hsu, H. C. Huang, D. Wu, A. Brik, F. S. Liang, R. S. Liu, J. M. Fang, S. T. Chen, P. H. Liang, C. H. Wong, Small molecules targeting severe acute respiratory syndrome human coronavirus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, 10012-10017, 2004
2004 C.-Y. Wu, J.-T. Jan, H.-H. Ma, C.-J. Kuo, H.-F. Juan, Y.-S. E. Cheng, H.-H. Hsu, H.-C. Huang, D. Wu, A. Brik, F.-S. Liang, R.-S. Liu, J.-M. Fang, S.-T. Chen, P.-H. Liang, C.-H. Wong, Small molecules targeting severe acute respiratory syndrome (SARS) human coronavirus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, 10012-10017, 2004
2004 C. H. Chou, C. S. Wu, C. H. Chen, L. D. Lu, S. S. Kulkarni, C. H. Wong, S. C. Hung, Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues, Org Lett, vol. 6, 585-588, 2004
2004 O. Blixt, S. Head, T. Mondala, C. Scanlan, M.E. Huflejt, R. Alvarez, M.C. Bryan, F. Fazio, D. Calarese, J. Stevens, N. Razi, I. van Die, D. Burton, I.A. Wilson, R. Cummings, N. Bovin, C.-H. Wong, J.C. Paulson, Printed covalent glycan array for ligand profiling of diverse glycan binding proteins, Proceedings of the National Academy of Sciences of the United States of America, vol. 101, 17033-17038, 2004
2004 C. M. Chien, J. L. Cheng, W. T. Chang, M. H. Tien, W. Y. Wu, Y. H. Chang, H. Y. Chang, J. F. Hsieh, C. H. Wong, S. T. Chen, Polysaccharides of Ganoderma lucidum Alter Cell Immunophenotypic Expression and Enhance CD56+ NK-Cell Cytotoxicity in Cord Blood, Bioorganic & medicinal chemistry, vol. 12, 5603-5609, 2004
2004 J. H. Chen, Y. W. Chang, C. W. Yao, T. S. Chiueh, S. C. Huang, K. Y. Chien, A. Chen, F. Y. Chang, C. H. Wong, Y. J. Chen, Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, 17039-17044, 2004
2004 H. Y. Hsu, K. F. Hua, C. C. Lin, C. H. Lin, C. H. Wong, Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways, J Immunol, vol. 173, 5989-5999, 2004
2004 C. F. Chang, C. W. Ho, C. Y. Wu, C. H. Wong, C. H. Lin, Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase, Chem Biol, vol. 11, 1301-1306, 2004
2004 D. Klostermeier, P. Sears, C. H. Wong, D. P. Millar, J. R. Williamson, A three-fluorophore FRET assay for high-throughput screening of small-molecule inhibitors of ribosome assembly, Nucleic Acids Res, vol. 32, 2707-2715, 2004