助研究員

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EDUCATION AND POSITIONS HELD:

• B.S., Department of Chemistry, National Taiwan University, Taipei, Taiwan, 2005–2009
• M.S., Department of Chemistry, National Taiwan University, Taipei, Taiwan, 2009–2011
• Ph.D., Department of Chemistry and Biochemistry, University of California Los Angeles (UCLA), Los Angeles, CA, USA, 2014–2019
• Postdoctoral fellow, Department of Chemistry and Biochemistry, University of California Los Angeles (UCLA), Los Angeles, CA, USA, 2019–2020
• Postdoctoral fellow, Center for Nanomedicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, 2020–2023
• Assistant Professor, Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2023-present

HONORS:

• 行政院國科會大專學生研究計畫, 2008-2009
• 行政院國科會大專學生研究計畫研究創意獎, 2009
• 國立臺灣大學理學院院長獎 (學士), 2009
• Thesis Award in Nanomaterial Chemistry, Chemical Society Located in Taipei, Taipei, Taiwan, 2010
• 斐陶斐榮譽會員, 2010
• 財團法人高雄市高英士中華文化典藏教育基金會-獎學金, 2010
• 國立臺灣大學理學院院長獎 (碩士), 2011
• 國立臺灣大學化學系碩士海報論文獎, 2011
• 美國加州大學洛杉磯分校理學院學者獎, 2014
• 行政院教育部留學獎學金, 2015
• 殷勤文教公益基金會及世台聯合基金會美國南加州留學獎學金, 2018
• 美國加州大學洛杉磯分校理學院Mautner Graduate Award (UCLA理學院優秀研究生獎), 2018
• 美國加州大學洛杉磯分校化學系Ralph & Charlene Bauer Award for research in Inorganic Chemistry (UCLA化學系無機化學研究獎), 2019
• 美國加州大學洛杉磯分校化學系Inorganic Faculty Chemistry Dissertation Award (UCLA化學系畢業論文獎), 2019
• 國際先進材料協會年輕科學家獎, 2022
• 美國心臟協會變革性計畫獎,共同研究員, 2023
• 中央研究院新聘學術研究獎金, 2023
• 英國皇家化學學會 Nanoscale 年度新興科學家, 2024

RESEARCH INTERESTS:

陳緯老師實驗室著重於發展奈米醫學，藥物輸送，RNA奈米技術，水凝膠，生物醫學工程，工程化細胞/細菌製劑，生物材料等技術與方法進行癌症，心血管疾病，炎症相關疾病的治療，免疫調控，免疫療法，抗老化，與組織再生等細胞與基因療法的應用，本實驗室期望發展與運用跨領域的策略，以解決目前疾病治療上之醫學瓶頸。

本實驗室積極招收與培養各領域(化學，生物醫學工程，生物化學，奈米科學，生命科學，醫學，免疫，材料科學工程，藥學，化學工程等相關領域)的專題生，碩士生，博士生，研究助理與博士後，有意者請將CV或履歷email至Email住址會使用灌水程式保護機制。你需要啟動Javascript才能觀看它 (陳緯老師實驗室)，期待與大家一起努力！

RESEARCH HIGHLIGHTS:

SELECTED PUBLICATIONS:

• Zhongshan He#, Wei Chen#*, Kuan Hu,# Yaoyao Luo, Wanqin Zeng, Xi He, Tingting Li, Jiang Ouyang, Yongjiang Li, Lin Xie, Yiding Zhang, Qin Xu, Shuping Yang, Mengran Guo, Wei Zou, Yanfei Li, Lingjing Huang, Lu Chen, Xingcai Zhang, Qimanguli Saiding, Rui Wang, Ming-Rong Zhang, Na Kong, Tian Xie, Xiangrong Song*, Wei Tao* *: Co-corresponding author; #: Co-first author, equal contribution, accepted, “Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment”, Nature Nanotechnology. (SCIE)
• Muhammad Muzamil Khan, Yongjiang Li, Zhuoming Zhou, Abigale Ni, Qimanguli Saiding, Duotian Qin, Wei Tao*, Wei Chen*, 2024, “Macrophage-modulating nanomedicine for cancer immunotherapy”, Nanoscale, Accepted article, Accepted article-Accepted article. (SCIE)
• Yesi Shi, Xueyan Zhen, Yiming Zhang, Yongjiang Li, Seyoung Koo, Qimanguli Saiding, Na Kong*, Gang Liu*, Wei Chen*, Wei Tao* *: Corresponding author, 2024, “Chemically Modified Platforms for Better RNA Therapeutics”, Chemical Reviews, 124, 929-1033. (SCIE)
• Yongjiang Li#, Wei Chen#, Yong Kang, Xueyan Zhen, Zhuoming Zhou, Chuang Liu, Shuying Chen, Xiangang Huang, Hai-Jun Liu, Seyoung Koo, Na Kong, Xiaoyuan Ji, Tian Xie*, Wei Tao* #: Co-first author, equal contribution, 2023, “Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity”, Nature Communications, 14, 6973. (SCIE)
• Zhongmin Tang#, Xinru You#, Yufen Xiao#, Wei Chen, Yongjiang Li, Xiangang Huang, Haijun Liu, Fan Xiao , Chuang Liu , Seyoung Koo, Na Kong, and Wei Tao*, 2023, “Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection”, Proceedings of the National Academy of Sciences USA, 120, e2304966120. (SCIE)
• Shuying Chen#, Xiangang Huang#, Yonger Xue#, Ester Álvarez-Benedicto#, Yesi Shi, Wei Chen, Seyoung Koo, Daniel J. Siegwart*, Yizhou Dong*, Wei Tao*, 2023, “Nanotechnology-based mRNA vaccines”, Nature Reviews Methods Primers, 3, 63. (SCIE)
• Siyue Ma#, Ji Hyeon Kim#, Wei Chen#, Lu Li, Jieun Lee, Junlian Xue, Yuxia Liu, Guang Chen,* Bo Tang,* Wei Tao,* Jong Seung Kim* #: Co-first author, equal contribution, 2023, “Cancer Cell-Specific Fluorescent Prodrug Delivery Platforms”, Advanced Science, 10, 2207768. (SCIE)
• Hai-Jun Liu#, Wei Chen#, Gongwei Wu#, Jun Zhou, Chuang Liu, Zhongmin Tang, Xiangang Huang, Jingjing Gao, Yufen Xiao, Na Kong, Nitin Joshi, Yihai Cao, Reza Abdi, Wei Tao* #: Co-first author, equal contribution, 2023, “Glutathione-scavenging nanoparticle-mediated PROTACs delivery for targeted protein degradation and amplified antitumor effects”, Advanced Science, 10, 2207439. (SCIE)
• Wei Chen, Yongjiang Li, Chuang Liu, Yong Kang, Duotian Qin, Shuying Chen, Jun Zhou, Hai-Jun Liu, Bijan Emiliano Ferdows, Dylan Neal Patel, Xiangang Huang, Seyoung Koo, Na Kong, Xiaoyuan Ji, Yihai Cao, Wei Tao*, Tian Xie*, 2023, “In situ Engineering of Tumor-Associated Macrophages via a Nanodrug-Delivering-Drug (β-Elemene@Stanene) Strategy for Enhanced Cancer Chemo-Immunotherapy.”, Angewandte Chemie International Edition, 62, e202308413. (SCIE)
• Liu Yu#, Mian Yu#, Wei Chen#, Shengjie Sun, Wenxin Huang, Tianqi Wang, Zhangwen Peng, Zewen Luo, Yixuan Fang, Yongjiang Li, Yang Deng,* Meiying Wu,* Wei Tao*, #: Co-first author, equal contribution, 2023, “In situ separable nanovaccines with stealthy bioadhesive capability for durable cancer immunotherapy”, Journal of the American Chemical Society, 145, 8375-8388. (SCIE)
• Yichu Nie#, Wei Chen#, Yong Kang#, Xue Yuan, Yongjiang Li, Jun Zhou, Wei Tao*, Xiaoyuan Ji*, #: Co-first author, equal contribution, 2023, “Two-dimensional porous vermiculite-based nanocatalysts for synergetic catalytic therapy”, Biomaterials, 295, 122031. (SCIE)
• Jiang Ouyang, Wei Chen*, Wei Tao*, 2022, “Design of application-optimized hydrogels based on a swollen polymer network model”, Matter, 5, 2471-2473. (SCIE)
• Yufen Xiao, Zhongmin Tang, Xiangang Huang, Wei Chen, Jun Zhou, Haijun Liu, Chuang Liu, Na Kong*, Wei Tao*, 2022, “Emerging mRNA technologies: delivery strategies and biomedical applications”, Chemical Society Reviews, 51, 3828-3845. (SCIE)
• Dongxiao Zhang, Danni Zhong, Jiang Ouyang, Jian He, Yuchen Qi, Wei Chen, Xingcai Zhang*, Wei Tao*, Min Zhou*, 2022, “Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy”, Nature Communications, 13, 1413. (SCIE)
• Wei Chen, Wei Tao*, 2022, “Precise Control of the Structure of Synthetic Hydrogel Networks for Precision Medicine Applications”, Matter, 5, 18-19. (SCIE)
• Bijan Ferdows, Dylan Patel, Wei Chen*, Xiangang Huang, Na Kong, Wei Tao*, 2022, “RNA cancer nanomedicine: nanotechnology-mediated RNA therapy”, Nanoscale, 14, 4448-4455. (SCIE)
• Wei Chen, Maaike Schilperoort, Yihai Cao, Jinjun Shi*, Ira Tabas*, Wei Tao*, 2021, “Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis”, Nature Reviews Cardiology, 19, 228-249. (SCIE)
• Danni Zhong#, Dongxiao Zhang#, Wei Chen#, Jian He, Chaojie Ren, Xingcai, Zhang, Na Kong, Wei Tao*, Min Zhou*, #: Co-first author, equal contribution, 2021, “Orally Deliverable Strategy Based on Microalgal Biomass for Intestinal Disease Treatment”, Science Advances, 7, abi9265. (SCIE)
• Wei Chen, Chi-An Cheng, Danlei Xiang, Jeffrey I. Zink*, 2021, “Expanding Nanoparticle Multifunctionality: Size-Selected Cargo Release and Multiple Logic Operations”, Nanoscale, 13, 5497-5506. (SCIE)
• Xiaoyuan Ji, Lanlan Ge, Chuang Liu, Zhongmin Tang, Yufen Xiao, Wei Chen, Zhouyue Lei, Wei Gao, Sara Blake, Diba De, Bingyang Shi, Xiaobing Zeng*, Na Kong*, Xingcai Zhang*, Wei Tao*, 2021, “Capturing Functional Two-Dimensional Nanosheets from Sandwich-Structure Vermiculite: Synthesis and Application in Cancer Theranostics”, Nature Communications, 12, 1124. (SCIE)
• Wei Chen, Chuang Liu, Xiaoyuan Ji, John Joseph, Zhongmin Tang, Jiang Ouyang, Yufen Xiao, Na Kong, Nitin Joshi, Omid C Farokhzad*, Wei Tao*, Tian Xie*, 2021, “Stanene-Based Nanosheets for β-Elemene Delivery and Ultrasound-Mediated Combination Cancer Therapy”, Angewandte Chemie International Edition, 60, 7155-7164. (SCIE)
• Chi-An Cheng, Wei Chen, Le Zhang, Holden H. Wu, Jeffrey I. Zink, 2020, “Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform”, Chemical Communications, 56, 10297-10300. (SCIE)
• Chi-An Cheng#, Wei Chen#, Le Zhang, Holden H. Wu*, Jeffrey I. Zink*, #: Co-first author, 2019, “A Responsive Mesoporous Silica Nanoparticle Platform for Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound-Stimulated Cargo Delivery with Controllable Location, Time, and Dose”, Journal of the American Chemical Society, 141, 17670-17684. (SCIE)
• Liping Ruan, Wei Chen, Ruining Wang, Jie Lu, and Jeffrey I. Zink*, 2019, “Magnetically Stimulated Drug Release Using Nanoparticles Capped by Self-Assembling Peptides”, ACS Appl. Mater. Interfaces, 11, 43835-43842. (SCIE)
• Wei Chen, Chi-An Cheng, Emily Cosco, Shyam Ramakrishnan, Jakob Lingg, Oliver Bruns*, Jeffrey I Zink*, Ellen Sletten*, 2019, “Shortwave Infrared Imaging with J-aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles.”, Journal of the American Chemical Society, 141, 12475-12480. (SCIE)
• Wei Chen, Carlotta A. Glackin, Marcus A. Horwitz, Jeffrey I. Zink*, 2019, “Nanomachines and Other Caps on Mesoporous Silica Nanoparticles for Drug Delivery”, Accounts of Chemical Research, 52, 1531-1542. (SCIE)
• Wei Chen, Chi-An Cheng, Jeffrey I. Zink*, 2019, “Spatial, Temporal, and Dose Control of Drug Delivery Using Noninvasive Magnetic Stimulation”, ACS Nano, 13, 1292-1308. (SCIE)
• Wei Chen, Chi-An Cheng, Bai-Yu Lee, Daniel L Clemens, Wen-Yen Huang, Marcus A Horwitz, Jeffrey I Zink*, 2018, “Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles”, ACS Applied Materials & Interfaces, 10, 31870-31881. (SCIE)
• Cheng-Chung Chou*, Wei Chen, Yann Hung, Chung-Yuan Mou, 2017, “Molecular Elucidation of Biological Response to Mesoporous Silica Nanoparticles in Vitro and in Vivo”, ACS Appl. Mater. Interfaces, 9, 22235-22251. (SCIE)
• Wei Chen, Ping-Hsing Tsai, Yann Hung, Shih-Hwa Chiou*, Chung-Yuan Mou*, 2013, “Nonviral Cell Labeling and Differentiation Agent for Induced Pluripotent Stem Cells Based on Mesoporous Silica Nanoparticles”, ACS Nano, 7, 8423-8440. (SCIE)
• Wei Chen, Fang Lu, Chiao-Chi V Chen, Kuan-Chi Mo, Yann Hung, Zhi-Xuan Guo, Chia-Hui Lin, Ming-Huang Lin, Yu-Hsuan Lin, Chen Chang, Chung-Yuan Mou, 2013, “Manganese-Enhanced Magnetic Resonance Imaging of Rat Brain Based on Slow Cerebral Delivery of Mn(II) with Silica-Encapsulated MnxFe1–xO Nanoparticles”, NMR in Biomedicine, 26, 1176-1185. (SCIE)