| 2025 |
Ya-Ling Chiang, Yu-Jen Chang, (Yun-Ru Chen, Ing-Shouh Hwang*, Evidence Supporting Enrichment of Dissolved Air Gases near Hydrophobic Macromolecules in Aqueous Solutions, Langmuir, vol. 41(1), 285-291, 2025具代表性; 任職中研院著作;
|
| 2025 |
Gary Jen-Wei Chen§, Ming-Yun Chang§, Xin-Peng Lin, Debapriya Kundu, Yu-Jen Chang, Yun-Ru Chen)*, Tau destabilization in a familial deletion mutant K280 accelerates its fibrillization and enhances the seeding effect, JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 301(2), 108184, 2025具代表性; 任職中研院著作;
|
| 2025 |
Hsiang-Ting Lee, Han-Wen Chang, Yeh-Tung Lin, Shing- Jong Huang, Meng-Hsin Wu, Chang-Shun Tsai, Ling-Hsien Tu, Ming-Che Lee, (Yun-Ru Chen)*, Jerry C. C. Chan*, Oligomeric Protein Complexes formed by Beta Amyloid Peptides and Their Molecular Associates, CHEMISTRY-A EUROPEAN JOURNAL, 2025具代表性; 任職中研院著作;
|
| 2025 |
Chia-Yi Ho, Yu-Jen Chang, Chih-Wen Yang, Orion Shih, U-Ser Jeng, Wan-Chen Huang, Ing-Shouh Hwang, (Yun-Ru Chen)*, Membrane disruption properties of poly-glycine arginine dipeptide repeats affected by peptide repeats continuity and membrane composition, Journal of Molecular Biology, 2025具代表性; 任職中研院著作;
|
| 2024 |
Chang, Yu-Jen; Chien, Yi-Hsin; Chang, Chieh-Chun; Wang, Pei-Ning; (Chen, Yun-Ru)*; Chang, Yun-Chorng*, Detection of Femtomolar Amyloid-β Peptides for Early-Stage Identification of Alzheimer's Amyloid-β Aggregation with Functionalized Gold Nanoparticles, ACS Applied Materials & Interfaces, vol. 16, 3, 3819-3828, 2024具代表性; 任職中研院著作;
|
| 2024 |
Tien-Ying Tsai, Wei-Ting Jhang, Hung-Kai Hsu, Yi-Tsu Chan, Chi-Fon Chang, (Yun-Ru Chen)*, Amyloid Modifier SERF1a Accelerates Alzheimers Amyloid-β Fibrillization and Exacerbates the Cytotoxicity, ACS Chemical Neuroscience, vol. 15, 3, 479-490, 2024具代表性; 任職中研院著作;
|
| 2024 |
Yu-Jen Chang, Kai-Tai Lin, Orion Shih, Chi-Hua Yang, Ching-Yu Chuang, Ming-Han Fang, Wei-Bin Lai, Yi-Chung Lee, Hung-Chih Kuo, Shang-Cheng Hung, Chi-Kuang Yao, U-Ser Jeng, (Yun-Ru Chen)*, Sulfated disaccharide protects membrane and DNA damages from arginine-rich dipeptide repeats in ALS, SCIENCE ADVANCES, vol. 10, eadj0347, 2024具代表性; 任職中研院著作;
|
| 2024 |
Tien-Chang Lin‡, Orion Shih, b‡, Tien-Ying Tsai, Yi-Qi Yeh, Kuei-Fen Liao, Bradley W. Mansel, Ying-Jen Shiu, Chi-Fon Chang, An-Chung Su, (Yun-Ru Chen)*, U-Ser Jeng*, Binding structures of SERF1a with NT17-polyQ peptides of huntingtin exon 1 revealed by SECSWAXS, NMR and molecular simulation, IUCrJ, vol. 11(Pt 5), 849-858, 2024具代表性; 任職中研院著作;
|
| 2023 |
Tien-Wei Lin, Jung-Kai Chang, Yih-Ru Wu, Tsung-Hsien Sun, Yang-Yu Cheng, Chien-Tai Ren, Mei-Hung Pan, Jin-Lin Wu, Kuo-Hsuan Chang, Hwai-I Yang, Chiung-Mei Chen*, Chung-Yi Wu*, Yun-Ru Chen)*, Ganglioside-focused Glycan Array Reveals Abnormal Anti-GD1b Auto-antibody in Plasma of Preclinical Huntington’s Disease, MOLECULAR NEUROBIOLOGY, vol. 60(7), 3873-3882, 2023具代表性; 任職中研院著作;
|
| 2023 |
Tien-Ying Tsai§, Chun-Yu Chen§, Tien-Wei Lin, Tien-Chang Lin, Feng-Lan Chiu, Orion Shih, Ming-Yun Chang, Yu-Chun Lin, An-Chung Su, U-Ser Jeng, Hung-Chih Kuo, Chi-Fon Chang, Yun-Ru Chen)*, Amyloid Modifier SERF1a Interacts with PolyQ-expanded Huntingtin Exon 1 via Helical Interactions and Exacerbates PolyQ-induced Toxicity, Communications Biology, vol. 6, 767, 2023具代表性; 任職中研院著作;
|
| 2022 |
Yuh Shen Lye, Yun-Ru Chen)*, TAR DNA-binding protein 43 oligomers in physiology and pathology, IUBMB LIFE, vol. 2022, 1-18, 2022具代表性; 任職中研院著作;
|
| 2022 |
Jin-Lin Wu, Tung-Hung Su, Pei-Jer Chen, Yun-Ru Chen)*, Acute‑phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level, Scientific Reports, vol. 12, 5799, 2022具代表性; 任職中研院著作;
|
| 2022 |
Wan-Chin Chiang§, Yu-Sheng Fang§, Yuh-Shen Lye, Tzu-Yu Wong, Kiruthika Ganesan, Shih-Chieh Chou, (Yun-Ru Chen)*, Hyperphosphorylation-mimetic TDP-43 Drives Amyloid Formation and Possesses Neuronal Toxicity at the Oligomeric Stage, ACS Chemical Neuroscience, vol. 37, 1, 2599-2612, 2022具代表性; 任職中研院著作;
|
| 2022 |
Ming-Che Lee‡, Yi-Hung Liao‡, Shih-Hui Chen, Yun-Ru Chen)*., Amyloid-β E22K Fibril in Familial Alzheimer’s Disease is More Thermo-stable and Susceptible to Seeding., IUBMB LIFE, vol. 74(8), 739-747, 2022具代表性; 任職中研院著作;
|
| 2022 |
Jin-Lin Wu, Yun-Ru Chen)*, Signal peptide stabilizes folding and inhibits misfolding of serum amyloid A, PROTEIN SCIENCE, vol. 31(12), e4485, 2022具代表性; 任職中研院著作;
|
| 2021 |
Ya-Ling Chiang, Yu-Jen Chang, (Yun-Ru Chen)*, Ing-Shouh Hwang*, Effects of Dissolved Gases on Amyloid Fibril Morphology, LANGMUIR, vol. 37, 1, 516-523, 2021具代表性; 任職中研院著作;
|
| 2021 |
Vu, Katrin; Lee, Ming-Che; Blankenburg, Gerhard; Chang, Yu-Jen; Chu, Ming-Lee; Erbe, Andreas; Lesser-Rojas, Leonardo; (Chen, Yun-Ru); Chou, Chia-Fu*, Time-evolved SERS signatures of DEP-trapped Aβ and Zn2+Aβ peptides revealed by a sub-10 nm electrode nanogap, ANALYTICAL CHEMISTRY, vol. 93(49), 16320-16329, 2021具代表性; 任職中研院著作;
|
| 2020 |
Shih-Ling Huang, Lien-Szu Wu, Min Lee, Chin-Wen Chang, Wei-Cheng Cheng, Yu-Sheng Fang, (Yun-Ru Chen, Pei-Lin Cheng, Che-Kun James Shen*, A Robust TDP-43 Knock-In Mouse Model of ALS, Acta Neuropathologica Communications, vol. 8(1),3, 2020具代表性; 任職中研院著作;
|
| 2020 |
Phillip Smethurst, Emmanuel Risse, Giulia E. Tyzack, Jamie S. Mitchell, Doaa M. Taha, (Yun-Ru Chen, Jia Newcombe, John Collinge, Katie Sidle, Rickie Patani*, Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis, BRAIN, vol. 143(2), 430-440, 2020具代表性; 任職中研院著作;
|
| 2020 |
Yao-Hsiang Shih§, Ling-Hsien Tu§, Ting-Yu Chang, Kiruthika Ganesan, Wei-Wei Chang, Pao-Sheng Chang, Yu-Sheng Fang, Yeh-Tung Lin, Lee-Way Jin, Yun-Ru Chen)*, TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease, NATURE COMMUNICATIONS, vol. 11, 5950, 2020具代表性; 任職中研院著作;
|
| 2018 |
Ming-Che Lee, Wan-Cheng Yu, Yao-Hsiang Shih, Chun-Yu Chen, Zhong-Hong Guo, Shing-Jong Huang, Jerry C. C. Chan, Yun-Ru Chen)*, Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease, Scientific Reports, vol. 8, 4772, 2018具代表性; 任職中研院著作;
|
| 2018 |
Chia-Jung Kuo, Hsu-Cheng Chiang, Chi-Ang Tseng, Chin-Fu Chang, Rajesh Kumar Ulaganathan, Tzu-Ting Ling, Yu-Jen Chang, Chiao-Chen Chen, (Yun-Ru Chen, Yit-Tsong Chen*., A Lipid-Modified Graphene-Transistor Biosensor for Monitoring Amyloid-β Aggregation, ACS APPLIED MATERIALS & INTERFACES, vol. 10(15), 12311-12316, 2018具代表性; 任職中研院著作;
|
| 2018 |
Ling-Hsien Tu, Ning-Hsuan Tseng, Ya-Ru Tsai, Tien-Wei Lin, Yi-Wei Lo, Jien-Lin Charng, Hua-Ting Hsu, Yu-Sheng Chen, Rong-Jie Chen, Ying-Da Wu, Yi-Tsu Chan, Chang-Shi Chen, Jim-Min Fang, *, Yun-Ru Chen)*, Rationally Designed Divalent Caffeic Amide Inhibits Amyloid-β Fibrillization, Induce Fibril Dissociation, and Ameliorate Cytotoxicity, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 158, 393-404, 2018具代表性; 任職中研院著作;
|
| 2017 |
Lin TW, Chang CF, Chang YJ, Liao YH, Yu HM, (Chen YR)*., Alzheimer's amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity, PLOS ONE, vol. 12(3), e0174561, 2017具代表性; 任職中研院著作;
|
| 2016 |
Chia‑Wei Lee, Lan‑Ling Jang, Huei‑Jyuan Pan, (Yun‑Ru Chen, Chih‑Cheng Chen, Chau‑Hwang Lee*, Membrane roughness as a sensitive parameter reflecting the status of neuronal cells in response to chemical and nanoparticle treatments, Journal of Nanobiotechnology, vol. 14, 9, 2016具代表性; 任職中研院著作;
|
| 2016 |
Yu-Jen Chang, U-Ser Jeng, Ya-Ling Chiang, Ing-Shouh Hwang, Yun-Ru Chen)*, Glycine-Alanine Dipeptide Repeat from C9orf72 Hexanucleotide Expansions Forms Toxic Amyloids Possessing Cell-to-cell Transmission Property, Journal of Biological Chemistry, vol. 291(10), 4903-4911, 2016具代表性; 任職中研院著作;
|
| 2016 |
Yu-Jen Chang, Nguyen Hoang Linh, Hui-Ming Yu, Mai Suan Li*, Yun-Ru Chen)*, Alzheimer’s Amyloid-β Sequesters Caspase-3 in vitro via its C-terminal Tail., ACS Chemical Neuroscience, vol. 7(8), 1097-1106, 2016具代表性; 任職中研院著作;
|
| 2016 |
Nguyen Quoc Thai, Ning-Hsuan Tseng, Mui Thi Vu, Tin Trung Nguyen, Huynh Quang Linh, Chin-Kun Hu*, (Yun-Ru Chen)*, Mai Suan Li*, Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for Alzheimer’s disease: in silico and in vitro study, JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 30(8), 639-50, 2016具代表性; 任職中研院著作;
|
| 2016 |
Smethurst, Phillip*; Newcombe, Jia; Troakes, Claire;Simone, Roberto; Wadsworth, John; Hardy, John; (Chen, Yun-Ru); Patani, Rickie; Sidle, Katie, In vitro prion-like mechanisms of TDP-43 in ALS, NEUROBIOLOGY OF DISEASE, vol. 96, 236-247, 2016任職中研院著作;
|
| 2015 |
Patricia F. Kao, (Yun-Ru Chen, Xiao-Bo Liu, Charles DeCarli, William W. Seeley, Lee-Way Jin*, Detection of TDP-43 oligomers in frontotemporal lobar degeneration-TDP, ANNALS OF NEUROLOGY, vol. 78(2), 211-221, 2015具代表性; 任職中研院著作;
|
| 2015 |
Yi-Hung Liao, Yun-Ru Chen*, A novel method for expression and purification of authentic amyloid-β with and without 15N labels., PROTEIN EXPRESSION AND PURIFICATION, vol. 113, 63-71, 2015任職中研院著作;
|
| 2014 |
Huei-Jyuan Pan, Ruei-Lin Wang, Jian-Long Xiao, Yu-Jen Chang, Ji-Yen Cheng, (Yun-Ru Chen, Chau-Hwang Lee, Using optical profilometry to characterize cell membrane roughness influenced by Amyloid-beta 42 aggregates and electric fields, Journal of Biomedical Optics, vol. 19(1), 011009, 2014具代表性; 任職中研院著作;
|
| 2014 |
Yu-Jen Chang, (Yun-Ru Chen)*, The Co-existence of an Equal Amount of Alzheimer’s Amyloid-β 40 and 42 forms Structurally Stable and Toxic Oligomers through a Distinct Pathway, FEBS JOURNAL, vol. 281(11), 2674-2687, 2014具代表性; 任職中研院著作;
|
| 2014 |
Yu-Sheng Fang, Kuen-Jer Tsai, Yu-Jen Chang, Patricia Kao, Rima Woods, Pan-Hsien Kuo, Cheng-Chun Wu, Jhih-Ying Liao, Shih-Chieh Chou, Vinson Lin, Lee-Way Jin, Hanna S. Yuan, Irene H Cheng, Pang-Hsien Tu, Yun-Ru Chen)*, Full-Length TDP-43 Forms Toxic Amyloid Oligomers that are Present in Frontotemporal Lobar Dementia-TDP Patients., Nature Communications, vol. 5, 4824, 2014具代表性; 任職中研院著作;
|
| 2013 |
Winny Ariesandi, Chi-Fon Chang, Tseng-Erh Chen, Yun-Ru Chen*, Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization, PLoS One, vol. 8(1), e53487, 2013具代表性; 任職中研院著作;
|
| 2013 |
Yi-Ting Wang, Pan-Hsien Kuo, Chien-Hao Chiang, Jhe-Ruei Liang, (Yun-Ru Chen, Shuying Wang, James C. K. Shen, Hanna S. Yuan*., The truncated C-terminal RRM domain of TDP-43 plays a key role in forming proteinaceous aggregates., J Biol. Chem., vol. 288(13), 9049-9057, 2013具代表性; 任職中研院著作;
|
| 2013 |
3. Wei-Chieh Cheng*, Chen-Yi Weng, Wen-Yi Yun, Shang-Yu Chang, Yu-Chun Lin, Fuu-Jen Tsai, Fu-Yung Huang, (Yun-Ru Chen)., Rapid modifications of N-substitution in iminosugars: Development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease. , BIOORGANIC & MEDICINAL CHEMISTRY, vol. 1, 5021-5028, 2013任職中研院著作;
|
| 2013 |
Rong-Jie Chen, Wei-Wei Chang, Yu-Chun Lin, Pei-Lin Pheng, (Yun-Ru Chen)*, Alzheimer’s Amyloid-β Oligomers Rescue Cellular Prion Protein Induced Tau Reduction via Fyn Pathways, ACS Chemical Neuroscience, vol. 4(9), 1287-1296, 2013具代表性; 任職中研院著作;
|
| 2013 |
Man Hoang Viet, Chun-Yu Chen, Chin-Kun Hu, (Yun-Ru Chen)*, Mai Suan Li*., Discovery of Dihydrochalcone as potential lead for Alzheimer's disease: in silico and in vitro study, PLoS One, vol. 8(11), e79151, 2013具代表性; 任職中研院著作;
|
| 2012 |
Wei-Ting Chen, Chen-Jee Hong, Ya-Tzu Lin, Wen-Han Chang, He-Ting Huang, Jhih-Ying Liao, Chih-Ya Cheng, Hsiu-Chih Liu, (Yun-Ru Chen)*, Irene H Cheng *, Amyloid-beta (Abeta) D7H mutation increases oligomeric Abeta42 and alters properties of Abeta-zinc/copper assemblies , PLos One, vol. 7(4), e35807, 2012具代表性; 任職中研院著作;
|
| 2012 |
Yi-Hung Liao, Yu-Jen Chang, Yuji Yoshiike, Yun-Chorng Chang*, Yun-Ru Chen)*, Negatively charged gold nanoparticles inhibit Alzheimer's amyloid-beta fibrillization, induce fibril dissociation, and mitigate neurotoxicity, SMALL, vol. 8(23), 3631-3639, 2012具代表性; 任職中研院著作;
|
| 2011 |
Wei-Ting Chen, Yi-Hung Liao, Hui-Ming Yu, Irene H. Cheng, Yun-Ru Chen)*, Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+ on Amyloid-beta Stability, Oligomerization, and Aggregation: Amyloid-beta Destabilization Promotes Annular Protofibril Formation, Journal of Biological Chemistry, vol. 286(11), 9646-9656, 2011具代表性; 任職中研院著作;
|
| 2011 |
Chun-Lun Ni, Hoi-Ping Shi, Kuo-Ging Lin, Hui-Ming Yu, Yun-Ru Chen)*, Folding Stability of Amyloid-beta 40 Monomer is an Important Determinant of the Nucleation Phase in Fibrillization, Faseb Journal, vol. 25(4),1390-1401, 2011具代表性; 任職中研院著作;
|
| 2010 |
Ni-Shian Lin, John Ching-Hao Chao, Fang-Chieh Chou, Chi-Fon Chang, (Yun-Ru Chen, Yu-Jen Chang, Shing-Jong Huang, Wei-Hsiang Tseng, Jerry C. C. Chan, Molecular Structure of Amyloid Fibrils Formed by Residues 127 to 147 of the Human Prion Protein, Chemistry - A European Journal, vol. 16(18), 5492-5499, 2010具代表性; 任職中研院著作;
|
| 2008 |
Yuji Yoshiike, Ryoichi Minai, Yo Matsuo, (Yun-Ru Chen, Tetsuya Kimura, Akihiko Takashima*, Amyloid Oligomer Conformation in a Group of Natively Folded Proteins, PLos ONE., vol. 3(9), e3235, 2008具代表性; 任職中研院著作;
|
| 2006 |
Yun-Ru Chen, A. Clay Clark*, Substitutions of prolines examine their role in kinetic trap formation of the caspase recruitment domain (CARD) of RICK, Protein Science, vol. 15, 395-409, 2006具代表性;
|
| 2006 |
Yun-Ru Chen, Charles G. Glabe*, Distinct Early Folding and Aggregation Properties of Alzheimer Amyloid-b Peptide Aβ40 and Aβ42: Stable Trimer or Tetramer Formation by Ab42, J Biol. Chem, vol. 281, 24414-24422, 2006具代表性;
|
| 2004 |
Yun-Ru Chen, A. Clay Clark*, Kinetic traps in the folding/unfolding of procaspase-1 CARD Domain, Protein Science, vol. 13, 2196-2206, 2004具代表性;
|
| 2003 |
Yun-Ru Chen, A. Clay Clark*, Equilibrium and Kinetic Folding of the α-Helical Greek Key Protein Domain: Caspase Recruitment Domain (CARD) of RICK, Biochemistry, vol. 42, 6310-6320, 2003具代表性;
|
| 2001 |
C. Pop, (Y. R. Chen, B. Smith, K. Bose, B. Bobay, A. Tripathy, S. Franzen, A. C. Clark*, Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer, Biochemistry, vol. 40, 14224-14235, 2001具代表性;
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