Key Achievements

Key Achievements

• 
  2024-01-11 Key Achievements

  Amyloid Modifier SERF1a Accelerates Alzheimer’s Amyloid-β Fibrillization and Exacerbates the Cytotoxicity

  Yun-Ru Chen
  ACS Chemical Neuroscience

• 
  2023-12-12 Key Achievements

  Single Site N‑Glycosylation of B Cell Maturation Antigen (BCMA) Inhibits γ‑Secretase-Mediated Shedding and Improves Surface Retention and Cell Survival

  Chi-Huey Wong
  ACS Chemical Biology

• 
  2023-11-27 Key Achievements

  Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA)

  Chi-Huey Wong
  Proceedings of the National Academy of Sciences

• 
  2023-11-14 Key Achievements

  Oncogenic KRAS, Mucin 4, and Activin A-Mediated Fibroblast Activation Cooperate for PanIN Initiation

  Chun-Mei Hu, Wen-Hwa Lee
  Advanced Science

• 
  2023-10-16 Key Achievements

  Core clock gene BMAL1 and RNA-binding protein MEX3A collaboratively regulate Lgr5 expression in intestinal crypt cells

  Wendy W. Hwang-Verslues
  Scientific Reports

• 
  2023-10-09 Key Achievements

  Quantitative mass spectrometric analysis of hepatocellular carcinoma biomarker alpha-fetoprotein

  Chi-Huey Wong
  RSC Chemical Biology

• 
  2023-07-27 Key Achievements

  Detecting intragenic trans-splicing events from non-co-linearly spliced junctions by hybrid sequencing

  Trees-Juen Chuang
  Nucleic Acids Research

• 
  2023-07-21 Key Achievements

  Amyloid modifier SERF1a interacts with polyQ-expanded huntingtin-exon 1 via helical interactions and exacerbates polyQ-induced toxicity

  Yun-Ru (Ruby) Chen
  communications biology

• 
  2023-06-02 Key Achievements

  Effective Organotin-Mediated Regioselective Functionalization of Unprotected Carbohydrates

  Chi-Huey Wong
  The Journal of Organic Chemistry

• 
  2023-05-22 Key Achievements

  Inhibition of SARS-CoV-2-mediated thromboinflammation by CLEC2.Fc

  Shie-Liang Hsieh
  EMBO Molecular Medicine