Key Achievements

Key Achievements

• 
  2024-02-23 Key Achievements

  Sulfated disaccharide protects membrane and DNA damages from arginine-rich dipeptide repeats in ALS

  Yun-Ru (Ruby) Chen
  Science Advances

• 
  2024-02-23 Key Achievements

  Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human α-Galactosidase

  Wei-Chieh Cheng
  JACS Au

• 
  2024-02-20 Key Achievements

  Synthesis and Quantitative Analysis of Glycans Conjugated to Gold Nanoparticles

  Chi-Huey Wong
  Helvetica Chimica Acta

• 
  2024-01-29 Key Achievements

  Chemically Modified Platforms for Better RNA Therapeutics

  Wei Chen
  Chemical Reviews

• 
  2024-01-22 Key Achievements

  Increased expression of SSEA-4 on TKI-resistant non-small cell lung cancer with EGFR-T790M mutation

  Chi-Huey Wong
  Proceedings of the National Academy of Sciences, U.S.A.

• 
  2024-01-12 Key Achievements

  Detection of Femtomolar Amyloid-β Peptides for Early-Stage Identification of Alzheimer’s Amyloid-β Aggregation with Functionalized Gold Nanoparticles

  Yun-Ru Chen
  ACS Applied Materials & Interfaces

• 
  2024-01-11 Key Achievements

  Amyloid Modifier SERF1a Accelerates Alzheimer’s Amyloid-β Fibrillization and Exacerbates the Cytotoxicity

  Yun-Ru Chen
  ACS Chemical Neuroscience

• 
  2023-12-12 Key Achievements

  Single Site N‑Glycosylation of B Cell Maturation Antigen (BCMA) Inhibits γ‑Secretase-Mediated Shedding and Improves Surface Retention and Cell Survival

  Chi-Huey Wong
  ACS Chemical Biology

• 
  2023-11-27 Key Achievements

  Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA)

  Chi-Huey Wong
  Proceedings of the National Academy of Sciences

• 
  2023-11-14 Key Achievements

  Oncogenic KRAS, Mucin 4, and Activin A-Mediated Fibroblast Activation Cooperate for PanIN Initiation

  Chun-Mei Hu, Wen-Hwa Lee
  Advanced Science