Tien-Hsien Chang
Name Tien-Hsien Chang
EDUCATION AND POSITIONS HELD
  • 2023-2025 Division director of the Physical and Computational Genomics division, Genomics Research Center, Academia Sinica
  • 2022-2023 Acting Director, Genomics Research Center, Academia Sinica
  • 2019-2025 Professor, Genomics Research Center, Academia Sinica
  • 2016-2019 Deputy Director, Genomics Research Center, Academia Sinica
  • 2007-2019 Associate Professor, Genomics Research Center, Academia Sinica
  • 1999-2006 Associate Professor, Ohio State University
  • 1992-1998 Assistant Professor, Ohio State University
  • 1987-1991 Postdoctoral Fellow, California Institute of Technology
HONORS
  • Dean's Award for Classroom Teaching, College of Biological Sciences, Ohio State University
  • Outstanding teacher, College of Biological Sciences, Ohio State University
  • Merck Sharp & Dohme Laboratories Postdoctoral Fellowship, California Institute of Technology
  • Genetic Graduate Group Predoctoral Fellowship, State University of New York at Buffalo
Year Paper Title
2025 Hsiao Wan-Yi, Yeh Chung-Shu, Liu Hsin-I, Tung Luh, (Chang Tien-Hsien*, Genome-wide screen uncovers novel host factors for L-A virus maintenance and a potential mutualistic-symbiosis relationship in yeast, BMC Microbiology, vol. 25(1), 2025具代表性; 任職中研院著作;
2024 Chen, Y.-L.*, Hsieh, J.-W. A., Kuo, S.-C., Kao, C.-T., Tung, C.-C., Yu, J.-H., 「Chang, T.-H.」, Ku, C., Xie, J., Zhang, D., Li, Q., Lin, Y.-C. J.*, Merit of integrating in situ transcriptomics and anatomical information for cell annotation and lineage construction in single-cell analyses of Populus, Genome Biol., vol. 25, 85, 2024任職中研院著作;
2022 Antika, T. R., Lee, Y.-H., Lo, Y.-T., Yeh, C.-S., Yeh, F.-L., 「Chang, T.-H.」, Wang, T.-L., Wang, C.-C.*, Human Thg1 displays tRNA-inducible GTPase activity, NUCLEIC ACIDS RESEARCH, vol. 50, 10015-10025, 2022具代表性; 任職中研院著作;
2021 Tsai, N.-C., Hsu, T.-S., Kuo, S.-C., Kao, C.-T., Hung, T.-H., Lin, D.-G., Yeh, C.-S., Chu, C.-C., Lin, J.-S., Lin, H.-H.; Ko, C.-Y., Chang, T.-H.*, Su, J.-C.*, Lin, Y.-C.*, Large-scale data analysis for robotic yeast one-hybrid platforms and multi-disciplinary studies using GateMultiplex, BMC Biology, vol. 19, 214, 2021具代表性; 任職中研院著作;
2021 Yeh, F.-L., Chang, S.-L., Ahmed, G. R., Liu, H.-I, Tung, L., Yeh, C.-S., Lanier, L. S., Maeder, C., Lin, C.-M., Tsai, S.-C., Hsiao, W.-Y., Chang, W.-H., Chang, T.-H.*, Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling, NATURE COMMUNICATIONS, vol. 12, 3082, 2021具代表性; 任職中研院著作;
2019 Yeh, C.-S., Wang, Z., Miao, F., Ma, H., Kao, C.-T., Hsu, T.-S., Yu, J.-H., Hung, E.-T., Lin, C.-C., Kuan, C.-Y., Zhou, C., Qu, G.-Z., Jiang, J., Liu, G., Wang, J. P., Li, W.*, Chiang, V. L.*, (Chang, T.-H.)*, Lin, Y.-C. J.*, A novel synthetic-genetic-array based yeast one-hybrid system for high discovery rate and short processing time., Genome Research, vol. 29(8),1343-1351, 2019具代表性; 任職中研院著作;
2019 Lee, Y.-H., Lo, Y.-T., Chang, C.-P., Yeh, C.-S., (Chang, T.-H., Chen, Y.-Wei, Tseng, Y.-K., Wang, C.-C*., Naturally occurring dual recognition of tRNAHis substrates with and without a universal identity element., RNA Biology, vol. 16(9),1275-1285, 2019任職中研院著作;
2018 Chuang, T.-J., Chen, Y.-J., Chen, C.-Y., Mai, T.-L., Wang, Y.-D., Yeh, C.-S., Yang, M.-Y., Hsiao, Y.-T., (Chang, T.-H., Kuo, T.-C., Cho, H.-H., Shen, C.-N., Kuo, H.-C., Lu, M.-Y., Chen, Y.-H., Hsieh, S.-C., Chiang, T.-W., Integrative transcriptome sequencing reveals extensive alternative trans-splicing and cis-backsplicing in human cells, Nucleic Acids Research, vol. 46(7), 3671-3691, 2018具代表性; 任職中研院著作;
2018 Chung, C.-y., Hsiao, Y.-m., Huang, T.-Y., (Chang, T.-H.)*, Chang, C-c.*, Germline expression of the hunchback orthologues in the asexual viviparous aphids: A conserved feature within the Aphididae, Insect Molecular Biology, vol. 27(6), 752-765, 2018具代表性; 任職中研院著作;
2018 Chang, S.-L., Wang, H.-K., Tung, L., Chang, T.-H.)*, Adaptive transcription-splicing resynchronization upon losing an essential splicing factor, NATURE ECOLOGY & EVOLUTION, vol. 2(11), 1818-1823, 2018具代表性; 任職中研院著作;
2017 Yeh, C.-S., Chang, S.-L., Chen, J.-H., Wang, H.-K., Chou, Y.-C., Wang, C.-H., Huang, S.-H., Larson, A., Pleiss, P. A., Chang, W.-h., Chang, T.-H.)*, The conserved AU-dinucleotide at the 5’ end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex, NUCLEIC ACIDS RESEARCH, vol. 45 (16), 9679-9693, 2017具代表性; 任職中研院著作;
2016 Fu-Lung Yeh, Luh Tung, Tien-Hsien Chang)*, Detection of protein-protein interaction within an RNA-protein complex via unnatural-amino-acid-mediated photochemical crosslinking, Methods in Molecular Biology, vol. 1421, 175-189, 2016具代表性; 任職中研院著作;
2016 Tsai, P.-W., Chien, C.-Y., Yeh, Y.-C., Tung, L., Chen, H.-F., (Chang, T.-H., Lan, C.Y., Candida albicans Hom6 is a homoserine dehydrogenase involved in protein synthesis and cell adhesion, JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, vol. 50, 863-871, 2016任職中研院著作;
2016 Lee, F. F.-Y., Hui, C.-F., (Chang, T.-H.)*, Chiou, P. P.*, Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-κB Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II, PLOS ONE, vol. 11(9), e0163415, 2016具代表性; 任職中研院著作;
2015 Hsiang-En Hsu, Tzu-Ning Liu, Chung-Shu Yeh, Yi-Chen Lo*, Cheng-Fu Kao*, Feedback control of Snf1 protein and its phosphorylation is necessary for adaptation to environmental stress, Journal of Biological Chemistry, vol. 290, 16786-16796, 2015具代表性; 任職中研院著作;
2015 Chang, S. L., Leu, J.-Y.*, Chang, T.-H.)*, A population study of killer viruses reveals different evolutionary histories of two closely related Saccharomyces sensu stricto yeasts, Molecular Ecology, vol. 24, 4312-4322, 2015具代表性; 任職中研院著作;
2013 Chang, C.-c., Hsiao, Y.-m., Huang, T.-Y., Cook, C. E., Shigenobu, S., Chang, T.-H., Noncanonical expression of caudal during early embryogenesis in the pea aphid Acyrthosiphon pisum: maternal cad-driven posterior development is not conserved, Insect Mol. Biol., vol. 22(4), 442-455, 2013具代表性; 任職中研院著作;
2013 Chang, T.-H.)*, Tung, L., Yeh, F.-L., Chen, J-H., Chang, S.-L., Functions of the DExD/H-box proteins in the nuclear pre-mRNA splicing pathway, Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, vol. 1829, 764-774, 2013具代表性; 任職中研院著作;
2012 Shea, F. F., Rowell, J. R., Li, Y., Chang, T.-H., Alvarez, C. E., Mammalian alpha arrestins link activated seven transmembrane receptors to Nedd4 family E3 ubiquitin ligases and interact with beta arrestins., PLoS One, vol. 7(12), e50557, 2012具代表性; 任職中研院著作;
2012 Huang, J.-Y., Su, W.-C., Jeng, K.-S., (Chang, T.-H.)*, Lai, M. M.-C.*, Attenuation of 40S Ribosomal Subunit Abundance Differentially Affects Host and HCV Translation and Suppresses HCV Replication., PLoS Pathogens, vol. 8(6), 1-14, 2012具代表性; 任職中研院著作;
2012 Wang, C.-Y., Wen, W.-L., Nilsson, D., Sunnerhagen, P., Chang, T.-H., Wang, S.-W., Analysis of stress granule assembly in Schizosaccharomyces pombe, RNA, vol. 18, 694-703, 2012具代表性; 任職中研院著作;
2011 Shieh, G. S., Pan, C.-H, Wu, J.-H., Sun, Y.-J., Wang, C.-C., Hsiao, W.-C., Lin, C.-Y., Tung, L., Chang, T.-H., Fleming, A. B., Hillyer, C., Lo, Y.-C., Berger, S.-L., Osley, M. A., Kao, C.-F., H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast, BMC Genomics, vol. 12, 627, 2011具代表性; 任職中研院著作;
2010 1. Chang, L.-C., Lin, Y.-C., Tung, L., Yeh, F.-L., Yeh, C.-S., Chang, T.-H., RNA helicases: promoting the conformation changes of cellular RNAs and RNPs, Chemistry, vol. 68(4), 259-270, 2010具代表性; 任職中研院著作;
2010 Su, C.-H., Shih, C.-H., Chang, T.-H., Tsai, H.-K., Genome-wide analysis of the cis-regulatory modules of divergent gene pairs in yeast., Genomics, vol. 96, 352-361, 2010具代表性; 任職中研院著作;
2009 Woan-Yuh Tarn, The current understanding of Ded1p/DDX3 homologs from yeast to human, RNA Biology, vol. 6(1), 17-20, 2009具代表性; 任職中研院著作;
2009 Hage, R., Tung, L., Du, H., Stands, L., Rosbash, M., Chang, T.-H., A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/pre-mRNA interaction, Molecular and Cellular Biology, vol. 29(14), 3941-3952, 2009具代表性; 任職中研院著作;
2009 Sung HM, Wang TY, Wang D, Huang YS, Wu JP, Tsai HK, Tzeng J, Huang CJ, Lee YC, Yang P, Hsu J, Chang T, Cho CY, Weng LC, Lee TC, Li WH, Shih MC, Roles of trans and cis variation in yeast intraspecies evolution of gene expression., Molecular Biology and Evolution, vol. 26(11), 2533-8, 2009具代表性; 任職中研院著作;
2007 Huai-Kuang Tsai*, Meng-Yuan Chou, Ching-Hua Shih, Grace Tzu-Wei Huang, Wen-Hsiung Li, MYBS: a comprehensive web server for mining transcription factor binding sites in yeast, Nucleic Acids Research, vol. 35(S), W221-W226, 2007
2006 Fehmida Kapadia, Annie Pryor, Lee F. Johnson*, Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49, Gene, vol. 384, 37-44, 2006
2005 T. Burckin, R. Nagel, Y. Mandel-Gutfreund, L. Shiue, T. Clark, J.-L. Chong, S. Squazzo, G. Hartzog, M. Jr. Ares, Exploring functional relationships between components of the transcription, splicing, and mRNA export machineries by gene expression phenotype analysis, Nat. Struct. Mol. Biol, vol. 12, 175-182, 2005具代表性;
2004 A. Pryor, L. Tung, L. Yang, F. Kapadia, L. F. Johnson, Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56, Nucleic Acids Research, vol. 32, 1857-1865, 2004
2004 J.-L. Chong, R.-Y. Chuang, L. Tung, Ded1p, a conserved DExD/H-box translation factor, can promote L-A virus negative-strand RNA synthesis in vitro, Nucleic Acids Research, vol. 32, 2031-2038, 2004具代表性;
2003 S. S.-I Tseng-Rogenski, J.-L. Chong, C. B. Thomas, S. Enomoto, J. Berman, Functional conservation of Dhh1p, a DExD/H-box protein in Saccharomyces cerevisiae, Nucleic Acids Research, vol. 31, 4995-5002, 2003具代表性;
2001 J. Y.-F. Chen, L. Stands, J. P. Staley, Jr. R. R. Jackups, L. J. Latus, Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD-box splicing factor, Molecular Cell, vol. 7, 227-232, 2001具代表性;
1998 S. S.-I Tseng, P. L. Weaver, Y. Liu, M. Hitomi, A. M. Tartakoff, A cyotosolic RNA helicase required for poly(A)+ RNA export, EMBO J, vol. 17, 2651-2662, 1998具代表性;
1997 R.-Y. Chuang, P. L. Weaver, Z. Liu, Requirement of the DEAD-box protein Ded1p for messenger RNA translation, Science, vol. 275, 1468-1471, 1997具代表性;
1997 Lori J. Latus, Zheng Liu, John Abbott, Genetic interactions of conserved regions in the DEAD-box protein Prp28p, Nucleic Acids Research, vol. 25(24), 5033-5040, 1997
1997 Paul L. Weaver, C. Sun, Dbp3p, a putative RNA helicase in Saccharomyces cerevisiae, is required for efficient pre-ribosomal RNA processing predominantly site A3, Mol. Cell. Biol., vol. 17(3), 1354-1365, 1997具代表性;