具代表性研究發表

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年度 論文名稱
2006 M. Fujio, D. Wu, R. Garcia-Navarro, D. D. Ho, M. Tsuji, C. H. Wong, Structure-Based Discovery of Glycolipids for CD1d-Mediated NKT Cell Activation: Tuning the Adjuvant versus Immunosuppression Activity, J Am Chem Soc, vol. 128, 9022-9023, 2006
2006 Brik A, Ficht S, Wong CH, Strategies for the preparation of homogenous glycoproteins., Current opinion in chemical biology, vol. 10(6), 638-44, 2006
2006 C. Y. Wu, K. Y. King, C. J. Kuo, P. H. Liang, Y. T. Wu, M. Y. Ho, C. L. Liao, J. M. Fang, C. H. Wong, Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease, Chem Biol, vol. 13, 261-268, 2006
2006 Y. S. Cheng, K. H. Lo, H. H. Hsu, Y. M. Shao, W. B. Yang, C. H. Lin, C. H. Wong, Screening for HIV protease inhibitors by protection against activity-mediated cytotoxicity in Escherichia coli, J Virol Methods, vol. 137(1), 82-87, 2006
2006 K.-I. Lin, Y.-Y. Kao, H.-K. Kuo, W.-B. Yang, A. Chou, H.-H. Lin, A. L.-T. Yu, C.-H. Wong, Reishi Polysaccharides Induce Immunoglobulin Production Through the TLR4/TLR2-mediated Induction of Transcription Factor Blimp-1, J. Biol. Chem., vol. 281(34):24111-123, 2006
2006 J. C. Lee, C. Y. Wu, J. V. Apon, G. Siuzdak, C. H. Wong, Reactivity-Based One-Pot Synthesis of the Tumor-Associated Antigen N3 Minor Octasaccharide for the Development of a Photocleavable DIOS-MS Sugar Array, Angewandte chemie-international edition, vol. 45, 2753-2757, 2006
2006 J. C. Lee, W. A. Greenberg, C. H. Wong, Programmable reactivity-based one-pot oligosaccharide synthesis, Nat Protoc, vol. 1, 3143-3152, 2006
2006 S.C. Cheng, W.B. Yang, S.W. Chin, C.C. Lin, C.-H. Lin, Y.J. Chen, P.C. Lin, M.F. Wu, C.-H. Wong, S.L. Hsieh, Profiling of Polysaccharide-receptor Interaction with Recombinant Innate Immunity Receptor-Fe Fusion Proteins, Glycobiology, vol. 16(11), 1131-1132, 2006
2006 P. H. Liang, W. C. Cheng, Y. L. Lee, H. P. Yu, Y. T. Wu, Y. L. Lin, C. H. Wong, Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis, Chembiochem, vol. 7, 165-173, 2006
2006 Y. Kinjo, E. Tupin, D. Wu, M. Fujio, R. Garcia-Navarro, M. R.E.I. Benhnia, D.M. Zajonc, G. Ben-Menachem, G.D. Ainge, G.F. Painter, A. Khurana, K. Hoebe, S.M. Behar, B. Beutler, I. A. Wilson, M. Tsuji, T.J. Sellati, C.-H. Wong, M. Kronenberg, NKT cells recognize diacylglycerol antigens from pathogenic bacteria, NATURE IMMUNOLOGY, vol. 7(9), 978-986, 2006
2006 Kinjo Y, Tupin E, Wu D, Fujio M, Garcia-Navarro R, Benhnia MR, Zajonc DM, Ben-Menachem G, Ainge GD, Painter GF, Khurana A, Hoebe K, Behar SM, Beutler B, Wilson IA, Tsuji M, Sellati TJ, Wong CH, Kronenberg M, Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria., Nature immunology, vol. 7(9), 978-86, 2006
2006 Huang KT, Wu BC, Lin CC, Luo SC, Chen C, Wong CH, Lin CC, Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide., Carbohydrate research, vol. 341(12), 2151-5, 2006
2006 K.-T. Huang, B.-C. Wu, C.-C. Lin, S.-C. Luo, C. Chen, C.-H. Wong, C.-C. Lin, Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide, CARBOHYDRATE RESEARCH, vol. 341(12), 2151-2155, 2006
2006 A. Brik, C.-Y. Wu, C.-H. Wong, Microtiter plate based chemistry and in situ screening: a useful approach for enzymatic inhibitor discovery, Org. Biomol. Chem., vol. 4:1446–14, 2006
2006 Sawa M, Hsu TL, Itoh T, Sugiyama M, Hanson SR, Vogt PK, Wong CH, Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo., Proceedings of the National Academy of Sciences of the United States of America, vol. 103 (33), 12371-12376, 2006
2006 Qiu H, Gabrielsen A, Agardh HE, Wan M, Wetterholm A, Wong CH, Hedin U, Swedenborg J, Hansson GK, Samuelsson B, Paulsson-Berne G, Haeggstrom JZ, Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability., Proceedings of the National Academy of Sciences of the United States of America, vol. 103(21), 8161-6, 2006
2006 H. Qiul, A. Gabrielsen, H.E. Agardh, M. Wan, A. Wetterholm, C.-H. Wong, U. Hedin, J. Swedenborg, G.K. Hansson, B. Samuelsson, G. Paulsson-Berne, J.Z. Haeggstrom, Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlate with symptoms of plaque instability, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103(21), 8161-8166, 2006
2006 Liang FS, Greenberg WA, Hammond JA, Hoffmann J, Head SR, Wong CH, Evaluation of RNA-binding specificity of aminoglycosides with DNA microarrays., Proceedings of the National Academy of Sciences of the United States of America, vol. 103(33), 12311-6, 2006
2006 F.-S. Liang, W. A. Greenberg, J. A. Hammond, J. Hoffmann, S. R. Head, C.-H. Wong, Evaluation of RNA Binding Specificity of Aminoglycosides with DNA Microarrays, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103(33), 12311-12316, 2006
2006 F. S. Liang, A. Brik, Y. C. Lin, J. H. Elder, C. H. Wong, Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates, Bioorganic & medicinal chemistry, vol. 14, 1058-1062, 2006
2006 L.J. Whalen, C-H. Wong, Enzymes in Organic Synthesis: Aldolase-mediated Synthesis of Iminocyclitols and Novel Heterocycles, Aldrichimica Acta, vol. 39(3), 63-71, 2006
2006 M.G. Sanna, S.-K. Wang, P.J. Gonzalez-Cabrera, A. Don, D. Marsolais, M.P. Matheu, S.H. Wei, I. Parker, E. Jo, W.-C. Cheng, M.D. Cahalan, C.-H. Wong, H. Rosen, Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo, Nature Chemical Biology, vol. 2(8):434-441, 2006
2006 D. Wu, D.M. Zajonc, M. Fujio, B.A. Sullivan, Y. Kinjo, M. Kronenberg, I.A. Wilson, C.-H. Wong, Design of NKT-cell activators: Structure and function of a microbial glycosphingolipid bound to mouse CD1d, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103(11), 3972-3977, 2006
2006 Wu D, Zajonc DM, Fujio M, Sullivan BA, Kinjo Y, Kronenberg M, Wilson IA, Wong CH, Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d., Proceedings of the National Academy of Sciences of the United States of America, vol. 103(11), 3972-7, 2006
2006 L. Liu, Z.-Y. Hong, C.-H. Wong, Convergent Glycopeptide Synthesis by Traceless Staudinger Ligation and Enzymatic Coupling, Chembiochem, vol. 7, 429-432, 2006
2006 M. Brigl, P. van den Elzen, X. Chen, J. H. Meyers, D. Wu, C. H. Wong, F. Reddington, P. A. Illarianov, G. S. Besra, M. B. Brenner, J. E. Gumperz, Conserved and Heterogeneous Lipid Antigen Specificities of CD1d-Restricted NKT Cell Receptors, J Immunol, vol. 176, 3625-3634, 2006
2006 Liu H, Wong CH, Characterization of a transglycosylase domain of Streptococcus pneumoniae PBP1b., Bioorganic & medicinal chemistry, vol. 14(21), 7187-95, 2006
2006 H. Liu, C.-H. Wong, Characterization of a transglycosylase domain of Streptococcus pneumoniae PBP1b, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, 7187-7195, 2006
2006 C. Y. Huang, D. A. Thayer, A. Y. Chang, M. D. Best, J. Hoffman, S. Head, C. H. Wong, Carbohydrate microarray for profiling the antibodies interacting with Globo H tumor antigen, Proceedings of the national academy of sciences of the united states of america, vol. 103, 15-20, 2006
2006 M. Sugiyama, L.J. Whalen, Z.-Y. Hong, W.A. Greenberg, C.-H. Wong, Borate as a Phosphate Ester Mimic in Aldolase-Catalyzed Reactions: Practical Syntheses of L-Fructose and L-Iminocyclitols, Advanced Synthesis and Catalysis, vol. 348, 2555-2559, 2006