張典顯
姓名 張典顯
經歷
  • 2023-2025 Division director of the Physical and Computational Genomics division, Genomics Research Center, Academia Sinica
  • 2022-2023 Acting Director, Genomics Research Center, Academia Sinica
  • 2019-present Professor, Genomics Research Center, Academia Sinica
  • 2016-2019 Deputy Director, Genomics Research Center, Academia Sinica
  • 2007-2019 Associate Professor, Genomics Research Center, Academia Sinica
  • 1999-2006 Associate Professor, Ohio State University
  • 1992-1998 Assistant Professor, Ohio State University
  • 1987-1991 Postdoctoral Fellow, California Institute of Technology
榮譽
  • Dean's Award for Classroom Teaching, College of Biological Sciences, Ohio State University
  • Outstanding teacher, College of Biological Sciences, Ohio State University
  • Merck Sharp & Dohme Laboratories Postdoctoral Fellowship, California Institute of Technology
  • Genetic Graduate Group Predoctoral Fellowship, State University of New York at Buffalo
  • Antika, T. R., Lee, Y.-H., Lo, Y.-T., Yeh, C.-S., Yeh, F.-L., 「Chang, T.-H.」, Wang, T.-L., and Wang, C.-C.*, 2022, “Human Thg1 displays tRNA-inducible GTPase activity”, NUCLEIC ACIDS RESEARCH, 50, 10015-10025. (SCIE)
  • Yeh, F.-L., Chang, S.-L., Ahmed, G. R., Liu, H.-I, Tung, L., Yeh, C.-S., Lanier, L. S., Maeder, C., Lin, C.-M., Tsai, S.-C., Hsiao, W.-Y., Chang, W.-H., and Chang, T.-H.*, 2021, “Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling”, NATURE COMMUNICATIONS, 12, 3082. (SCIE)
  • Tsai, N.-C., Hsu, T.-S., Kuo, S.-C., Kao, C.-T., Hung, T.-H., Lin, D.-G., Yeh, C.-S., Chu, C.-C., Lin, J.-S., Lin, H.-H.; Ko, C.-Y., Chang, T.-H.*, Su, J.-C.*, and Lin, Y.-C.*, 2021, “Large-scale data analysis for robotic yeast one-hybrid platforms and multi-disciplinary studies using GateMultiplex”, BMC Biology, 19, 214. (SCIE)
  • Yeh, C.-S., Wang, Z., Miao, F., Ma, H., Kao, C.-T., Hsu, T.-S., Yu, J.-H., Hung, E.-T., Lin, C.-C., Kuan, C.-Y., Zhou, C., Qu, G.-Z., Jiang, J., Liu, G., Wang, J. P., Li, W.*, Chiang, V. L.*, Chang, T.-H.*, Lin, Y.-C. J.*, 2019, “A novel synthetic-genetic-array based yeast one-hybrid system for high discovery rate and short processing time.”, Genome Research, 29(8),1343-1351. (SCIE)
  • Chang, S.-L., Wang, H.-K., Tung, L., and Chang, T.-H.*, 2018, “Adaptive transcription-splicing resynchronization upon losing an essential splicing factor”, NATURE ECOLOGY & EVOLUTION, 2(11), 1818-1823. (SCIE)
  • Chung, C.-y., Hsiao, Y.-m., Huang, T.-Y., Chang, T.-H.*, and Chang, C-c.*, 2018, “Germline expression of the hunchback orthologues in the asexual viviparous aphids: A conserved feature within the Aphididae”, Insect Molecular Biology, 27(6), 752-765. (SCIE)
  • Chuang, T.-J., Chen, Y.-J., Chen, C.-Y., Mai, T.-L., Wang, Y.-D., Yeh, C.-S., Yang, M.-Y., Hsiao, Y.-T., Chang, T.-H., Kuo, T.-C., Cho, H.-H., Shen, C.-N., Kuo, H.-C., Lu, M.-Y., Chen, Y.-H., Hsieh, S.-C., and Chiang, T.-W., 2018, “Integrative transcriptome sequencing reveals extensive alternative trans-splicing and cis-backsplicing in human cells”, Nucleic Acids Research, 46(7), 3671-3691. (SCIE)
  • Yeh, C.-S., Chang, S.-L., Chen, J.-H., Wang, H.-K., Chou, Y.-C., Wang, C.-H., Huang, S.-H., Larson, A., Pleiss, P. A., Chang, W.-h., and Chang, T.-H.*, 2017, “The conserved AU-dinucleotide at the 5’ end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex”, NUCLEIC ACIDS RESEARCH, 45 (16), 9679-9693. (SCIE)
  • Lee, F. F.-Y., Hui, C.-F., Chang, T.-H.*, Chiou, P. P.*, 2016, “Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-κB Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II”, PLOS ONE, 11(9), e0163415. (SCIE)
  • Fu-Lung Yeh, Luh Tung, and Tien-Hsien Chang*, 2016, “Detection of protein-protein interaction within an RNA-protein complex via unnatural-amino-acid-mediated photochemical crosslinking”, Methods in Molecular Biology, 1421, 175-189.
  • Chang, S. L., Leu, J.-Y.*, and Chang, T.-H.*, 2015, “A population study of killer viruses reveals different evolutionary histories of two closely related Saccharomyces sensu stricto yeasts”, Molecular Ecology, 24, 4312-4322. (SCIE)
  • Hsiang-En Hsu, Tzu-Ning Liu, Chung-Shu Yeh, Tien-Hsien Chang, Yi-Chen Lo*, and Cheng-Fu Kao*, 2015, “Feedback control of Snf1 protein and its phosphorylation is necessary for adaptation to environmental stress”, Journal of Biological Chemistry, 290, 16786-16796. (SCIE)
  • Chang, T.-H.*, Tung, L., Yeh, F.-L., Chen, J-H., and Chang, S.-L., 2013, “Functions of the DExD/H-box proteins in the nuclear pre-mRNA splicing pathway”, Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1829, 764-774. (SCIE)
  • Chang, C.-c., Hsiao, Y.-m., Huang, T.-Y., Cook, C. E., Shigenobu, S., and Chang, T.-H. , 2013, “Noncanonical expression of caudal during early embryogenesis in the pea aphid Acyrthosiphon pisum: maternal cad-driven posterior development is not conserved”, Insect Mol. Biol., 22(4), 442-455. (SCIE)
  • Wang, C.-Y., Wen, W.-L., Nilsson, D., Sunnerhagen, P., Chang, T.-H., and Wang, S.-W., 2012, “Analysis of stress granule assembly in Schizosaccharomyces pombe”, RNA, 18, 694-703. (SCIE)
  • Huang, J.-Y., Su, W.-C., Jeng, K.-S., Chang, T.-H.*, and Lai, M. M.-C.*, 2012, “Attenuation of 40S Ribosomal Subunit Abundance Differentially Affects Host and HCV Translation and Suppresses HCV Replication.”, PLoS Pathogens, 8(6), 1-14. (SCIE)
  • Shea, F. F., Rowell, J. R., Li, Y., Chang, T.-H., and Alvarez, C. E., 2012, “Mammalian alpha arrestins link activated seven transmembrane receptors to Nedd4 family E3 ubiquitin ligases and interact with beta arrestins.”, PLoS One, 7(12), e50557. (SCIE)
  • Shieh, G. S., Pan, C.-H,, Wu, J.-H., Sun, Y.-J., Wang, C.-C., Hsiao, W.-C., Lin, C.-Y., Tung, L., Chang, T.-H., Fleming, A. B., Hillyer, C., Lo, Y.-C., Berger, S.-L., Osley, M. A., and Kao, C.-F., 2011, “H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast”, BMC Genomics, 12, 627. (SCIE)
  • Su, C.-H., Shih, C.-H., Chang, T.-H., and Tsai, H.-K., 2010, “Genome-wide analysis of the cis-regulatory modules of divergent gene pairs in yeast.”, Genomics, 96, 352-361. (SCIE)
  • 1. Chang, L.-C., Lin, Y.-C., Tung, L., Yeh, F.-L., Yeh, C.-S., and Chang, T.-H. ,2010,〈RNA helicases: promoting the conformation changes of cellular RNAs and RNPs〉,《Chemistry》,68(4), 259-270。(Others)
  • Sung HM, Wang TY, Wang D, Huang YS, Wu JP, Tsai HK, Tzeng J, Huang CJ, Lee YC, Yang P, Hsu J, Chang T, Cho CY, Weng LC, Lee TC, Chang TH, Li WH, Shih MC, 2009, “Roles of trans and cis variation in yeast intraspecies evolution of gene expression.”, Molecular Biology and Evolution, 26(11), 2533-8. (SCIE)
  • Hage, R., Tung, L., Du, H., Stands, L., Rosbash, M., and Chang, T.-H., 2009, “A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/pre-mRNA interaction”, Molecular and Cellular Biology, 29(14), 3941-3952. (SCIE)
  • Woan-Yuh Tarn, Tien-Hsien Chang*, 2009, “The current understanding of Ded1p/DDX3 homologs from yeast to human”, RNA Biology, 6(1), 17-20. (SCIE)
  • T. Burckin, R. Nagel, Y. Mandel-Gutfreund, L. Shiue, T. Clark, J.-L. Chong, T.-H. Chang, S. Squazzo, G. Hartzog and M. Jr. Ares, 2005, “Exploring functional relationships between components of the transcription, splicing, and mRNA export machineries by gene expression phenotype analysis”, Nat. Struct. Mol. Biol, 12, 175-182. (SCIE)
  • J.-L. Chong, R.-Y. Chuang, L. Tung and T.-H. Chang, 2004, “Ded1p, a conserved DExD/H-box translation factor, can promote L-A virus negative-strand RNA synthesis in vitro”, Nucleic Acids Research, 32, 2031-2038. (SCIE)
  • S. S.-I Tseng-Rogenski, J.-L. Chong, C. B. Thomas, S. Enomoto, J. Berman and T.-H. Chang, 2003, “Functional conservation of Dhh1p, a DExD/H-box protein in Saccharomyces cerevisiae”, Nucleic Acids Research, 31, 4995-5002. (SCIE)
  • J. Y.-F. Chen, L. Stands, J. P. Staley, Jr. R. R. Jackups, L. J. Latus and T.-H. Chang*, 2001, “Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD-box splicing factor”, Molecular Cell, 7, 227-232. (SCIE)
  • S. S.-I Tseng, P. L. Weaver, Y. Liu, M. Hitomi, A. M. Tartakoff and T.-H. Chang, 1998, “A cyotosolic RNA helicase required for poly(A)+ RNA export”, EMBO J, 17, 2651-2662. (SCIE)
  • Paul L. Weaver, C. Sun, Tien-Hsien Chang* , 1997, “Dbp3p, a putative RNA helicase in Saccharomyces cerevisiae, is required for efficient pre-ribosomal RNA processing predominantly site A3”, Mol. Cell. Biol., 17(3), 1354-1365. (SCIE)
  • R.-Y. Chuang, P. L. Weaver, Z. Liu and T.-H. Chang, 1997, “Requirement of the DEAD-box protein Ded1p for messenger RNA translation”, Science, 275, 1468-1471. (SCIE)