語言

Lin, Kuo-I

LinKI 6x7bDistinguished Professor
Division Director of Medical Biology


kuoilingateEmail
+886-2-27871253
[ CV ]

 

 

EDUCATION AND POSITIONS HELD:

  • B.S., Medical Technology, National Taiwan University, 1991
  • M.S., Medical Technology, National Taiwan University, 1993
  • Ph.D., Molecular Microbiology and Immunology, The Johns Hopkins University, 1998
  • Postdoctoral Fellow, Columbia University, 1998-2003
  • Associate Research Scientist, Columbia University, 2003-2004
  • Assistant Professor, Genomics Research Center, Academia Sinica, Taiwan 2004-2009
  • Associate Professor, Genomics Research Center, Academia Sinica, Taiwan 2009-2014
  • Adjunct Associate Professor, Institute of Immunology, National Taiwan University, Taipei, Taiwan 2010-2016
  • Professor, Genomics Research Center, Academia Sinica, Taiwan 2014-2022
  • Division Director of Medical Biology, Genomics Research Center, Academia Sinica, Taipei, Taiwan 2014-present
  • Adjunct Professor, Graduate Institute of Immunology, National Taiwan University, Taipei, Taiwan 2016-present
  • Distinguished Professor, Genomics Research Center, Academia Sinica, 2022-present

HONORS:

  • National Taiwan University Presidential Award (top 5% student), 1987-1991
  • Betty Lee Hampil Honorary Fellowship, Molecular Microbiology and Immunology.The Johns Hopkins University, 1995
  • Phi Beta Kappa, The Johns Hopkins University, 1999
  • The Leukemia and Lymphoma Society Fellowship, 1999-2002
  • Li Foundation Heritage Prize, 2005
  • ASAIHL-Scopus Young Scientist Award, 2008
  • Academia Sinica Career Development Award, 2010
  • Oustanding Research Award, National Science Council, Taiwan, 2013
  • Young Scientist Research Award, Tien-Te Lee Biomedical Foundation, Taiwan, 2014
  • Outstanding Research Award, The Chinese Society of Immunology, Taiwan, 2014
  • Chair in Biotechnology, Taiwan Bio-Development Foundation, 2015
  • Outstanding Research Award, Ministry of Science and Technology, Taiwan, 2016
  • Academia Sinica Investigator Award, 2018
  • Outstanding Research Achievement to National Health, Ming-Ning Wang Memorial Foundation, 2019
  • Academia Sinica Significant Research Publications 2012, 2013, 2016 & 2019

RESEARCH INTERESTS:

Regulatory mechanisms in the immune system

Research work in Lin’s laboratory combines molecular biology and mouse gene knockout models to study the mechanisms of gene expression or post-translational modifications in the regulation of immune system development and functions. Dr. Lin’s group employs single B cell-screening platform to isolate pathogen-specific or cancer-associated monoclonal antibodies. Her group studies the mode of action of monoclonal antibodies in disease progression, as well as in the applications of disease therapy.

Her major research interests are listed as follows:

  • Gene regulatory circuits in the immune system, focusing on studying the mode of action of a master regulator of cellular differentiation, Blimp-1
  • Molecular mechanisms of tumorigenesis of plasma cells and mature B cells
  • Post-translational modification by glycosylation in B cells
  • Single B cell-screening platform and the effector functions of antibody

RESEARCH HIGHLIGHTS:

SELECTED PUBLICATIONS:

  • Wu, J.-L., Wu, H.-Y., Wu, S.-J., Tsai, H.-Y., Weng, S.-H., Lin, K.-T., Lin, L.-I., Yao, C.-Y., Zamanova, M., Lee, Y.-Y., Angata, T., Tien, H.-F., Chen, Y.-J.* and Lin, K.-I*, 2022, “Phosphoproteomics reveals the role of constitutive KAP1 phosphorylation by B-cell receptor signaling in chronic lymphocytic leukemia”, Molecular Cancer Research, 20(8), 1222-1232. (SCIE)
  • Chang, L.-Y., Liang, S.-Y., Lu, S.-C., Tseng, H.-C., Tsai, H.-Y., Tang, C.-J., Sugata, M., Chen, Y.-J., Chen, Y. -J. Wu, S.-J., Lin, K.-I, Khoo, K.-H., and Angata, T., 2022, “Molecular basis and role of Siglec-7 ligand expression on chronic lymphocytic leukemia B cells”, Frontiers in Immunology, 13, 840388. (SCIE)
  • Huang, H.-Y., Liao, H.-Y., Chen, X., Wang, S.-W., Cheng, C.-W., Shahed-Al-Mahmud, M. Chen, T.-H., Lo, J. M., Liu, Y.-M., Wu, Y.-M., Ma, H.-H., Chang, Y.-H., Tsai, H.-Y., Chou, Y.-C., Hsieh, Y.-P., Tsai, C.-Y., Huang, P.-Y., Chang, S.-Y., Chao, T.-L., Kao, H.-C., Tsai, Y.-M., Chen, Y.-H., Wu, C.-Y., Jan, J.-T., Cheng, T.-J. R., Lin, K.-I*, Ma, C*. and Wong, C.-H.*, 2022, “Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models”, Science Translational Medicine, 14(639), eabm0899. (SCIE)
  • Gebreyesus, S. T., Siyal, A. A., Kitata, R. B., Chen, S.-W., Enkhbayar, B., Angata, T., Lin, K.-I, Chen, Y.-J. and Tu., S.-L., 2022, “Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry”, NATURE COMMUNICATIONS, 13(1), 37. (SCIE)
  • Hsieh, W.-C., Lai, E.-Y., Liu, Y.-T., Wang, Y.-F., Tzeng, Y.-S., Cui, L, Lai, Y.-J., Huang, H.-C., Huang, J.-H., Ni, H.-C., Tsai, D.-Y., Liang, J.-J., Liao, C.-C., Jiang, L, Liu, M.-T., Wang, J.-T., Chang, S.-Y., Chen, C.-Y., Tsai, H.-C., Chang, Y.-M., Wernig, G., Li, C.-W., Lin, K.-I, Lin, Y.-L., Tsai, H.-K., Huang, Y.-T. and Chen, S.-Y, 2021, “NK cell receptor and ligand composition influences the clearance of SARS-CoV-2”, JOURNAL OF CLINICAL INVESTIGATION, 131 (21), e146408. (SCIE)
  • Ko, Y.-A., Yu, Y.-H., Wu, Y.-F., Tseng, Y.-C., Chen, C.-L., Goh, K.-S, Liao, H.-Y., Chen, T.-H., Cheng, R. T.-J., Yang, A.-S., Wong, C.-H., Ma, C. and Lin, K.-I*, 2021, “A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells”, PLOS PATHOGENS, 17(8), e1009724. (SCIE)
  • Lo, L.-W., Chang, C.-W., Chiang, M.-F., Lin, I-Y., and Lin, K.-I*, 2021, “Marginal zone B cells assist with neutrophil accumulation to fight against systemic Staphylococcus aureus infection”, FRONTIERS IN IMMUNOLOGY, 12, 636818. (SCIE)
  • Lee, W., Wang, L.-T., Yen, M.-L., Hsu, P.-J., Lee, Y.-W., Liu, K.-J., Lin, K.-I, Su, Y.-W., Sytwu, H.-K., and Yen, B. L., 2021, “Resident vs. nonresident multipotent mesenchymal stromal cell interactions with B lymphocytes result in disparate outcomes”, Stem Cells Transi Med, 10(5), 711-724.
  • Liao, H.-Y., Wang, S.-C., Ko, Y.-A. Lin, K.-I, Ma, C., Cheng, R. T.-J., and Wong, C.-H., 2020, “Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes”, Proc Natl Acad Sci USA, 117(30), 17757-17763.
  • Chang, Y.-H., Weng, C.-L, and Lin, K.-I*, 2020, “O-GlcNAcylation and its role in the immune system.”, J Biomed Sci., 27(1):57. (SCIE)
  • Chen, H.-Y., Wu, Y.-F., Chou, F.-C., Wu, Y.-H., Yeh, L.-T., Lin, K.-I, Liu, F.-T., Sytwu, H.-K, 2020, “Intracellular galectin-9 enhances proximal TCR signaling and potentiates autoimmune disease”, JOURNAL OF IMMUNOLOGY, 204(5):1158-1172. (SCIE)
  • Liu, C.-H., Chou, C.-T., Chen, C.-H., Chen, C.-H., Yang, S.-Y., Ko, Y.-A., Wu, Y.-T., Wang, C.-C., Liu, F.-C., Yue, C.-T., Hung, S.-C., Tzeng, I-S., Tsai, W.-C. *, and Lin, K.-I*, 2020, “Aberrant distribution and function of plasmacytoid dendritic cells in patients with ankylosing spondylitis are associated with unfolded protein response”, KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, doi: 10.1002/kjm2.12184. (SCIE)
  • Liu, C.-H., Raj, S, Chen, C.-H., Hung, K.-H., Chou, C.-T., Chen, I.-Ho., Chien, J.-T., Lin, I-Y., Yang, S.-Y., Angata, T., Tsai, W.-C., Wei. J. C.-C., Tzeng, I-S., Hung, S.-C.*, and Lin, K.-I*, 2019, “HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis”, JOURNAL OF CLINICAL INVESTIGATION, 129 (12): 5357-5373. (SCIE)
  • Tsai, D.-Y., Hung, K.-H., Chang, C.-W., and Lin, K.-I*, 2019, “Regulatory Mechanisms of B cell responses and the implication in B cell-related diseases”, JOURNAL OF BIOMEDICAL SCIENCE, 26(1):64. (SCIE)
  • Wang, Y.-H., Tsai, D.-Y., Ko, Y.-A., Yang, T.-T., Lin, I-Y., Hung, K.-H., and Lin, K.-I*, 2019, “Blimp-1 contributes to the development and function of regulatory B cells”, FRONTIERS IN IMMUNOLOGY, 10:1909. (SCIE)
  • Tseng, Y,-C., Wu, C.-Y., Liu, M.-L., Chen, T.-H., Chinag, W.-L., Yu, Y.-H., Jan, J.-T., Lin, K.-I, Wong, C.-H., and Ma, C., 2019, “Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections.”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116 (10) ,4200-4205. (SCIE)
  • Ko, Y.-A., Chan, Y.-H., Liu, C.-H., Liang, J.-J., Chuang, T.-H., Hsueh, Y.-P., Lin, Y.-L., and Lin, K.-I*, 2018, “Blimp-1-mediated pathway promotes Type I IFN production in plasmacytoid dendritic cells by targeting to Interleukin-1 receptor-associated kinase M”, FRONTIERS IN IMMUNOLOGY, 9, 1828. (SCIE)
  • Tsai, M.-S., Chiang, M.-T., Tsai, D.-L., Yang, C.-W., Hou, H.-S., Li, Y.-R., Chang, P.-C., Lin, H.-H., Chen, H.-Y., Hwang, I.-S., Wei, P.-K., Hsu, C.-P., Lin, K.-I, Liu, F.-T., and Chau, L.-Y, 2018, “Galectin-1 restricts vascular smooth muscle cell motility via modulating adhesion force and focal adhesion dynamics”, Scientific Reports, 8(1), 11497. (SCIE)
  • Hung, K.-H., Woo, Y. H., Lin, I-Y., Liu, C.-H., Wang, L.-C., Chen, H.-Y., Chiang, B.-L., and Lin, K.-I*, 2018, “The KDM4A/KDM4C/NF-κB and WDR5 epigenetic cascade regulates the activation of B cells”, NUCLEIC ACIDS RESEARCH, 46(11), 5547-5560. (SCIE)
  • Wu, J.-L., Chiang, M.-F., Hsu, P.-H., Tsai, D.-Y., Hung, K.-H., Wang, Y.-H., Angata, T.* and Lin, K.-I*, 2017, “O-GlcNAcylation is required for B cell homeostasis and antibody responses”, NATURE COMMUNICATIONS, 8(1):1854. (SCIE)
  • Lai, C.-Y., Su, Y.-W., Lin, K.-I, Hsu, L.-C. and Chuang, T.-H., 2017, “Natural modulators of endosomal Toll-like receptor-mediated psoriatic skin inflammation”, Journal of Immunology Research, 10.1155/2017, 7807313. (SCIE)
  • Chen, T.-T., Tsai, M.-H., Kung, J.T., Lin, K.-I, Decker, T. and Lee, C.-K., 2016, “STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria”, Journal of Experimental Medicine, 213, 3025-3039. (SCIE)
  • Chien, C.-Y., Lee, H.-S. Lee, Cho, C.H.H., Lin, K.-I, Tosh, D., Wu, R.-R., Mao, W.-Y., Shen, C.-N., 2016, “Maternal Vitamin A deficiency during pregnancy affects vascularized islet development”, Journal of Nutritional Biochemistry, 36, 51-59. (SCIE)
  • Wu, J.-L., Wu, H.-Y., Tsai, D.-Y., Chiang, M.-F., Chen, Y.-J., Gao, S., Lin, C.-C., Lin, C.-H., Khoo, K.-H., Chen, Y.-J.* and Lin, K.-I *, 2016, “Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells”, Nature Communications, 7, 12526. (SCIE)
  • Hung, K.-H., Su, S.-T., Chen, C.-Y., Hsu, P.-H., Huang, S.-Y., Wu, W.-J., Chen, M.M., Chen, H.-Y., Wu, P.-C., Lin, F.-R., Tsai, M.-D., and Lin, K.-I*, 2016, “Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells”, CELL DEATH AND DIFFERENTIATION, 23, 1175-1184. (SCIE)
  • Yu, Y.-H., and Lin, K.-I*, 2016, “Factors that regulate the generation of antibody-secreting plasma cells.”, Advances in Immunology, 131, 61-99. (SCIE)
  • Tsai, D.-Y., Hung, K.-H., Lin, I-Y., Su, S.-T., Wu, S.-Y., Chung, C.-H., Wang, T.-C., Li, W.-H., Shih, A. C.-C.*, and Lin, K.-I* , 2015, “Uncovering miRNA regulatory hubs that modulate plasma cell differentiation”, Scientific Reports, 5, 17957. (SCIE)
  • Tsai, C.-M. and Lin, K.-I*, 2015, “Examination of the role of galectins in plasma cell differentiation”, Methods in Molecular Biology, 1207, 153-167.
  • Kretzschmar, K., Cottle, D.L., Donati, G, Chiang, M.-F., Quist, S.R., Gollnick, H.P., Natsuga, K., Aoyagi, S., Lin, K.-I, and Watt, F. M., 2014, “BLIMP1 does not define a sebaceous gland progenitor population but is required for epidermal homeostasis”, Stem Cell Reports, 3(4), 620-633. (SCIE)
  • Chiu, Y.-K., Lin, I-Y., Su, S.-T., Wang, K.-H., Yang, S.-Y., Tsai, D.-Y., Hsieh, Y.-T., and Lin, K.-I*, 2014, “Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation”, JOURNAL OF IMMUNOLOGY, 193(5), 2207-2217. (SCIE)
  • Tsai, C.-M. Wu, H.-Y., Su, T.-H., Kuo, C.-W., Huang, H.-W., Chung, C.-H., Chen, C.-S., Khoo, K.-H., Chen, Y.-J.* and Lin, K.-I*, 2014, “Phosphoproteomic analyses reveal that galectin-1 augments the dynamics of B-cell receptor signaling”, Journal of Proteomics, 103, 241-253. (SCIE)
  • Huang, K.-Y.; Wu, H.-Y.; Chen, Y.-J.; Lu, C.-T.; Su, M.-G.; Hsieh, Y.-C.; Tsai, C.-M.; Lin, K.-I; Huang, H.-D.; Lee, T.-Y. and Chen, Y.-J, 2014, “RegPhos 2.0: an updated resource to explore protein kinase-substrate phosphorylation networks in mammals.”, Database-The Journal of Biological Databases and Curation, bau034. (SCIE)
  • Lin, I-Y., Chiu, F.-L., Yeang, C.-H., Chen, H.-F., Chuang, C.-Y., Yang, S.-Y., Hou, P.-S., Sintupisut, N., Ho, H.-N., Kuo, H.-C.*, and Lin, K.-I*, 2014, “Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells”, Stem Cell Reports, 2(2), 189-204. (SCIE)
  • Lin, M.-H., Yeh, L.-T., Chen, S.-J., Chiou, H.-Y., Chu, C.-C., Yen, L. B., Lin, K.-I, Chang, D.-M., and Sytwu, H.-K., 2014, “T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells”, CLINICAL IMMUNOLOGY, 151(2), 101-113. (SCIE)
  • Chen, J.-R., Yu, Y.-H., Tseng, Y.-C., Chiang, W.-L., Chiang, M.-F., Ko, Y.-A., Chiu, Y.-K., Ma, S.-H., Wu, C.-Y., Jan, J.-T., Lin, K.-I*, Ma, C.*, and Wong, C.-H.* , 2014, “Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against Influenza virus infections”, Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2476-2481. (SCIE)
  • Liao, S.-F, Liang, C.-H., Ho, M.-Y., Hsu, T.-L., Tsai, T.-I, Hsieh, Y. S.-Y., Tsai, C.-M., Li, S.-T., Cheng, Y.-Y., Tsao, S.-M., Lin, T.-Y., Lin, Z.-Y. , Yang, W.-B., Ren, C.-T., Lin, K.-I, Khoo, K.-H., Lin, C.-H., Hsu, H.-Y., Wu, C.-Y., and Wong, C.-H., 2013, “Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(34), 13809-13814. (SCIE)
  • Huang, H.-W., Chen, C.-H., Lin, C.-H., Wong, C.-H.*, and Lin, K.-I*, 2013, “B cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(27), 10928-10933. (SCIE)
  • Tu, Z., Hsieh, H.-W., Tsai, C.-M., Hsu, C.-W., Wang, S.-G., Wu, K.-J., Lin, K.-I*, and Lin, C.-H*, 2013, “Synthesis and characterization of sulfated Gal-beta-1, 3/4-GlcNAc disaccharides via consecutive Protection/glycosylation steps”, Chemistry-An Asian Journal, 8 (7), 1536-1550. (SCIE)
  • Wang, S.-H., Tsai, C.-M., Lin, K.-I* and Khoo, K.-H.*, 2013, “Advanced mass spectrometry and chemical analyses reveal the presence of terminal disialyl motif on mouse B-cell glycoproteins”, GLYCOBIOLOGY, 23(6), 677-689. (SCIE)
  • Chiang, M.-F., Yang, S.-Y., Lin, I-Y., Hong, J.-B., Lin, S.-J., Ying, H.-Y., Chen, C.-M., Wu, S.-Y., Liu, F.-T., and Lin, K.-I*, 2013, “ Inducible deletion of Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in mice”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(16), 6476-6481. (SCIE)
  • Lin, M.-H., Chou, F.-F., Yeh, L.-T., Fu, S.-H., Chiou, H.-Y., Lin, K.-I, Chang, D.-M. and Sytwu H.-K., 2013, “B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells”, DIABETOLOGIA, 56(1), 136-146. (SCIE)
  • Lin, F.-R., Huang, S.-Y., Hung, K.- H., Su, S.-T., Chung, C.-H., Matsuazwa, A., Hsiao, M., Ichijo, H. and Lin, K.-I*, 2012, “ASK1 promotes apoptosis of normal and malignant plasma cells”, Blood, 120(5), 1039-1047. (SCIE)
  • Ying, H.-Y., Su, S.-T., Hsu, P.-H., Chang, C.-C., Lin, I-Y., Tseng, Y.-H., Tsai, M.-D., Shih, H.-M. and Lin, K.-I*, 2012, “SUMOylation of Blimp-1 is critical for plasma cell differentiation”, EMBO REPORTS, 13, 631-637. (SCIE)
  • Hsu Y, Lu XA, Zulueta MM, Tsai CM, Lin KI, Hung SC, Wong CH., 2012, “Acyl and Silyl Group Effects in Reactivity-Based One-Pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc(4) and IV(2)Fuc-Lc(4)”, J Am Chem Soc., 134(10), 4549-4552. (SCIE)
  • Chuang, C.-Y., Lin, K.-I, Hsiao, M., Stone, L., Chen, H.-F., Huang, Y.-H., Lin, S.-P., Ho, H.-N.,and Kuo, H.-C., 2012, “Meiotic competent human germ cell-like cells derived from human embryonic stem cells induced by BMP4/WNT3A signaling and OCT4/EpCAM selection.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 287, 14389-14401. (SCIE)
  • Wu, Y.-H., Yang, C.-Y., Chien, W.-L., Lin, K.-I and Lai, M.-Z., 2012, “Removal of Syndecan-1 promotes TRAIL-induced apoptosis in myeloma cells.”, J. Immunol., 188, 2914-2921. (SCIE)
  • Tsai, C.-M., Guan, C.-H., Hsieh, H.-W, Hsu, T.-L., Tu, Z., Wu, K.-J., Lin, C.-H.* and Lin, K.-I* , 2011, “Galectin-1 and galectin-8 have redundant roles in promoting plasma cell formation”, JOURNAL OF IMMUNOLOGY, 187(4),1643-1652. (SCIE)
  • Chan, Y.-H., Chiang, M.-F., Tsai, Y.-C., Su, S.-T., Chen M.-H., Hou, M.-S., and Lin, K.-I*, 2009, “Absence of the transcriptional repressor Blimp-1 in hematopoietic lineages reveals its role in the conventional dendritic cell homeostatic development and function.”, Journal of Immunology, 183 (11), 7039-7046. (SCIE)
  • Su, S.-T., Ying, H.-Y., Chiu, Y.-K., Lin, F.-R., Chen, M.-Y. and Lin, K.-I*, 2009, “Involvement of LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation”, MOLECULAR AND CELLULAR BIOLOGY, 29 (6), 1421-1431. (SCIE)
  • Tsai, C.-M., Chiu,Y.-K., Hsu, T.-L., Lin, I-Y., Hsieh, S.-L., and Lin, K.-I*, 2008, “Galectin-1 promotes immunoglobulin production during plasma cell differentiation”, Journal of Immunology, 181, 4570-4579. (SCIE)
  • Lin, F.-R., Kuo, H.-K., Ying, H.-Y., Yang, F.-H., and Lin, K.-I* , 2007, “Induction of apoptosis in plasma cells by B lymphocyte-induced maturation protein-1 knockdown”, CANCER RESEARCH, 67(24), 11914-11923. (SCIE)
  • K.I Lin*, Y.Y. Kao, H.K. Kuo, W.B. Yang, A Chou, H.H. Lin, A.L. Yu and C.H.Wong, 2006, “Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor blimp-1”, J. Biol. Chem, 281, 24111-24123. (SCIE)
  • M. Shapiro-Shelef, K. I. Lin, D. Savitsky, J. Liao and K. Calame, 2005, “Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow”, J Exp Med, 202, 1471-1476. (SCIE)
  • K. Johnson, D. L. Pflugh, D. Yu, D. G. Hesslein, K. I. Lin, A. L. Bothwell, A. Thomas-Tikhonenko, D. G. Schatz and K. Calame, 2004, “B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locusdepends on Pax5”, Nat Immunol, 5, 853-861. (SCIE)
  • K. I. Lin, K. Calame, 2004, “Introduction of genes into primary murine splenic B cells using retrovirus vectors”, Methods Mol Biol, 271, 139-148.
  • M. Shapiro-Shelef, K. I. Lin, L. J. McHeyzer-Williams, J. Liao, M. G. McHeyzer-Williams and K. Calame, 2003, “Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells”, Immunity, 19, 607-620. (SCIE)
  • K. L. Calame, K. I. Lin and C. Tunyaplin, 2003, “Regulatory mechanisms that determine the development and function of plasma cells”, Annu Rev Immunol, 21, 205-230. (SCIE)
  • K. I. Lin, C. Tunyaplin and K. Calame, 2003, “Transcriptional regulatory cascades controlling plasma cell differentiation”, Immunol Rev, 194, 19-28. (SCIE)
  • A. L. Shaffer#, K. I. Lin#, T. C. Kuo, X. Yu, E. M. Hurt, A. Rosenwald, J. M. Giltnane, L. Yang, H. Zhao, K. Calame and L. M. Staudt. #co-first authors, 2002, “Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program”, Immunity, 17, 51-62. (SCIE)
  • K. I. Lin, C. Angelin-Duclos, T. C. Kuo and K. Calame, 2002, “Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells”, Mol Cell Biol, 22, 4771-4780. (SCIE)
  • J. F. Piskurich#, K. I. Lin#, Y. Lin, Y. Wang, J. P. Ting and K. Calame. #co-first authors, 2000, “BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cells”, Nat Immunol, 1, 526-532. (SCIE)