Distinguished Professor
Director

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EDUCATION AND POSITIONS HELD:

• B.S., Chemical Engineering, National Tsing-Hua University, Taiwan, 1989
• Ph.D., University of Minnesota,USA, 1999
• Postdoctoral fellow, Salk Institute, 1999-2004
• Assistant Professor, Harvard School of Public Health, 2004-2010
• Associate Professor, Harvard School of Public Health, 2010-2015
• Professor, Harvard School of Public Health, 2015-2023
• Distinguished Professor, Genomics Research Center, Academia Sinica, 2023-present
• Director, Genomics Research Center, Academia Sinica, 2023-present

HONORS:

• The Scientist Development Grant awarded by the American Heart Association, 2006
• The Mentoring Award by the HSPH graduating class of 2011, 2011
• Armen H. Tashjian Jr. Award for Excellence in Endocrine Research, 2012

RESEARCH INTERESTS:

The main research interest of the lab is to understand bioenergetic controls of physiological processes that impact metabolic health. Approaches employed include a variety of tools in molecular/cell biology, biochemistry and metabolomics as well as mouse models of obesity and related metabolic diseases. Current projects, with an emphasis on the crosstalk between metabolic and immune signaling, focus on the following areas:

• Molecular basis of endurance exercise-induced metabolic adaptation
• Mitochondrial dynamics in liver metabolism and feeding/fasting responses
• Circadian/metabolic rhythm and metabolites mediated inter-organ communication
• Mitochondrial bioenergetics in inflammatory activation and resolution of immune cells

SELECTED PUBLICATIONS: