Li, Tsung-Lin 李宗璘

TLLi 6x7研究員
中心副主任


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[ CV ]

 

 

EDUCATION AND POSITIONS HELD:

  • Ph.D., Chemistry, University of Cambridge (UK), 2004
  • Specialist, National Quarantine Service, Department of Health, Executive Yuan, Taipei, Taiwan, 1991.6-1991.12
  • Specialist, Chemistry Division, National Laboratories of Foods & Drugs, Department of Health, Executive Yuan, Taipei, Taiwan, 1991-1995
  • Teaching assistant, Food Science & Technology, The Ohio State University, 1995-1997
  • Specialist, Microbiology Division, National Laboratories of Foods and Drugs, Department of Health, Executive Yuan, Taipei, Taiwan, 1998-2000
  • Associate Research Scientist, University of Cambridge, 2003-2004
  • Postdoctoral Fellow, Genomics Research Center, 2004-2004
  • Assistant Professor, Biotechnology, Food Science, National Taiwan Ocean University, 2004-2007
  • Assistant Professor, Genomics Research Center, Academia Sinica, 2007-2011
  • Adjunct Assistant/Associate/Professor, Biotechnology Center, National Chung Hsing University, 2009-present
  • Adjunct Assistant/Associate/Professor, Marine Biotechnology Center, National Sun Yat-sen University, 2010-present
  • Associate Professor, Genomics Research Center, Academia Sinica, 2011-2019
  • Professor, Genomics Research Center, Academia Sinica, 2019-present
  • Deputy Director, Genomics Research Center, Academia Sinica, 2019-present

HONORS:

  • Investigator Award (Academia Sinica), 2020-2024
  • Career Development Award (Academia Sinica), 2014-2018
  • Career Development Award (National Health Research Institutes), 2012-2015
  • Academia Sinica Significant Research, 2018
  • Academia Sinica Significant Research, 2014
  • Academia Sinica Significant Research, 2011
  • Academia Sinica Major Discovery, 2007
  • Overseas PhD Fellowship (in Chemistry, Ministry of Education, MOE), 1998
  • National Certificate in Hygiene Analysis, Advanced National Senior Civil Service Examination (Examination Yuan), 1998
  • Researcher Award, National Annual Research Award (Executive Yuan), 1997
  • Researcher Award, Annual Research Award (Department of Health), 1996
  • National Certificate in Environmental Hygiene, National Senior Civil Service Examination (Examination Yuan), 1991
  • National Certificate in Dietician Profession (Department of Health), 1991
  • National Certificate in Nutrition, Professionals and Technologists Examination (Examination Yuan), 1991

RESEARCH INTERESTS:

Natural product chemistry

Research in the Li lab encompasses a broad spectrum of natural product chemistry in particular in the scopes of elucidation and manipulation of biosynthetic pathways to vital natural products. Natural product chemistry had its genesis in the study of naturally occurring substances, and this remains intellectual challenge and certainly a constant source of information. Current targets include glycopeptides (mannopeptimycin, enduracidine, A40926, teicoplanin, chloroeremomycin), aminoglycosides (moenomycin, minosaminomycin), and marine toxin (tetrodotoxin).

Microbial pathogenicity

The lab is also involved in a multidisciplinary study for characterizing mechanisms of microbial pathogenicity. The current targeted microbe is Klebsiella pneaumoniae K1, which is the major causative bacterium of hospital-acquired, debilitated and immuno-compromised infections in Taiwan. Its complete genome has been sequenced recently. The overall goal of the program project is to understand the relationship between virulence, CPS (capsular polysaccharide) structure, and biosynthesis of the CPS.

Current Research Targe

Current Research Target

Proposed CPS assembly machinery

Proposed CPS assembly machinery

 

我們的研究工作主要著重於天然產物化學,特別是對於天然產物生合成路徑的闡釋及運用基因工程來發展更具生理效能的藥物。目前研究的重點天然產物包含:醣胜 肽類藥物(glycopeptides: mannopeptimycin, enduracidine, A40926, teicoplanin, chloroeremomycin), 氨基糖類藥物(aminoglycosides: moenomycin, minosaminomycin)及海洋毒素(marine toxins: tetrodotoxin)等。此外,我們也參與探討微生物致病性的群體研究,目前研究重點是針對一株對台灣公共衛生造成潛在威脅的克雷伯氏菌—K1 (Klebsiella Pneumoniae K1),我們正進行此菌表面多醣體分子的成份與結構分析,及其獨特表面多醣體分子的生合成機制與侵入宿主所引發免疫反應等的研究,期以建構克雷伯氏菌的致病模型。

RESEARCH HIGHLIGHTS:

  Li-TL-Research highlight
 Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds

 

  1. Overcoming resistance (The Scientist)
  2. Dbv29 translation (SciBX) 
  3. Building a better germ-killer (A-IMBN) 
  4. 抗生素興亡史 (科學人第112期2011年6月號) 
  5. 李宗璘博士研究團隊以調整酵素方式成功增強現有抗生素藥效 (中央研究院 院新聞稿) 
  6. 巧手調整酵素,李宗璘實驗室以綠化學解除抗藥性窘境 (中央研究院基因體研究中心 新聞) 
  7. 醣胜肽類抗生素生合成酵素之探討 (中央研究院 週報第1125期 知識天地) 
  8. 功能基因體研究群發現關鍵酵素,可解決抗生素失效困境 (中央研究院基因體研究中心 新聞)

SELECTED PUBLICATIONS:

  • B. R. Chen, K. T. Hsu, W. H. Hsu, B. H. Lee, T. L. Li, Y. L. Chan, C. J. Wu*, 2021, “Immunomodulation and mechanisms of fucoidan from Cladosiphon okamuranus ameliorates atopic dermatitis symptoms”, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 189, 537-543. (SCIE)
  • T. S. A. Wang*, R. Y. Wu, Y. Hong, Z. C. Wang, T. L. Li, J. J. Shie, C. C. Hsu,, 2021, “Labeling and characterization of phenol‐containing glycopeptides using chemoselective probes with isotope tags”, CHEMBIOCHEM, 22(14), 2415-2419. (SCIE)
  • Y. M Liu, T. H. Wu, Y. H. Chiu, H. Wang, T. L. Li, S. Hsia, Y. L. Chan*, C. J. Wu*, 2020, “Positive effects of preventive nutrition supplement on anticancer radiotherapy in lung cancer bearing mice”, CANCERS, 12(9), 2445. (SCIE)
  • S. Malek Zadeh, E. Astani, Z. C. Wang, K. Adhikari, R. Rattinam, T. L. Li*, 2020, “Theoretical study of intermolecular interactions between critical residues of membrane protein MraYAA and Promising Antibiotic Muraymycin D2”, ACS OMEGA, 5(36), 22739–22749. (SCIE)
  • K. Adhikari, I. W. Lo, C. L. Chen, Y. L. Wang, K. H. Lin, S. MalekZadeh, R. Rattinam, Y. S. Li, C. J. Wu, T. L. Li*, 2020, “Chemoenzymatic synthesis and biological evaluation for bioactive molecules derived from bacterial benzoyl coenzyme A ligase and plant type III polyketide synthase”, BIOMOLECULES, 10(5), 738. (SCIE)
  • K. H. Lin, S. Y. Lyu, H. W. Yeh, Y. S. Li, N. S. Hsu, C. M. Huang, Y. L. Wang, H. W. Shih, Z. C. Wang, C. J. Wu, T. L. Li*, 2020, “Structural and chemical trapping of short-lived flavin-oxide intermediates reveals substrate-directed reaction multiplicity”, PROTEIN SCIENCE, 29, 1655-1666. (SCIE)
  • T. H. Wu, K. Y. Yeh, C. H. Wang, H. Wang, T. L Li, Y. L. Chan, C. J. Wu*, 2019, “The combination of Astragalus membranaceus and Angelica sinensis inhibits lung cancer and cachexia through its immunomodulatory function”, JOURNAL OF ONCOLOGY, 2019, 9206951. (SCIE)
  • T. H. Huang, T. H. Wu, Y. H. Guo, T. L. Li, Y. L. Chan, C. J. Wu*, 2019, “The concurrent treatment of Scutellaria baicalensis Georgi enhances the therapeutic efficacy of cisplatin but also attenuates chemotherapy-induced cachexia and acute kidney injury”, JOURNAL OF ETHNOPHARMACOLOGY, 243, 112075. (SCIE)
  • Y. M. Liu, Y. L. Chan, T. H. Wu, T. L. Li, S. Hsia, Y. H. Chiu*, C. J. Wu*, 2019, “Antitumor, inhibition of metastasis and radiosensitizing effects of total nutrition formula on Lewis tumor-bearing mice”, NUTRIENTS, 11(8), 1944. (SCIE)
  • S. Y. Lyu, K. H. Lin, H. W. Yeh, Y. S. Li, C. M. Huang, Y. L. Wang, H. W. Shih, N. S. Hsu, C. J. Wu, T. L. Li*, 2019, “The flavin mononucleotide cofactor in α-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate oxidation level”, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 75(10), 918-929.
  • H. W. Yeh, K. H. Lin, S. Y. Lyu, Y. S. Li, C. M. Huang, Y. L. Wang, H. W. Shih, N. S. Hsu, C. J. Wu, T. L. Li*, 2019, “Biochemical and structural explorations for alpha-hydroxyacid oxidases reveal a 4-electron oxidative decarboxylation reaction”, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 75(Pt 8), 733–742.
  • C. M. Huang, S. Y. Lyu, K. H. Lin, C. L. Chen, M. H. Chen, H. W. Shih, N. H. Hsu, I. W. Lo, Y. L. Wang, Y. S. Li, C. J. Wu, T. L. Li*, 2019, “Teicoplanin reprogrammed with the N-Acyl-glucosamine pharmacophore at the penultimate residue of aglycone acquires broad-spectrum antimicrobial activities effectively killing gram-positive and -negative pathogens”, ACS INFECTIOUS DISEASES, 5(3), 430-442. (SCIE)
  • N. S. Hsu, Y. L. Wang, K. H. Lin, C. F. Chang, S. C. Ke, S. Y. Lyu, L. J. Hsu, Y. S. Li, S. C. Chen, K. C. Wang, T. L. Li*, 2018, “Evidence of diradicals involved in the yeast transketolase catalyzed keto-transferring reactions”, CHEMBIOCHEM, 19(22), 2395-2402. (SCIE)
  • N. S. Hsu, Y. L. Wang, K. H. Lin, C. F. Chang, S. Y. Lyu, L. J. Hsu, Y. C. Liu, C. Y. Chang, C. J. Wu, T. L. Li*, 2018, “The mesomeric effect of thiazolium on non-Kekule diradicals in Pichia stipitis transketolase”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 57(7), 1802-1807. (SCIE)
  • Y. W. Chen, C. H. Lee, Y. L. Wang, T. L. Li, and H. C. Chang*, 2017, “Nanodiamonds as nucleating agents for protein crystallization”, LANGMUIR, 33(26), 6521-6527. (SCIE)
  • L. J. Hsu, N. S. Hsu, Y. L. Wang, C. J. Wu, T. L. Li*, 2016, “Structural and biochemical interrogation on transketolase from Pichia stipitis for new functionality”, PROTEIN ENGINEERING DESIGN & SELECTION, 29(11), 513-522. (SCIE)
  • 李宗璘,2016,〈生物技術的工具〉,楊盛行編,《食品生物技術》,頁2-1~2-44,台中市:華格那。
  • H. J. Chai, C. J. Wu, S. H. Yang, T. L. Li, P. B. Sun*, 2016, “Peptides from hydrolysate of lantern fish (Benthosema pterotum) proved neuroprotective in vitro and in vivo”, JOURNAL OF FUNCTIONAL FOODS, 24, 438-449. (SCIE)
  • T. H. Huang, Y. H. Chiu, Y. L. Chan, H. Wang, T. L. Li, Y. Chu, C. Y. Liu, C. T. Yang, T. Y. Lee, J. S. You, K. H. Hsu, C. J. Wu*, 2015, “Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice”, ONCOTARGET, 6(28), 25741-25754.
  • Y. C. Liu, Y. S. Li, S. Y. Lyu, L. J. Hsu, Y. H. Chen, Y. T. Huang, H. C. Chan, C. J. Huang, G. H. Chen, C. C. Chou, M. D. Tsai, T. L. Li*, 2015, “Addendum: Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds”, NATURE CHEMICAL BIOLOGY, 11(5), 361. (SCIE)
  • T. H. Huang, Y. H. Chiu, Y. L. Chan, Y. H. Chiu, H. Wang, K. C. Huang, T. L. Li, K. H. Hsu*, C. J. Wu* , 2015, “Prophylactic administration of fucoidan represses cancer metastasis by inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in Lewis tumor-bearing mice”, MARINE DRUGS, 13, 1882-1900. (SCIE)
  • H. Wang, T. L. Li, S. Hsia, I. L. Su, Y. L. Chan*, C. J. Wu*, 2015, “Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium”, ONCOTARGET, 6(10), 7758-7773.
  • S. Y. Lyu, Y. C. Liu, C. Y. Chang, C. J. Huang, Y. H. Chiu, C. M. Huang, N. S. Hsu, K. H. Lin, C. J. Wu, M. D. Tsai, T. L. Li*, 2014, “Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics effectively killing vancomycin-resistant Enterococcus”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(31), 10989-10995. (SCIE)
  • X. W. Zou, Y. C. Liu, N. S. Hsu, C. J. Huang, S. Y. Lyu, H. C. Chan, C. Y. Chang, H. W. Yeh, K. H. Lin, C. J. Wu, M. D. Tsai, T. L. Li*, 2014, “Structure and mechanism of a non-heme iron-SAM dependent C-methyltransferase and its engineering to hydratase and O-methyltransferase”, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 70(6), 1549-1560.
  • K. C. Wang, S. Y. Lyu, Y. C. Liu, C. Y. Chang, C. J. Wu, T. L. Li*, 2014, “Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple-reaction complexes”, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 70(5), 1401-1410.
  • C. Y. Chang, S. Y. Lyu, Y. C. Liu, N. S. Hsu, C. C. Wu, C. F. Tang, K. H. Lin, J. Y. Ho, C. J. Wu, M. D. Tsai, T. L. Li*, 2014, “Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(7), 1943-1948. (SCIE)
  • C. J. Chai, Y. L. Chan, T. L. Li, Y. K. Tsai, C. H. Wu, C. Y. Shiaua, C. J. Wu*, 2013, “Evaluation of lanternfish (Benthosema pterotum) hydrolysates as antioxidants against hydrogen peroxide induced oxidative injury”, FOOD RESEARCH INTERNATIONAL, 54(2), 1409-1418. (SCIE)
  • H. Wang, Y. L. Chan, T. L. Li, B. A. Bauer, S. Hsia, C. H. Wang, J. S. Huang, H. M. Wang, K. Y. Yeh, T. H. Huang, C. J. Wu*, 2013, “Reduction of splenic immunosuppressive cells and enhancement of anti-tumor immunity by synergy of fish oil and selenium yeast”, PLOS ONE, 8(1), e52912. (SCIE)
  • T. L. Lin, F. L. Yang, A. S. Yang, H. P. Peng, T. L. Li, M. D. Tsai, S. H. Wu, J. T. Wang*, 2012, “Amino acid substitutions of MagA in Klebsiella pneumoniae affect the biosynthesis of the capsular polysaccharide”, PLOS ONE, 7(10), e46783. (SCIE)
  • H. C. Wu, Y. S. Li, Y. C. Liu, S. Y. Lyu, C. J. Wu, T. L. Li*, 2012, “Chain elongation and cyclization in type III PKS DpgA”, CHEMBIOCHEM, 13(6), 862-871. (SCIE)
  • T. L. Li*, Y. C. Liu, S. Y. Lyu, 2012, “Combining biocatalysis and chemoselective chemistries for glycopeptide antibiotics modification”, CURRENT OPINION IN CHEMICAL BIOLOGY, 16, 170-178. (SCIE)
  • S. H. Chen, D. R. Hwang, G. H. Chen, N. S. Hsu, Y. T. Wu, T. L. Li*, C. H. Wong*, 2012, “Engineering transaldolase in Pichia stipitis to improve bioethanol production”, ACS CHEMICAL BIOLOGY, 7(3), 481-486. (SCIE)
  • H. J. Chai, Y. L. Chan, T. L. Li, C. H. Wu, Y. C. Chen, C. Y. Shiau, C. J. Wu*, 2012, “Composition characterization of Myctophids (Benthosema pterotum): antioxidation and safety evaluations for Myctophids protein hydrolysates”, FOOD RESEARCH INTERNATIONAL, 46, 118-126. (SCIE)
  • H. Wang, Y. L. Chan, T. L. Li, C. J. Wu*, 2012, “Improving cachectic symptoms and immune strength of tumor-bearing mice in chemotherapy by a combination of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang”, EUROPEAN JOURNAL OF CANCER, 48, 1074-1084. (SCIE)
  • Y. H. Chiu, Y. L. Chan, T. L. Li, C. J. Wu*, 2012, “Inhibition of Japanese encephalitis virus infection by the sulfated polysaccharide extracts from Ulva lactuca”, MARINE BIOTECHNOLOGY, 14, 468-478.
  • Y. H. Chiu, Y. L. Chan, L. W. Tsai, T. L. Li, C. J. Wu*, 2012, “Prevention of human enterovirus 71 infection by carrageenan”, ANTIVIRAL RESEARCH, 95, 128-134. (SCIE)
  • J. Y. Ho, T. L. Lin, A. Lee, A. N. Cheng, C. Y. Li, M. C. Chen, S. H. Wu, J. T. Wang*, T. L. Li*, M. D. Tsai*, 2011, “Functions of some capsular polysaccharide biosynthetic genes in Klebsiella pneumoniae NTUH K-2044”, PLOS ONE, 6(7), e21664. (SCIE)
  • H. Wang, Y. J. Lai, Y. L. Chan, T. L. Li, C. J. Wu*, 2011, “Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia”, CANCER LETTERS, 305(1):40-49. (SCIE)
  • Y. C. Liu, Y. S. Li, S. Y. Lyu, L. J. Hsu, Y. H. Chen, Y. T. Huang, H. C. Chan, C. J. Huang, G. H. Chen, C. C. Chou, M. D. Tsai, T. L. Li*, 2011, “Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds”, NATURE CHEMICAL BIOLOGY, 7, 304-309. (SCIE)
  • C. J. Wu, H. Wang, Y. L. Chan, T. L. Li, 2011, “Passive immune-protection of small abalone against Vibrio alginolyticus infection by anti-Vibrio IgY-encapsulated feed”, FISH & SHELLFISH IMMUNOLOGY, 30, 1042-1048.
  • H. C. Chan, Y. T. Huang, S. Y. Lyu, C. J. Huang, Y. S. Li, Y. C. Liu, C. C. Chou, M. D. Tsai, and T. L. Li*, 2011, “Regioselective deacetylation based on teicoplanin-complexed Orf2* crystal structures”, MOLECULAR BIOSYSTEMS, 7(4), 1224-1231. (SCIE)
  • H. J. Chai, J. H. Li, H. N. Huang, T. L. Li, Y. L. Chan, C. Y. Shiau, C. J. Wu*, 2010, “Effects of sizes and conformations of fish scale collagen peptides (FSCPs) on facial skin qualities and transdermal penetration efficiency”, J BIOMED BIOTECHNOL, 2010, 757301.
  • Y. T. Huang, S. Y. Lyu, P. H. Chuang, N. S. Hsu, Y. S. Li, H. C. Chan, C. J. Huang, Y. C. Liu, C. J. Wu, W. B. Yang, T. L. Li*, 2009, “In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-b-methylphenylalanine in glycopeptide antibiotic mannopeptimycin”, CHEMBIOCHEM, 10, 2480-2487. (SCIE)
  • H. N. Huang, T. L. Li, Y. L. Chan, C. L. Chen, C. J. Wu*, 2009, “Transdermal immunization with low-pressure-gene-gun mediated chitosan-based DNA vaccines against Japanese encephalitis virus”, BIOMATERIALS, 30(30), 6017-6025. (SCIE)
  • J. Y. Cheng, H. N. Huang, W. C. Tseng, T. L. Li, Y. L. Chan, K. C. Cheng, C. J. Wu*, 2009, “Transcutaneous immunization by lipoplex-patch based DNA vaccines is effective vaccination against Japanese encephalitis virus infection”, J CONTROL RELEASE, 135, 242-249. (SCIE)
  • T. L. Li*, D. Spiteller, J. B. Spencer, 2009, “Identification of a pentaketide stilbene produced by a type III polyketide synthase from Pinus sylvestris and characterisation of free coenzyme A intermediates”, CHEMBIOCHEM, 10, 896-901. (SCIE)
  • 李宗璘,2007,〈生物技術的工具〉,潘崇良編,《食品生物技術》,頁2-1~2-44,台中市:華格那。
  • Y. S. Li, J. Y. Ho, C. C. Huang, S. Y. Lyu, C. Y. Lee, Y. T. Huang, C. J. Wu, H. C. Chan, C. J. Huang, N. S. Hsu, M. D. Tsai and T. L. Li*, 2007, “A unique flavin mononucleotide-linked primary alcohol oxidase for glycopeptide A40926 maturation”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129, 13384-13385. (SCIE)
  • C. J. Wu*, T. L. Li, H. W. Huang, Y. L. Chan and M. H. Tao, 2006, “Development of an effective Japanese encephalitis virus-specific DNA vaccine”, MICROBES AND INFECTION, 8, 2578-2586. (SCIE)
  • J. Y. Ho, Y. T. Huang, C. J. Wu, Y. S. Li, M. D. Tsai and T. L. Li*, 2006, “Glycopeptide Biosynthesis: Dbv21/Orf2* from dbv/tcp Gene Clusters Are N-Ac-Glm Teicoplanin Pseudoaglycone Deacetylases and Orf15 from cep Gene Cluster Is a Glc-1-P Thymidyltransferase”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(42), 13694-13695. (SCIE)
  • F. Huang, S. F. Haydock, D. Spiteller, T. Mironenko, T. L. Li, P. F. Leadlay, D. O'Hagan and J. B. Spencer*, 2006, “The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A.”, CELL CHEMICAL BIOLOGY (CHEMISTRY & BIOLOGY), 13(5), 475-484.
  • T. L. Li, F. Huang, S. F. Haydock*, T. Mironenko, P. F. Leadlay and J. B. Spencer*, 2004, “Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase”, CELL CHEMICAL BIOLOGY (CHEMISTRY & BIOLOGY), 11(1), 107-119.
  • T. L. Li*, Y. J. Chung-Wang and Y. C. Shih, 2002, “Determination and confirmation of chloramphenicol residues in swine muscle and liver”, JOURNAL OF FOOD SCIENCE, 67(1), 21-28. (SCIE)
  • T. L. Li, O. W. Choroba, H. Hong, D. H. Williams and J. B. Spencer*, 2001, “Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine”, CHEMICAL COMMUNICATIONS, 20, 2156-2157. (SCIE)
  • T. L. Li, O. W. Choroba, E. H. Charles, A. M. Sandercock, D. H. Williams and J. B. Spencer*, 2001, “Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics”, CHEMICAL COMMUNICATIONS, -18, 1752-1753. (SCIE)
  • T. L. Li, W. C. Lee*, P. C. Chang and S. S. Chou, 2001, “High performance chromatographic determination of asulam residue in agricultural products”, JOURNAL OF FOOD AND DRUG ANALYSIS, 9(1), 40-44. (SCIE)
  • W. C. Lee, T. L. Li*, P. C. Chang and S. S. Chou, 2001, “High performance liquid chromatographic determination of maleic hydrazide residue in potatoes”, JOURNAL OF FOOD AND DRUG ANALYSIS, 9(3), 167-172. (SCIE)
  • T. L. Li, J. M. King and Y. B. Min*, 2000, “Quenching mechanisms and kinetics of carotenoids in riboflavin photosensitized singlet oxygen oxidation of vitamin D-2”, JOURNAL OF FOOD BIOCHEMISTRY, 24(6), 477-492. (SCIE)
  • D. B. Min*, T. L. Li and H. O. Lee, 1998, “Effects of processing steps on the contents of minor compounds and oxidation of soybean oil”, ADV EXP MED BIOL, 434, 161-180. (SCIE)
  • T. L. Li* and D. B. Min*, 1998, “Stability and photochemistry of vitamin D-2 in model system”, JOURNAL OF FOOD SCIENCE, 63(3), 413-417. (SCIE)
  • W. C. Lee, T. L. Li*, W. J. Cheng, P. C. Chang and S. S. Chou, 1998, “Survey of nicotine and tar yields of domestic and imported cigarettes”, JOURNAL OF FOOD AND DRUG ANALYSIS, 6(4), 691-701. (SCIE)