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Li, Tsung-Lin 李宗璘

TLLi 6x7研究員
中心副主任

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[ CV ]

 

 

EDUCATION AND POSITIONS HELD:

  • Ph.D., Chemistry, University of Cambridge (UK), 2004
  • Specialist, National Quarantine Service, Department of Health, Executive Yuan, Taipei, Taiwan, 1991.6-1991.12
  • Specialist, Chemistry Division, National Laboratories of Foods & Drugs, Department of Health, Executive Yuan, Taipei, Taiwan, 1991-1995
  • Teaching assistant, Food Science & Technology, The Ohio State University, 1995-1997
  • Specialist, Microbiology Division, National Laboratories of Foods and Drugs, Department of Health, Executive Yuan, Taipei, Taiwan, 1998-2000
  • Associate Research Scientist, University of Cambridge, 2003-2004
  • Postdoctoral Fellow, Genomics Research Center, 2004-2004
  • Assistant Professor, Biotechnology, Food Science, National Taiwan Ocean University, 2004-2007
  • Assistant Professor, Genomics Research Center, Academia Sinica, 2007-2011
  • Adjunct Assistant/Associate/Professor, Biotechnology Center, National Chung Hsing University, 2009-present
  • Adjunct Assistant/Associate/Professor, Marine Biotechnology Center, National Sun Yat-sen University, 2010-present
  • Associate Professor, Genomics Research Center, Academia Sinica, 2011-2019
  • Professor, Genomics Research Center, Academia Sinica, 2019-present
  • Deputy Director, Genomics Research Center, Academia Sinica, 2019-present

HONORS:

  • Investigator Award (Academia Sinica), 2020-2024
  • Career Development Award (Academia Sinica), 2014-2018
  • Career Development Award (National Health Research Institutes), 2012-2015
  • Academia Sinica Significant Research, 2018
  • Academia Sinica Significant Research, 2014
  • Academia Sinica Significant Research, 2011
  • Academia Sinica Major Discovery, 2007
  • Overseas PhD Fellowship (in Chemistry, Ministry of Education, MOE), 1998
  • National Certificate in Hygiene Analysis, Advanced National Senior Civil Service Examination (Examination Yuan), 1998
  • Researcher Award, National Annual Research Award (Executive Yuan), 1997
  • Researcher Award, Annual Research Award (Department of Health), 1996
  • National Certificate in Environmental Hygiene, National Senior Civil Service Examination (Examination Yuan), 1991
  • National Certificate in Dietician Profession (Department of Health), 1991
  • National Certificate in Nutrition, Professionals and Technologists Examination (Examination Yuan), 1991

RESEARCH INTERESTS:

Natural product chemistry

Research in the Li lab encompasses a broad spectrum of natural product chemistry in particular in the scopes of elucidation and manipulation of biosynthetic pathways to vital natural products. Natural product chemistry had its genesis in the study of naturally occurring substances, and this remains intellectual challenge and certainly a constant source of information. Current targets include glycopeptides (mannopeptimycin, enduracidine, A40926, teicoplanin, chloroeremomycin), aminoglycosides (moenomycin, minosaminomycin), and marine toxin (tetrodotoxin).

Microbial pathogenicity

The lab is also involved in a multidisciplinary study for characterizing mechanisms of microbial pathogenicity. The current targeted microbe is Klebsiella pneaumoniae K1, which is the major causative bacterium of hospital-acquired, debilitated and immuno-compromised infections in Taiwan. Its complete genome has been sequenced recently. The overall goal of the program project is to understand the relationship between virulence, CPS (capsular polysaccharide) structure, and biosynthesis of the CPS.

Current Research Targe

Current Research Target

Proposed CPS assembly machinery

Proposed CPS assembly machinery

 

我們的研究工作主要著重於天然產物化學，特別是對於天然產物生合成路徑的闡釋及運用基因工程來發展更具生理效能的藥物。目前研究的重點天然產物包含：醣胜 肽類藥物(glycopeptides: mannopeptimycin, enduracidine, A40926, teicoplanin, chloroeremomycin), 氨基糖類藥物(aminoglycosides: moenomycin, minosaminomycin)及海洋毒素(marine toxins: tetrodotoxin)等。此外，我們也參與探討微生物致病性的群體研究，目前研究重點是針對一株對台灣公共衛生造成潛在威脅的克雷伯氏菌—K1 (Klebsiella Pneumoniae K1)，我們正進行此菌表面多醣體分子的成份與結構分析，及其獨特表面多醣體分子的生合成機制與侵入宿主所引發免疫反應等的研究，期以建構克雷伯氏菌的致病模型。

RESEARCH HIGHLIGHTS:

 

 Li TL Research highlight2023
N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry
 Li TL Research highlight
 Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds

 

  1. Overcoming resistance (The Scientist)
  2. Dbv29 translation (SciBX) 
  3. Building a better germ-killer (A-IMBN) 
  4. 抗生素興亡史 (科學人第112期2011年6月號) 
  5. 李宗璘博士研究團隊以調整酵素方式成功增強現有抗生素藥效 (中央研究院 院新聞稿) 
  6. 巧手調整酵素，李宗璘實驗室以綠化學解除抗藥性窘境 (中央研究院基因體研究中心 新聞) 
  7. 醣胜肽類抗生素生合成酵素之探討 (中央研究院 週報第1125期 知識天地) 
  8. 功能基因體研究群發現關鍵酵素，可解決抗生素失效困境 (中央研究院基因體研究中心 新聞)
  9. 轉酮酶解密 發現前所未見的雙自由基中間體 (中央研究院基因體研究中心 新聞)
  10. 大自然為師 解鎖酵素StnK3翻轉生物合成路徑 (中央研究院基因體研究中心 新聞)
  11. 首揭酵素利用蛋白質與受質間氮氧硫鍵橋化學–氨基糖苷類抗生素逆轉勝 (中央研究院基因體研究中心 新聞)

 

SELECTED PUBLICATIONS: