Yang, Hwai-I 楊懷壹

YangHI6x7副研究員
中心副主任


hiyanggateEmail
02-27871308

 

 

EDUCATION AND POSITIONS HELD:

  • Ph.D., Graduate Institute of Epidemiology, School of Public Health, National Taiwan University, Taipei, Taiwan (2006)
  • Postdoctoral Fellow, Genomics Research Center, Academia Sinica, Taipei, Taiwan (2006- 2011)
  • Associate Professor, Graduate Institute of Clinical Medicine, China Medical University, Taichung, Taiwan (2011 - 2013)
  • Associate Research Fellow, Molecular and Genomic Epidemiology Center (MaGEC), China Medical University Hospital, Taichung, Taiwan (2011 - 2013)
  • Associate Professor, Genomics Research Center, Academia Sinica, Taipei, Taiwan (2012 - present)
  • Adjunct Associate Professor, Graduate Institute of Clinical Medicine, National Yang-Ming University (2014 – present)
  • Deputy Director, Genomics Research Center, Academia Sinica (2019-present)

HONORS:

  • Prof. K-P Chen Award for the Best Public Health Paper, Taiwan Public Health Association (2004)
  • Honorary Member, Phi Tau Phi Scholastic Honor Society (2006)
  • Distinguished Postdoctoral Scholar of Academia Sinica (2007-2008)
  • The 20th Wang Ming-Ning Award (2010; as a member of the REVEAL-HBV study group led by Prof. Chien-Jen Chen)
  • Ta-You Wu Memorial Award, National Science Council, Taiwan (2013)
  • The 2013 Award for Outstanding Contributions in Science and Technology, Executive Yuan (2013; co-awardee: Prof. Chien-Jen Chen and Dr. Mei-Hsuan Lee)

RESEARCH INTERESTS:

  • Epidemiology of viral hepatitis: Delineating incidence and determinants (including viral, host, and environmental factors) of milestone transitions and disease progression in the natural history of chronic hepatitis B and C using longitudinal follow-up study.
  • Development of risk prediction scores: Derivation and validation of risk prediction instruments which integrated multiple clinical parameters for the prediction of progression and adverse sequelae of chronic hepatitis B and C.
  • Delineating etiology and Identifying high risk group of liver diseases among populations without chronic viral Hepatitis.
  • Biomarkers for early detection of cancers: Exploring useful multi-omics pre-diagnostic biosignatures for predicting major cancers in order to develop novel tactics in early diagnosis and preventive measures.

我們主要致力於下列研究工作:

  • 病毒性肝炎的自然史及推動其演進的病毒、宿主和環境決定因子
  • 風險預測模式之開發及驗證
  • 沒有慢性肝炎病毒感染人群之肝臟疾病成因和高危險群
  • 癌症的早期偵測生物指標

SELECTED PUBLICATIONS:

  • Hsu YC, Tseng CH, Huang YT, Yang HI, to appear, “Application of Risk Scores for Hepatocellular Carcinoma in Patients with Chronic Hepatitis B: Current Status and Future Perspective.”, Seminars in liver disease. (SCIE)
  • Liu PC, Chan C, Huang YH, Chen YJ, Liao SF, Lin YJ, Huang C, Lu SN, Jen CL, Wang LY, Yang HI, Shen CY, Chen CJ, Lee MH, accepted, “Genetic variants associated with serum alanine aminotransferase levels among patients with hepatitis C virus infection: A genome-wide association study.”, Journal of viral hepatitis. (SCIE)
  • Wu S, Zeng N, Sun F, Zhou J, Wu X, Sun Y, Wang B, Zhan S, Kong Y, Jia J, You H*, Yang HI*, to appear, “HCC prediction models in chronic hepatitis B: a systematic review of 14 models and external validation”, Clinical Gastroenterology and Hepatology : the official clinical practice journal of the American Gastroenterological Association. (SCIE)
  • Liu Z, Huang CJ, Huang YH, Pan MH, Lee MH, Yu KJ, Pfeiffer RM, Viard M, Yuki Y, Gao X, Carrington M, Chen CJ*, Hildesheim A*, Yang HI*, to appear, “HLA zygosity increases risk of hepatitis B virus-associated hepatocellular carcinoma.”, The Journal of infectious diseases. (SCIE)
  • Park J, Le AK, Tseng TC, Yeh ML, Jun DW, Trinh H, Wong GLH, Chen CH, Peng CY, Kim SE, Oh H, Kwak MS, Cheung KS, Toyoda H, Hsu YC, Jeong JY, Yoon EL, Ungtrakul T, Zhang J, Xie Q, Ahn SB, Enomoto M, Shim JJ, Cunningham C, Jeong SW, Cho YK, Ogawa E, Huang R, Lee DH, Takahashi H, Tsai PC, Huang CF, Dai CY, Tseng CH, Yasuda S, Kozuka R, Li J, Wong C, Wong CC, Zhao C, Hoang J, Eguchi Y, Wu C, Tanaka Y, Gane E, Tanwandee T, Cheung R, Yuen MF, Lee HS, Yu ML, Kao JH, Yang HI, Nguyen MH, to appear, “Progression Rates by Age, Sex, Treatment, and Disease Activity by AASLD and EASL Criteria: Data for Precision Medicine.”, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. (SCIE)
  • Li Jie, Yang Hwai-I, Yeh Ming-Lun, Le Michael H, Le An K, Yeo Yee Hui, Dai Chia-Yen, Barnett Scott, Zhang Jian Q, Huang Jee-Fu, Trinh Huy N, Wong Christopher, Wong Clifford, Hoang Joseph K, Cheung Ramsey, Yu Ming-Lung, Nguyen Mindie H, 2021, “Association between fatty liver and cirrhosis, hepatocellular carcinoma, and HBsAg seroclearance in chronic hepatitis B”, The Journal of Infectious Diseases, 224 (2) , 294-302. (SCIE)
  • Pan WC*, Yeh SY, Wu CD, Huang YT, Chen YC, Chen CJ, Yang HI*, 2021, “Association between Traffic Count and Cardiovascular Mortality: A Prospective Cohort Study in Taiwan.”, JOURNAL OF EPIDEMIOLOGY, 31(5), 343-349. (SCIE)
  • Le AK, Yang HI, Yeh ML, Jin M, Trinh HN, Henry L, Liu A, Zhang JQ, Li J, Wong C, Wong C, Cheung R, Yu ML, Nguyen MH, 2021, “Development and validation of a risk score for liver cirrhosis prediction in untreated and treated chronic hepatitis B.”, JOURNAL OF INFECTIOUS DISEASES, 223(1), 139-146. (SCIE)
  • Yang HI*, Hsu YC, 2021, “Editorial: incorporating liver stiffness to risk scores for HCC in patients with chronic hepatitis B treated with oral antivirals: ready to use or not?”, Alimentary pharmacology & therapeutics, 53(6), 753-754. (SCIE)
  • Chen Chien-Jen, You San-Lin, Hsu Wan-Lun, Yang Hwai-I, Lee Mei-Hsuan, Chen Hui-Chi, Chen Yun-Yuan, Liu Jessica, Hu Hui-Han, Lin Yu-Ju, Chu Yu-Ju, Huang Yen-Tsung, Chiang Chun-Ju, Chien Yin-Chu, 2021, “Epidemiology of Virus Infection and Human Cancer”, Recent Results Cancer Res, 217, 13-45.
  • Huang Daniel Q., Li Xiaohe, Le Michael H., Le An K., Yeo Yee Hui, Trinh Huy N., Zhang Jian, Li Jiayi, Wong Christopher, Wong Clifford, Cheung Ramsey C., Yang Hwai-I*, Nguyen Mindie H.*, 2021, “Natural History and Hepatocellular Carcinoma Risk in Untreated Chronic Hepatitis B Patients with Indeterminate Phase”, Clinical Gastroenterology and Hepatology, S1542-3565(21)00069-0, doi: 10.1016/j.cgh.2021.01.019. (SCIE)
  • Tsai TY, Huang MT, Sung PS, Peng CY, Tao MH, Yang HI, Chang WC, Yang AS, Yu CM, Lin YP, Bau CY, Huang CJ, Pan MH, Wu CY, Hsiao CD, Yeh YH, Duan S, Paulson JC, Hsieh SL, 2021, “SIGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection.”, The Journal of clinical investigation, 131(11), e141965. (SCIE)
  • Liu Matt, Tseng Tai-Chung, Jun Dae Won, Yeh Ming-Lun, Trinh Huy, Wong Grace L. H., Chen Chien-Hung, Peng Cheng-Yuan, Kim Sung Eun, Oh Hyunwoo, Kwak Min-Sun, Cheung Michael, Toyoda Hidenori, Hsu Yao-Chun, Jeong Jae Yoon, Yoon Eileen L., Ungtrakul Teerapat, Zhang Jian, Xie Qing, Ahn Sang Bong, Enomoto Masaru, Shim Jae-Jun, Cunningham Chris, Jeong Soung Won, Cho Yong Kyun, Ogawa Eiichi, Huang Rui, Lee Dong-Hyun, Takahashi Hirokazu, Tsai Pei-Chien, Huang Chung-Feng, Dai Chia-Yen, Tseng Cheng-Hao, Yasuda Satoshi, Kozuka Ritsuzo, Li Jiayi, Wong Christopher, Wong Clifford C., Zhao Changqing, Hoang Joseph, Eguchi Yuichiro, Wu Chao, Tanaka Yasuhito, Gane Ed, Tanwandee Tawesak, Cheung Ramsey, Yuen Man-Fung, Lee Hyo-Suk, Yu Ming-Lung, Kao Jia-Horng, Yang Hwai-I, Nguyen Mindie H., 2021, “Transition rates to cirrhosis and liver cancer by age, gender, disease and treatment status in Asian chronic hepatitis B patients”, Hepatology International, 15(1), 71-81. (SCIE)
  • Gao X, Yang HI, Trinh H, Jeong D, Li J, Zhang J, Le A, Hoang J, Nguyen P, Henry L, Nguyen MH, 2020, “Antiviral therapy and hepatocellular carcinoma risk in hepatitis B patients with cirrhosis.”, European Journal of Gastroenterology & Hepatology, 32(9),1207-1211. (SCIE)
  • Wongjarupong N, Yonli AT, Nagalo BM, Djigma FW, Somda SK, Hassan MA, Mohamed EA, Sorgho AP, Compaore TR, Soubeiga ST, Kiendrebeogo I, Sanou M, Diarra B, Yang HI, Chen CJ, Ouattara AK, Zohoncon TM, Martinson JJ, Buetow K, Chamcheu JC, Antwi SO, Borad MJ, Simpore J, Roberts LR, 2020, “Characteristics of Patients With Chronic Hepatitis B Virus Infection With Genotype E Predominance in Burkina Faso”, Hepatology Communications, 4(12), 1781-1792.
  • Petrick JL, Florio AA, Koshiol J, Pfeiffer RM, Yang B, Yu K, Chen CJ, Yang HI, Lee MH, McGlynn KA, 2020, “Prediagnostic concentrations of circulating bile acids and hepatocellular carcinoma risk: REVEAL-HBV and HCV studies.”, INTERNATIONAL JOURNAL OF CANCER, doi: 10.1002/ijc.33051. (SCIE)
  • Yang HI*, Yeh ML, Wong GL, Peng CY, Chen CH, Trinh HN, Cheung KS, Xie Q, Su TH, Kozuka R, Lee DH, Ogawa E, Zhao C, Ning HB, Huang R, Li J, Zhang JQ, Ide T, Xing H, Iwane S, Takahashi H, Wong C, Wong C, Lin CH, Hoang J, le A, Henry L, Toyoda H, Ueno Y, Gane EJ, Eguchi Y, Kurosaki M, Wu C, Liu C, Shang J, Furusyo N, Enomoto M, Kao JH, Yuen MF, Yu ML, Nguyen MH*, 2020, “Real-world Effectiveness from the Asia Pacific Rim Liver Consortium for HBV Risk Score for the Prediction of Hepatocellular Carcinoma in Chronic Hepatitis B Patients Treated with Oral Antiviral Therapy.”, JOURNAL OF INFECTIOUS DISEASES, 221(3):389-399. (SCIE)
  • Hsu YC, Wong GL, Chen CH, Peng CY, Yeh ML, Cheung KS, Toyoda H, Huang CF, Trinh H, Xie Q, Enomoto M, Liu L, Yasuda S, Tanaka Y, Kozuka R, Tsai PC, Huang YT, Wong C, Huang R, Jang TY, Hoang J, Yang HI, Li J, Lee DH, Takahashi H, Zhang JQ, Ogawa E, Zhao C, Liu C, Furusyo N, Eguchi Y, Wong C, Wu C, Kumada T, Yuen MF, Yu ML, Nguyen MH, 2020, “Tenofovir Versus Entecavir for Hepatocellular Carcinoma Prevention in an International Consortium of Chronic Hepatitis B.”, The American Journal of Gastroenterology, 115(2), 271-280. (SCIE)
  • Yoshida K, Desbiolles A, Feldman SF, Ahn SH, Alidjinou EK, Atsukawa M, Bocket L, Brunetto MR, Buti M, Carey I, Caviglia GP, Chen EQ, Cornberg M, Enomoto M, Honda M, Zu Siederdissen CH, Ishigami M, Janssen H, Maasoumy B, Matsui T, Matsumoto A, Nishiguchi S, Riveiro-Barciela M, Takaki A, Tangkijvanich P, Toyoda H, van Campenhout MJ, Wang B, Wei L, Yang HI, Yano Y, Yatsuhashi H, Yuen MF, Tanaka E, Lemoine M, Tanaka Y, Shimakawa Y, 2020, “Assay for Hepatitis B Core-related Antigen Identify Patients With High Viral Load: Systematic Review and Meta-analysis of Individual Participant Data.”, CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 19(1), 46-60.e8. (SCIE)
  • Jackson SS, Adami HO, Andreotti G, Beane-Freeman LE, Berrington de Gonzalez A, Buring JE, Fraser GE, Freedman ND, Gapstur SM, Gierach G, Giles GG, Grodstein F, Hartge P, Jenab M, Kirsh V, Knutsen SF, Lan Q, Larsson SC, Lee IM, Lee MH, Liao LM, Milne RL, Monroe KR, Neuhouser ML, O'Brien KM, Petrick JL, Purdue MP, Rohan TE, Sandin S, Sandler DP, Sawada N, Shadyab AH, Simon TG, Sinha R, Stolzenberg-Solomon R, Tsugane S, Weiderpass E, Wolk A, Yang HI, Zheng W, McGlynn KA, Campbell PT, Koshiol J, 2020, “Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project.”, JOURNAL OF HEPATOLOGY, 73(4), 863-872. (SCIE)
  • Muhammad Irham Lalu, Chou Wan-Hsuan, Wang Yu-Shiuan, Adikusuma Wirawan, Sung-Ching Wong Henry, Aryani Perwitasari Dyah, Huang Wan-Chen, Chen Ben-Kuen*, Yang Hwai-I*, Chang Wei-Chiao*, 2020, “Evaluation for the Genetic Association between Store-Operated Calcium Influx Pathway (STIM1 and ORAI1) and Human Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection”, BIOLOGY, 9(11), 388.
  • Tanaka Yasuhito, , Ogawa Eiichi, Huang Chung-Feng, Toyoda Hidenori, Jun Dae Won, Tseng Cheng-Hao, Hsu Yao-Chun, Enomoto Masaru, Takahashi Hirokazu, Furusyo Norihiro, Yeh Ming-Lun, Iio Etsuko, Yasuda Satoshi, Lam Carla Pui-Mei, Lee Dong Hyun, Haga Hiroaki, Yoon Eileen L., Ahn Sang Bong, Wong Grace, Nakamuta Makoto, Nomura Hideyuki, Tsai Pei-Chien, Jung Jang Han, Song Do Seon, Dang Hansen, Maeda Mayumi, Henry Linda, Cheung Ramsey, Yuen Man-Fung, Ueno Yoshiyuki, Eguchi Yuichiro, Tamori Akihiro, Yu Ming-Lung, Hayashi Jun, Nguyen Mindie H., 2020, “HCC risk post-SVR with DAAs in East Asians: findings from the REAL-C cohort”, Hepatology International, 14(6), 1023-1033. (SCIE)
  • Yeo Yee Hui, Tseng Tai-Chung, Hosaka Tetsuya, Cunningham Chris, Fung James Yan Yue, Ho Hsiu J., Kwak Min-Sun, Trinh Huy N., Ungtrakul Teerapat, Yu Ming-Lung, Kobayashi Mariko, Le An K., Henry Linda, Li Jiayi, Zhang Jian, Sriprayoon Tassanee, Jeong Donghak, Tanwandee Tawesak, Gane Ed, Cheung Ramsey C., Wu Chun-Ying, Lok Anna S., Lee Hyo-Suk, Suzuki Fumitaka, Yuen Man-Fung, Kao Jia-Horng, Yang Hwai-I, Nguyen Mindie H., 2020, “Incidence, Factors, and Patient-Level Data for Spontaneous HBsAg Seroclearance: A Cohort Study of 11,264 Patients”, Clinical and Translational Gastroenterology, 11(9), e00196. (SCIE)
  • Liu Zhiwei, Derkach Andriy, Yu Kelly J., Yeager Meredith, Chang Yu-Sun, Chen Chien-Jen, Gyllensten Ulf, Lan Qing, Lee Mei-Hsuan, McKay James D., Rothman Nathaniel, Yang Hwai-I, Hildesheim Allan, Pfeiffer Ruth M., 2020, “Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer”, Cancer Research, 81(4), 1148-1152. (SCIE)
  • Polaris Observatory Collaborators, 2020, “The case for simplifying and using absolute targets for viral hepatitis elimination goals”, Journal of Viral Hepatitis, 28(1), 12-19. (SCIE)
  • Liu J, Hu HH, Chang CL, Jen CL, Lee MH, Lu SN, Wang LY, Yuan Q, Xia NS, Sugiyama M, Nishida N, Mizokami M, Chen CJ, Chen PJ, Yang HI*, 2019, “Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B e Antigen in Individuals With Chronic Hepatitis B Virus Infection.”, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 17(7):1413-1415. (SCIE)
  • Kong Y, Jia J, Yang HI*, 2019, “Lower Risk of Hepatocellular Carcinoma With Tenofovir vs Entecavir in Patients With Chronic Hepatitis B.”, JAMA oncology, 5(6):915-916. (SCIE)
  • Lin SH, Huang YT, Yang HI, 2019, “On identification of agonistic interaction: Hepatitis B and C interaction on hepatocellular carcinoma.”, Statistics in medicine, 38(13),2467-2476. (SCIE)
  • Peng HY, Chang MC, Hu CM, Yang HI, Lee WH, Chang YT, 2019, “Thrombospondin-2 is a Highly Specific Diagnostic Marker and is Associated with Prognosis in Pancreatic Cancer.”, Annals of surgical oncology, 26(3),807-814. (SCIE)
  • Yeo YH, Ho HJ, Yang HI, Tseng TC, Hosaka T, Trinh HN, Kwak MS, Park YM, Fung JYY, Buti M, Rodriguez M, Treeprasertsuk S, Preda CM, Ungtrakul T, Charatcharoenwitthaya P, Li X, Li J, Zhang J, Le MH, Wei B, Zou B, Le A, Jeong D, Chien N, Kam L, Lee CC, Riveiro-Barciela M, Istratescu D, Sriprayoon T, Chong Y, Tanwandee T, Kobayashi M, Suzuki F, Yuen MF, Lee HS, Kao JH, Lok AS, Wu CY, Nguyen MH, 2019, “Factors Associated with Rates of HBsAg Seroclearance in Adults with Chronic HBV Infection: A systematic review and meta-analysis.”, Gastroenterology, 156(3):635-646. (SCIE)
  • Hu HH, Liu J, Chang CL, Jen CL, Lee MH, Lu SN, Wang LY, Quan Y, Xia NS, Chen CJ, Chen PJ*, Yang HI*, 2019, “Level of hepatitis B (HB) core antibody associates with seroclearance of HBV DNA and HB surface antigen in HB e antigen-seronegative patients.”, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 17(1):172-181. (SCIE)
  • Nguyen MH, Yang HI, Le A, Henry L, Nguyen N, Lee MH, Zhang J, Wong C, Wong C, Trinh H, 2019, “Reduced Incidence of Hepatocellular Carcinoma with Tenofovir in Chronic Hepatitis B Patients with and without Cirrhosis - a Propensity Score Matched Study.”, The Journal of infectious diseases, 219(1):10-18. (SCIE)
  • Chien RN, Kao JH, Peng CY, Chen CH, Liu CJ, Huang YH, Hu TH, Yang HI, Lu SN, Ni YH, Chuang WL, Lee CM, Wu JC, Chen PJ, Liaw YF, 2019, “Taiwan consensus statement on the management of chronic hepatitis B.”, JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 118(1):7-38. (SCIE)
  • Wen YH, Yang HI, Chou HC, Chen CY, Hsieh WS, Tsou KI, Tsao PN, 2019, “Association of Maternal Preeclampsia with Neonatal Respiratory Distress Syndrome in Very-Low-Birth-Weight Infants.”, Scientific reports, 9(1), 13212. (SCIE)
  • Huang CF, Iio E, Jun DW, Ogawa E, Toyoda H, Hsu YC, Haga H, Iwane S, Enomoto M, Lee DH, Wong G, Liu CH, Tada T, Chuang WL, Cheung R, Hayashi J, Tseng CH, Yasuda S, Tran S, Kam L, Henry L, Jeong JY, Nomura H, Park SH, Nakamuta M, Huang JF, Tai CM, Lo GH, Lee MH, Yang HI, Kao JH, Tamori A, Eguchi Y, Ueno Y, Furusyo N, Tanaka Y, Yu ML, Nguyen MH, 2019, “Direct-acting antivirals in East Asian hepatitis C patients: real-world experience from the REAL-C Consortium.”, Hepatology international, 13(5), 587-598. (SCIE)
  • Jeng WJ, Yang HI*, 2019, “Discrepant range of sPD-1 in different studies of chronic hepatitis B. A letter in response to Soluble programmed death-1 is a useful indicator for inflammatory and fibrosis severity in chronic hepatitis B.”, Journal of viral hepatitis, 26(7), 930. (SCIE)
  • Ogawa E, Toyoda H, Iio E, Jun DW, Huang CF, Enomoto M, Hsu YC, Haga H, Iwane S, Wong G, Lee DH, Tada T, Liu CH, Chuang WL, Hayashi J, Cheung R, Yasuda S, Tseng CH, Takahashi H, Tran S, Yeo YH, Henry L, Barnett SD, Nomura H, Nakamuta M, Dai CY, Huang JF, Yang HI, Lee MH, Jung Jun M, Kao JH, Eguchi Y, Ueno Y, Tamori A, Furusyo N, Yu ML, Tanaka Y, Nguyen MH, Ahn SB, Azuma K, Dohmen K, Yoon Jeong J, Jung JH, Kajiwara E, Kato M, Kawano A, Koyanagi T, Ooho A, Park SH, Satoh T, Shimoda S, Song DS, Takahashi K, Yeh ML, Yoon EL, 2019, “HCV Cure Rates are Reduced in Patients with Active but not Inactive Hepatocellular Carcinoma- A Practice Implication.”, Clinical Infectious Diseases, 71(11), 2840-2848. (SCIE)
  • Teng W, Jeng WJ, Yang HI, Chen WT, Hsieh YC, Huang CH, Lin CC, Lin CY, Lin SM, Sheen IS, 2019, “Interferon Is Superior to Direct Acting Antiviral Therapy in Tertiary Prevention of Early Recurrence of Hepatocellular Carcinoma.”, Cancers, 12(1), 23. (SCIE)
  • Irham LM, Wong HS, Perwitasari DA, Chou WH, Yang HI*, Chang WC*, 2019, “Single-nucleotide polymorphism of rs7944135 (macrophage-expressed gene 1) is associated with hepatitis B surface antigen seroclearance in chronic hepatitis B infection: A cohort study.”, Medicine, 98(51), e17936. (SCIE)
  • Hsu YC, Wong GL, Chen CH, Peng CY, Yeh ML, Cheung KS, Toyoda H, Huang CF, Trinh H, Xie Q, Enomoto M, Liu L, Yasuda S, Tanaka Y, Kozuka R, Tsai PC, Huang YT, Wong C, Huang R, Jang TY, Hoang J, Yang HI, Li J, Lee DH, Takahashi H, Zhang JQ, Ogawa E, Zhao C, Liu C, Furusyo N, Eguchi Y, Wong C, Wu C, Kumada T, Yuen MF, Yu ML, Nguyen MH, 2019, “Tenofovir Versus Entecavir for Hepatocellular Carcinoma Prevention in an International Consortium of Chronic Hepatitis B.”, The American journal of gastroenterology, 115(2), 271-280. (SCIE)
  • Liu SY, Yang HI, Chen CY, Chou HC, Hsieh WS, Tsou KI, Tsao PN, 2019, “The gestational effect of antenatal corticosteroids on respiratory distress syndrome in very low birth weight infants: A population-based study.”, Journal of the Formosan Medical Association, 119(8), 1267-1273. (SCIE)
  • Tsai TY, Peng CY, Yang HI, Huang YL, Tao MH, Yuan SS, Lai HC, Hsieh SL, 2018, “The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection.”, Journal of biomedical science, 25,59. (SCIE)
  • Lin YJ, Chang CL, Chen LC, Hu HH, Liu J, Korenaga M, Huang YH, Jen CL, Su CY, Nishida N, Sugiyama M, Lu SN, Wang LY, Yuan Y, L'Italien G, Yang HI, Mizokami M, Chen CJ, Lee MH, 2018, “A Glycomarker for Short-term Prediction of Hepatocellular Carcinoma: A Longitudinal Study With Serial Measurements.”, Clinical and translational gastroenterology, 9(9), 183. (SCIE)
  • Shih S, Huang YT, Yang HI, 2018, “A multiple mediator analysis approach to quantify the effects of the ADH1B and ALDH2 genes on hepatocellular carcinoma risk.”, Genetic epidemiology, 42(2), 394-404. (SCIE)
  • Chu YJ, Yang HI, Wu HC, Lee MH, Liu J, Wang LY, Lu SN, Jen CL, You SL, Santella RM, Chen CJ, 2018, “Aflatoxin B1 exposure increases the risk of hepatocellular carcinoma associated with hepatitis C virus infection or alcohol consumption.”, EUROPEAN JOURNAL OF CANCER, 94, 37-46. (SCIE)
  • O'Brien TR, Yang HI, Groover S, Jeng WJ, 2018, “Genetic Factors That Affect Spontaneous Clearance of Hepatitis C or B Virus, Response to Treatment, and Disease Progression.”, Gastroenterology, 156(2)(SI), 400-417. (SCIE)
  • Polaris Observatory Collaborators, 2018, “Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study.”, The Lancet Gastroenterology & Hepatology, 3(6), 383-403. (SCIE)
  • Lai TS, Lee MH, Yang HI, You SL, Lu SN, Wang LY, Yuan Y, L'Italien G, Chien KL, Chen CJ, 2017, “Hepatitis C Viral Load, Genotype, and Increased Risk of Developing End-stage Renal Disease: REVEAL-HCV Study.”, HEPATOLOGY, 66(3), 784-793. (SCIE)
  • Huang CF, Yeh ML, Huang CI, Lin YJ, Tsai PC, Lin ZY, Chan SY, Chen SC, Yang HI, Huang JF, Lu SN, Dai CY, Jen CL, Yuan Y, L'Italien G, Wang LY, Lee MH, Yu ML, Chuang WL, Chen CJ, 2017, “Risk of hepatitis C virus related hepatocellular carcinoma between subjects with spontaneous and treatment-induced viral clearance.”, Oncotarget, 8(27), 43925-43933.
  • Chu YJ, Yang HI, Wu HC, Liu J, Wang LY, Lu SN, Lee MH, Jen CL, You SL, Santella RM, Chen CJ, 2017, “Aflatoxin B1 exposure increases the risk of cirrhosis and hepatocellular carcinoma in chronic hepatitis B virus carriers.”, International journal of cancer, 141(4), 711-720. (SCIE)
  • Huang YT, Yang HI, 2017, “Causal Mediation Analysis of Survival Outcome with Multiple Mediators.”, EPIDEMIOLOGY, 28(3), 370-378. (SCIE, SSCI) (IF: 5.071; SCI ranking: 8.3%; SSCI ranking: 4.7%)
  • Lee MH, Huang CF, Lai HC, Lin CY, Dai CY, Liu CJ, Wang JH, Huang JF, Su WP, Yang HC, Kee KM, Yeh ML, Chuang PH, Hsu SJ, Huang CI, Kao JT, Chen CC, Chen SH, Jeng WJ, Yang HI, Yuan Y, Lu SN, Sheen IS, Liu CH, Peng CY, Kao JH, Yu ML, Chuang WL, Chen CJ, 2017, “Clinical Efficacy and Post-Treatment Seromarkers Associated with the Risk of Hepatocellular Carcinoma among Chronic Hepatitis C Patients.”, Scientific reports, 7(1), 3718. (SCIE)
  • Choijilsuren G, Jhou RS, Chou SF, Chang CJ, Yang HI, Chen YY, Chuang WL, Yu ML, Shih C, 2017, “Heparin at physiological concentration can enhance PEG-free in vitro infection with human hepatitis B virus.”, Scientific reports, 7(1), 14461. (SCIE)
  • Lai TS, Lee MH, Yang HI, You SL, Lu SN, Wang LY, Yuan Y, L'Italien G, Chien KL, Chen CJ, 2017, “High hepatitis C viral load and genotype 2 are strong predictors of chronic kidney disease.”, Kidney international, 92(3), 703-709. (SCIE)
  • Lee MH, Huang YH, Chen HY, Khor CS, Chang YH, Lin YJ, Jen CL, Lu SN, Yang HI, Nishida N, Sugiyama M, Mizokami M, Yuan Y, L'Italien G, Tokunaga K, Chen CJ, 2017, “Human Leukocyte Antigen Variants and Risk of Hepatocellular Carcinoma Modified by HCV Genotypes: A Genome-wide Association Study.”, HEPATOLOGY, 67(2), 651-661. (SCIE)
  • Lin D, Yang HI*, Hoang J, Nguyen MH*, 2017, “Letter: reduction in chronic hepatitis B-related hepatocellular carcinoma with anti-viral therapy, including low-risk patients - more questions than answers. Authors' reply.”, Alimentary pharmacology & therapeutics, 45(1), 186-187. (SCIE)
  • Lin D, Yang HI*, Hoang J, Nguyen MH*, 2017, “Letter: should anti-viral therapy be recommended for individuals chronically infected with hepatitis B virus and at low risk of hepatocellular carcinoma? Authors' reply.”, Alimentary pharmacology & therapeutics, 45(1), 182-183. (SCIE)
  • Wu HC, Yang HI, Wang Q, Chen CJ, Santella RM, 2017, “Plasma DNA methylation marker and hepatocellular carcinoma risk prediction model for the general population.”, Carcinogenesis, 38(10), 1021-1028. (SCIE)
  • Huang YW, Yang HI, Wu YT, Hsu TL, Lin TW, Kelly JW, Wong CH, 2017, “Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency.”, Journal of the American Chemical Society, 139(37), 12947-12955. (SCIE)
  • Pan WC, Yang HI*, 2017, “Response to RE: Fine Particle Pollution, Alanine Transaminase, and Liver Cancer: A Taiwanese Prospective Cohort Study (REVEAL-HBV)”, JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 109(1), djw185. (SCIE)
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  • Hu HH, Liu J, Lin YL, Luo WS, Chu YJ, Chang CL, Jen CL, Lee MH, Lu SN, Wang LY, You SL, Yang HI*, Chen CJ, 2016, “The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B.”, Gut, 65, 1514-1521. (SCIE)
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  • Liu J, Tseng TC, Yang HI, Lee MH, Batrla-Utermann R, Jen CL, Lu SN, Wang LY, You SL, Chen PJ, Chen CJ, Kao JH, 2015, “Predicting Hepatitis B Virus (HBV) Surface Antigen Seroclearance in HBV e Antigen-Negative Patients With Chronic Hepatitis B: External Validation of a Scoring System.”, The Journal of infectious diseases, 211(10), 1566-1573. (SCIE)
  • Chen HY, Yu SL, Ho BC, Su KY, Hsu YC, Chang CS, Li YC, Yang SY, Hsu PY, Ho H, Chang YH, Chen CY, Yang HI, Hsu CP, Yang TY, Chen KC, Hsu KH, Tseng JS, Hsia JY, Chuang CY, Yuan S, Lee MH, Liu CH, Wu GI, Hsiung CA, Chen YM, Wang CL, Huang MS, Yu CJ, Chen KY, Tsai YH, Su WC, Chen HW, Chen JJ, Chen CJ, Chang GC, Yang PC, Li KC, 2015, “R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability.”, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(20), 2303-2310. (SCIE)
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  • Chen CL, Yang WS, Yang HI, Chen CF, You SL, Wang LY, Lu SN, Liu CJ, Kao JH, Chen PJ, Chen DS, Chen CJ, 2014, “Plasma adipokines and risk of hepatocellular carcinoma in chronic hepatitis B virus infected carriers: a prospective study in Taiwan.”, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 23(8), 1659-1671. (SCIE)
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  • Liu J, Yang HI, Lee MH, Lu SN, Jen CL, Batrla-Utermann R, Wang LY, You SL, Hsiao CK, Chen PJ, Chen CJ, 2014, “Spontaneous seroclearance of hepatitis B seromarkers and subsequent risk of hepatocellular carcinoma.”, Gut, 63(10), 1648-1657. (SCIE)
  • Liu J, Lee MH, Batrla-Utermann R, Jen CL, Iloeje UH, Lu SN, Wang LY, You SL, Hsiao CK, Yang HI, Chen CJ, 2013, “A predictive scoring system for the seroclearance of HBsAg in HBeAg-seronegative chronic hepatitis B patients with genotype B or C infection.”, JOURNAL OF HEPATOLOGY, 58(5), 853-860. (SCIE)
  • Loomba R, Yang HI, Chen CJ, 2013, “Author reply.”, American journal of epidemiology, 178(6), 1011-1012. (SCIE)
  • Wu HC, Wang Q, Yang HI, Tsai WY, Chen CJ, Santella RM, 2013, “Global DNA methylation in a population with aflatoxin B1 exposure.”, Epigenetics, 8(9), 962-969. (SCIE)
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  • Lin YJ, Lee MH, Yang HI, Jen CL, You SL, Wang LY, Lu SN, Liu J, Chen CJ, 2013, “Predictability of liver-related seromarkers for the risk of hepatocellular carcinoma in chronic hepatitis B patients.”, PLoS One, 8(4), e61448. (SCIE)
  • Lee MH, Yang HI, Liu J, Batrla-Utermann R, Jen CL, Iloeje UH, Lu SN, You SL, Wang LY, Chen CJ, 2013, “Prediction models of long-term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles.”, HEPATOLOGY, 58(2), 546-554. (SCIE)
  • Yen TA, Yang HI, Hsieh WS, Chou HC, Chen CY, Tsou KI, Tsao PN, 2013, “Preeclampsia and the Risk of Bronchopulmonary Dysplasia in VLBW Infants: A Population Based Study.”, PloS one, 8(9), e75168. (SCIE)
  • Lin PH, Lin CC, Yang HI, Li LY, Bai LY, Chiu CF, Liao YM, Lin CY, Hsieh CY, Lin CY, Ho CM, Yang SF, Peng CT, Tsai FJ, Yeh SP, 2013, “Prognostic impact of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with internal tandem duplication of FLT3.”, LEUKEMIA RESEARCH, 37(3), 287-292. (SCIE)
  • Loomba R*, Yang HI*, Su J, Brenner D, Barrett-Connor E, Iloeje U, Chen CJ, 2013, “Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study.”, AMERICAN JOURNAL OF EPIDEMIOLOGY, 177(4), 333-342. (SCIE)
  • Loomba R*, Liu J, Yang HI*, Lee MH, Lu SN, Wang LY, Iloeje UH, You SL, Brenner D, Chen CJ, 2013, “Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma.”, CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 11(12), 1636-1645.e1-3. (SCIE)
  • Lee MH, Yang HI, Lu SN, Jen CL, You SL, Wang LY, Wang CH, Chen WJ, Chen CJ, 2012, “Chronic hepatitis C virus infection increases mortality from hepatic and extrahepatic diseases: a community-based long-term prospective study.”, JOURNAL OF INFECTIOUS DISEASES, 206(4), 469-477. (SCIE)
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  • Wu HC, Wang Q, Yang HI, Tsai WY, Chen CJ, Santella RM, 2012, “Global DNA methylation levels in white blood cells as a biomarker for hepatocellular carcinoma risk: a nested case-control study.”, CARCINOGENESIS, 33(7), 1340-1345. (SCIE)
  • Yang HI*, Hung HL, Lee MH, Liu J, Jen CL, Su J, Wang LY, Lu SN, You SL, Iloeje UH, Chen CJ, 2012, “Incidence and determinants of spontaneous seroclearance of hepatitis B e antigen and DNA in patients with chronic hepatitis B.”, CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 10(5), 527-534. (SCIE)
  • Huang HC, Yang HI, Chang YH, Chang RJ, Chen MH, Chen CY, Chou HC, Hsieh WS, Tsao PN, 2012, “Model to predict hyperbilirubinemia in healthy term and near-term newborns with exclusive breast feeding.”, Pediatrics and Neonatology, 53(6), 354-358. (SCIE)
  • Iloeje UH, Yang HI*, Chen CJ, 2012, “Natural history of chronic hepatitis B: what exactly has REVEAL revealed?”, LIVER INTERNATIONAL, 32(9), 1333-1341. (SCIE)
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  • Wei SC, Ni YH, Yang HI, Su YN, Chang MC, Chang YT, Shieh MJ, Wang CY, Wong JM, 2011, “A hospital-based study of clinical and genetic features of Crohn's disease.”, JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 110(9), 600-606. (SCIE)
  • Chen CF, Lee WC, Yang HI, Chang HC, Jen CL, Iloeje UH, Su J, Hsiao CK, Wang LY, You SL, Lu SN, Chen CJ, 2011, “Changes in serum levels of HBV DNA and alanine aminotransferase determine risk for hepatocellular carcinoma.”, GASTROENTEROLOGY, 141(4), 1240-1248.e2. (SCIE)
  • Lee MH, Yang HI, Jen CL, Lu SN, Yeh SH, Liu CJ, You SL, Sun CA, Wang LY, Chen WJ, Chen CJ, 2011, “Community and personal risk factors for hepatitis C virus infection: a survey of 23,820 residents in Taiwan in 1991-2.”, GUT, 60(5), 688-694. (SCIE)
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  • Chen JD, Yang HI, Iloeje UH, You SL, Lu SN, Wang LY, Su J, Sun CA, Liaw YF, Chen CJ, 2010, “Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death.”, GASTROENTEROLOGY, 138(5), 1747-1754. (SCIE)
  • Wang CH, Chen CJ, Lee MH, Yang HI, Hsiao CK, 2010, “Chronic hepatitis B infection and risk of atherosclerosis-related mortality: A 17-year follow-up study based on 22,472 residents in Taiwan.”, ATHEROSCLEROSIS, 211(2), 624-629. (SCIE)
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  • Iloeje UH, Yang HI, Jen CL, Su J, Wang LY, You SL, Lu SN, Chen CJ, 2010, “Risk of pancreatic cancer in chronic hepatitis B virus infection: data from the REVEAL-HBV cohort study.”, LIVER INTERNATIONAL, 30(3), 423-429. (SCIE)
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  • Yang HI, Yeh SH, Chen PJ, Iloeje UH, Jen CL, Su J, Wang LY, Lu SN, You SL, Chen DS, Liaw YF, Chen CJ, 2008, “Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma.”, JNCI-Journal of the National Cancer Institute, 100(16), 1134-1143. (SCIE)
  • Chen CL, Yang HI, Yang WS, Liu CJ, Chen PJ, You SL, Wang LY, Sun CA, Lu SN, Chen DS, Chen CJ, 2008, “Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan.”, GASTROENTEROLOGY, 135(1), 111-121. (SCIE)
  • Wu HC, Wang Q, Yang HI, Ahsan H, Tsai WY, Wang LY, Chen SY, Chen CJ, Santella RM, 2008, “Urinary 15-F2t-isoprostane, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan.”, CARCINOGENESIS, 29(5), 971-976. (SCIE)
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  • Zhang YJ, Wu HC, Shen J, Ahsan H, Tsai WY, Yang HI, Wang LY, Chen SY, Chen CJ, Santella RM, 2007, “Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA.”, CLINICAL CANCER RESEARCH, 13(8), 2378-2384. (SCIE)
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  • Wu HC, Wang Q, Wang LW, Yang HI, Ahsan H, Tsai WY, Wang LY, Chen SY, Chen CJ, Santella RM, 2007, “Urinary 8-oxodeoxyguanosine, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan.”, CARCINOGENESIS, 28(5), 995-999. (SCIE)
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