Shen, Chia-Ning 沈家寧

ShenCN 6x7 研究員

cnshen

02-2787-1220

[ CV ]

EDUCATION AND POSITIONS HELD:

Ph.D., Developmental Biology Program, University of Bath, 2002
Postdoctoral Fellow, Centre For Regenerative Medicine, University of Bath, 2002-2004
Assistant Professor, Genomics Research Center, Academia Sinica, 2004-2012
Associate Professor, Genomics Research Center, Academia Sinica, 2012-2022
Deputy Director and Associate Research Fellow, Genomics Research Center, Academia Sinica, 2013-2019
Acting Division Director of Biotechnology Incubation Center, Genomics Research Center, Academia Sinica, 2018-2021
Acting Chief Executive Officer, Innovation & Incubation Center, Biomedical Translation Research Center, Academia Sinica, Taiwan, 2019-2022
Professor, Genomics Research Center, Academia Sinica, 2022-present

HONORS:

ORS Award, Committee of Vice-chancellors and Principals of Universities of United Kingdom, 1999-2002
Conference Scholarship of International Federation of Cell Biology, 2000
Entrant of Santa Cruz Investigator Award, 2001
Conference Scholarship of British Society of Developmental Biology, 2000, 2001
Conference Scholarship of International Society of Differentiation, 2002
Travel award of Japan Society for the promotion of science for attending NPG Nature Asia-Pacific network meeting, 2007
Academia Sinica Significant Research Achievements, 2010
Travel award of International Society of Stem Cell Research, 2012
Rotary International Presidential Charity Award 2014-2015
Keystone Symposia Best Poster Prize (Regenerative Biology and Applications), 2017

RESEARCH INTERESTS:

Dr. Chia-Ning Shen is currently a research fellow in the Genomics Research Center, Academia Sinica, Taiwan. Dr. Shen earned his PhD from Developmental Biology Program, Department of Biology and Biochemistry, University of Bath, United Kingdom in 2002. From 2002 to 2004, Dr. Shen worked as a research officer in the Centre for Regenerative Medicine in University of Bath. Dr. Shen came back to Taiwan and joined the Genomics Research Center of Academia Sinica in the summer of 2004. Dr. Shen's research interest primarily focuses on two fields, cancer stem cells and regenerative medicine. He currently focuses on investigating mechanisms involved in naturally occurring somatic cell reprogramming. Based dissecting the basis of cell differentiation and transdifferentiation, Dr. Shen aims to develop methodologies to trigger tissue regeneration and to identify the initial factors for neoplastic transformation in somatic cells. As of today, Dr. Shen has published over 90 articles in world-renowned journals which have been cited for more than 3300 times.

Dr. Shen had spared time to attend several training courses. For example, in 2008, he has completed the course program in legal studies in National Taiwan University. In 2012, he also attended the international training program of Multidisciplinary Management of Technology in National Cheng-Chi University. Aside from conducting research, Dr. Shen has also been responsible for coordinating academic activities and overseeing administrative work at the Genomics Research Center as the Deputy Director from 2013 to 2019. He has also served as Acting Division Director of Biotechnology Incubation Center in the Genomics Research Center for incubating biotechnology companies that licensed technologies from Academia Sinica. Dr. Shen was involved in the establishment of Taiwan Society for stem cell research (TSSCR) in 2005 aiming at providing opportunities for close interactions among stem cell researchers in Taiwan. Dr. Shen has been served as TSSCR president from 2017 to 2021. TSSCR cooperates with the government to implement relevant cell therapy legislation and policies, and jointly establish a cell therapy physician training course with Taiwan Association for Cell Therapy (TACT) and Formosa Association for Regenerative Medicine (FARM).Currently, Dr. Shen is a chief PI managing the core facilities for translational medicine at National Biotechnology Research Park. Dr. Shen joined Biomedical Translation Research Center in September 2019 as Acting CEO of BioHub Taiwan (Innovation & Incubation Center, Biomedical Translation Research Center) to aid to incubate biotech startups at National Biotechnology Research Park.

沈家寧博士致力於幹細胞及再生醫學兩大研究領域，透過研究體細胞重新編程的機轉，探討細胞分化及轉化的關鍵機制，以發展組織再生的方法及發現細胞轉化瘤變的早期起始因素，研究至今共計發表90篇期刊論文並被引用近3300次。沈博士主要研究體細胞重新編程，除可找尋細胞分化的關鍵，並進而可解構組織修復的機制外，亦可應用於解析疾病產生過程及細胞轉化原因。

主要的研究方向包括：
(1)利用體細胞重新編程技術，發展糖尿病細胞治療策略；
(2)應用病患誘導性多能幹細胞解構代謝疾病機轉，開發調控血糖之新穎藥物；
(3) 結合三維組織影像技術及解析胰臟腫瘤幹細胞的代謝體重編程特性，進行胰腺組織瘤變轉化機制探索；
(4) 結合基因及細胞治療技術，開發胰臟癌治療策略。

除了研究工作，沈博士利用公餘時間進入台灣大學法律學分班及政治大學科管與智財研究所之「跨領域產業創新科技管理與智財運用人才培訓班」進修，並且參與多項學術服務並擔任行政主管。沈博士曾擔任基因體研究中心副主任並代理生技育成專題中心執行長，負責統整協調中心內學術行政及育成等事務；此外，沈博士曾參與臺灣幹細胞學會創建並擔任首任秘書長，建構以促進幹細胞研究之發展並強化幹細胞研究交流平台；並曾在2017年至2021擔任臺灣幹細胞學會理事長，目前為常務監事並同時在台灣細胞醫療協會擔任常務理事及再生醫學學會但任理事，參與推行相關細胞治療之立法及政策，並規劃開設細胞治療醫師訓練課程。沈博士從2019年1月起主持生醫轉譯核心共儀設施，建構核心共儀多項關鍵技術平台，以服務進駐國家生技研究園區研究團隊、育成產業及國內外學研及生技研發單位醫藥產業。從2019年9月起代理中研院生醫轉譯研究中心創服育成中心的執行長，協助國家生技研究園區創服育成業務執行，培育台灣生技新創產業。

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