Lin, Su-Chang 林世昌

LinSC 6x7副研究員

[ CV ]



  • B.S., Agricultural chemistry, National Taiwan University, 1992
  • M.S., Biotechnology, National Taiwan Ocean University, 1997
  • Ph.D., Life Sciences, National Defense Medical Center, 2004
  • Postdoctoral Associate, Weill Medical College, Cornell University, 2005-2011
  • Research Associate, Weill Medical College, Cornell University, 2011
  • Assistant Professor, Genomics Research Center, Academia Sinica, 2011-2020
  • Associate Professor, Genomics Research Center, Academia Sinica, 2020-present


  • Postdoctoral Fellowship, Cancer Research Institute, 2006-2009


Our future research goal is to unravel the signaling mechanisms in immune responses and cancers by structural and biochemical studies. Specifically, our goal is to better understand the signaling pathways that lead to or are involved in inflammatory diseases, which will help the development of therapies that could relieve the symptoms or treat the diseases. Our recent research effort has concentrated on the signaling complexes involved in TLR/IL-1R signaling that initiates innate immunity. One example is the death domain complex of MyD88:IRAK4:IRAK2. The complex has a unique helical assembly that control signaling leading to NF-kB activation.

  Drosophila vs_Human
 Toll-like receptor signaling complexes in Drosophila (left) and humans (right).


  • Jhen-Yi Hong, Su-Chang Lin, Bai-Jiun Kuo, Yu-Chih Lo*, 2021, “Structural and Biochemical Basis for Higher-Order Assembly between A20-Binding Inhibitor of NF-κB 1 (ABIN1) and M1-Linked Ubiquitins”, JOURNAL OF MOLECULAR BIOLOGY, 433(18), 167116-167116. (SCIE, Scopus)
  • Sorzano COS*; Semchonok D; Lin SC; Lo YC; Vilas JL; Jiménez-Moreno A; Gragera M; Vacca S; Maluenda D; Martínez M; Ramírez-Aportela E; Melero R; Cuervo A; Conesa JJ; Conesa P; Losana P; Caño LD; de la Morena JJ; Fonseca YC; Sánchez-García R; Strelak D; Fernández-Giménez E; de Isidro F; Herreros D; Kastritis PL; Marabini R; Bruce BD; Carazo JM, 2021, “Algorithmic robustness to preferred orientations in single particle analysis by CryoEM”, JOURNAL OF STRUCTURAL BIOLOGY, 213(1), 107695-107695. (SCIE)
  • This is for your information, 2019, “For the information of my publications, please refer to PubMed and original publication websites. I am not responsible for any errors from any sources outside of original publication websites.”, Announcement, 1-1.
  • Tsung-Wei Su, Chao-Yu Yang, Wen-Pin Kao, Bai-Jiun Kuo, Shan-Meng Lin, Jung-Yaw Lin, Yu-Chih Lo*, Su-Chang Lin*, 2017, “Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome”, STRUCTURE, 25(3), 407-420. (SCIE)
  • Lin Shan-Meng, Lin Su-Chang, Hong Jhen-Yi, Su Tsung-Wei, Kuo Bai-Jiun, Chang Wei-Hsin, Tu Yi-Fan, Lo Yu-Chih*, 2017, “Structural Insights into Linear Tri-ubiquitin Recognition by A20-Binding Inhibitor of NF-κB, ABIN-2”, STRUCTURE, 25(1), 66-78. (SCIE)
  • Lo YC*, Lin SC, Yang CY, Tung JY, 2015, “Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly.”, Apoptosis : an international journal on programmed cell death, 20(2), 124-35. (SCIE)
  • Kao WP, Yang CY, Su TW, Wang YT, Lo YC*, Lin SC*, 2015, “The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-kappaB signaling.”, Apoptosis : an international journal on programmed cell death, 20(2), 174-95. (SCIE)
  • Lin SC, Lo YC, Wu H, 2010, “Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.”, Nature, 465(7300), 885-890. (SCIE)
  • Wu H, Lo YC, Lin SC, 2010, “Recent advances in polyubiquitin chain recognition.”, F1000 biology reports, 2(20), 1-5.
  • Yin Q, Lin SC, Lamothe B, Lu M, Lo YC, Hura G, Zheng L, Rich RL, Campos AD, Myszka DG, Lenardo MJ, Darnay BG, Wu H, 2009, “E2 interaction and dimerization in the crystal structure of TRAF6.”, Nature structural & molecular biology, 16(6), 658-666. (SCIE)
  • Lo YC, Lin SC, Rospigliosi CC, Conze DB, Wu CJ, Ashwell JD, Eliezer D, Wu H, 2009, “Structural basis for recognition of diubiquitins by NEMO.”, MOLECULAR CELL, 33(5), 602-615. (SCIE)
  • Lin SC, Chung JY, Lamothe B, Rajashankar K, Lu M, Lo YC, Lam AY, Darnay BG, Wu H, 2008, “Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20.”, Journal of molecular biology, 376(2), 526-540. (SCIE)
  • Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC, Wu H, Darnay BG, 2007, “TAK1-dependent signaling requires functional interaction with TAB2/TAB3.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(6), 3918-3928. (SCIE)
  • Park HH, Lo YC, Lin SC, Wang L, Yang JK, Wu H, 2007, “The death domain superfamily in intracellular signaling of apoptosis and inflammation.”, Annual review of immunology, 25, 561-586. (SCIE)
  • Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H, 2007, “XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.”, Molecular cell, 26(5), 689-702. (SCIE)
  • Lee CY, Tai CL, Lin SC, Chen YT, 1994, “Occurrence of plasmids and tetracycline resistance among Campylobacter jejuni and Campylobacter coli isolated from whole market chickens and clinical samples.”, International journal of food microbiology, 24(1-2), 161-170. (SCIE)