副研究員
02-27871262
EDUCATION AND POSITIONS HELD:
- B.S., Chemistry, National Cheng-Kung University Taiwan, 1991
- M.S., Chemistry National Tsing-Hua University Taiwan, 1993
- Ph.D., Chemistry, University of California, Davis CA, USA, 1997-2002
- Postdoctoral Fellow, the Scripps Research Institute, USA, 2002-2004
- Assistant Professor, Genomics Research Center, Academia Sinica, Taiwan, 2004-2010
- Associate Professor, Genomics Research Center, Academia Sinica, Taiwan, 2010-present
HONORS:
- Skaggs Postdoctoral Fellowship, 2002-2004
- The distinguished lectureship award (Natural products synthesis), the CSJ (Chemical Society of Japan) Asian International Symposium, Japan, 2007
RESEARCH INTERESTS:
The major research efforts of this group are directed toward the development of new synthetic strategies for biologically interesting natural products and heterocyclics. To understand the relationships between small molecules and biological systems, combinatorial approaches are applied in our diverse molecule library synthesis (core diversity, substituent diversity, and configuration diversity) with the assistance of automated or semi-automated equipment.
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Organic Chemistry and Chemical Biology
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Development of new synthetic methodology
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Natural product and natural product-like molecule synthesis
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Synthesis of biologically interesting molecule libraries
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Development of new high-throughput library synthesis
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Combinatorial approach towards the synthesis of natural product-like or novel heterocyclic molecule libraries
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Study of the cell wall transglycosylase as a potential antibacterial target
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Lead discovery of cell wall synthesis enzymes in mycobacterium
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Novel chemical probe synthesis and application
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Synthesis of chemical chaperones towards lysosomal storage disease associated enzymes
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Synthesis of novel five- and six-membered iminosugars
我的研究興趣包括各式生化活性產物的全合成、新的合成方法學、組合式化學、固相有機合成、化學生物學，以及新藥開發等。
同時也根據理論設計與組合式化學的合成方法，將包括雜環、非天然之氨基酸 (胜肽)、lysophosphatidic acid衍生物以及iminocyclotals等之新穎的小分子設計並合成為抑制劑或抗頡劑(agonists)，以與疾病有關的酵素或受體 (receptors)為標的，研究其結構與活性之間的關係(SARs)。
由於近來在小分子組合式化學的研究日趨活絡，因此固相有機合成(SPOS)方面的應用與研究也受到高度關注。在此領域裡，我們的興趣在於新功能化樹 脂開發、linker開發(尤其是traceless linkers)、化學轉換、SPOS裂解策略，以及利用新方法來更有效率地建置小分子資料庫以供生化篩選使用。