Chemical Biology Division 2022


Chen, Yun-Ru Ruby

  • Jin-Lin Wu and Yun-Ru Chen*, 2022, “Signal peptide stabilizes folding and inhibits misfolding of serum amyloid A”, PROTEIN SCIENCE, 31(12), e4485. (SCIE)
  • Ming-Che Lee‡, Yi-Hung Liao‡, Shih-Hui Chen, and Yun-Ru Chen*., 2022, “Amyloid-β E22K Fibril in Familial Alzheimer’s Disease is More Thermo-stable and Susceptible to Seeding.”, IUBMB LIFE, 74(8), 739-747. (SCIE)
  • Wan-Chin Chiang§, Yu-Sheng Fang§, Yuh-Shen Lye, Tzu-Yu Wong, Kiruthika Ganesan, Shih-Chieh Chou, Yun-Ru Chen*, 2022, “Hyperphosphorylation-mimetic TDP-43 Drives Amyloid Formation and Possesses Neuronal Toxicity at the Oligomeric Stage”, ACS Chemical Neuroscience, 37, 1,, 2599-2612. (SCIE)
  • Jin-Lin Wu, Tung-Hung Su, Pei-Jer Chen, and Yun-Ru Chen*, 2022, “Acute‑phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level”, Scientific Reports, 12, 5799. (SCIE)
  • Yuh Shen Lye and Yun-Ru Chen*, 2022, “TAR DNA-binding protein 43 oligomers in physiology and pathology”, IUBMB LIFE, 2022, 1-18. (SCIE)

Cheng, Wei-Chieh

  • Guo CW, Chen KT, You TY, Lin CC, Cheng WC, 2022, “Synthesis and Evaluation of Diverse N-Substituted Disaccharide Dipeptides for Human NOD2 Stimulation Activity.”, Chemistry, an Asian journal, 17(4), e202101169.
  • Chen WA, Li HY, Sayyad A, Huang CY, Cheng WC, 2022, “Synthesis of Nitrone-derived Pyrrolidine Scaffolds and Their Combinatorial Libraries to Develop Selective alpha-l-Rhamnosidase Inhibitors.”, Chemistry, an Asian journal, 17(14), e202200172.

Hung, Shang-Cheng

  • Byung-sun Jeon, Teng-Yi Huang, Mark W. Ruszczycky, Sei-hyun Choi, Namho Kim, Joseph Livy Franklin, Shang-Cheng Hung*, Hung-wen Liu*, 2022, “Byproduct formation during the biosynthesis of spinosyn A and evidence for an enzymatic interplay to prevent its formation”, TETRAHEDRON, 103, 132569. (SCIE)

Li, Tsung-Lin

  • H. T. Huang, I. W. Lo, Y. C. Lin, G. Y. Liao, Y. S. Lin, L. J. Zhang, T. L. Li, C. Ching Liaw*, Y. H. Kuo*, 2022, “Kaguacidine A: a novel spirohydantoin-containing cucurbitane glycoside from vines of Momordica charantia”, NATURAL PRODUCT RESEARCH, DOI:, 10.1080/14786419.2022.2164278. (SCIE)
  • H. T. Huang, I. W. Lo, G. Y. Liao, Y. C. Lin, Y. C. Shen, H. C. Huang, T. L. Li, K. T. Lee, Y. H. Kuo*, C. C. Liaw*, 2022, “Anti-inflammatory sesquiterpene and triterpene acids from Mesona procumbens Hemsley”, FRONTIERS IN CHEMISTRY, 10:1003356, 1-13. (SCIE)
  • I. W. Lo, G. Y. Liao, J. C. Lee, C. I. Chang, Y. C. Wu, S. P. Liu, H. J. Su, C. I. Liu, C. Y. Kuo, Z.Y. Lin, T. L. Li*, Y. S. Lin*, C. C. Liaw*, 2022, “Novel Aporphine- and Proaporphine-Clerodane Hybrids Identified from the Barks of Taiwanese Polyalthia Longifolia var. pendula with Strong Anti-DENV2 Activity”, PHARMACEUTICS, 15(10), 1218, 1-15. (SCIE)
  • Z. C. Wang, I. W. Lo, K. H. Lin, A. N. Cheng, S. M. Zadeh, Y. H. Huang, T. L. Li*, 2022, “Genetic and biochemical characterization of halogenation and drug-transportation genes encoded in the albofungin biosynthetic gene cluster”, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 88(17):e0080622, 1-20. (SCIE)
  • E. Astani, S. M. Zadeh, N. S. Hsu, K. H. Lin, S. Sardari, T. L. Li*, 2022, “Intermolecular Interactions of Nucleoside Antibiotic Tunicamycin with On-Target MraYcb-TUN and Off-Target DPAGT1-TUN in the Active Sites Delineated by Quantum Mechanics/Molecular Mechanics Calculations”, ACS OMEGA, 7(37), 32970-32987. (SCIE)
  • 李宗璘,2022,〈生物技術的工具〉,楊盛行,林世斌編,《新編食品生物技術 2nd》,頁2-1~2-44,台中:華格那。
  • S. M. Zadeh, M. H. Chen, Z. C. Wang, E. K. Astani, I. W. Lo, K. H. Lin, N. S. Hsu, K. Adhikari, S. Y. Lyu, H. Y. Tsai, Y. Terasawa, M. Yabe, K. Yamamoto, S. Ichikawa, T. L. Li*, 2022, “β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin”, COMMUNICATIONS CHEMISTRY, 5, 87, 1-16. (SCIE)
  • C. C. Liaw, I. W. Lo, Y. C. Lin, H. T. Huang, L. J. Zhang, P. C. Hsiao, T. L. Li,* Y. H. Kuo*, 2022, “Four cucurbitane glycosides taimordisins A–D with novel furopyranone skeletons isolated from the fruits of Momordica charantia”, FOOD CHEMISTRY: X, 14, 100286. (SCIE)
  • Y. C. Pan, Y. L. Wang, S. I. Toh, N. S. Hsu, K. H. Lin, Z. Xu, S. C. Huang, T. K. Wu, T. L. Li, C. Y. Chang*, 2022, “Dual-mechanism confers self-resistance to the antituberculosis antibiotic capreomycin”, ACS CHEMICAL BIOLOGY, 17(1), 138-146. (SCIE) (IF: 5.1; SCI ranking: 29.3%)
  • B. R. Chen, W. M. Li, T. L. Li , Y. L. Chan, C. J. Wu*, 2022, “Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori”, SCIENTIFIC REPORTS, 12(1), 429. (SCIE)
  • R. Rattinam, R. S. Basha, Y. L. Wang, Z. C. Wang, N. S. Hsu, K. H. Lin, S. Malek Zadeh, K. Adhikari, J. P. Lin, T. L. Li*, 2022, “KasQ an epimerase primes the biosynthesis of aminoglycoside antibiotic kasugamycin and KasF/H acetyltransferases inactivate its activity”, BIOMEDICINES, 10(2), 212. (SCIE)
  • M. H. Chen, Y. S. Li, N. S. Hsu, K. H. Lin, Y. L. Wang, Z. C. Wang, C. F. Chang, J. P. Lin, C. Y. Chang, T. L. Li*, 2022, “Structural and mechanistic bases for StnK3 and its mutants-mediated Lewis-acid-dependent epimerization and retro aldol reactions”, ACS CATALYSIS, 12, 1945-1956. (SCIE)

Ma, Che Alex

  • Lee WH, Chen X, Liu IJ, Lee JH, Hu CM, Wu HC, Wang SK, Lee WH, Ma C*, 2022, “Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation”, Cell Reports, 41(4), 111555. (SCIE)
  • HY Huang, HY Liao, X Chen, SW Wang, CW Cheng, M Shahed-Al-Mahmud, YM Liu, A Mohapatra, TH Chen, JM Lo, YM Wu, HH Ma, YH Chang, HY Tsai, YC Chou, YP Hsueh, CY Tsai, PY Huang, SY Chang, TL Chao, HC Kao, YM Tsai, YH Chen, CY Wu, JT Jan, TJR Cheng, KI Lin*, C Ma* and CH Wong*, 2022, “Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models”, SCIENCE TRANSLATIONAL MEDICINE, 14, eabm0899. (SCIE)
  • T Yong, KK Chang, YS Wang and C Ma*, 2022, “Active humoral response reverts tumorigenicity through disruption of key signaling pathway”, Vaccines, 10, 163. (SCIE)
  • KYA Huang, D Zhou, TK Tan, C Chen, HME Duyvesteyn, Y Zhao, HM Ginn, L Qin, P Rijal, L Schimanski, R Donat, A Harding, J Gilbert-Jaramillo, W James, JA Tree, K Buttigieg, M Carroll, S Charlton, CE Lien, MY Lin, CP Chen, SH Cheng, X Chen, TY Lin, EE Fry, J Ren, C Ma, AR Townsend, DI Stuart, 2022, “Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2”, THERANOSTICS, 12, 1-17. (SCIE)
  • Daniell H, Nair SK, Guan H, Guo Y, Kulchar RJ, Torres MDT, Shahed-Al-Mahmud M, Wakade G, Liu YM, Marques AD, Graham-Wooten J, Zhou W, Wang P, Molugu SK, de Araujo WR, de la Fuente-Nunez C, Ma C, Short WR, Tebas P, Margulies KB, Bushman FD, Mante FK, Ricciardi RP, Collman RG, Wolff MS, 2022, “Debulking different Corona (SARS-CoV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmission.”, Biomaterials, 288, 121671. (SCIE)
  • Wu CY, Cheng CW, Kung CC, Liao KS, Jan JT, Ma C, Wong CH*, 2022, “Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine.”, Proceedings of the National Academy of Sciences of the United States of America, 119(9), e2119995119. (SCIE)

Wong, Chi-Huey

  • Y.-Y. Tseng, J.-M. Liou, W.-C. Cheng, J.-T. Hsu, T.-L. Hsu, M.-S. Wu, C.-H. Wong, 2022, “Combating multidrug-resistant Helicobacter pylori with moenomycin A in combination with clarithromycin or metronidazole.”, Frontiers in chemistry, 10, 897578. (SCIE)
  • K. Uchimura, K. Nishitsuji, L.-T. Chiu, T. Ohgita, H. Saito, F. Allain, V. Gannedi, C.-H. Wong, S.-C. Hung, 2022, “Design and Synthesis of 6-O-Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid beta Aggregation.”, Chembiochem : a European journal of chemical biology, Epub ahead of print, e202200191. (SCIE)
  • S. S. Shivatare, V. S. Shivatare and C.-H. Wong, 2022, “Glycoconjugates: Synthesis, Functional Studies, and Therapeutic Developments.”, Chemical reviews, 122(20), 15603-15671. (SCIE)
  • C.-Y. Wu, C.-W. Cheng, C.-C. Kung, K.-S. Liao, J.-T. Jan, C. Ma, C.-H. Wong, 2022, “Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine.”, Proceedings of the National Academy of Sciences of the United States of America, 119(9), e2119995119. (SCIE)
  • C.-Y. Chen, Y.-W. Lin, S.-W. Wang, Y.-C. Lin, Y.-Y. Cheng, C.-T. Ren, C.-H. Wong, and C.-Y. Wu, 2022, “Synthesis of Azido-Globo H Analogs for Immunogenicity Evaluation.”, ACS central science, 8(1), 77-85. (SCIE)
  • H.-Y. Huang, H.-Y. Liao, X. Chen, C.-W. Cheng, S.-W. Wang, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, H.-H. Ma, Y.-H. Chang, C.-Y. Tsai, P.-Y. Huang, S.-Y. Chang, T.-L. Chao, H.-C. Kao, Y.-M. Tsai, Y.-H. Chen, C.-Y. Chen, K.-C. Lee, C.-Y. Wu, J.-T. Jan, K.-I. Lin, T.-J. R. Cheng, C. Ma, and C.-H. Wong, 2022, “Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models.”, Science translational medicine, 14(639), eabm0899. (SCIE)