Ren, Chien-Tai

RenCT6x7 Associate Research Specialist




  • Ph.D., Department of Chemistry, Florida State University, 1989-1996
  • Postdoctoral Research Fellow, Florida State University, 1996–1999
  • Research Associate, Sinon Corporation, 1999-2000
  • Postdoctoral Research Fellow, Institute of Biological Chemistry, Academia Sinica, 2000–2006
  • Assistant Research Specialist, Genomics Research Center, Academia Sinica, 2006-2016
  • Associate Research Specialist, Genomics Research Center, Academia Sinica, 2016-present



My laboratory works are mainly focusing on the synthesis of biologically active oligosaccharides to support GRC glycan array research programs. A long term goal is to establish a representative glycan library with sufficiently structural complexity and diversity to meet the demand. At present, I am maintaining a small but steadily growing collection of carbohydrate antigens to support glycan array development, such as early diagnosis of infectious diseases and cancers. I also collaborate with researchers in the area of carbohydrate-based vaccine development and glycopeptides synthesis.

RenCT_oligosaccharides1   RenCT_oligosaccharides2


  • Chein-Hung Chen, Ya-Ping Lin, Chien-Tai Ren, Sachin S. Shivatare, Nan-Hon Lin, Chung-Yi Wu, Chung-Hsuan Chen, Jung-Lee Lin∗, 2020, “Enhancement of fucosylated N -glycan isomer separation with an ultrahigh column temperature in porous graphitic carbon liquid chromatography-mass spectrometry”, Journal of Chromatography A, 1632, 461610. (SCIE) (IF: 4.049; SCIE ranking: 16.9%,16.3%)
  • Sujeet Pawar, Li Hsu, Thatikonda Narendar Reddy, Mettu Ravinder, Chien-Tai Ren, Yu-Wei Lin, Yang-Yu Cheng, Tzu-Wen Lin, Tsui-Ling Hsu, Sheng-Kai Wang, Chi-Huey Wong,* and Chung-Yi Wu*, 2020, “Synthesis of Asymmetric N‑Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation”, ACS CHEMICAL BIOLOGY, 2020, 15, 2382−2394. (SCIE) (IF: 4.434; SCIE ranking: 26.6%)
  • Lee I-Ming, Yang Feng-Ling, Chen Te-Li, Liao Kuo-Shiang, Ren Chien-Tai, Lin Nien-Tsung, Chang Yu-Pei, Wu Chung-Yi*, Wu Shih-Hsiung*, 2018, “Pseudaminic acid on exopolysaccharide of Acinetobacter baumannii plays a critical role in phage-assisted preparation of glycoconjugate vaccine with high antigenicity”, Journal of the American Chemical Society, 140(28), 8639-8643. (SCIE) (IF: 14.612; SCIE ranking: 7.3%)
  • Yasuhiko Kizuka, Miyako Nakano, Yoshiki Yamaguchi, Kazuki Nakajima, Ritsuko Oka, Keiko Sato, Chien-Tai Ren, Tsui-Ling Hsu, Chi-Huey Wong, and Naoyuki Taniguchi*, 2017, “An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3”, Cell Chemical Biology, 24, 1467–1478. (SCIE) (IF: 7.739; SCIE ranking: 10.1%)
  • I-Ming Lee, I-Fan Tu, Feng-Ling Yang, Tzu-Ping Ko, Jiahn-Haur Liao, Nien-Tsung Lin, Chung-Yi Wu, Chien-Tai Ren, Andrew H.-J. Wang, Ching-Ming Chang, Kai-Fa Huang*, Shih-Hsiung Wu*, 2017, “Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage ΦAB6 tailspike protein”, Scientific Reports, 7, 42711. (SCIE) (IF: 3.998; SCIE ranking: 23.9%)
  • • Sachin S Shivatare, Shih-Huang Chang, Tsung-I Tsai, Susan Yu Tseng, Yih-Shyan Lin,Yang-Yu Cheng, Chien-Tai Ren, Chang-Chun David Lee, Sujeet Pawar, Charng-Sheng Tsai,Hao-Wei Shih, Yi-Fang Zeng, Chi-Hui Liang Peter D. Kwong, Dennis R. Burton, Chung-Yi Wu,* Chi-Huey Wong*, 2016, “Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies”, Nature Chemistry, 8, 338-346. (SCIE) (IF: 21.687; SCIE ranking: 3.4%)
  • *Chen CH; Lin YP; Lin JL; Li ST; Ren CT; Wu CY; Chen CH., 2015, “Rapid identification of terminal sialic acid linkage isomers by pseudo-MS3 mass spectrometry”, ISRAEL JOURNAL OF CHEMISTRY, 55, 412-422. (SCIE) (IF: 2.32; SCIE ranking: 52%)
  • Hsin-Yu Lee, Chien-Yu Chen, Tsung-I Tsai, Shiou-Ting Li, Kun-Hsien Lin, Yang-Yu Cheng, Chien-Tai Ren, Ting-Jen R. Cheng, Chung-Yi Wu,* and Chi-Huey Wong*, 2014, “Immunogenicity Study of Globo H Analogues with Modification at the Reducing or Nonreducing End of the Tumor Antigen”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(48), 16844−16853.. (SCIE) (IF: 14.612; SCIE ranking: 7.3%)
  • Sachin S. Shivatare, Shih-Huang Chang, Tsung-I Tsai,Chien-Tai Ren, Hong-Yang Chuang,Li Hsu, Chih-Wei Lin, Shiou-Ting Li, Chung-Yi Wu,*and Chi-Huey Wong*, 2013, “Efficient Convergent Synthesis of Bi‑, Tri‑, and Tetra-antennary Complex Type N‑Glycans and Their HIV‑1 Antigenicity”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135, 15382−15391. (SCIE) (IF: 14.612; SCIE ranking: 7.3%)
  • Hong-Yang Chuang, Chien-Tai Ren, Chung-An Chao, Chung-Yi Wu, Sachin S Shivatare, Ting-Jen R. Cheng,Chung-Yi Wu*, and Chi-Huey Wong*, 2013, “Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135, 11140-11150. (SCIE) (IF: 14.612; SCIE ranking: 7.3%)
  • Yen-Lin Huang, Jung-Tung Hung, Sarah K. C. Cheung, Hsin-Yu Lee, Kuo-Ching Chu, Shiou-Ting Li, Yu-Chen Lin, Chien-Tai Ren, Ting-Jen R. Cheng, Tsui-Ling Hsu, Alice L. Yu, Chung-Yi Wu*, and Chi-Huey Wong* , 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110, 2517-2522. (SCIE) (IF: 9.412; SCIE ranking: 11.3%)
  • Ting-Jen R. Cheng, Shi-Yun Wang, Wen-Hsien Wen, Ching-Yao Su, Mengi Lin, Wen-I Huang, Ming-Tsan Liu, Ho-Sheng Wu, Nung-Sen Wang, Chung-Kai Cheng, Chun-Lin Chen, Chien-Tai Ren, Chung-Yi Wu, Jim-Min Fang,* Yih-Shyun E. Cheng,* and Chi-Huey Wong*, 2013, “Chemical Probes for Drug-Resistance Assessment by Binding Competition (RABC): Oseltamivir Susceptibility Evaluation”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(1), 366-370. (SCIE) (IF: 12.959; SCIE ranking: 8.5%)
  • Chen-Shiou Wu, Chia-Jui Yen, Ruey-Hwang Chou, Shiou-Ting Li, Wei-Chien Huang, Chien-Tai Ren, Chung-Yi Wu*, Yung-Luen Yu*, 2012, “Cancer-Associated Carbohydrate Antigens as Potential Biomarkers for Hepatocellular Carcinoma”, PLoS One, 7(7), e39466. (SCIE) (IF: 2.74; SCIE ranking: 38%)
  • Chen, M. W.; Liao, H.-Y.; Huang, Y.; Jan, J.-T.; Huang, C.-C.; Ren, C.-T.; Wu, C.-Y.; Cheng, T.-J.; Ho, D.*; Wong, C.-H.*, 2011, “Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar binding activities of influenza hemagglutinin”, Proceedings of the National Academy of Sciences of the United States of America, 108(9),3510-3515. (SCIE) (IF: 9.412; SCIE ranking: 11.3%)
  • Chu, K.-C.; Ren, C.-T.; Liu, C.-P.; Hsu, C.-H.; Sun, T.-H.; Han, J.-L.; Pal, B.; Chao, T.-A.; Lin, Y.-F.; Wu, S.-H.; Wong, C.-H.*; Wu, C.-Y.*, 2011, “Efficient and Stereoselective Synthesis of alpha(2→9) Oligosialic acids: From Monomers to Dodecamers”, Angewandte Chemie International Edition, 50, 9391-9395. (SCIE) (IF: 12.959; SCIE ranking: 8.5%)
  • Tsai, B.-L.; Han, J.-L.; Ren, C.-T.; Wu, C.-Y.*; Wong, C.-H., 2011, “Programmable One-Pot Synthesis of Tumor-Associated Carbohydrate Antigens Lewis X dimer and KH-1 epitopes”, Tetrahedron Letters, 52, 2132-2135. (SCIE) (IF: 2.275; SCIE ranking: 47.4%)
  • Liao, H.-Y., Hsu, C.-H., Wang, S.-C., Liang C.-H., Ye H.-Y., Su C.-Y., Jan J.-T., Ren C.-T., Cheng T.-J. R.,* Wu, C.-Y.*, Wong C.-H.*, 2010, “Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132, 14849-14856. (SCIE) (IF: 14.612; SCIE ranking: 7.3%)
  • Hsu, C.-H.; Chu, K.-C.; Lin, Y.-S.; Han, J.-L.; Peng, Y.-S.; Ren, C.-T.;Wu, C.-Y. and Wong, C.-H., 2010, “Highly Alpha-Selective Sialyl Phosphate Donors for Efficient Preparation of Natural Sialosides”, Chemistry-A European Journal, 16(6),1754-1760. (SCIE) (IF: 4.857; SCIE ranking: 24.9%)
  • Wang, S. Y.; Su, C. Y.; Lin, M.; Huang, S. Y.; Huang, W. I.; Wang, C. C.; Wu, Y. T.; Cheng, T. J. R.; Yu, H. M.; Ren, C. T.; Wu, C. Y.; Wong, C. H.; Cheng. Y. S. E., 2009, “HA-pseudotyped retroviral vectors for influenza antagonist screening”, JOURNAL OF BIOMOLECULAR SCREENING, 14, 294-302.
  • Cheng-Chi Wang, Yen-Lin Huang, Chien-Tai Ren, Chin-Wei Lin, Jung-Tung Hung, Jyh-Cherng Yu, Alice L. Yu, Chung-Yi Wu, and Chi-Huey Wong , 2008, “Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer”, Proceedings of the National Academy of Sciences of the United States of America, 105, 11661-11666. (SCIE) (IF: 9.412; SCIE ranking: 11.3%)
  • Nien-Yeen Hsu, Susan Yu Tseng, Chung-Yi Wu, Chien-Tai Ren, Yuan-Chang Lee, Chi-Huey Wong and Chung-Hsuan Chen , 2008, “Desorption ionization of biomolecules on metals”, ANALYTICAL CHEMISTRY, 80, 5203-5210. (SCIE) (IF: 6.785; SCIE ranking: 8.1%)
  • Lu, C.-P., Ren, C.-T., Wu, S.-H.*, Chu, C.-Y., Lo, L.-C.*, 2007, “Development of an activity-based probe for steroid sulfatases”, CHEMBIOCHEM, 8(18), 2187-2190. (SCIE) (IF: 2.576; SCIE ranking: 57.4%,63.3%)
  • Chien-Tai Ren, Yu-Hsuan Tsai, Yu-Liang Yang, Wei Zou and Shih-Hsiung Wu, 2007, “Synthesis of a Tetrasaccharide Glycosyl Glycerol. Precursor to Glycolipids of Meiothermus taiwanensis ATCC-BAA-400”, J. Org. Chem, 72(14), 5427-5430. (SCIE) (IF: 4.335; SCIE ranking: 15.8%)
  • An-Tai Wu, Yi-Ping Yu, Chien-Tai Ren, Wei Zou and S.-H. Wu, 2005, “9-O-Sulfation on α-NeuAc-(2-8)-NeuAc and inter-residue lactonization”, CARBOHYDRATE RESEARCH, 340, 1219-1223. (SCIE) (IF: 1.841; SCIE ranking: 82.5%,61.4%,46.5%)
  • Chun-Ping Lu, Chien-Tai Ren, Yi-Ning Lai, S.-H. Wu, Wei-Man Wang, Jean-Yin Chen and Lee-Chiang Lo, 2005, “Design of a Mechanism-Based Probe for Neuraminidase to Capture Influenza Viruses”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 44, 6888-6892. (SCIE) (IF: 12.959; SCIE ranking: 8.5%)
  • Hao.-Ping Chen, Fang-Ciao Hsui, Li-Ying Lin, Chien-Tai Ren and S.-H. Wu, 2004, “Coexpression, purification and characterization of the E and S subunits of coenzyme B12 and B6 dependent Clostridium sticklandii D-ornithine aminomutase in Escherichia coli”, European Journal of Biochemistry, 271, 4293-4297.
  • C.-T. Ren, C.-S. Chen, Y.-P. Yu, Y.-F. Tsai, P.-Y. Lin, Y.-J. Chen, W. Zou and S.-H. Wu, 2003, “Synthesis of α-(2→5)Neu5Gc Oligomers”, CHEMISTRY-A EUROPEAN JOURNAL, 9, 1085-1095. (SCIE) (IF: 4.857; SCIE ranking: 24.9%)
  • C.-T. Ren, C.-S. Chen and S.-H. Wu, 2002, “Synthesis of a Sialic Acid Dimer Derivative 2α-O-Benzyl Neu5Ac-α-(2-5) Neu5Gc”, J. Org. Chem, 67, 1376-1379. (SCIE) (IF: 4.335; SCIE ranking: 15.8%)