Hsieh, Shie-Liang

SLHsieh2Distinguished Professor


slhsiehgateEmail
+886-2-27871245
[ CV ]

 

 

EDUCATION AND POSITIONS HELD:

  • M.D., National Yang-Ming University, 1984
  • D.Phil., University of Oxford, UK, 1992
  • Postdoctoral fellow, Stanford University, 1993
  • Director, Institute of Clinical Medicine, Natl. Yang-Ming Univ., Taipei,Taiwan, 2010-2013
  • Distinguished Professor, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan, 2007-2013
  • Professor, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan ,2001-2013
  • Director, Immunology Research Center, Natl. Yang-Ming Univ., Taiwan, 2000-2013
  • Director, Immunology Research Center, Taipei Veterans’ General Hospital, Taiwan, 2005-present
  • Co-appointed Senior Investigator, National Health Research Center, Taipei, Taiwan ,2004-present
  • Co-appointed Senior Investigator, Academia Sinica, Taipei, Taiwan, 2004-present
  • Adjunct Research Fellow, Academia Sinica, Taipei, Taiwan, 2009-2013
  • Distinguished Professor, Academia Sinica, Taipei, Taiwan, 2013-present
  • Adjunct Distinguished Professor, Institute of Clinical Medicine, Natl. Yang-Ming Univ., Taipei, Taiwan ,2013-present
  • Adjunct Professor, National Taiwan University ,2014-present
  • Director, IRB on Biomedical Science Research, Academia Sinica, 2018-present

HONORS:

  • 2021    Outstanding Research Fellow award from the Ministry of Science and Technology (科技部109年度傑出特約研究員)
  • 2020    The 18th Y. Z. Hsu Scientific Chair Professor (第十八屆有庠科技講座)
  • 2013    The 8th Session TienTe Lee Award (第八屆永信李天德卓越醫藥科技獎)
  • 2012    The 16th National Chair Professor Award, Ministry of Education (教育部第16屆國家講座)
  • 2010    Outstanding Researcher Award from the National Science Council (國科會傑出獎)
  • 2009    The 4th Long-Term Award from Acer Foundation (第四屆宏碁基金會龍騰微笑得獎人)
  • 2009    The 53th Academic Achievement Award, Ministry of Education (教育部第53屆學術獎)
  • 2009    Tsungming Tu Award, Taiwan Medical Society (台灣醫學會杜聰明獎)
  • 2008    The 18th Outstanding research Achievement to National Health, “Ming-Ning Wang Memorial Foundation” (第十八屆王民寧獎-傑出貢獻獎得獎人)
  • 2003    The 1st Outstanding Alumni, National Yang-Ming University (第一屆陽明大學 傑出校友)
  • 2003    Outstanding Researcher Award from the National Science Council (國科會傑出獎)
  • 1999    Outstanding Researcher Award from the National Science Council (國科會傑出獎)
  • 1992    Irvington Medial Foundation post-doctoral fellowship ‘Robert Wood Johnson Fellow
  • 1989    Oversea Research Scholarship (ORS) from the University of Oxford
  • 1989    Oversea PhD studentship from the Ministry of Education, Taiwan

RESEARCH INTERESTS:

My laboratories are interested in elucidating the molecular mechanism of pathogen-induced cytokine storm and lethality, and identify potential targets for immunotherapy in order to prevent tissue damage and fibrosis. We address these questions from wo aspects: Host-Pathogen Interaction and Immunomodulation.

Host-Pathogen Interaction

Initiation of inflammatory reaction is via the activation of innate immunity receptors on NK cells, monocytes, macrophages, PMNs and platelets by either infectious agents, foreign antigens or aberrant expressed endogenous antigens. Thus, understanding the molecular mechanisms of innate immune responses to exogenous and endogenous antigens would be able to develop novel strategy to treat numerous human diseases such as infection, autoimmunity, and allergic reactions. We developed innate immunity receptor array (IIR-EIA) and C-type lectin receptor array (CLRA) to identify receptors critical in virus-induced cytokine storm and host-defense mechanism. We are systemically identifying the functions of novel CLRs by gene-deficient mice, and generate human antibody against CLRs and other IIRs potential therapeutic agents to treat human diseases. We have identified the spleen-tyrosine kinase (Syk)-coupled C-type lectin receptors CLEC5A and CLEC2 are critical receptor in dengue virus-induced cytokine storm and thrombocytopenia, and antagonistic mAbs against CLEC5A and CLEC2 are being developed for therapeutic agents.

HsiehSL Host Pathogen Interaction

Immunomodulation

We develop serial recombinant proteins to skew monocyte differentiation into M2 macrophages to promote tissue regeneration and repairing, as well as attenuate septic and aseptic inflammatory reactions. Two recombinant proteins (DcR3.Fc and HBD.Fc) have been shown to induce M2macrophage differentiation via epigenetic regulation. These proteins have potent immunosuppressive effect to attenuate beta-amyloid induced-neuroinflammation, promote neuronal regeneration, and preserve memory in an Alzheimer mouse model.

HsiehSL Immunomodulation

SELECTED PUBLICATIONS:

  • Tsai TY, Huang MT, Sung PS, Peng CY, Tao MH, Yang HI, Chang WC, Yang AS, Yu CM, Lin YP, Ching-Yu Bau3, Huang CJ, Pan MH, Wu CY, Hsiao CD, Yeh YH, Shiteng Duan, James C Paulson, Hsieh SL*, 2021, “Siglec-3 (CD33) is the immune checkpoint receptor in HBV infection”, JOURNAL OF CLINICAL INVESTIGATION, 131(11), 141965. (SCIE)
  • Pan YG, Huang MT, P. Sekar, Huang DY, Lin WW, Hsieh SL*, 2021, “Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture”, FRONTIERS IN IMMUNOLOGY, 12: 638676, 1-16. (SCIE)
  • Cheng Lie, Liu WL, Tsou YT, Li JC, Chien CH, Matthew P Su, Liu KL, Huang YL, Wu SC, Tsai JJ, Hsieh SL, Chen CH*, 2021, “Transgenic Expression of Human C-Type Lectin Protein CLEC18A Reduces Dengue Virus Type 2 Infectivity in Aedes aegypti”, FRONTIERS IN IMMUNOLOGY, 12: 640367, 1-14. (SCIE)
  • Huang YL , Huang MT, Sung PS, Chou TY, Yang RB, Yang AS, Yu CM, Hsu YW, Chang WC, Hsieh SL*, 2021, “Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection”, Communications biology, 4(1): 229, 1-13. (SCIE)
  • Ho HL, Wang FY, Lee HR, Huang YL, Lai CL, Jen WC, Hsieh SL, Chou TY*, 2020, “Seroprevalence eof COVID-19 in Taiwan revealed by testing anti-SARS-CoV-2 serological antibodies on 14,765 hospital patients”, The Lancet Regional Health-Western Pacific, 3, 1-7. (SCIE)
  • Lalu Muhammad Irham, Chou WH, Marcus J Calkins, Wirawan Adikusuma, Hsieh SL, Chang WC*, 2020, “Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents”, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 529(2), 263-269. (SCIE)
  • Chang FY, Chen HC, Chen PJ, Ho MS, Hsieh SL, Lin JC, Liu FT, Sytwu HK*, 2020, “Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)”, JOURNAL OF BIOMEDICAL SCIENCE, 27(1), 72. (SCIE)
  • Chen PK, Hsieh SL, Lan JL, Lin CC, Chang SH, Chen DY*, 2020, “Elevated Expression of C-Type Lectin Domain Family 5-Member A (CLEC5A) and Its Relation to Inflammatory Parameters and Disease Course in Adult-Onset Still's Disease”, JOURNAL OF IMMUNOLOGY RESEARCH, 2020, 9473497. (SCIE)
  • Hsieh SL, 2020, Lectin in Host Defense Against Microbial Infections, Advances in Experimental Medicine and Biology, 230 pages, Singapore: Springer Nature Singapore Pte Ltd.
  • Sung PS, Chang WC, Hsieh SL*, 2020, “CLEC5A: A Promiscuous Pattern Recognition Receptor to Microbes and Beyond”, editor(s): (Hsieh SL), Lectin in Host Defense Against Microbial Infections, Advances in Experimental Medicine and Biology, pp. 1204: 57-73, 新加坡: Springer Nature Singapore Pte Ltd.
  • Chen MH, Huang MT, Yu WK, Lee SS, Wang JH, Cheng TR, Bowman MR, Hsieh SL*, 2019, “Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients”, JOURNAL OF BIOMEDICAL SCIENCE, 26(1), 97. (SCIE)
  • Sung PS, Hsieh SL*, 2019, “CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections”, FRONTIERS IN IMMUNOLOGY, 10: 2867, 1-9. (SCIE)
  • Tung YT, Liang JJ, Feng HT, Jhang RN, Hsieh SL, Lin YL, Wang GJ*, 2019, “Investigation of the extremely weak interaction between the Japanese encephalitis virus and CLEC5A using a multivalent-interaction-enhancement sensing electrode”, BIOSENSORS & BIOELECTRONICS, 2, 1-6. (SCIE)
  • Sameh Obeid, Sung PS, Benoit Le Roy, de Boiseaumarie Engineer, Chou ML, Hsieh SL, Celine Elie-Caille, Thierry Burnouf, Wilfrid Boireau*, 2019, “NanoBioAnalytical characterization of extracellular vesicles in 75-nm nanofiltered human plasma for transfusion: A tool to improve transfusion safety”, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 20: 101977, 1-14. (SCIE)
  • Chang WC, Yeh YC, Ho HL, Hsieh SL, Chou TY*, 2019, “Decoy Receptor 3 Expression Is Associated With Wild-Type EGFR Status, Poor Differentiation of Tumor, and Unfavorable Patient Outcome”, AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 152(2), 207-216. (SCIE)
  • Sung PS, Huang TF, Hsieh SL*, 2019, “Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2”, NATURE COMMUNICATIONS, 10(1): 2402, 1-13. (SCIE)
  • Yeh CC, Yang MJ, Lussier EC, Tsai HW, Lo PF, Hsieh SL, Wang PH*, 2019, “Low plasma levels of decoy receptor 3 (DcR3) in the third trimester of pregnancy with preeclampsia”, TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, 58(3), 349-353. (SCIE)
  • Tseng WC, Chen YT, Lin YP, Ou SM, Yang CY, Lin CH, Tarng DC*, WC Tseng, MT Tsai, SM Ou, CY Yang, YP Lin, YH Chen, Yi-Fang Chuang, LK Chen, KY Wang, CJ Shih, YT Chen, YS Lin, SC Hung, KL Kuo, TP Hung, FH Hu, NJ Chen, YC Chen, CH Lin, TH Tsai, SL Hsieh, YH Wei, CC Hsu, JS Liu, YK Chang & MH Chiang, 2019, “Hyperuricemia Predicts an Early Decline in Renal Function among Older People: A Community-Based Cohort Study”, SCIENTIFIC REPORTS, 9(1): 980, 1-10. (SCIE)
  • Sekar P, Huang DY, Hsieh SL, Chang SF, Lin WW*, 2018, “AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia”, CELL COMMUNICATION AND SIGNALING, 16(1): 83, 1-15. (SCIE)
  • Liao TL, Huang YL, Chen YM, Lee HC, Chen DY, Hsieh SL*, 2018, “Association of C-type lectin 18 levels with extrahepatic manifestations in chronic HCV infection”, SCIENTIFIC REPORTS, 8(1): 17287, 1-11. (SCIE)
  • Liao TL, Hsieh SL, Chen YM, Chen HH, Liu HJ, Lee HC, Chen DY*, 2018, “Rituximab may cause increased hepatitis C virus viremia in rheumatoid arthritis patients through declining exosomal microRNA-155”, ARTHRITIS & RHEUMATOLOGY, 70(8), 1209-1219. (SCIE)
  • Lai YC, Chuang YC, Chang CP, Lin YS, Perng GC, Wu HC, Hsieh SL, Yeh TM*, 2018, “Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy”, ANTIVIRAL RESEARCH, 155, 28-38. (SCIE)
  • Tsai TY, Peng CY, Yang HI, Huang YL, Tao MH, Yuan SS, Lai HC, Hsieh SL*, 2018, “The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection”, JOURNAL OF BIOMEDICAL SCIENCE, 25(1): 59, 1-10. (SCIE)
  • Tsai HW, Huang MT, Wang PH, Huang BS, Chen YJ, Hsieh SL*., 2018, “Decoy receptor 3 promotes cell adhesion and enhances endometriosis development”, JOURNAL OF PATHOLOGY, 244(2), 189-202. (SCIE)
  • Tseng WC, Chen YT, Ou SM, Shih CJ, Tarng DC, Tseng WC, Ou SM, Yang CY, Lin YP, Chuang YF, Chen LK, Wang KY, Chen YH, Tsai MT, Shih CJ, Chen YT, Lin YS, Hung SC, Kuo KL, Hung TP, Hu FH, Chen NJ, Chen YC, Lin CH, Tsai TH, Hsieh SL, Wei YH, Hsu CC, Liu JS, Chang YK, Chiang MH*, 2018, “U-Shaped Association Between Serum Uric Acid Levels With Cardiovascular and All-Cause Mortality in the Elderly: The Role of Malnourishment”, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(4): e007523, 1-18. (SCIE)
  • Lee PC, Yang LY, Wang YW, Huang SF, Lee KC, Hsieh YC, Yang YY, Hsieh SL, Hou MC, Lin HC, Lee FY, Lee SD*, 2017, “Mechanisms of the prevention and inhibition of the progression and development of NASH by genetic and pharmacological DcR3 supplementation.”, HEPATOLOGY RESEARCH, 47(12), 1260-1271. (SCIE)
  • Cheng AC, Yang KY, Chen NJ, Hsu TL, Jou R, Hsieh SL, Tseng PH*, 2017, “CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra”, PLoS One, 12(10), e0186780. (SCIE)
  • Chen ST, Chen JW, Wu WC, Chou TY, Yang CY, Hsieh SL*, 2017, “CLEC5A is a critical receptor in innate immunity against Listeria infection”, NATURE COMMUNICATIONS, 8(1): 299, 1-13. (SCIE)
  • Li TH, Liu CW, Lee PC, Huang CC, Lee KC, Hsieh YC, Yang YY, Hsieh SL, Lin HC, Tsai CY*, 2017, “Decoy receptor 3 analogous supplement protects steatotic rat liver from ischemia-reperfusion injury”, JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, 80(7), 391-400. (SCIE)
  • Chiu CW, Cheng H, Hsieh SL*, 2017, “Contusion spinal cord injury rat model”, Bio-protocol, 7(12), e2337.
  • Hsieh SL*, Lin WW*, 2017, “Decoy receptor 3: An endogenous immunomodulator in cancer growth and inflammatory reactions”, JOURNAL OF BIOMEDICAL SCIENCE, 24(1): 39, 1-9. (SCIE)
  • Liu YL, Chen WT, Lin YY, Lu PH, Hsieh SL*, Cheng, IH*, 2017, “Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model”, MOLECULAR NEURODEGENERATION, 12(1), 1-17. (SCIE)
  • Lai JH, Lin YL, Hsieh SL* , 2017, “Pharmacological intervention for dengue virus infection”, BIOCHEMICAL PHARMACOLOGY, 129, 14-25. (SCIE)
  • Wen KC, Sung PL, Hsieh SL, Chou YT, Lee OK, Wu CW, Wang PH*, 2017, “α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells”, ONCOTARGET, 8(17), 29013-29027.
  • Yeh C C, Horng H C, Chou H, Tai H Y, Shen H D, Hsieh S L, Wang PH*, 2017, “Dectin-1-Mediated Pathway Contributes to Fusarium proliferatum-Induced CXCL-8 Release from Human Respiratory Epithelial Cells”, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(3): 624, 1-10. (SCIE)
  • Teng, O, Chen, ST, Hsu TL, Sia SF, Cole S, Valkenburg SA, Hsu TY, Zheng JT, Tu W, Bruzzone R, Peiris JSM, Hsieh SL*, Yen HL*, 2017, “CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo”, JOURNAL OF VIROLOGY, 91(1), e01813-e01816. (SCIE)
  • Chen MH, Kan HT, Liu CY, Yu WK, Lee SS, Wang JH, Hsieh SL*, 2017, “Serum decoy receptor 3 is a biomarker for disease severity in nonatopic asthma patients”, JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 116(1), 49-56. (SCIE)
  • Li TH, Lee PC, Lee KC, Hsieh YC, Tsai CY, Yang YY, Huang SF, Tsai TH, Hsieh SL, Hou MC, Lin HC, Lee SD*, 2016, “Down-regulation of common NFκB-iNOS pathway by chronic Thalidomide treatment improves Hepatopulmonary Syndrome and Muscle Wasting in rats with Biliary Cirrhosis”, SCIENTIFIC REPORTS, 6: 39405, 1-14. (SCIE)
  • Fan WC, Liu CW, Ou SM, Huang CC, Li TH, Lee KC, Huang SF, Yang YY, Hsieh YC, Hsieh SL, Hou MC, Lin HC*, 2016, “TLR4/CD14 Variants-Related Serologic and Immunologic Dys-Regulations Predict Severe Sepsis in Febrile De-Compensated Cirrhotic Patients”, PLoS One, 11(11): e0166458, 1-19. (SCIE)
  • Huang YL, Chen ST, Liu RS, Chen YH, Lin CY, Huang CH, Su PY, Liao CL, Hsieh SL*, 2016, “CLEC5A is Critical for Dengue Virus-induced Osteoclast Activation and Bone Homeostasis”, JOURNAL OF MOLECULAR MEDICINE-JMM, 94(9), 1025-1037. (SCIE)
  • Chiu CW, Huang WH, Lin SJ, Tsai MJ, Ma H, Hsieh SL, Cheng H*, 2016, “The immunomodulator decoy receptor 3 improves locomotor functional recovery after spinal cord injury”, JOURNAL OF NEUROINFLAMMATION, 13(1): 154, 1-12. (SCIE)
  • 陳斯婷、吳明芳、黃雅蘭、黃明停、謝世良, 2016, “C型凝集素CLEC5A在登革致病機制的角色”, editor(s): 林以行等, 登革熱的台灣經驗-從流行病學及臨床到基礎科學的新視野, pp. 142-155, 台灣: 科技部.
  • Shie-Liang Hsieh, 2016, “Chapter 3: The DAP12-Associated Myeloid C-Type Lectin 5A (CLEC5A).”, editor(s): Sho Yamasaki, C-type Lectin Receptors in Immunity, pp. 35-48, Japan: Springer Japan.
  • Tung YT, Chang CC, Lin YL, Hsieh SL, Wang GJ*, 2016, “Development of double-generation gold nanoparticle chip-based dengue virus detection system combining fluorescence turn-on probes”, BIOSENSORS & BIOELECTRONICS, 77, 90-98. (SCIE)
  • Tarng DC, Tseng WC, Lee PY, Chiou SH, Hsieh SL*., 2016, “Induced Pluripotent Stem Cell-derived Conditioned Medium Attenuates Acute Kidney Injury by Downregulating the Oxidative Stress-Related Pathway in Ischemia-Reperfusion Rats”, CELL TRANSPLANTATION, 25(3), 517-530. (SCIE)
  • Li TH, Huang CC, Yang YY, Lee KC, Hsieh SL, Hsieh YC, Alan L, Lin HC, Lee SD, Tsai CY*, 2016, “Thalidomide Improves the Intestinal Mucosal Injury and Suppresses Mesenteric Angiogenesis and Vasodilatation by Down-Regulating Inflammasomes-Related Cascades in Cirrhotic Rats”, PLoS One, 11(1): e0147212, 1-17. (SCIE)
  • Huang MT, Chen ST, Wu HY, Chen YJ, Chou TY, Hsieh SL*, 2015, “DcR3 suppresses influenza virus-induced macrophage activation and attenuates pulmonary inflammation and lethality”, JOURNAL OF MOLECULAR MEDICINE-JMM, 93(10), 1131-1143. (SCIE)
  • Weng SC, Shu KH, Wu MJ, Wen MC, Hsieh SL, Chen NJ, Tarng DC*, 2015, “Expression of decoy receptor 3 in kidneys is associated with allograft survival after kidney transplant rejection”, SCIENTIFIC REPORTS, 5: 12769, 1-14. (SCIE)
  • Huang YL, Tso YT, Pai FS, Chou TY, Mon HC, Hsu TL, Wu CY, Yang WB, Chen CH, Wong CH, Hsieh SL*, 2015, “Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity”, JOURNAL OF BIOLOGICAL CHEMISTRY, 290(35), 21252-21263. (SCIE)
  • Tarng DC, Ou SM, Yang CY, Lin YP, Chuang YF, Chen LK, Wang KY, Chen YT, Shih CJ, Tseng WC, Chen YH, Lin YS, Hung SC, Kuo KL, Hung TP, Tsai MT, Hu FH, Chen NJ, Chen YC, Lin CH, Tsai TH, Hsieh SL, Wei YH, Hsu CC, Liu JS, Chang YK, Chiang MH*, 2015, “Periodontal Disease and Risks of Kidney Function Decline and Mortality in Older People: A Community-Based Cohort Study”, AMERICAN JOURNAL OF KIDNEY DISEASES, 66(2), 223-230. (SCIE)
  • Tsui KH, Li HY, Cheng JT, Sung YJ, Yen MS, Hsieh SL, Wang PH*, 2015, “The role of nitric oxide in the outgrowth of trophoblast cells on human umbilical vein endothelial cells”, TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, 54(3), 227-231. (SCIE)
  • Lin YT, Yen CH, Chen HL, Liao YJ, Lin IF, Chen M, Lan YC, Chuang SY, Hsieh SL, Chen YM*., 2015, “The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients”, JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 114(6), 498-503. (SCIE)
  • Lee PC, Yang YY, Huang CS, Hsieh SL, Lee KC, Hsieh YC, Lee TY, Lin HC*, 2015, “Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen-rich saline and N-acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats”, HEPATOLOGY RESEARCH, 45(5), 578-588. (SCIE)
  • Lin YC, Huang DY, Wang JS, Lin YL, Hsieh SL, Huang KC, Lin WW, 2015, “Syk involves in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization”, JOURNAL OF LEUKOCYTE BIOLOGY, 97(5), 825-835. (SCIE)
  • Lo TH, Tseng KY, Tsao WS, Yang CY, Hsieh SL, Chiu AW, Takai T, Mak TW, Tarng DC, Chen NJ., 2014, “TREM-1 regulates macrophage polarization in ureteral obstruction”, KIDNEY INTERNATIONAL, 86(6), 1174-1186. (SCIE)
  • Yang YY, Hsieh SL, Lee PC, Yeh YC, Lee KC, Hsieh YC, Wang YW, Lee TY, Huang YH, Chan CC, Lin HC, 2014, “Long-term cannabinoid type 2 receptor agonist therapy decreases Bacterial Translocation In Rats with cirrhosis and ascites”, JOURNAL OF HEPATOLOGY, 61(5), 1004-1013. (SCIE)
  • Tung YL, Wu MF, Wang GJ*, Hsieh SL*, 2014, “Nanostructured electrochemical biosensor for the detection of the weak binding between the dengue virus and the CLEC5A receptor”, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 10(6), 1335-1341. (SCIE)
  • Chang YL, Chen TH, Wu YH, Chen GA, Weng TH, Tseng PH, Hsieh SL, Fu SL, Lin CH, Chen CJ, Chu CL, Chio II, Mak TW, Chen NJ*, 2014, “A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction”, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 18(7), 1344-1357. (SCIE)
  • Hsu WC, Yang FC, Lin CH, Hsieh SL, Chen NJ*, 2014, “C5L2 is required for C5a-triggered receptor internalization and ERK signaling”, CELLULAR SIGNALLING, 26(7), 1409-1419. (SCIE)
  • Chen DY, Yao L, Chen YM, Lin CC, Huang KC, Chen ST, Lan JL*, Hsieh SL*, 2014, “A Potential Role of Myeloid DAP12-Associating Lectin (MDL)-1 in the Regulation of Inflammation in Rheumatoid Arthritis Patients”, PLoS One, 9(1): e86105, 1-11. (SCIE)
  • Huang BS, Sun HD, Hsu YM, Chang WH, Horng HC, Yen MS, Chao KC, Hsieh SL, Wang PH*, 2014, “Clinical presentation and outcome of adult-type granulosa cell tumors: A retrospective study of 30 patients in a single institute”, JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, 77(1), 21-25. (SCIE, SCIE)
  • Hsu TL, Gerardo Lin, Akihiko Koizumi, Klaus Brehm, Noriyasu Hada, Chuang PK, Wong CH, Hsieh SL, Alvaro Díaz*, 2013, “The surface carbohydrates of the Echinococcus granulosus larva interact selectively with the rodent Kupffer cell receptor”, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 192(1-2), 55-59. (SCIE)
  • Wu NL, Huang DY, Hsieh SL, Hsiao CH, Lee TA, Lin WW*, 2013, “EGFR-driven up-regulation of decoy receptor 3 in keratinocytes contributes to the pathogenesis of psoriasis”, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1832(10), 1538-1548. (SCIE)
  • Tseng WC, Yang WC, Yang AH, Hsieh SL, Tarng DC*, 2013, “Expression of TNFRSF6B in kidneys is a novel predictor for progression of chronic kidney disease”, MODERN PATHOLOGY, 26(7), 984-994. (SCIE)
  • Yang CY, Chen JB, Tsai TF, Tsai YC, Tsai CY, Liang PH, Hsu TL, Wu CY, Netea MG, Wong CH, Hsieh SL*, 2013, “CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver”, PLoS One, 8(6): e65070, 1-14. (SCIE)
  • Wu MF, Chen ST, Hsieh SL*, 2013, “Distinct regulation of dengue virus-induced inflammasome activation in human macrophage subsets”, JOURNAL OF BIOMEDICAL SCIENCE, 20(1): 36, 1-9. (SCIE)
  • Shu CC, Wu MF, Hsu CL, Huang CT, Wang JY, Hsieh SL, Yu CJ, Lee LN, Yang PC*, 2013, “Apoptosis-associated biomarkers in tuberculosis: promising for diagnosis and prognosis prediction”, BMC INFECTIOUS DISEASES, 13: 45, 1-7. (SCIE)
  • Wu MF, Chen ST, Yang AH, Lin WW, Lin YL, Chen NJ, Tsai IS, Li L, Hsieh SL*, 2013, “CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages”, BLOOD, 121(1), 95-106. (SCIE)
  • Lee WL, Lee FK, Su WH, Tsui KH, Kuo CD, Hsieh SL, Wang PH*, 2012, “Hormone therapy for younger patients with endometrial cancer”, TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, 51(4), 495-505. (SCIE, SCIE)
  • Kuo SC, Lee YT, Yang SP, Chen CP, Chen TL, Hsieh SL, Siu LK, Fung CP*, 2012, “Eradication of multidrug-resistant Acinetobacter baumannii from the respiratory tract with inhaled colistin methanesulfonate: a matched case-control study”, CLINICAL MICROBIOLOGY AND INFECTION, 18(9), 870-876. (SCIE)
  • Lee WC, Lee WL, Shyong WY, Yang LW, Ko MC, Yeh CC, Hsieh SL, Wang PH*, 2012, “Altered ganglioside GD3 in HeLa cells might influence the cytotoxic abilities of NK cells”, TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, 51(2), 199-205. (SCIE, Others)
  • Huang ZM, Kang JK, Chen CY, Tseng TH, Chang CW, Chang YC, Tai SK, Hsieh SL, Leu CM*, 2012, “Decoy receptor 3 suppresses TLR2-mediated B cell activation by targeting NF-kappaB”, JOURNAL OF IMMUNOLOGY, 188(12), 5867-5876. (SCIE)
  • Lee WC, Lee WL, Shyong WY, Yang LW, Ko MC, Sheu BC, Hsieh SL, Wang PH*, 2012, “Increased concentration of sialidases by HeLa cells might influence the cytotoxic ability of NK cells”, TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, 51(2), 192-198. (SCIE)
  • Chen ST, Liu RS, Wu MF, Lin YL, Chen SY, Tan DT, Chou TY, Tsai IS, Li L, Hsieh SL*, 2012, “CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality”, PLOS PATHOGENS, 8(4): e1002655, 1-18. (SCIE)
  • Tai SK, Chang HC, Lan KL, Lee CT, Yang CY, Chen NJ, Chou TY, Tarng DC, Hsieh SL*, 2012, “Decoy receptor 3 enhances tumor progression via induction of tumor-associated macrophages”, JOURNAL OF IMMUNOLOGY, 188(5), 2464-2471. (SCIE)
  • Hwang SJ, Chang SC, Yu CJ, Chan YJ, Chen TJ, Hsieh SL, Lai HY, Lin MH, Liu JY, Ong G, Roman F, Drame M, Bock HL, Yang PC*, 2011, “Immunogenicity and safety of an AS03(A)-adjuvanted H5N1 influenza vaccine in a Taiwanese population”, JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 110(12), 780-786. (SCIE, SCIE)
  • Chen ST , Lin YL , Huang MT , Wu MF , Hsieh SL*, 2011, “Targeting C-type lectin for the treatment of flaviviral infections.”, editor(s): Albert M. Wu, The Molecular Immunology of Complex Carbohydrates-3, pp. 769-776, USA: Springer.
  • Lin WW, Hsieh SL*, 2011, “Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer”, BIOCHEMICAL PHARMACOLOGY, 81(7), 838-847. (SCIE)
  • Tai SK, Yang MH, Chang SY, Chang YC, Li WY, Tsai TL, Wang YF, Chu PY, Hsieh SL*, 2011, “Persistent Kruppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma”, CANCER SCIENCE, 102(4), 895-902. (SCIE)
  • Lee RT, Hsu TL, Huang SK, Hsieh SL, Wong CH, Lee YC*, 2011, “Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities”, GLYCOBIOLOGY, 21(4), 512-520. (SCIE)
  • Hsieh SL, Lin WW*, 2011, “Decoy Receptor 3”, editor(s): Manfred Schwab, Encyclopedia of Cancer, pp. 1070-1072, Berlin: Springer, Berlin, Heidelberg.
  • Chao WW, Kuo YH, Hsieh SL, Lin BF*, 2011, “Inhibitory Effects of Ethyl Acetate Extract of Andrographis paniculata on NF-κB Trans-Activation Activity and LPS-Induced Acute Inflammation in Mice”, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011: 254531, 1-9. (SCIE)
  • Liu PF, Shi W, Zhu W, Smith JW, Hsieh SL, Gallo RL, Huang CM*, 2010, “Vaccination targeting surface FomA of Fusobacterium nucleatum against bacterial co-aggregation: Implication for treatment of periodontal infection and halitosis”, VACCINE, 28(19), 3496-3505. (SCIE)
  • Kuo WC, Yang KT, Hsieh SL, Lai MZ*, 2010, “Ezrin is a negative regulator of death receptor-induced apoptosis”, ONCOGENE, 29(9), 1374-1383. (SCIE)
  • Hsu TL, Cheng SC, Yang WB, Chin SW, Chen BH, Huang MT, Hsieh SL*, Wong CH*, 2009, “Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins”, JOURNAL OF BIOLOGICAL CHEMISTRY, 284(50), 34479-34489. (SCIE)
  • Chen CY, Yang KY, Chen MY, Chen HY, Lin MT, Lee YC, Perng RP, Hsieh SL, Yang PC, Chou TY*, 2009, “Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome”, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180(8), 751-760. (SCIE)
  • Wu MF, Yang CY, Lin TL, Wang JT, Yang FL, Wu SH, Hu BS, Chou TY, Tsai MD, Lin CH, Hsieh SL*, 2009, “Humoral immunity against capsule polysaccharide protects the host from magA+ Klebsiella pneumoniae-induced lethal disease by evading Toll-like receptor 4 signaling”, INFECTION AND IMMUNITY, 77(2), 615-621. (SCIE)
  • How CK, Chern CH, Wu MF, Wang LM, Huang CI, Lee CH, Hsieh SL*., 2009, “Expression of the triggering receptor expressed on myeloid cells-1 mRNA in a heterogeneous infected population”, INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 63(1), 126-133. (SCIE)
  • Chen ML, Adak AK, Yeh NC, Yang WB, Chuang YJ, Wong CH, Hwang KC, Hwu JR, Hsieh SL, Lin CC*, 2008, “Fabrication of an oriented Fc-fused lectin microarray through boronate formation”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47(45), 8627-8630. (SCIE)
  • Tsai CM, Chiu YK, Hsu TL, Lin IY, Hsieh SL, Lin KI*, 2008, “Galectin-1 promotes immunoglobulin production during plasma cell differentiation”, JOURNAL OF IMMUNOLOGY, 181(7), 4570-4579. (SCIE)
  • Chang PM, Chen PM, Hsieh SL, Tzeng CH, Liu JH, Chiou TJ, Wang WS, Yen CC, Gau JP, Yang MH*, 2008, “Expression of a soluble decoy receptor 3 in patients with diffuse large B-cell lymphoma predicts clinical outcome”, INTERNATIONAL JOURNAL OF ONCOLOGY, 33(3), 549-554. (SCIE)
  • Hsieh SL*, 2008, “Decoy Receptor 3 (DcR3): A Pleiotropic Immunomodulator”, BLOOD, 112(3), 916-917. (SCIE)
  • Chen ST, Lin YL, Huang MT, Wu MF, Cheng SC, Lei HY, Lee CK, Chiou TW, Wong CH, Hsieh SL*, 2008, “CLEC5A is critical for dengue-virus-induced lethal disease”, NATURE, 453(7195), 672-676. (SCIE)
  • Chang YC, Chen TC, Lee CT, Yang CY, Wang HW, Wang CC, Hsieh SL*, 2008, “Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3”, BLOOD, 111(10), 5054-5063. (SCIE)
  • Lee CS, Hu CY, Tsai HF, Wu CS, Hsieh SL, Liu LC, Hsu PN*, 2008, “Elevated serum decoy receptor 3 with enhanced T cell activation in systemic lupus erythematosus”, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 151(3), 383-390. (SCIE)
  • Wang SK, Liang PH, Astronomo RD, Hsu TL, Hsieh SL, Burton DR, Wong CH*, 2008, “Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(10), 3690-3695. (SCIE)
  • You RI, Chang YC, Chen PM, Wang WS, Hsu TL, Yang CY, Lee CT, Hsieh SL*, 2008, “Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3)”, BLOOD, 111(3), 1480-1488. (SCIE)
  • Ka SM, Sytwu HK, Chang DM, Hsieh SL, Tsai PY, Chen A*, 2007, “Decoy Receptor 3 Ameliorates an Autoimmune Crescentic Glomerulonephritis Model in Mice”, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 18(9), 2473-2485. (SCIE)
  • Wang PH, Horng HC, Chen YJ, Hsieh SL, Chao HT, Yuan CC*, 2007, “Effect of a selective nonsteroidal anti-inflammatory drug, celecoxib, on the reproductive function of female mice”, JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, 70(6), 245-248. (SCIE)
  • Ho CH, Hsu CF, Fong PF, Tai SK, Hsieh SL, Chen CJ*, 2007, “Epstein-Barr Virus Transcription Activator Rta Upregulates Decoy Receptor 3 Expression by Binding to its Promoter”, JOURNAL OF VIROLOGY, 81(9), 4837-4847. (SCIE)
  • Tang CH, Hsu TL, Lin WW, Lai MZ, Yang RS, Hsieh SL*, Fu WM*, 2007, “Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice”, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(4), 2346-2354. (SCIE)
  • Lian WN, Chang CH, Chen YJ, Dao RL, Luo YC, Chien JY, Hsieh SL, Lin H*, 2007, “Intracellular delivery can be achieved by bombarding cells or tissues with accelerated molecules or bacteria without the need for carrier particles”, EXPERIMENTAL CELL RESEARCH, 313(1), 53-64. (SCIE)
  • Wei CY, Chou YH, Ho FM, Hsieh SL, Lin WW*, 2006, “Signaling Pathways of LIGHT Induced Macrophage Migration and Vascular Smooth Muscle Cell Proliferation”, JOURNAL OF CELLULAR PHYSIOLOGY, 209(3), 735-743. (SCIE)
  • Chen SJ, Chu ML, Wang CJ, Liao CL, Hsieh SL, Sytwu HK, Wang CC*, 2006, “Kinetic Th1/Th2 responses of transgenic mice with bacterial meningitis induced by Haemophilus influenzae”, CLINICAL SCIENCE, 111(4), 253-263. (SCIE)
  • Chen SJ, Liao CL, Hsieh SL, Chu ML, Fang MC, Sytwu HK, Wang CC*, 2006, “Kinetics of adaptive immunity to Haemophilus influenzae type b meningitis in transgenic mice: Evidence from diverse expression of double T1/T2 transgenes and Th1/Th2-related cytokines”, IMMUNOLOGY LETTERS, 105(1), 6-15. (SCIE)
  • Liu SJ, Leng CH, Lien SP, Chi HY, Huang CY, Lin CL, Lian WC, Chen CJ, Hsieh SL, Chong P*, 2006, “Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates”, VACCINE, 24(16), 3100-3108. (SCIE)
  • You RI, Chen MC, Wang HW, Chou YC, Lin CH, Hsieh SL*, 2006, “Inhibition of Lymphotoxin-{beta} Receptor-Mediated Cell Death by Survivin-{Delta}Ex3”, CANCER RESEARCH, 66(6), 3051-3061. (SCIE)
  • Su WB, Chang YH, Lin WW, Hsieh SL*, 2006, “Differential regulation of interleukin-8 gene transcription by deathreceptor 3 (DR3) and type I TNF receptor (TNFRI)”, EXPERIMENTAL CELL RESEARCH, 312(3), 266-277. (SCIE)
  • Lu YT, Yen CY, Ho HC, Chen CJ, Wu MF, Hsieh SL*, 2006, “Preparation and characterization of monoclonal antibody against protein TREM-like transcript-1 (TLT-1)”, HYBRIDOMA, 25(1), 20-26.
  • Chang YC, Chan YH, David G Jackson, Hsieh SL*, 2006, “The glycosaminoglycan-binding domain of decoy receptor 3 is essential forinduction of monocyte adhesion”, JOURNAL OF IMMUNOLOGY, 176(1), 173-180. (SCIE)
  • Wang PH*, Lee WL, Juang CM, Yang YH, Lo WH, Lai CR, Hsieh SL, Yuan CC, 2005, “Altered mRNA expressions of sialyltransferases in ovarian cancers”, GYNECOLOGIC ONCOLOGY, 99(3), 631-639. (SCIE)
  • Chang YC, Hsieh SL*, 2005, “Immonomodulatory Effects of Decoy Receptor 3(DcR3)”, FORMOSAN JOURNAL OF RHEUMATOLOGY, 19(3-4): 91-6.
  • Hung JT, Liao JH, Lin YC, Chang HY, Wu SF, Chang TH , John T. Kung, Hsieh SL, Hugh McDevitt, Sytwu HK*, 2005, “Immunopathogenic role of TH1 cells in autoimmune diabetes: Evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model”, JOURNAL OF AUTOIMMUNITY, 25(3), 181-192. (SCIE)
  • Hsu TL, Wu YY, Chang YC, Yang CY, Lai MZ, Su WB, Hsieh SL*, 2005, “Attenuation of Th1 response in decoy receptor 3 transgenic mice”, JOURNAL OF IMMUNOLOGY, 175(8), 5135-5145. (SCIE)
  • Huang LF, Liu YK, Lu CA, Hsieh SL, Yu SM*, 2005, “Production of human serum albumin by sugar starvation induce”, TRANSGENIC RESEARCH, 14(5), 569-581. (SCIE)
  • Chi KH, Liu SJ, Li CP, Kuo HP, Wang YS, Chao Y, Hsieh SL*, 2005, “Combination of conformal radiotherapy and intratumoral injection ofadoptive dendritic cell immunotherapy in refractory hepatoma”, JOURNAL OF IMMUNOTHERAPY, 28(2), 129-135. (SCIE)
  • Yang CR, Hsieh SL, Ho FM, Lin WW*, 2005, “Decoy receptor 3 increases monocyte adhesion to endothelial cells via NF-kappa B-dependent up-regulation of intercellular adhesion molecule-1, VCAM-1, and IL-8 expression”, JOURNAL OF IMMUNOLOGY, 174(3), 1647-1656. (SCIE)
  • Chang YH, Hsieh SL, Chao Y, Chou YC, Lin WW*, 2005, “Proinflammatory effects of LIGHT through HVEM and LTbetaR interactions incultured human umbilical vein endothelial cells”, JOURNAL OF BIOMEDICAL SCIENCE, 12(2), 363-375. (SCIE)
  • Chang YH, Chao Y, Hsieh SL, Lin WW*, 2004, “Mechanism of LIGHT/interferon-gamma-induced cell death in HT-29 cell”, JOURNAL OF CELLULAR BIOCHEMISTRY, 93(6), 1188-1202. (SCIE)
  • Wu YY, Chang YC, Hsu TL, Hsieh SL, Lai MZ*, 2004, “Sensitization of cells to TRAIL-induced apoptosis by decoy receptor 3”, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(42), 44211-44218. (SCIE)
  • Yang CR, Wang JH, Hsieh SL, Wang SM, Hsu TL, Lin WW*, 2004, “Decoy receptor 3 (DcR3) induces osteoclast formation frommonocyte/macrophage lineage precursor cells”, CELL DEATH AND DIFFERENTIATION, 11(1), 97-107. (SCIE)
  • Chen CC, Yang YH, Lin YT, Hsieh SL, Chiang BL*, 2004, “Soluble decoy receptor 3: increased levels in atopic patients”, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 114(1), 195-197. (SCIE)
  • Sung HH, Juang JH, Lin YC, Kuo CH, Hung JT, Chen A, Chang DM, Chang SY, Hsieh SL, Sytwu HK*, 2004, “Transgenic expression of decoy receptor 3 protects islets from spontaneousand chemical-induced autoimmune destruction in nonobese diabetic mice”, JOURNAL OF EXPERIMENTAL MEDICINE, 199(8), 1143-1151. (SCIE)
  • Lee OK, Kuo TK, Chen WM, Lee KD, Hsieh SL, Chen TH*, 2004, “Isolation of multipotent mesenchymal stem cells from umbilical cord blood”, BLOOD, 103(5), 1669-1675. (SCIE)
  • Chang YC, Hsu TL, Lin HH, Chio CC, Chiu AW, Chen NJ, Lin CH, Hsieh SL*, 2004, “Modulation of macrophage differentiation and activation by decoy receptor 3”, JOURNAL OF LEUKOCYTE BIOLOGY, 75(3), 486-494. (SCIE)
  • Wu SF, Liu TM, Lin YC, Sytwu HK, Juan HF, Chen ST, Shen KL, Hsi SC, Hsieh SL*, 2004, “Immunomodulatory effect of decoy receptor 3 on the differentiation andfunction of bone marrow-derived dendritic cells in nonobese diabetic mice”, JOURNAL OF LEUKOCYTE BIOLOGY, 75(2), 293-306. (SCIE)
  • Yang CR, Hsieh SL, Teng CM, Ho FM, Su WL, Lin WW*, 2004, “Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, acytokine belonging to tumor necrosis factor superfamily and exhibitin”, CANCER RESEARCH, 64(3), 1122-1129. (SCIE)
  • Hsu MJ, Lin WW, Tsao WC, Chang YC, Hsu TL, Chiu AW, Chio CC, Hsieh SL*, 2004, “Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3”, EXPERIMENTAL CELL RESEARCH, 292(2), 241-251. (SCIE)
  • 謝世良,2003,〈第十七章:流式細胞技術〉,醫藥基因生物技術教學資源中心編,《後基因體時代之生物技術》,頁249-261,台灣台北:教育部顧問室。
  • Chen MC, Hwang MJ, Chou YC, Chen WH, Cheng G, Hiroyasu Nakano, Luh TY, Mai SC, Hsieh SL*, 2003, “The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death”, JOURNAL OF BIOLOGICAL CHEMISTRY, 278(18), 16073-16081. (SCIE)
  • Huang YL, Liu CJ, Chiu AW, Wang YC, Huan SK, Lee FL, Chen SJ, Hsu WM, Hsieh SL*., 2002, “A feasible tool to detect mRNA expression of matrix metalloproteinases and their tissue inhibitors in human Tenon's capsule”, OPHTHALMIC RESEARCH, 34(6), 375-379. (SCIE)
  • Chang YH, Hsieh SL, Chen MC, Lin WW*, 2002, “Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation”, EXPERIMENTAL CELL RESEARCH, 278(2), 166-174. (SCIE)
  • Hung SC, Chen NJ, Hsieh SL, Li H, Ma HL, Lo WH*, 2002, “Isolation and characterization of size-sieved stem cells from human bone marrow”, STEM CELLS, 20(3), 249-258. (SCIE)
  • Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL*, 2002, “Modulation of dendritic cell differentiation and maturation by decoy receptor 3”, JOURNAL OF IMMUNOLOGY, 168(10), 4846-4853. (SCIE)
  • Chow KP, Lu HC, Chou HF, Liu HP, Hsieh SL, Chang YS, Choo KB*, 2002, “Induction of chemosensitivity in nasopharyngeal carcinoma cells using ahuman papillomavirus regulatory sequence and the thymidine kinase gene”, JOURNAL OF BIOMEDICAL SCIENCE, 9(1), 41-46. (SCIE)
  • Chou AH, Tsai HF, Lin LL, Hsieh SL, Hsu PI, Hsu PN*, 2001, “Enhanced proliferation and increased IFN-gamma production in T cells bysignal transduced through TNF-related apoptosis-inducing ligand”, JOURNAL OF IMMUNOLOGY, 167(3), 1347-1352. (SCIE)
  • Hsu PN, Lin HH, Tu CF, Chen NJ, Wu KM, Tsai HF, Hsieh SL*, 2001, “Expression of human Fas ligand on mouse beta islet cells does not induce insulitis but is insufficient to confer immune privilege for islet grafts”, JOURNAL OF BIOMEDICAL SCIENCE, 8(3), 262-269. (SCIE)
  • Chen BC, Hsieh SL, Lin WW*, 2001, “Involvement of protein kinases in the potentiation of lipopolysaccharide-induced inflammatory mediator formation by thapsigargin in peritoneal macrophages”, JOURNAL OF LEUKOCYTE BIOLOGY, 69(2), 280-288. (SCIE)
  • Chen NJ, Huang MW, Hsieh SL*, 2001, “Enhanced secretion of IFN-gamma by activated Th1 cells occurs via reverse signaling through TNF-related activation-induced cytokine”, JOURNAL OF IMMUNOLOGY, 166(1), 270-276. (SCIE)
  • Huang TH, Wu PY, Lee CN, Huang HI, Hsieh SL, Kung J, Tao MH*, 2000, “Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen”, BLOOD, 96(12), 3663-3670. (SCIE)
  • Chen MC, Hsu TL, Luh TY, Hsieh SL*, 2000, “Overexpression of bcl-2 enhances LIGHT- and interferon-gamma -mediatedapoptosis in Hep3BT2 cells”, JOURNAL OF BIOLOGICAL CHEMISTRY, 275(49), 38794-38801. (SCIE)
  • Chen W, Lin Y, Liao C, Hsieh SL*, 2000, “Modulatory effects of the human heat shock protein 70 on DNA vaccinatio”, JOURNAL OF BIOMEDICAL SCIENCE, 7(5), 412-419. (SCIE)
  • Tu CF, Hsieh SL, Lee JM, Yang LL, Sato T, Lee KH, Weng CN, Mao SJ, Tsuji K, Lee CJ*, 2000, “Successful generation of transgenic pigs for human decay-accelerating factor and human leucocyte antigen DQ”, TRANSPLANTATION PROCEEDINGS, 32(5), 913-915. (SCIE)
  • K Tamada, K Shimozaki, AI Chapoval, Zhai Y, Su J, Chen SF, Hsieh SL, S Nagata, Ni J, Chen L*, 2000, “LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response”, JOURNAL OF IMMUNOLOGY, 164(8), 4105-4110. (SCIE)
  • Hsieh SL*, Chen N, K Tarbell, Liao N, Lai Y, Lee K, Lee K, Wu S, Sytwu H, Han SH, H McDevitt., 2000, “Transgenic mice expressing surface markers for IFN-γ and IL-4 producing cells”, MOLECULAR IMMUNOLOGY, 37(6), 281-293. (SCIE)
  • Wu MY, Wang PY, Han SH, Hsieh SL*, 1999, “The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells”, JOURNAL OF BIOLOGICAL CHEMISTRY, 274(17), 11868-11873. (SCIE)
  • N Gomez-Escobar, Chou CF, Lin WW, Hsieh SL, RD Campbell*, 1998, “The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase”, JOURNAL OF BIOLOGICAL CHEMISTRY, 273(47), 30954-30960. (SCIE)
  • Zhai Y, R. Guo, Hsu TL, Yu GL, Ni J, Kwon BS, Jiang GW, Lu Tan JJ, M. Ugustus, K. Carter, L. Rojas, Zhu F, C. Lincoln, G. Endress, Xing L, Wang S, K. O. Oh, R. Gentz, S. Ruben, M. E. Lippman, Hsieh SL, Yang D*, 1998, “LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM inducesapoptosis and suppresses in vivo tumor formation via gene transfer”, JOURNAL OF CLINICAL INVESTIGATION, 102(6), 1142-1151. (SCIE)
  • Wu MY, Hsu TL, Lin WW, RD Campbell, Hsieh SL*, 1997, “Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells”, JOURNAL OF BIOLOGICAL CHEMISTRY, 272(27), 17154-17159. (SCIE)
  • Hsieh SL, RE March, A Khanna, SJ Cross, RD Campbell*, 1997, “Mapping of 10 novel microsatellites in the MHC class III region:application to the study of autoimmune disease”, JOURNAL OF RHEUMATOLOGY, 24(1), 220-222. (SCIE)
  • CA Sargent, MJ Anderson, Hsieh SL, E Kendall, N Gomez-Escobar, RD Campbell*, 1994, “Characterisation of the novel gene G11 lying adjacent to the complementC4A gene in the human major histocompatibility complex”, HUMAN MOLECULAR GENETICS, 3(3), 481-488. (SCIE)
  • Zhu ZB, Hsieh SL, DR Bentley, RD Campbell, JE Volanakis*, 1992, “A variable number of tandem repeats locus within the human complement C2gene is associated with a retroposon derived from a human endogenou”, JOURNAL OF EXPERIMENTAL MEDICINE, 175(6), 1783-1787. (SCIE)
  • Hsieh SL, RD Campbell*, 1991, “Evidence that gene G7a in the human major histocompatibility complexencodes valyl-tRNA synthetase”, The Biochemical journal, 278(3), 809-816. (SCIE)
  • Yeh NH, Chen CM, Hsieh SL*, 1988, “Rapid identification of monoclonal antibodies to differential antigens bydot immunobinding assay”, Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology, 21(4), 210-223.

BOOK:

  • Shie-Liang Hsieh*: Lectins in Host-Pathogen Interaction (Editor, Springer Publisher, to be completed in 2018)

BOOK CHAPTER:

  • Shie-Liang Hsieh* "C-Type Lectin Receptors in Immunity" Chapter 3: C-type lectin member 5A. 2016 (editor: Sho Yamasaki) Springer Publisher Ltd. ISBN 978-4-431-56015-9
  • Szu-Ting Chen, Yi-Ling Lin, Ming-Ting Huang, Ming-Fang Wu, Shie-Liang Hsieh*(2011). "The Molecular Immunology of Complex Carbohydrates-3" Chapter 40: Targeting C-Type Lectin for the Treatment of Flavivirus Infections. Springer Publisher Ltd. ISBN 978-1-4419-7877-6