語言

Cheng, Wei-Chieh

WCCheng6x7Associate Professor

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EDUCATION AND POSITIONS HELD:

  • B.S., Chemistry, National Cheng-Kung University Taiwan, 1991
  • M.S., Chemistry National Tsing-Hua University Taiwan, 1993
  • Ph.D., Chemistry, University of California, Davis CA, USA, 1997-2002
  • Postdoctoral Fellow, the Scripps Research Institute, USA, 2002-2004
  • Assistant Professor, Genomics Research Center, Academia Sinica, Taiwan, 2004-2010
  • Associate Professor, Genomics Research Center, Academia Sinica, Taiwan, 2010-present

HONORS:

  • Skaggs Postdoctoral Fellowship, 2002-2004
  • The distinguished lectureship award (Natural products synthesis), the CSJ (Chemical Society of Japan) Asian International Symposium, Japan, 2007

RESEARCH INTERESTS:

The major research efforts of this group are directed toward the development of new synthetic strategies for biologically interesting natural products and heterocyclics. To understand the relationships between small molecules and biological systems, combinatorial approaches are applied in our diverse molecule library synthesis (core diversity, substituent diversity, and configuration diversity) with the assistance of automated or semi-automated equipment.

  • Organic Chemistry and Chemical Biology
  • Development of new synthetic methodology
  • Natural product and natural product-like molecule synthesis
  • Synthesis of biologically interesting molecule libraries
  • Development of new high-throughput library synthesis
  • Combinatorial approach towards the synthesis of natural product-like or novel heterocyclic molecule libraries
  • Study of the cell wall transglycosylase as a potential antibacterial target
  • Lead discovery of cell wall synthesis enzymes in mycobacterium
  • Novel chemical probe synthesis and application
  • Synthesis of chemical chaperones towards lysosomal storage disease associated enzymes
  • Synthesis of novel five- and six-membered iminosugars

SELECTED PUBLICATIONS: