Medical Biology Division 2021


Chen, Chien-Jen

  • Tsai TL, Kuo CC, Hsu LI, Tsai SF, Chiou HY, Chen CJ*, Hsu KH, Wang SL, 2021, “Association between arsenic exposure, DNA damage, and urological cancers incidence: A long-term follow-up study of residents in an arseniasis endemic area of northeastern Taiwan.”, Chemosphere, 266, 129094. (SCIE)
  • Pan WC, Yeh SY, Wu CD, Huang YT, Chen YC, Chen CJ, Yang HI, 2021, “Association between Traffic Count and Cardiovascular Mortality: A Prospective Cohort Study in Taiwan.”, Journal of Epidemiology, 31(5), 343-349. (SCIE)
  • Yu KJ, Hsu WL, Chiang CJ, Chen TC, Liu Z, Lou PJ, Diehl S, Goldstein AM, Chen CJ, Wang CP, Hildesheim A, 2021, “Cancer patterns in nasopharyngeal carcinoma multiplex families over 15 years.”, Cancer, ONLINE, ONLINE-ONLINE. (SCIE)
  • Chen CJ*, You SL, Hsu WL, Yang HI, Lee MH, Chen HC, Chen YY, Liu J, Hu HH, Lin YJ, Chu YJ, Huang YT, Chiang CJ, Chien YC, 2021, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 217, 13-45 pages, Switzerland: Springer, Cham.
  • Lee MH, Huang YH, Coghill AE, Liu Z, Yu KJ, Hsu WL, Chien YC, Wang CP, Chen TC, Chen CJ, Hildesheim A, 2021, “Epstein-Barr Virus-Based Nasopharyngeal Carcinoma (NPC) Risk Prediction Scores Are Elevated in NPC Multiplex Family Members in Taiwan.”, JOURNAL OF INFECTIOUS DISEASES, 223(3), 441-444. (SCIE)
  • Liu PC, Chan C, Huang YH, Chen YJ, Liao SF, Lin YJ, Huang C, Lu SN, Jen CL, Wang LY, Yang HI, Shen CY, Chen CJ, Lee MH, 2021, “Genetic variants associated with serum alanine aminotransferase levels among patients with hepatitis C virus infection: A genome-wide association study.”, Journal of viral hepatitis, 00, 1-9. (SCIE)
  • Wu Meei-Maan, Hsieh Fang-I, Hsu Ling-I, Lee Te-Chang, Chiou Hung-Yi, Chen Chien-Jen, 2021, “GT-Repeat Polymorphism in the HO-1 Gene Promoter Is Associated with Risk of Liver Cancer: A Follow-Up Study from Arseniasis-Endemic Areas in Taiwan”, Journal of Clinical Medicine, 10(7), 1489. (SCIE)
  • NCD Risk Factor Collaboration NCD-RisC, 2021, “Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight.”, eLife, 10, e60060. (SCIE)
  • Koshiol J, Argirion I, Liu Z, Kim Lam T, O'Brien TR, Yu K, McGlynn KA, Petrick JL, Pinto L, Chen CJ, Hildesheim A, Pfeiffer RM, Lee MH, Yang HI, 2021, “Immunologic markers and risk of hepatocellular carcinoma in hepatitis B virus- and hepatitis C virus-infected individuals.”, Alimentary pharmacology & therapeutics, 00, 1-10. (SCIE)
  • Liu Z, Derkach A, Yu KJ, Yeager M, Chang YS, Chen CJ, Gyllensten U, Lan Q, Lee MH, McKay JD, Rothman N, Yang HI, Hildesheim A, Pfeiffer RM, 2021, “Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer.”, Cancer Research, 81(4), 1148-1152. (SCIE)
  • Liao SF, Koshiol J, Huang YH, Jackson SS, Huang YH, Chan C, Huang C, Liu PC, Chen YJ, Hsieh RJ, Huang CP, Lu SN, Chen CJ, Shen CY, Lee MH, 2021, “Postdiagnosis Aspirin Use Associated With Decreased Biliary Tract Cancer-Specific Mortality in a Large Nationwide Cohort.”, HEPATOLOGY, 0, 1-13. (SCIE)
  • Lin JH, Wen CP, Jiang CQ, Yuan JM, Chen CJ, Ho SY, Gao W, Zhang W, Wang R, Chien YC, Xu L, Wu X, Jin YL, Koh WP, Hsu WL, Zhu F, Wen C, Zhu T, Lee JH, Mai ZM, Lung ML, Lam TH, 2021, “Smoking and nasopharyngeal cancer: individual data meta-analysis of six prospective studies on 334 935 men.”, International Journal of Epidemiology, 20(3), 975-986. (SCIE)
  • Blechter B, Wong JYY, Agnes Hsiung C, Hosgood HD, Yin Z, Shu XO, Zhang H, Shi J, Song L, Song M, Zheng W, Wang Z, Caporaso N, Burdette L, Yeager M, Berndt SI, Teresa Landi M, Chen CJ, Chang GC, Hsiao CF, Tsai YH, Chen KY, Huang MS, Su WC, Chen YM, Chien LH, Chen CH, Yang TY, Wang CL, Hung JY, Lin CC, Perng RP, Chen CY, Chen KC, Li YJ, Yu CJ, Chen YS, Chen YH, Tsai FY, Jie Seow W, Bassig BA, Hu W, Ji BT, Wu W, Guan P, He Q, Gao YT, Cai Q, Chow WH, Xiang YB, Lin D, Wu C, Wu YL, Shin MH, Hong YC, Matsuo K, Chen K, Pik Wong M, Lu D, Jin L, Wang JC, Seow A, Wu T, Shen H, Fraumeni JF, Yang PC, Chang IS, Zhou B, Chanock SJ, Rothman N, Chatterjee N, Lan Q, 2021, “Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia.”, ENVIRONMENT INTERNATIONAL, 147, 105975. (SCIE)

Hsiao, Michael

  • Chi LH, Wu ATH, Hsiao M*, Li YC, 2021, “A Transcriptomic Analysis of Head and Neck Squamous Cell Carcinomas for Prognostic Indications”, JOURNAL OF PERSONALIZED MEDICINE, 11(8), 782. (SCIE)
  • Tsai HF, Chang YC, Li CH, Chan MH, Chen CL, Tsai WC, Hsiao M*, 2021, “Type V Collagen Alpha Promotes the Malignancy of Glioblastoma through the PPRC1-ESM1 Axis Activation and Extracellular Matrix Remodeling”, CELL DEATH DISCOVERY, In Press, e-pub. (SCIE)
  • Kuo KT, Yeh CT, Chen TT, Satriyo PB, Wang CH, Wu ATH, Chao TY, Lee KY, Hsiao M, Wang LS, 2021, “Bruton’s Tyrosine Kinase (BTK) Mediates Resistance to EGFR Inhibition in Non-Small Cell Lung Cancer”, ONCOGENESIS, 10(7), 56. (SCIE)
  • Hsu HJ, Tung CP, Yu CM, Chen CY, Chen HS, Huang YC, Tsai PH, Lin SI Peng HP, Chiu YK, Tsou YL, Kuo WY, Jian JW, Hung FH, Hsieh CY, Hsiao M, Chuang SS, Shen CN, Wang YA, Yang AS, 2021, “Eradicating Mesothelin-positive Human Gastric and Pancreatic Tumors in Xenograft Models with Optimized Anti-mesothelin Antibody–drug Conjugates from Synthetic Antibody Libraries”, SCIENTIFIC REPORTS, 11(1), 15430. (SCIE)
  • Chang YC, Chan MH, Li CH, Fang CY, Hsiao M*, Chen CL, 2021, “Exosomal Components and Modulators in Colorectal Cancer: Novel Diagnosis and Prognosis Biomarkers [Invited Review]”, BIOMEDICINES, 9(8), 931. (SCIE)
  • Chung SY, Hung YP, Pan YR, Chang YC, Wu CE, Hsu DS, Chang PM, Lu ML, Huang CY, Su Y, Hsiao M, Yeh CN, Chen MH, 2021, “Ruxolitinib Combined with Gemcitabine against Cholangiocarcinoma Growth via the JAK2/STAT1/3/ALDH1A3 Pathway”, BIOMEDICINES, 9(8), 885. (SCIE)
  • Chan MH, Chen W, Li CH, Fang CY, Chang YC, Wei DH, Liu RS, Hsiao M*, 2021, “An Advanced In Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood–Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles”, ACS APPLIED MATERIALS & INTERFACES, 13(23), 26759-26769. (SCIE)
  • Chang YC, Chan MH, Li CH, Yang CJ, Tseng YW, Tsai HF, Chiou J, Hsiao M*, 2021, “Metabolic protein phosphoglycerate kinase 1 confers lung cancer migration by directly binding HIV Tat specific factor 1”, CELL DEATH & DISCOVERY, 7(1), 135. (SCIE)
  • Yuan LT, Lee WJ, Yang YC, Chen BR, Yang CY, Chen MW, Chen JQ, Hsiao M, Chien MH, Hua KT, 2021, “Histone Methyltransferase G9a-Promoted Progression of Hepatocellular Carcinoma Is Targeted by Liver-Specific Hsa-miR-122”, CANCERS, 13(10), 2376. (SCIE)
  • Yang YC, Chien MH, Lai TC, Tung MC, Jan YH, Chang WM, Jung SM, Chen MH, Yeh CN, Hsiao M*, 2021, “Proteomics-based identification of TMED9 is linked to vascular invasion and poor prognoses in patients with hepatocellular carcinoma”, JOURNAL OF BIOMEDICAL SCIENCE, 28(1), 29. (SCIE)
  • Lin TC, Hsiao M*, 2021, “Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments - [Invited Reviews]”, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(6), 2870. (SCIE)
  • Pan JK, Lin CH, Kuo YL, Ger LP, Cheng HC, Yao YC, Hsiao M, Lu PJ, 2021, “MiR-211 determines brain metastasis specificity through SOX11/NGN2 axis in triple-negative breast cancer”, ONCOGENE, 40(9), 1737-1751. (SCIE)
  • Huang WT, Su TY, Chan MH, Tsai JY, Do YY, Huang PL, Hsiao M*, Liu RS, 2021, “Near-infrared Nanophosphor Embedded in Mesoporous Silica Nanoparticle with High Light-Harvesting Efficiency to Promote Dual Photosystem”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 60(13), 6955-6959. (SCIE)
  • Chuang HH, Zhen YY, Tsai YC, Chuang CH, Huang MS, Hsiao M*, Yang CJ, 2021, “Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy - [Invited Reviews]”, BIOMEDICINES, 9(4), 359. (SCIE)
  • Li LJ, Chang WM, Hsiao M*, 2021, “Aberrant Expression of microRNA Clusters in Head and Neck Cancer Development and Progression: Current and Future Translational Impacts - [Invited Reviews]”, PHARMACEUTICALS, 14(3), 194. (SCIE)
  • Chen CL, Chen CC, Yu WH, Chen SH, Chang YC, Hsu TI, Hsiao M, Yeh CY, Chen CY, 2021, “An annotation-free whole-slide training approach to pathological classification of lung cancer types using deep learning”, NATURE COMMUNICATIONS, 12(1), 1193. (SCIE)
  • Pan KF, Lee WJ, Chou CC, Yang YC, Chang YC, Chien MH, Hsiao M, Hua KT, 2021, “Direct interaction of β‐catenin with nuclear ESM1 supports stemness of metastatic prostate cancer”, EMBO JOURNAL, 40(4), e105450. (SCIE)
  • Cheng CL, Chan MH, Feng SJ, Hsiao M*, Liu RS, 2021, “Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites”, ACS APPLIED MATERIALS & INTERFACES, 13(5), 6099-6108. (SCIE)
  • Chen WY, Wen YC, Lin SR, Yeh HL, Jiang KC, Chen WH, Lin YS, Zhang Q, Liew PL, Hsiao M, Huang J, Liu YN, 2021, “Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance”, COMMUNICATIONS BIOLOGY, 4(1), 22. (SCIE)

Hsieh, Shie-Liang

  • Tsai TY, Huang MT, Sung PS, Peng CY, Tao MH, Yang HI, Chang WC, Yang AS, Yu CM, Lin YP, Ching-Yu Bau3, Huang CJ, Pan MH, Wu CY, Hsiao CD, Yeh YH, Shiteng Duan, James C Paulson, Hsieh SL*, 2021, “Siglec-3 (CD33) is the immune checkpoint receptor in HBV infection”, JOURNAL OF CLINICAL INVESTIGATION, 131(11), 141965. (SCIE)
  • Pan YG, Huang MT, P. Sekar, Huang DY, Lin WW, Hsieh SL*, 2021, “Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture”, FRONTIERS IN IMMUNOLOGY, 12: 638676, 1-16. (SCIE)
  • Huang YL , Huang MT, Sung PS, Chou TY, Yang RB, Yang AS, Yu CM, Hsu YW, Chang WC, Hsieh SL*, 2021, “Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection”, Communications biology, 4(1): 229, 1-13. (SCIE)

Hwang-Verslues, Wendy W.

  • Ling-Chih Chen, Yung-Lin Hsieh, Grace Y.T. Tan, Tai-Yun Kuo, Yu-Chi Chou, Pang-Hung Hsu, Wendy W Hwang-Verslues*, 2021, “Differential Effects of SUMO1 and SUMO2 on Circadian Protein PER2 Stability and Function”, SCIENTIFIC REPORTS, 11, 14431. (SCIE) (IF:  ;  )
  • Po-Hao Chang, Min-Che Chen, Ya-Ping Tsai, Grace Y.T. Tan, Pang-Hung Hsu, Yung-Ming Jeng, Yi-Fang Tsai, Muh-Hwa Yang, Wendy W. Hwang-Verslues*, 2021, “Interplay between Desmoglein2 and hypoxia controls metastasis in breast cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(3), e2014408118. (SCIE)

Lin, Kuo-I

  • Ko, Y.-A., Yu, Y.-H., Wu, Y.-F., Tseng, Y.-C., Chen, C.-L., Goh, K.-S, Liao, H.-Y., Chen, T.-H., Cheng, R. T.-J., Yang, A.-S., Wong, C.-H., Ma, C. and Lin, K.-I*, 2021, “A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells”, PLOS PATHOGENS, 17(8), e1009724. (SCIE)
  • Lo, L.-W., Chang, C.-W., Chiang, M.-F., Lin, I-Y., and Lin, K.-I*, 2021, “Marginal zone B cells assist with neutrophil accumulation to fight against systemic Staphylococcus aureus infection”, FRONTIERS IN IMMUNOLOGY, 12, 636818. (SCIE)
  • Lee, W., Wang, L.-T., Yen, M.-L., Hsu, P.-J., Lee, Y.-W., Liu, K.-J., Lin, K.-I, Su, Y.-W., Sytwu, H.-K., and Yen, B. L., 2021, “Resident vs. nonresident multipotent mesenchymal stromal cell interactions with B lymphocytes result in disparate outcomes”, Stem Cells Transi Med, 10(5), 711-724.

Lu, Joyce Jean

  • Lai YP, Kuo LC, Lin BR, Lin HJ, Lin CY, Chen YT, Hsiao PW, Chang HT, Ko PC, Chen HC, Chang HY, Lu J, Ho HN, Wu-Hsieh BA, Kung JT, Chen SC, 2021, “CD28 engagement inhibits CD73-mediated regulatory activity of CD8(+) T cells.”, Communications biology, 4(1), 595. (SCIE)

Shen, Chia-Ning

  • Hsu HJ, Tung CP, Yu CM, Chen CY, Chen HS, Huang YC, Tsai PH, Lin SI, Peng HP, Chiu YK, Tsou YL, Kuo WY, Jian JW, Hung FH, Hsieh CY, Hsiao M, Chuang SS, Shen CN, Wang YA, Yang AS, 2021, “Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody-drug conjugates from synthetic antibody libraries.”, Scientific reports, 11(1), 15430. (SCIE)
  • Wu, H.H., L.H. Tsai, C.K. Huang, S.C. Huang, P.H. Hsu, M.Y. Chen, Y.I. Chen, C.M. Hu, C.N.Shen, C.C. Lee, M.C. Chang, Y.T. Chang, Y.W. Tien, Y.M. Jeng, E. Lee, and W.H. Lee*, 2021, “Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer”, Science Translational Medicine, 13, eabc2823. (SCIE)

Yang, Hwai-I

  • Li Jie, Yang Hwai-I, Yeh Ming-Lun, Le Michael H, Le An K, Yeo Yee Hui, Dai Chia-Yen, Barnett Scott, Zhang Jian Q, Huang Jee-Fu, Trinh Huy N, Wong Christopher, Wong Clifford, Hoang Joseph K, Cheung Ramsey, Yu Ming-Lung, Nguyen Mindie H, 2021, “Association between fatty liver and cirrhosis, hepatocellular carcinoma, and HBsAg seroclearance in chronic hepatitis B”, The Journal of Infectious Diseases, jiaa739. (SCIE)
  • Pan WC*, Yeh SY, Wu CD, Huang YT, Chen YC, Chen CJ, Yang HI*, 2021, “Association between Traffic Count and Cardiovascular Mortality: A Prospective Cohort Study in Taiwan.”, JOURNAL OF EPIDEMIOLOGY, 31(5), 343-349. (SCIE)
  • Le AK, Yang HI, Yeh ML, Jin M, Trinh HN, Henry L, Liu A, Zhang JQ, Li J, Wong C, Wong C, Cheung R, Yu ML, Nguyen MH, 2021, “Development and validation of a risk score for liver cirrhosis prediction in untreated and treated chronic hepatitis B.”, JOURNAL OF INFECTIOUS DISEASES, 223(1), 139-146. (SCIE)
  • Yang HI*, Hsu YC, 2021, “Editorial: incorporating liver stiffness to risk scores for HCC in patients with chronic hepatitis B treated with oral antivirals: ready to use or not?”, Alimentary pharmacology & therapeutics, 53(6), 753-754. (SCIE)
  • Chen Chien-Jen, You San-Lin, Hsu Wan-Lun, Yang Hwai-I, Lee Mei-Hsuan, Chen Hui-Chi, Chen Yun-Yuan, Liu Jessica, Hu Hui-Han, Lin Yu-Ju, Chu Yu-Ju, Huang Yen-Tsung, Chiang Chun-Ju, Chien Yin-Chu, 2021, “Epidemiology of Virus Infection and Human Cancer”, Recent Results Cancer Res, 217, 13-45.
  • Huang Daniel Q., Li Xiaohe, Le Michael H., Le An K., Yeo Yee Hui, Trinh Huy N., Zhang Jian, Li Jiayi, Wong Christopher, Wong Clifford, Cheung Ramsey C., Yang Hwai-I*, Nguyen Mindie H.*, 2021, “Natural History and Hepatocellular Carcinoma Risk in Untreated Chronic Hepatitis B Patients with Indeterminate Phase”, Clinical Gastroenterology and Hepatology, S1542-3565(21)00069-0, doi: 10.1016/j.cgh.2021.01.019. (SCIE)
  • Tsai TY, Huang MT, Sung PS, Peng CY, Tao MH, Yang HI, Chang WC, Yang AS, Yu CM, Lin YP, Bau CY, Huang CJ, Pan MH, Wu CY, Hsiao CD, Yeh YH, Duan S, Paulson JC, Hsieh SL, 2021, “SIGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection.”, The Journal of clinical investigation, 131(11), e141965. (SCIE)
  • Liu Matt, Tseng Tai-Chung, Jun Dae Won, Yeh Ming-Lun, Trinh Huy, Wong Grace L. H., Chen Chien-Hung, Peng Cheng-Yuan, Kim Sung Eun, Oh Hyunwoo, Kwak Min-Sun, Cheung Michael, Toyoda Hidenori, Hsu Yao-Chun, Jeong Jae Yoon, Yoon Eileen L., Ungtrakul Teerapat, Zhang Jian, Xie Qing, Ahn Sang Bong, Enomoto Masaru, Shim Jae-Jun, Cunningham Chris, Jeong Soung Won, Cho Yong Kyun, Ogawa Eiichi, Huang Rui, Lee Dong-Hyun, Takahashi Hirokazu, Tsai Pei-Chien, Huang Chung-Feng, Dai Chia-Yen, Tseng Cheng-Hao, Yasuda Satoshi, Kozuka Ritsuzo, Li Jiayi, Wong Christopher, Wong Clifford C., Zhao Changqing, Hoang Joseph, Eguchi Yuichiro, Wu Chao, Tanaka Yasuhito, Gane Ed, Tanwandee Tawesak, Cheung Ramsey, Yuen Man-Fung, Lee Hyo-Suk, Yu Ming-Lung, Kao Jia-Horng, Yang Hwai-I, Nguyen Mindie H., 2021, “Transition rates to cirrhosis and liver cancer by age, gender, disease and treatment status in Asian chronic hepatitis B patients”, Hepatology International, 15(1), 71-81. (SCIE)