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Chemical Biology Division 2013

Chen, Yun-Ru Ruby

  • Man Hoang Viet, Chun-Yu Chen, Chin-Kun Hu, Yun-Ru Chen*, and Mai Suan Li*., 2013, “Discovery of Dihydrochalcone as potential lead for Alzheimer's disease: in silico and in vitro study”, PLoS One, 8(11), e79151. (SCIE)
  • Rong-Jie Chen, Wei-Wei Chang, Yu-Chun Lin, Pei-Lin Pheng, Yun-Ru Chen*, 2013, “Alzheimer’s Amyloid-β Oligomers Rescue Cellular Prion Protein Induced Tau Reduction via Fyn Pathways”, ACS Chemical Neuroscience, 4(9), 1287-1296. (SCIE)
  • 3. Wei-Chieh Cheng*, Chen-Yi Weng, Wen-Yi Yun, Shang-Yu Chang, Yu-Chun Lin, Fuu-Jen Tsai, Fu-Yung Huang, Yun-Ru Chen., 2013, “Rapid modifications of N-substitution in iminosugars: Development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease. ”, BIOORGANIC & MEDICINAL CHEMISTRY, 1, 5021-5028. (SCIE)
  • Yi-Ting Wang, Pan-Hsien Kuo, Chien-Hao Chiang, Jhe-Ruei Liang, Yun-Ru Chen, Shuying Wang, James C. K. Shen, and Hanna S. Yuan*., 2013, “The truncated C-terminal RRM domain of TDP-43 plays a key role in forming proteinaceous aggregates.”, J Biol. Chem., 288(13), 9049-9057. (SCIE)
  • Winny Ariesandi, Chi-Fon Chang, Tseng-Erh Chen,Yun-Ru Chen*, 2013, “Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization”, PLoS One, 8(1), e53487. (SCIE)

Cheng, Wei-Chieh

  • Cheng TJ, Chan TH, Tsou EL, Chang SY, Yun WY, Yang PJ, Wu YT, Cheng WC, 2013, “From Natural Product-Inspired Pyrrolidine Scaffolds to the Development of New Human Golgi alpha-Mannosidase II Inhibitors.”, Chemistry-An Asian Journal, 8(11), 2600-2604. (SCIE)
  • Huang SH, Wu WS, Huang LY, Huang WF, Fu WC, Chen PT, Fang JM, Cheng WC, Cheng TJ, Wong CH, 2013, “New continuous fluorometric assay for bacterial transglycosylase using Forster resonance energy transfer.”, Journal of the American Chemical Society, 135(45), 17078-17089. (SCIE)
  • Cheng WC, Weng CY, Yun WY, Chang SY, Lin YC, Tsai FJ, Huang FY, Chen YR, 2013, “Rapid modifications of N-substitution in iminosugars: development of new beta-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease.”, Bioorganic & medicinal chemistry, 21(17), 5021-5028. (SCIE)
  • Chen KT, Kuan YC, Fu WC, Liang PH, Cheng TJ, Wong CH, Cheng WC, 2013, “Rapid preparation of mycobacterium N-glycolyl Lipid I and Lipid II derivatives: a biocatalytic approach.”, Chemistry-a European Journal, 19(3), 834-838. (SCIE)
  • Pan YW, Guo CW, Tu HY, Tsai CW, Cheng WC, 2013, “Solid-Phase Synthesis of Diverse Spiroisoxazolinodiketopiperazines.”, ACS combinatorial science, 15(8), 425-434. (SCIE)

Hung, Shang-Cheng

  • Chen, Z.-G.; Hu, Y.-P.; Hung, S.-C., 2013, “Development and Application of Flow Chemistry”, Instruments Today, 66-73.
  • Zulueta, M. M. L.; Lin, S.-Y.; Hung, S.-C., 2013, “Chemical Synthesis of Oligosaccharides Based on Heparin and Heparan Sulfate”, Trends in Glycoscience and Glycotechnology, 25, 141-158. (SCIE)
  • Patil, P. S.; Lee, C.-C.; Huang, Y.-W.; Zulueta, M. M. L.; Hung, S.-C., 2013, “Regioselective and Stereoselective Benzylidene Installation and One-pot Protection of D-mannose”, Organic & Biomolecular Chemistry, 11(16), 2605-2612. (SCIE)
  • Lu, F.-C.; Lico, L. S.; Hung, S.-C., 2013, “Synthesis of Fluorogenic Substrate for α-L-Iduronidase”, ARKIVOC, 2013(2), 13-21. (SCIE, Science Citation Index Expande)
  • Zulueta, M. M. L.; Zhong, Y.-Q.; Hung, S.-C., 2013, “Synthesis of Rare L-Hexoses and Their Related Biomolecules”, Chemical Communications, 49(32), 3275-3287. (SCIE)
  • Woolfson, D. N.; Hung, S.-C., 2013, “Synthetic Biomolecules”, Current Opinion in Chemical Biology, 17(6), 925-928. (SCIE)
  • Zulueta, M. M. L.; Lin, S.-Y.; Hu, Y.-P.; Hung, S.-C., 2013, “Synthetic Heparin and Heparan Sulfate Oligosaccharides and their Protein Interactions”, Current Opinion in Chemical Biology, 17(6), 1023-1029. (SCIE)

Juan, Li-Jung

  • Teng YC, Lee CF, Li YS, Chen YR, Hsiao PW, Chan MY, Lin FM, Huang HD, Chen YT, Jeng YM, Hsu CH, Yan Q, Tsai MD, Juan LJ, 2013, “Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis.”, Cancer research, 73(15), 4711-21. (SCIE)

Li, Tsung-Lin

  • C. J. Chai, Y. L. Chan, T. L. Li, Y. K. Tsai, C. H. Wu, C. Y. Shiaua, C. J. Wu*, 2013, “Evaluation of lanternfish (Benthosema pterotum) hydrolysates as antioxidants against hydrogen peroxide induced oxidative injury”, FOOD RESEARCH INTERNATIONAL, 54(2), 1409-1418. (SCIE)
  • H. Wang, Y. L. Chan, T. L. Li, B. A. Bauer, S. Hsia, C. H. Wang, J. S. Huang, H. M. Wang, K. Y. Yeh, T. H. Huang, C. J. Wu*, 2013, “Reduction of splenic immunosuppressive cells and enhancement of anti-tumor immunity by synergy of fish oil and selenium yeast”, PLOS ONE, 8(1), e52912. (SCIE)

Ma, Che Alex

  • Huang CK, Yang CY, Jeng YM, Chen CL, Wu HH, Chang YC, Ma C, Kuo WH, Chang KJ, Shew JY, Lee WH, 2013, “Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-kappaB-mediated antiapoptotic pathway.”, Oncogene, in press. (SCI)

Wong, Chi-Huey

  • K. J. Doores, M. Huber, K. M. Le, S.-K. Wang, C. Doyle-Cooper, A. Cooper, R. Pantophlet, C.-H. Wong, D. Nemazee, D. R. Burton, 2013, “2G12-expressing B cell lines inform HIV carbohydrate vaccine design strategies”, Journal of Virology, 87(4),2234-2241. (SCIE)
  • E. Al-Shareffi, J.-L. Chaubard, C. Leonhard-Melief, C.-H. Wong, and R. S. Haltiwanger,, 2013, “6-Alkynyl Fucose is a bioorthogonal analogue for O-fucosylation of Epidermal Growth Factor-like repeats and Thrombospondin Type-1 repeats by Protein O-Fucosyltransferases 1 and 2.”, Glycobiology, 23(2), 188-198. (SCIE)
  • C.-S. Tsai, H.-Y. Yen, M.-I. Lin, T.-I. Tsai, S.-Y. Wang, W.-I. Huang, T.-L. Hsu, Y.-S. E. Cheng, J.-M. Fang, C.-H. Wong, 2013, “A Cell Permeable Probe for Identification and Imaging of Sialidases”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(7), 2466-2471. (SCIE)
  • N. Padte, M. B. Carrera, C. A. McManus, B. Grasperge, A. Gettie, J. Coelho-dos-Reis, X. Li, N. Levenkova, D. Wu, J. T. Bruder, M. Sedegah, N. Petterson, T. Richie, C.-H. Wong, D. D. Ho, S. Vasan, M. Tsuji, 2013, “A Glycolipid Adjuvant, 7DW8-5, Enhances CD8+ T Cell Responses Induced by an Adenovirus-Vectored Malaria Vaccine in Non-Human Primates.”, PloS one, 8(10), e78407. (SCIE)
  • H.-W. Huang, C.-H. Chen, C.-H. Lin, C.-H. Wong, K.-I. Lin, 2013, “B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention.”, Proceedings of the National Academy of Sciences of the United States of America, 110(27), 10928-10933. (SCIE)
  • Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu, C.-H. Wong, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, Proceedings of the National Academy of Sciences of the United States of America, 110(7), 2517-2522. (SCIE)
  • T.-J. R. Cheng, S.-Y. Wang, W.-H. Wen, C.-Y. Su, M. Lin, W.-I. Huang, M.-T. Liu, H.-S. Wu, N-S. Wang, C.-K. Cheng, C.-L. Chen, C.-T. Ren, C.-Y. Wu, J.-M. Fang, Y.-S. E. Cheng and C.-H. Wong, 2013, “Chemical probes for drug resistance assessment by binding competition (RABC) oseltamivir susceptibility evaluation”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(1), 366-370. (SCIE)
  • C.-Y. Yang, J.-B. Chen, T.-F. Tsai, Y.-C. Tsai, C.-Y. Tsai, P.-H. Liang, T.-L. Hsu, C.-Y. Wu, M. G. Netea, C.-H. Wong, S.-L. Hsieh, 2013, “CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver.”, PloS one, 8(6), e65070. (SCIE)
  • S.-C. Lin, J.-T. Jan, B. Dionne, M. Butler, M.-H. Huang, C.-Y. Wu, C.-H. Wong, S.-C. Wu, 2013, “Different Immunity Elicited by Recombinant H5N1 Hemagglutinin Proteins Containing Pauci-Mannose, High-Mannose, or Complex Type N-Glycans.”, PloS one, 8(6), e66719. (SCIE)
  • T.-I. Tsai, H.-Y. Lee, S.-H. Chang, C.-H. Wang, Y.-C. Tu, Y.-C. Lin, D.-R. Hwang, C.-Y. Wu, C.-H. Wong, 2013, “Effective sugar nucleotide regeneration for the large-scale enzymatic synthesis of Globo H and SSEA4.”, Journal of the American Chemical Society, 135(39), 14831-14839. (SCIE)
  • S. Shivatare, S.-H.Chang, T.-I. Tsai, C.-T. Ren, H.-Y. Chuang, L. Hsu, C.-W. Lin, S.-T. Li, C.-Y. Wu, C.-H. Wong, 2013, “Efficient Convergent Synthesis of Bi-, Tri-, and Tetra-antennary Complex Type N-Glycans and Their HIV-1 Antigenicity.”, Journal of the American Chemical Society, 135(41), 15382-15391. (SCIE)
  • C.-Y. Chen, Y.-H. Jan, Y.-H. Juan, C.-J. Yang, M.-S. Huang, C.-J. Yu, P.-C. Yang, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2013, “Fucosyltransferase 8 as a Functional Regulator of Non-Small Cell Lung Cancer”, Proceedings of the National Academy of Sciences of the United States of America, 110(2), 630-635. (SCIE)
  • S.-F. Liao, C.-H. Liang, M.-Y. Ho, T.-L. Hsu,T.-I. Tsai, Y. S.-Y. Hsieh, S.-T. Li, Y.-Y. Cheng, S.-M. Tsao,T.-Y. Lin, Z.-Y. Lin,W.-B. Yang,C.-T. Ren, K.-I. Lin, K.-K. Khoo, C.-H. Lin, H.-Y. Hsu,C.-Y. Wu, C.-H. Wong, 2013, “Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies against tumor-associated Globo H-series epitopes”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110, 13809-13814. (SCIE)
  • T.-C. Hung, C.-W. Lin, T.-L. Hsu, C.-Y. Wu, C.-H. Wong, 2013, “Investigation of SSEA-4 binding protein in breast cancer cells.”, Journal of the American Chemical Society, 135(16), 5934-5937. (SCIE)
  • R. Bryk, N. Arango, C. Maksymiuk, A. Balakrishnan, Y.-T. Wu, C.-H. Wong, T. Masquelin, P. Hipskind, C. D. Lima, and C. Nathan, 2013, “Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase”, BIOCHEMISTRY, 52(51), 9375-9384. (SCIE)
  • S.-H. Huang, W.-S. Wu, L.-Y., Huang, W.-F., Huang, W.-C., Fu,; S.-T. Yang, P.-T. Chen, J.-M. Fang, W.-C. Cheng, T.-J. Cheng, C.-H. Wong, 2013, “New continuous fluorometric assay for bacterial transglycosylase using forster resonance energy transfer.”, Journal of the American Chemical Society, 135(45), 17078-17089. (SCIE)
  • K.-T. Chen, Y.-C. Kuan, W.-C. Fu, H.-W. Shih, P.-H. Liang, T.-J. R. Cheng, C.-H. Wong, and W.-C. Cheng, 2013, “Rapid Preparation of Mycobacterium N-Glycolyl Lipid I and Lipid II Derivatives via a Biocatalytic Approach”, Chemistry a European Journal, 19(3), 834-838. (SCIE)
  • W. Chen, S. Enck, J. Price, D. Powers, E. Powers, C.-H. Wong, H. J. Dyson, J. Kelly, 2013, “Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins.”, Journal of the American Chemical Society, 135(26), 9877-9884. (SCIE)
  • K. Ohara, C.-C. Lin, P.-J. Yang, W.-T. Hung, W.-B. Yang, T.-J. Cheng, J.-M. Fang, C.-H. Wong, 2013, “Synthesis and Bioactivity of beta-(1-->4)-Linked Oligomannoses and Partially Acetylated Derivatives.”, The Journal of organic chemistry, 78(13), 6390-6411. (SCIE)
  • H.-Y.Chuang, C.-T. Ren, C.-A. Chao, C.-Y. Wu, S. Shivatare; T.-J. R. Cheng, C.-Y. Wu, C.-H. Wong, 2013, “Synthesis and Vaccine Evaluation of the Tumor-Associated Carbohydrate Antigen RM2 from Prostate Cancer.”, Journal of the American Chemical Society, 135(30), 11140-11150. (SCIE)
  • C.-H. Wang, S.-T. Li, T.-L. Lin, Y.-Y. Cheng, T.-H. Sun, J.-T. Wang, T.-J. Cheng, K.-K. Mong, C.-H. Wong, C.-Y. Wu, 2013, “Synthesis of Neisseria meningitidis Serogroup W135 Capsular Oligosaccharides for Immunogenicity Comparison and Vaccine Development.”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(35), 9157-9161. (SCIE)
  • C.-C.Tsai, C.-R. Lin, H.-Y. Tsai, C.-J. Chen, W.-T. Li, H.-M.Yu, Y.-Y. Ke, W.-Y. Hsieh, C.-Y. Chang, C.-Y. Wu, S.-T. Chen, C.-H. Wong, 2013, “The Immunologically Active Oligosaccharides Isolated from Wheatgrass Modulate Monocytes via Toll-like Receptor-2 Signaling.”, The Journal of biological chemistry, 288(24), 17689-17697. (SCIE)
  • T.-L. Hsu, G. Lin, A. Koizumi, K. Brehm, N. Hada, P.-K.Chuang, C.-H. Wong, S.-L. Hsieh, A. Diaz, 2013, “The surface carbohydrates of the Echinococcus granulosus larva interact selectively with the rodent Kupffer cell receptor.”, Molecular and biochemical parasitology, 192(1-2), 55-9. (SCIE)

Wu, Chung-Yi

  • Yen-Ju Chen; Mike W.C. Thang; Yu-Feng Huang; Yu-Tzu Chan; Nianhan Ma; Chung-Yi Wu; Miao-Lin Hu; Kuo Ping Chiu, 2013, “Global Assessment of Antrodia cinnamomea-induced MicroRNA Alterations in Hepatocarcinoma Cells”, PLoS One, 8(12), e82751. (SCIE)
  • Sachin S Shivatare, Shih-Huang Chang, Tsung-I Tsai, Chein-Tai Ren, Hong-Yang Chuang, Li Hsu, Chih-Wei Lin, Shiou-Ting Li, Chung-Yi Wu,* and Chi-Huey Wong*, 2013, “Efficient Convergent Synthesis of Bi-, Tri-, and Tetraantennary Complex Type N-Glycans and Their HIV-1 Antigenicity.”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135(41), 15382-15391. (SCIE)
  • Tsung-I Tsai, Hsin-Yu Lee, Shih-Huang Chang, Chia-Hung Wang, Yu-Chen Tu, Yu-Chen Lin, Der-Ren Hwang, Chung-Yi Wu, Chi-Huey Wong*, 2013, “Effective Sugar Nucleotide Regenertion for the Large-scale Enzymatic Synthesis of Globo H and SSEA4”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135(39), 14831-14839. (SCIE)
  • S.-F Liao, C.-H. Liang, M.-Y. Ho, T.-L. Hsu, T.-I. Tsai, Y.S.-Y. Hsieh, S.-T. Li, Y.-Y. Cheng, S.-M. Tsao, T.-Y. Lin, Z.-Y. Lin, W.-B. Yang, C.-T. Ren, K.-I. Lin, K.-H. Khoo, C.-H. Lin, H.-Y. Hsu*, C.-Y. Wu*, C.-H. Wong*, 2013, “Immunization of fucosucosucose-containing polysaccharides from Reishi mushroom induced antibodies against tumor-associated Globo H-series epitopes.”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(34), 13809-13814. (SCIE)
  • Hong-Yang Chuang, Chien-Tai Ren, Chung-An Chao, Chung-Yi Wu, Sachin S Shivatare, Ting-Jen R. Cheng,Chung-Yi Wu*, and Chi-Huey Wong*, 2013, “Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135(30), 11140-11150. (SCIE)
  • Chia-Hung Wang, Shiou-Ting Li, Tzu-Lung Lin, Yang-Yu Cheng, Tsung-Hsien Sun, Jin-Town Wang, Ting-Jen R. Cheng, Kwok Kong Tony Mong, Chi-Huey Wong and Chung-Yi Wu*, 2013, “Synthesis of Neisseria meningitidis Serogroup W135 Capsular Oligosaccharides for Immunogenicity Comparison and Vaccine Development”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(35), 9157-9161. (SCIE)
  • C.-Y. Yang, J.-B. Chen, T.-F. Tsai, Y.-C. Tsai, C.-Y. Tsai, P.-H. Liang, T.-L. Hsu, C.-Y. Wu, C.-H. Wong, S.-L. Hsieh*, 2013, “CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver ”, PLoS One, 8(6), e65070. (SCIE)
  • S.-C. Lin, J.-T. Jan, B. Dionne, M. Butler, M.-H. Huang, C.-Y. Wu, C.-H. Wong, S.-C. Wu, 2013, “ Different Immunity Elicited by Recombinant H5N1 Hemagglutinin Proteins Containing Pauci-mannose, High-mannose, or Complex type N-Glycans.”, PLoS One, 8(6), e66719. (SCIE)
  • T.-C. Hung, C.-W. Lin, T.-L. Hsu, C.-Y. Wu, C.-H. Wong* , 2013, “Investigation of SSEA-4 Binding Protein in Breast Cancer Cells”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135(16), 5934-5937. (SCIE)
  • Chia-Che Tsai, Chih-Ru Lin, Hsien-Yu Tsai, Chia-Jung Chen, Wen-Tai Li, Hui-Ming Yu, Yi-Yu Ke, Wei-Ying Hsieh, Cheng-Yen Chang, Chung-Yi Wu, Shui-Tein Chen,* Chi-Huey Wong , 2013, “The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 288(24), 17689-17697. (SCIE)
  • Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu*, C.-H. Wong*, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(7), 2517-22. (SCIE)
  • T.-J. R. Cheng, S.-Y. Wang, W.-H. Wen, C.-Y. Su, M. Lin, W.-I. Huang, M.-T. Liu, H.-S. Wu, N-S. Wang, C.-K. Cheng, C.-L. Chen, C.-T. Ren, C.-Y. Wu, J.-M. Fang,* Y.-S. E. Cheng* and C.-H. Wong*, 2013, “Chemical probes for drug resistance assessment by binding competition (RABC) oseltamivir susceptibility evaluation”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(1), 366-370. (SCIE)

Publications