Chien, Yin-Chu 簡吟曲

ChienYC 6x7研究技師




  • Ph.D., Epidemiology, National Taiwan University, 2003
  • Senior Specialist in Minister’s Office, Department of Health, 2003-2005
  • Postdoctoral Fellow, Graduate Institute of Epidemiology, National Taiwan University, 2005-2006
  • Senior Specialist in Minister’s Office, National Science Council, 2006-2008
  • Postdoctoral Fellow, Genomics Research Center, Academia Sinica, 2008-2011
  • Visiting Assistant Professor, Department of Pediatrics and Human Development, MSU College of Human Medicine, USA, 2009
  • Associate Research Fellow, Molecular and Genomic Epidemiology Center, China Medical University Hospital, 2011-2014
  • Senior Research Scientist, Genomics Research Center, Academia Sinica, 2014-present


  • 8th Chen Kong-Pei Best Public Health Paper Award, 陳拱北教授最佳論文獎 2002


Research and Management of the Health Cloud Research Program

Taiwan's National Health Insurance (NHI) program has been considered as one of the most successful program in the past twenty years since the program was launched in 1995. This nationwide program provides medical and healthcare services with the highest coverage rate, most comprehensive welfare, and the highest accessibility than any other health insurance programs in the world. There are increasing amount of research using sampling data from the NHI claims database have been published. It is extremely important to carry out a multidisciplinary study to integrate these nationwide scaled databases such as household registry, cancer registry, death certification, national screening projects, Taiwan Biobank, and national health insurance to construct a nationwide health database with high quality and accuracy of data. I take in charge the Research and Management of the Health Cloud Research Program in Academia Sinica. The goal of the program is to set up a National Big Health Data Center in Academia Sinica. I have good experiences in the management and analysis of large scaled health data, and have some publications in high-impact journals. I am interested in the research of applications with nationwide scaled dataset for health improvement.



  • Hsu WL, Chien YC, Chiang CJ, Yang HI, Lou PJ, Wang CP, Yu KJ, You SL, Wang LY, Chen SY, Yang CS, Chen CJ., 2014, “Lifetime Risk of Distinct Upper Aerodigestive Tract Cancers and Consumption of Alcohol, Betel and Cigarette”, INTERNATIONAL JOURNAL OF CANCER, 135(6), 1480-1486. (SCIE)
  • Chien YC, Jan CF, Chiang CJ, Liu CJ, Kuo HS, You SL, and Chen CJ. , 2014, “Incomplete Hepatitis B Immunization, Maternal Carrier Status and Increased Risk of Liver Diseases: A 20-year Cohort Study of 3.8 Million Vaccinees”, HEPATOLOGY, 60(1), 125-132. (SCIE)
  • Hsu WL, Tse KP, Liang S, Chien YC, Su WH, Yu KJ, Cheng YJ, Tsang NM, Hsu MM, Chang KP, Chen IH, Chen TI, Yang CS, Goldstein AM, Chen CJ, Chang YS, and Hildesheim A., 2012, “Evaluation of Human Leukocyte Antigen-A (HLA-A), Other Non-HLA Markers on Chromosome 6p21 and Risk of Nasopharyngeal Carcinoma”, PLoS One, 7(8), e42767. (SCIE)
  • Hsu WL, Pan WH, Chien YC, Yu KJ, Cheng YJ, Chen JY, Liu MY, Hsu MM, Lou PJ, Chen IH, Yang CS, Hildesheim A, and Chen CJ. , 2012, “Lowered Risk of Nasopharyngeal Carcinoma and Intake of Plant Vitamin, Fresh Fish, Green Tea and Coffee: A Case-Control Study in Taiwan ”, PLoS One, 7(7), e41779. (SCIE)
  • Hsu WL, Yu KJ, Chien YC, Chiang CJ, Cheng YJ, Chen JY, Liu MY, Chou SP, You SL, Hsu MM, Lou PJ, Wang CP, Hong JH, Leu YS, Tsai MH, Su MC, Tsai ST, Chao WY, Ger LP, Chen PR, Yang CS, Hildesheim A, Diehl SR, Chen CJ., 2011, “Familial Tendency and Risk of Nasopharyngeal Carcinoma in Taiwan: Effects of Covariates on Risk”, AMERICAN JOURNAL OF EPIDEMIOLOGY, 173(3), 292-299. (SCIE)
  • Fwu CW, Chien YC, You SL, Nelson KE, Kirk GD, Kuo HS, Feinleib M, Chen CJ., 2011, “Hepatitis B Virus Infection and Risk of Intrahepatic Cholangiocarcinoma and Non-Hodgkin Lymphoma: A Cohort Study of Parous Women in Taiwan”, HEPATOLOGY, 53(4), 1217-1225. (SCIE)
  • Jan CF, Huang KC, Chien YC, Greydanus DE, Davies HD, Chiu TY, Huang LM, Chen CJ, Chen DS., 2010, “Determination of immune memory to hepatitis B vaccination through early booster response in college students”, HEPATOLOGY, 51(5), 1547-1554. (SCIE)
  • Fwu CW, Chien YC, Nelson KE, Kirk GD, You SL, Kuo HS, Feinleib M, Chen CJ., 2010, “Mortality after chronic hepatitis B virus infection: a linkage study of two million parous women from Taiwan”, JOURNAL OF INFECTIOUS DISEASES, 201(7), 1016-1023. (SCIE)
  • Fwu CW, Chien YC, Kirk GD, Nelson KE, You SL, Kuo HS, Feinleib M, Chen CJ., 2009, “Hepatitis B Virus Infection and Hepatocellular Carcinoma among Parous Taiwanese Women: Nationwide Cohort Study”, JNCI-Journal of the National Cancer Institute, 101(14), 1019-1027. (SCIE)
  • Hsu WL, Chen JY, Chien YC, Liu MY, Yang HI, Hsu MM, Yang CS, Chen CJ., 2009, “Independent effect of EBV and cigarette smoking on nasopharyngeal carcinoma: a 20-year follow-up study on 9,622 males without family history in Taiwan”, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 18(4), 1218-1226. (SCIE)
  • Chien YC, Jan CF, Kuo HS, Chen CJ., 2006, “Nationwide Hepatitis B Vaccination Program in Taiwan: Effectiveness in the 20 Years After it was Launched”, EPIDEMIOLOGIC REVIEWS, 28, 126-135. (SCIE)
  • Chien YC, Chen CJ., 2003, “Epidemiology and Etiology of Nasopharyngeal Carcinoma: Gene-Environment Interaction”, CANCER REVIEWS: ASIA-PACIFIC, 1(1), 1-19.
  • Cheng YJ, Chien YC, Hildesheim A, Hsu MM, Chen IH, Chuang J, Chang J, Ma YD, Luo CT, Hsu WL, Hsu HH, Huang H, Chang JF, Chen CJ, Yang CS., 2003, “No Association Between Genetic Polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, NAT2, and Nasopharyngeal Carcinoma in Taiwan”, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 12(2), 179-180. (SCIE)
  • Chien YC, Chen JY, Liu MY, Yang HI, Hsu MM, Chen CJ, Yang CS, 2001, “Serologic Markers of Epstein-Barr Virus Infection and Nasopharyngeal Carcinoma in Taiwanese men”, NEW ENGLAND JOURNAL OF MEDICINE, 345(26), 1877-1882. (SCIE)