Cheng, Ting-Jen 鄭婷仁

ChengTJ6x7 2研究技師


tingjencgateEmail
02-27871267
[ CV ]

 

 

EDUCATION AND POSITIONS HELD:

  • B.Eng, Chemical Engineering, National Tsing Hua University, Taiwan, 1993
  • Ph.D., Life Sciences, National Tsing Hua University, Taiwan, 1999
  • Post-doctoral Research Associate, Keck Graduate Institute of Applied Life Science, USA, 2000-2005
  • Assistant Research scientist, Genomics Research Center, Academia Sinica, 2005-2008
  • Associate Research scientist, Genomics Research Center, Academia Sinica, 2008-2012
  • Senior research scientist, Genomics Research Center, Academia Sinica, 2012-present

EXPERTISE:

Development of biological assays for functional evaluation of therapeutically significant targets or molecules.

RESPONSIBILITY:

My main responsibilities towards GRC mission is to develop bioassay platforms for high-throughput screening, to conduct activity evaluations for lead identification/optimization, and to support the needs in assay development for researchers with main focuses on:

I. High-Throughput Screening

  • Design and develop high-throughput compatible target- and cell-based assays
  • Conduct high-throughput screening and hit confirmation
  • Support further studies for lead identification/optimization

II. Assay Development

  • Develop assays and evaluate inhibitor potencies for cell-wall synthesis enzymes to support efforts in discovery of small molecules against methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, and Gram-negative bacteria
  • Support the needs for reagent preparation and for animal studies in vaccine as well as therapeutics evaluation for infectious diseases and cancer
  • Evaluate the biological activities of fractions and small molecules derived from Chinese medicinal herbs to support the identification of active molecules for drug discovery

主要支援基因體中心研究團隊對活性分析的需求;例如針對有興趣的藥物標的建立生化分析及活體內活性分析系統並執行藥物篩選。目前的協助範圍包含了:

  • 利用分生及生化技術發展藥物標的之生化活性偵測系統, 如酵素反應
  • 設計藥物標的之活體內活性偵測系統來決定化合物在活體內之活性,
  • 應用分析系統進行高速藥物篩選選擇具活性之化合物,
  • 評估及測試小分子及天然化合物的生物活性, 以及
  • 評估疫苗的效果等。

SELECTED PUBLICATIONS:

  • Woodring JL, Lu SH, Krasnova L, Wang SC, Chen JB, Chou CC, Huang YC, Cheng TR, Wu YT, Chen YH, Fang JM, Tsai MD, Wong CH, to appear, “Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein.”, Journal of medicinal chemistry, 63(1), 205-215. (SCIE)
  • Jan JT, Cheng TR, Juang YP, Ma HH, Wu YT, Yang WB, Cheng CW, Chen X, Chou TH, Shie JJ, Cheng WC, Chein RJ, Mao SS, Liang PH, Ma C, Hung SC, Wong CH, 2021, “Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection.”, Proceedings of the National Academy of Sciences of the United States of America, 118 (5), e2021579118. (SCIE)
  • Chang SY, Huang KY, Chao TL, Kao HC, Pang YH, Lu L, Chiu CL, Huang HC, Cheng TR, Fang JM, Yang PC, 2021, “Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses.”, Scientific reports, 11(1), 8692. (SCIE)
  • Liao HY, Wang SC, Ko YA, Lin KI, Ma C, Cheng TR, Wong CH, 2020, “Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes.”, Proceedings of the National Academy of Sciences of the United States of America, 117(30), 17757-17763. (SCIE)
  • Woodring JL, Lu SH, Krasnova L, Wang SC, Chen JB, Chou CC, Huang YC, Cheng TR, Wu YT, Chen YH, Fang JM, Tsai MD, Wong CH, 2020, “Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein”, Journal of medicinal chemistry, 63(1), 205-215. (SCIE)
  • Wang WF, Lu MJ, Cheng TR, Tang YC, Teng YC, Hwa TY, Chen YH, Li MY, Wu MH, Chuang PC, Jou R, Wong CH, Li WH, 2020, “Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome.”, Genome biology and evolution, 12(2), 3890-3905. (SCIE)
  • Lin CY, Wu HY, Hsu YL, Cheng TR, Liu JH, Huang RJ, Hsiao TH, Wang CJ, Hung PF, Lan A, Pan SH, Chein RJ, Wong CH, Yang PC, 2020, “Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein.”, Journal of medicinal chemistry, 63(6), 3172-3187. (SCIE)
  • Chiu LT, Sabbavarapu NM, Lin WC, Fan CY, Wu CC, Cheng TR, Wong CH, Hung SC, 2020, “Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1.”, Journal of the American Chemical Society, 142(11), 5282-5292. (SCIE)
  • Chen MH, Huang MT, Yu WK, Lee SS, Wang JH, Cheng TR, Bowman MR, Hsieh SL, 2019, “Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients.”, Journal of biomedical science, 26(1), 97. (SCIE)
  • Lin MS, Hong TM, Chou TH, Yang SC, Chung WC, Weng CW, Tsai ML, Cheng TR, Chen JJW, Lee TC, Wong CH, Chein RJ, Yang PC, 2019, “4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of beta-tubulin.”, European journal of medicinal chemistry, 181, 111584. (SCIE)
  • Huang MR, Hsu YL, Lin TC, Cheng TJ, Li LW, Tseng YW, Chou YS, Liu JH, Pan SH, Fang JM, Wong CH, 2019, “Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer.”, European journal of medicinal chemistry, 181, 111551. (SCIE)
  • Wang SC, Liao HY, Zhang JY, Cheng TR, Wong CH, 2019, “Development of a universal influenza vaccine using hemagglutinin stem protein produced from Pichia pastoris.”, Virology, 526, 125-137. (SCIE)
  • Wang X, Krasnova L, Wu KB, Wu WS, Cheng TJ, Wong CH, 2018, “Towards new antibiotics targeting bacterial transglycosylase: Synthesis of a Lipid II analog as stable transition-state mimic inhibitor.”, Bioorganic & medicinal chemistry letters, 28(16), 2708-2712. (SCIE)
  • Cheng HW, Chein RJ, Cheng TJ, Wu PS, Wu HY, Hung PF, Wang CJ, Hsu YL, Wong JM, Yuan A, Wong CH, Yang PC, Pan SH, 2018, “2-anilino-4-amino-5-aroylthiazole-type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction.”, Cancer science, 109(3), 832-842. (SCIE)
  • Wu WS, Cheng WC, Cheng TR, Wong CH, 2018, “Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase.”, Journal of the American Chemical Society, 140(8), 2752-2755. (SCIE)
  • Wang PC, Chiu DC, Jan JT, Huang WI, Tseng YC, Li TT, Cheng TJ, Tsai KC, Fang JM, 2018, “Peramivir conjugates as orally available agents against influenza H275Y mutant.”, European journal of medicinal chemistry, 145, 224-234. (SCIE)
  • Huang LY, Wang SC, Cheng TJR, Wong CH, 2017, “Undecaprenyl Phosphate Phosphatase Activity of Undecaprenol Kinase Regulates the Lipid Pool in Gram-Positive Bacteria.”, Biochemistry, 56(40), 5417-5427. (SCIE)
  • Wang PC, Fang JM, Tsai KC, Wang SY, Huang WI, Tseng YC, Cheng YS, Cheng TJ, Wong CH, 2016, “Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors.”, Journal of medicinal chemistry, 59(11), 5297-310. (SCIE)
  • Kuo TC, Li LW, Pan SH, Fang JM, Liu JH, Cheng TJ, Wang CJ, Hung PF, Chen HY, Hong TM, Hsu YL, Wong CH, Yang PC, 2016, “Purine-Type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin.”, Journal of medicinal chemistry, 59(18), 8521-34. (SCIE)
  • Chen KT, Chen PT, Lin CK, Huang LY, Hu CM, Chang YF, Hsu HT, Cheng TJ, Wu YT, Cheng WC, 2016, “Structural Investigation of Park\'s Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors.”, Scientific reports, 6, 31579. (SCIE)
  • Zuegg J, Muldoon C, Adamson G, McKeveney D, Le Thanh G, Premraj R, Becker B, Cheng M, Elliott AG, Huang JX, Butler MS, Bajaj M, Seifert J, Singh L, Galley NF, Roper DI, Lloyd AJ, Dowson CG, Cheng TJ, Cheng WC, Demon D, Meyer E, Meutermans W, Cooper MA, 2015, “Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity.”, Nature communications, 6, 7719. (SCIE)
  • Lin MI, Su BH, Lee CH, Wang ST, Wu WC, Dangate P, Wang SY, Huang WI, Cheng TJ, Lin OA, Cheng YS, Tseng YJ, Sun CM, 2015, “Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1.”, European journal of medicinal chemistry, 102, 477-86. (SCIE)
  • Patil PS, Cheng TJ, Zulueta MM, Yang ST, Lico LS, Hung SC, 2015, “Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity.”, Nature communications, 6, 7239. (SCIE)
  • Chen YS, Yu HM, Shie JJ, Cheng TJ, Wu CY, Fang JM, Wong CH, 2014, “Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity.”, Bioorganic & medicinal chemistry, 22(5), 1766-1772. (SCIE)
  • Huang LY, Huang SH, Chang YC, Cheng WC, Cheng TJ, Wong CH, 2014, “Enzymatic synthesis of lipid II and analogues.”, Angewandte Chemie-International Edition, 53(31), 8060-8065. (SCIE)
  • Hsu CH, Schelwies M, Enck S, Huang LY, Huang SH, Chang YF, Cheng TJ, Cheng WC, Wong CH, 2014, “Iminosugar C-glycoside analogues of alpha-D-GlcNAc-1-phosphate: synthesis and bacterial transglycosylase inhibition.”, The Journal of organic chemistry, 79(18), 8629-8637. (SCIE)
  • Lee HY, Chen CY, Tsai TI, Li ST, Lin KH, Cheng YY, Ren CT, Cheng TJ, Wu CY, Wong CH, 2014, “Immunogenicity study of Globo H analogues with modification at the reducing or nonreducing end of the tumor antigen.”, Journal of the American Chemical Society, 136(48), 16844-53. (SCIE)
  • Cheng TJ, Wang SY, Wen WH, Su CY, Lin M, Huang WI, Liu MT, Wu HS, Wang NS, Cheng CK, Chen CL, Ren CT, Wu CY, Fang JM, Cheng YS, Wong CH, 2013, “Chemical Probes for Drug-Resistance Assessment by Binding Competition (RABC): Oseltamivir Susceptibility Evaluation.”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(1), 366-370. (SCIE)
  • Huang YL, Hung JT, Cheung SK, Lee HY, Chu KC, Li ST, Lin YC, Ren CT, Cheng TJ, Hsu TL, Yu AL, Wu CY, Wong CH, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer.”, Proceedings of the National Academy of Sciences of the United States of America, 110(7), 2517-2522. (SCIE)
  • Cheng TJ, Wang SY, Wen WH, Su CY, Lin M, Huang WI, Liu MT, Wu HS, Wang NS, Cheng CK, Chen CL, Ren CT, Wu CY, Fang JM, Cheng YS, Wong CH, 2013, “Chemical probes for drug-resistance assessment by binding competition (RABC): oseltamivir susceptibility evaluation.”, Angewandte Chemie-International Edition, 52(1), 366-370. (SCIE)
  • Tsai TI, Lee HY, Chang SH, Wang CH, Tu YC, Lin YC, Hwang DR, Wu CY, Wong CH, 2013, “Effective sugar nucleotide regeneration for the large-scale enzymatic synthesis of Globo H and SSEA4.”, Journal of the American Chemical Society, 135(39), 14831-14839. (SCIE)
  • Huang SH, Wu WS, Huang LY, Huang WF, Fu WC, Chen PT, Fang JM, Cheng WC, Cheng TJ, Wong CH, 2013, “New continuous fluorometric assay for bacterial transglycosylase using forster resonance energy transfer.”, Journal of the American Chemical Society, 135(45), 17078-17089. (SCIE)
  • Huang SH, Wu WS, Huang LY, Huang WF, Fu WC, Chen PT, Fang JM, Cheng WC, Cheng TJ, Wong CH, 2013, “New continuous fluorometric assay for bacterial transglycosylase using Forster resonance energy transfer.”, Journal of the American Chemical Society, 135(45), 17078-89. (SCIE)
  • Chen KT, Kuan YC, Fu WC, Liang PH, Cheng TJ, Wong CH, Cheng WC, 2013, “Rapid preparation of mycobacterium N-glycolyl Lipid I and Lipid II derivatives: a biocatalytic approach.”, Chemistry-a European Journal, 19(3), 834-838. (SCIE)
  • Ohara K, Lin CC, Yang PJ, Hung WT, Yang WB, Cheng TJ, Fang JM, Wong CH, 2013, “Synthesis and bioactivity of beta-(1-->4)-linked oligomannoses and partially acetylated derivatives.”, The Journal of organic chemistry, 78(13), 6390-6411. (SCIE)
  • Chuang HY, Ren CT, Chao CA, Wu CY, Shivatare SS, Cheng TJ, Wu CY, Wong CH, 2013, “Synthesis and vaccine evaluation of the tumor-associated carbohydrate antigen RM2 from prostate cancer.”, Journal of the American Chemical Society, 135(30), 11140-11150. (SCIE)
  • Wang CH, Li ST, Lin TL, Cheng YY, Sun TH, Wang JT, Cheng TJ, Mong KK, Wong CH, Wu CY, 2013, “Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development.”, Angewandte Chemie-International Edition, 52(35), 9157-9161. (SCIE)
  • Huang CY, Shih HW, Lin LY, Tien YW, Cheng TJ, Cheng WC, Wong CH, Ma C, 2012, “Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism.”, Proceedings of the National Academy of Sciences of the United States of America, 109(17), 6496-6501. (SCIE)
  • Cheng TJ, Weinheimer S, Tarbet EB, Jan JT, Cheng YS, Shie JJ, Chen CL, Chen CA, Hsieh WC, Huang PW, Lin WH, Wang SY, Fang JM, Hu OY, Wong CH, 2012, “Development of oseltamivir phosphonate congeners as anti-influenza agents.”, Journal of medicinal chemistry, 55(20), 8657-8670. (SCIE)
  • Cheng TJ, Weinheimer S, Tarbet EB, Jan JT, Cheng YS, Shie JJ, Chen CL, Chen CA, Hsieh WC, Huang PW, Lin WH, Wang SY, Fang JM, Hu OY, Wong CH, 2012, “Development of Oseltamivir Phosphonate Congeners as Anti-influenza Agents.”, Journal of medicinal chemistry, 55(20), 8657-8670. (SCIE)
  • Shih HW, Chang YF, Li WJ, Meng FC, Huang CY, Ma C, Cheng TJ, Wong CH, Cheng WC, 2012, “Effect of the peptide moiety of Lipid II on bacterial transglycosylase.”, Angewandte Chemie-International Edition, 51(40), 10123-10126. (SCIE)
  • Liu KC, Fang JM, Jan JT, Cheng TJ, Wang SY, Yang ST, Cheng YS, Wong CH, 2012, “Enhanced Anti-influenza Agents Conjugated with Anti-inflammatory Activity.”, Journal of medicinal chemistry, 55(19), 8493-8501. (SCIE)
  • Shih HW, Chen KT, Cheng TJ, Wong CH, Cheng WC, 2011, “A new synthetic approach toward bacterial transglycosylase substrates, Lipid II and Lipid IV.”, Organic letters, 13(17), 4600-4603. (SCIE)
  • Chen MW, Liao HY, Huang Y, Jan JT, Huang CC, Ren CT, Wu CY, Cheng TJ, Ho DD, Wong CH, 2011, “Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin.”, Proceedings of the National Academy of Sciences of the United States of America, 108(9), 3510-3515. (SCIE)
  • Meng FC, Chen KT, Huang LY, Shih HW, Chang HH, Nien FY, Liang PH, Cheng TJ, Wong CH, Cheng WC, 2011, “Total synthesis of polyprenyl N-glycolyl lipid II as a mycobacterial transglycosylase substrate.”, Organic letters, 13(19), 5306-5309. (SCIE)
  • Shih HW, Chen KT, Chen SK, Huang CY, Cheng TJ, Ma C, Wong CH, Cheng WC, 2010, “Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors.”, Organic & biomolecular chemistry, 8(11), 2586-2593. (SCIE)
  • Liao HY, Hsu CH, Wang SC, Liang CH, Yen HY, Su CY, Chen CH, Jan JT, Ren CT, Chen CH, Cheng TJ, Wu CY, Wong CH, 2010, “Differential receptor binding affinities of influenza hemagglutinins on glycan arrays.”, Journal of the American Chemical Society, 132(42), 14849-14856. (SCIE)
  • Cheng TJ, Wu YT, Yang ST, Lo KH, Chen SK, Chen YH, Huang WI, Yuan CH, Guo CW, Huang LY, Chen KT, Shih HW, Cheng YS, Cheng WC, Wong CH, 2010, “High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase.”, Bioorganic & medicinal chemistry, 18(24), 8512-8529. (SCIE)
  • Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Cheng WC, Wu YT, Tsai MD, Cheng YS, Wong CH, 2010, “High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.”, Proceedings of the National Academy of Sciences of the United States of America, 107(45), 19151-19156. (SCIE)
  • Shie JJ, Chen CA, Lin CC, Ku AF, Cheng TJ, Fang JM, Wong CH, 2010, “Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities.”, Organic & biomolecular chemistry, 8(19), 4451-4462. (SCIE)
  • Wang SY, Su CY, Lin M, Huang SY, Huang WI, Wang CC, Wu YT, Cheng TJ, Yu HM, Ren CT, Wu CY, Wong CH, Cheng YS, 2009, “HA-pseudotyped retroviral vectors for influenza antagonist screening”, Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening, 14(3), 294-302.
  • Chen MW, Cheng TJ, Huang Y, Jan JT, Ma SH, Yu AL, Wong CH, Ho DD, 2008, “A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses.”, Proceedings of the National Academy of Sciences of the United States of America, 105(36), 13538-13543. (SCIE)
  • Cheng TJ, Sung MT, Liao HY, Chang YF, Chen CW, Huang CY, Chou LY, Wu YD, Chen YH, Cheng YS, Wong CH, Ma C, Cheng WC, 2008, “Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics.”, Proceedings of the National Academy of Sciences of the United States of America, 105(2), 431-436. (SCIE)
  • Hsieh YS, Chien C, Liao SK, Liao SF, Hung WT, Yang WB, Lin CC, Cheng TJ, Chang CC, Fang JM, Wong CH, 2008, “Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense.”, Bioorganic & medicinal chemistry, 16(11), 6054-6068. (SCIE)
  • Tsou EL, Chen SY, Yang MH, Wang SC, Cheng TR, Cheng WC, 2008, “Synthesis and biological evaluation of a 2-aryl polyhydroxylated pyrrolidine alkaloid-based library.”, Bioorganic & medicinal chemistry, 16(24), 10198-10204. (SCIE)
  • Cheng TJ, Brik A, Wong CH, Kan CC, 2004, “Model system for high-throughput screening of novel human immunodeficiency virus protease inhibitors in Escherichia coli.”, Antimicrobial agents and chemotherapy, 48(7), 2437-2447. (SCIE)
  • Cheng TJ, Tseng YF, Chang WM, Chang MD, Lai YK, 2003, “Retaining of the assembly capability of vimentin phosphorylated by mitogen-activated protein kinase-activated protein kinase-2.”, Journal of cellular biochemistry, 89(3), 589-602. (SCIE)
  • Cheng TJ, Rey PG, Poon T, Kan CC, 2002, “Kinetic studies of human tyrosyl-DNA phosphodiesterase, an enzyme in the topoisomerase I DNA repair pathway.”, European journal of biochemistry / FEBS, 269(15), 3697-3704.
  • Cheng TJ, Lin YL, Chiang AS, Lai YK, 2000, “Association of protein phosphatase 2A with its substrate vimentin intermediate filaments in 9L rat brain tumor cells.”, Journal of cellular biochemistry, 79(1), 126-138. (SCIE)
  • Wang TT, Chiang AS, Chu JJ, Cheng TJ, Chen TM, Lai YK, 1998, “Concomitant alterations in distribution of 70 kDa heat shock proteins, cytoskeleton and organelles in heat shocked 9L cells.”, The international journal of biochemistry & cell biology, 30(6), 745-759. (SCIE)
  • Hung JJ, Cheng TJ, Lai YK, Chang MD, 1998, “Differential activation of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinases confers cadmium-induced HSP70 expression in 9L rat brain tumor cells.”, The Journal of biological chemistry, 273(48), 31924-31931. (SCIE)
  • Cheng TJ, Lai YK, 1998, “Identification of mitogen-activated protein kinase-activated protein kinase-2 as a vimentin kinase activated by okadaic acid in 9L rat brain tumor cells.”, Journal of cellular biochemistry, 71(2), 169-181. (SCIE)
  • Cheng TJ, Chen TM, Chen CH, Lai YK, 1998, “Induction of stress response and differential expression of 70 kDa stress proteins by sodium fluoride in HeLa and rat brain tumor 9L cells.”, Journal of cellular biochemistry, 69(2), 221-231. (SCIE)
  • Hung JJ, Cheng TJ, Chang MD, Chen KD, Huang HL, Lai YK, 1998, “Involvement of heat shock elements and basal transcription elements in the differential induction of the 70-kDa heat shock protein and its cognate by cadmium chloride in 9L rat brain tumor cells.”, Journal of cellular biochemistry, 71(1), 21-35. (SCIE)
  • Perng MD, Cheng TJ, Chen CM, Lai YK, 1994, “Induction of aggregation and augmentation of protein kinase-mediated phosphorylation of purified vimentin intermediate filaments by withangulatin A.”, Molecular pharmacology, 46(4), 612-617. (SCIE)
  • Cheng TJ, Lai YK, 1994, “Transient increase in vimentin phosphorylation and vimentin-HSC70 association in 9L rat brain tumor cells experiencing heat-shock.”, Journal of cellular biochemistry, 54(1), 100-109. (SCIE)