語言

Chang, Chi-Fon

CFChang6x7Senior Research Specialist/Scientist

chifongateEmail
+886-2-27871236

 

EDUCATION AND POSITIONS HELD:

  • Ph.D. , Biophysics, The Ohio State University ,1997
  • Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica , 1997-1999
  • NMR Supporting Team Manager, Institute of Biomedical Sciences, Academia Sinica,1999-2002
  • NMR Facility Manager, High-Field Biomacromolecular Solution NMR Core Facility, Academia Sinica ,2002-present
  • Associate Research Specialist/Scientist, Genomics Research Center, Academia Sinica, 2004-2010
  • Senior Research Specialist/Scientist, Genomics Research Center, Academia Sinica, 2010-present

FACILITY MANAGEMENT / EXPERTISE:

As a research specialist, I am responsible for the daily operation on NMR facility and assist researchers carrying out NMR related researches. I have dedicated myself to provide competent and efficient routine service, as well as all aspects of advance technical support on NMR spectroscopy. The duty of my job includes: keeping track of machine time usage; supervising the facility staff members; training users on using NMR spectrometers; developing and implementing new NMR experiments; assisting users setting up advanced NMR experiments; advising users on specific NMR experiments and applications; and providing technical consultation. My expertise is using biophysical methods, especially the NMR approach, to obtain structural and functional information for biomolecules.

 NMR Facility
 GRC NMR Facility

SELECTED PUBLICATIONS:

  • Lin GM, Yu TA, Chang CF, Hsu CH, 2024, “Proline Isomerization and Molten Globular Property of TgPDCD5 Secreted from Toxoplasma gondii Confers Its Regulation of Heparin Sulfate Binding.”, JACS Au, 4(5), 1763-1774. (SCIE, SSCI, A&HCI, Scopus, EI, TSSCI, THCI, Others)
  • Mariasina Sofia S., Chang Chi-Fon, Navalayeu Tsimafei L., Chugunova Anastasia A., Efimov Sergey V., Zgoda Viktor G., Ivlev Vasily A., Dontsova Olga A., Sergiev Petr V., Polshakov Vladimir I.*, 2022, “Williams-Beuren Syndrome Related Methyltransferase WBSCR27: From Structure to Possible Function”, Frontiers in Molecular Biosciences, 9, 865743. (SCIE)
  • Lin MH, Huang YP, Chang CF*, Hsu CH*, 2021, “NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).”, Biomolecular NMR assignments, 15(1), 137-142. (SCIE)
  • Lin MH, Cho CC, Chiu YC, Chien CY, Huang YP, Chang CF, Hsu CH, 2021, “Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites.”, Communications biology, 4(1), 123. (SCIE)
  • Mariasina SS, Chang CF, Petrova OA, Efimov SV, Klochkov VV, Kechko OI, Mitkevich VA, Sergiev PV, Dontsova OA, Polshakov VI, 2020, “Williams-Beuren syndrome-related methyltransferase WBSCR27: cofactor binding and cleavage.”, The FEBS journal, 287(24), 5375-5393. (SCIE)
  • Mariasina SS, Petrova OA, Osterman IA, Sergeeva OV, Efimov SV, Klochkov VV, Sergiev PV, Dontsova OA, Huang TH, Chang CF*, Polshakov VI*, 2018, “NMR assignments of the WBSCR27 protein related to Williams-Beuren syndrome.”, Biomolecular NMR assignments, 12(2), 303-308. (SCIE)
  • Chou CY, Chu M, Chang CF, Yu T, Huang TH, Sakellariou D, 2016, “High sensitivity high-resolution full range relaxometry using a fast mechanical sample shuttling device and a cryo-probe.”, Journal of biomolecular NMR, 66(3), 187-194. (SCIE)
  • Huang YP, Cho CC, Chang CF*, Hsu CH*, 2016, “NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV).”, Biomolecular NMR assignments, 10(2), 245-248. (SCIE)
  • Hsu CH, Chang CF, Liao YD, Wu SH, Chen C, 2015, “Solution structure and base specificity of cytotoxic RC-RNase 2 from Rana catesbeiana.”, Archives of biochemistry and biophysics, 584, 70-8. (SCIE)
  • Ming-Yuan Su, Chung-I Chang and Chi-Fon Chang* , 2013, “1H, 13C and 15N resonance assignments of the pyrin domain from human PYNOD ”, Biomolecular NMR Assignments, 7(2), 141-143. (SCIE)
  • Ming-Yuan Su, Chiao-I Kuo, Chi-Fon Chang*, Chung-I Chang*, 2013, “Three-Dimensional Structure of Human NLRP10/PYNOD Pyrin Domain Reveals a Homotypic Interaction Site Distinct from Its Mouse Homologue”, PLoS One, 8(7), e67843. (SCIE)
  • Chou CY, Chu M, Chang CF, Huang TH*, 2012, “A compact high-speed mechanical sample shuttle for field-dependent high-resolution solution NMR.”, Journal of magnetic resonance (San Diego, Calif. : 1997), 214(1), 302-8.