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Activation of Prp28 ATPase at the Heart of Spliceosome for Spliceosomal Remodeling
Remarkably, the most accomplished players can solve a completely scrambled Rubik’s Cube in less than twelve seconds. Few people, however, know that there is an equally complex Rubik’s Cube-like molecular machine in the cell. This machine is called “Spliceosome”, which must be sequentially remodeled or tweaked, just like the Rubik’s Cube... Read More
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Anti-Siglec-3 mAb as immune checkpoint inhibitor to combat Hepatitis B infection
Hepatitis B virus (HBV) infection is a worldwide health problem. According to WHO’s report, there are over 257 million peoples globally infected by hepatitis B virus. HBV infection is prevalent in China, Tai-wan, and Southeast Asia countries. Approximately 887,000 individuals die each year from HBV-related liver diseases or liver cancer. The team led by Dr. Shie-Liang Hsieh in... Read More
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Monoglycosylated spike vaccine is highly effective against COVID-19 variants
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in more than 170 million confirmed cases and over 3.5 million deaths so far. Although there are COVID-19 vaccines available, viruses constantly change through mutations. Key questions remain about how quickly the variants can spread, their potential to evade immunity and how effective the vaccines... Read More
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One Amino Acid Change Twice Immune Effect in CLEC18A to H5N1
LEC18A is a member of C-type lectin family which is known to have influence over innate and adaptive antimicrobial immune responses, and its unknown biological mechanisms is to be unveiled. In the journal Communications Biology, Professor Shi-Liang Hsieh’s team published an article and gave the insight of how CLEC18A ... Read More
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Simplified Procedure to Prepare Remdesivir for SARS-CoV-2 and Nipah Virus
After grappling with the corona virus, SARS-CoV-2, for more than a year, the world is still being haunt-ed by Covid-19. Remdesivir is the first drug approved by the US Food and Drug Administration (FDA) to treat Covid-19. In May 2020, Taiwanese authority also approved the use of remdesivir in patients with severe COVID-19 symptoms. In reality, that price tag is still a price too much to pay for many people. Read More
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NMR: An essential tool to explore biological mysteries at the molecular level
Nuclear magnetic resonance(NMR) is a widely used analytical technique, it has become an essential tool when studying physics, chemistry, materials, and life sciences. With NMR, scientists can dig into the molecular level of a matter to dissect its chemical constructs. Let's see how researchers in Genome Research Center and other Institutes are doing with NMR to leverage their research work in solving the mysteries of the biological matters. Read More
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LATEST PUBLICATIONS
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Differential effects of SUMO1 and SUMO2 on circadian protein PER2 stability and function
Wendy W. Hwang-Verslues
Scientific Reports
July 13, 2021 -
SIGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection
Shie-Liang Hsieh
The Journal of Clinical Investigation
June 1, 2021 -
Activation of Prp28 ATPase by Phosphorylated Npl3 at a Critical Step of Spliceosome Remodeling
Tien-Hsien Chang
Nature Communications
May 25, 2021
HONORS & APPOINTMENTS
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Congratulations to Dr. Yun-Ru Ruby Chen for receiving "the 19th Far Eastern Y. Z. Hsu Science and Technology Research Thesis Award"Read More
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Congratulations to Dr. Li-Jung Juan for receiving the MOST 2020 Outstanding Research AwardRead More
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Congratulations to Dr. Shie-Liang Hsieh for receiving the MOST 2020 Outstanding Researcher AwardRead More
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