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PD‐1 levels can predict spontaneous functional cure in inactive chronic hepatitis B carriers
Hepatitis B is a viral infection that attacks the liver. It causes both acute and chronic disease that can lead to liver cirrhosis and liver cancer. Identifying carriers requires a blood test for hepatitis B surface antigen (HBsAg), which must be repeated regularly to ensure virus inactive. Read More
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Excess sugar intake increases the risk of pancreatic tumorigenesis
About 1.02 billion hand-shaken drinks are sold every year in Taiwan, working out to over 30% of people consume at least one cup a day. Excess sugar's impact on obesity and diabetes is well known. Still, one area that may surprise many men is consuming sugar in excessive amounts may contribute to the in-creased risk of Pancreatic ductal adenocarcinoma (PDAC). Read More
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The critical point to treatment from the inside out: hybrid inorganic/organic nanoparticles with exosomes for cancer treatment
Since James E. Rothman, Randy W. Schekman, and Thomas C. Sudhof won the Nobel Prize in 2013 for revealing intracellular vesicles’ transport regulation mechanism, such as exosomes, which initially believed the primary function was only exosomes that transport cellular waste. Read More
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Learning from nature: StnK3 is the epimerase controlling β-methyl amino acid stereochemistry
Natural products are a significant source of structurally diverse bioactive compounds for pharmaceutical, cosmetic, and food applications. Bioactive compounds often carry desired biological activities, such as anti-inflammation, anticancer, analgesics, and pain killing. Read More
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Mono-GlcNAc-decorated spike vaccine is highly effective against COVID-19 variants
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in more than 440 million confirmed cases and over 6 million deaths so far. Although there are COVID-19 vaccines available, viruses constantly change through mutations. Key questions remain about how quickly the variants can spread, their potential to evade immunity and how effective the vaccines... Read More
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mRNA vaccine of SARS-CoV-2 spike protein with deletion of multiple glycosites is broadly protective against variants of concern
Vaccination is an effective strategy to control the spread of SARS-CoV-2. However, current vaccines may lose their efficacy because of the high mutation rate of SARS-CoV-2. To overcome this problem, development of a universal SARS-CoV-2 vaccine with broad protection against the current and upcoming variants is needed. Read More
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LATEST PUBLICATIONS
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Differential effects of glucose and N-acetylglucosamine on genome instability
Chun-Mei Hu, Wen-Hwa Lee
American Journal of Cancer Research
April 30, 2022 -
Serum soluble programmed death-1 levels predict the spontaneous HBeAg seroclearance in chronic hepatitis B
Hwai-I Yang, Chien-Jen Chen
Journal of Gastroenterology
April 22, 2022
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Making the right tools for tough jobs – how to build a scientific instrument / Dr. Yi-Sheng WangRead More
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Scientific Fortune Telling: Predicting Risk of Liver Cancer for Patients with Chronic Hepatitis B / Dr. Hwai-I Yang / 2013Read More
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