Dr. Li has long dedicated to the specialty of natural products biosynthesis, antibiotics development, and structural mechanistic design of biocatalysts. Antibiotic drug resistance is an intrinsic urgent threat; it is happening right now facing our entire community. His most recent finding is a non-canonical FAD-dependent enzyme Orf1 committing N-formimidoylation of antibiotic BD-12. Such a modification enables antibiotics immune to aminoglycoside-modifying enzymes, a strategy useful for developing next-generation antibiotics.