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Dr. Shang-Cheng Hung awarded the 2023 Taiwan Bio-Development Foundation (TBF) Chair in Biotechnology
In recognition of Dr. Shang-Cheng Hung 's contributions to glycoscience, which provide crucial molecular insights for disease diagnosis, prevention, and the development of small molecule drugs. Read More
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Unveiling Antigen Presentation and Cross-reactive Antibody Response of an Oligosaccharide-conjugate Vaccine, Paving the Way for Advanced Cancer Vaccines
An oligosaccharide-conjugate cancer vaccine has shown promising results by eliciting antibodies against glycan moieties found in various cancer types and their stem cells. However, the fate of oligosaccharide antigen in dendritic cells has never been investigated. Read More
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Dr. Chi-Huey Wong awarded the Israel Chemical Society International Barry Cohen Award and the Federation of Asian Chemical Societies (FACS) Foundation Lectureship Award
To honor Dr. Chi-Huey Wong's contributions to glycoscience, especially his pioneering work on elucidating the role of glycosylation in health and disease.... Read More
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Inhibition of SARS-CoV-2-mediated thromboinflammation by CLEC2.Fc
Immunothrombosis is the major cause of mortality and morbidity in acute COVID-19 and long COVID patients. However, the underlying mechanism is unclear. Dr. Hsieh’s research team unravel the mystery by showing that CLEC2 is the pattern recognition receptor for SARS CoV-2 spike protein... Read More
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N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry
We report a non-canonical FAD-dependent enzyme Orf1 that adds a glycine-derived N-formimidoyl group to glycinothricin to form BD-12. Orf1 has two substrate-binding sites unlike canonical FAD-dependent oxidoreductases. Read More
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Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome
Membrane protein FtsB-FtsL-FtsQ (FtsBLQ) complex are essential component of divisome, which play important roles in the divisome assembling and the division-mediated peptidoglycan synthesis regulation, yet with the unclear mechanism. In the latest publication in Nature Communications... Read More
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LATEST PUBLICATIONS
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Inhibition of SARS-CoV-2-mediated thromboinflammation by CLEC2.Fc
Shie-Liang Hsieh
EMBO Molecular Medicine
May 22, 2023
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