Mao, Shi-Shan 毛溪山





  • B.S. National Tsing Hua University, Tsin-chu, Taiwan, ROC, 1978
  • Ph. D. The Johns Hopkins University, Baltimore, MD, 1987
  • Postdoctoral Fellow, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA, 1987-1990
  • Senior Research Fellow, MERCK & CO., INC., West Point, PA, 1990-2006
  • Senior Research Specialist, Genomics Research Center, Academia Sinica, 2007-2021


  • American Chemical Society
  • American Association for the Advancement of Science
  • American Society for Biochemistry and Molecular Biology


The combined experience in both academic and industrial provides me the foundation for both basic research and drug discovery and development. I have extensive learning in biochemistry, enzymology, natural product biosynthesis during my academic years. My current works at Academia Sinica are in two parts: helping technology transfer of Academia Sinica research discoveries and coordinating the operation and collaboration of high through-put screening.



  • Liverton, N et al, 2008, “A Molecular Modeling Based Approach to Potent P2-P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130, 4608-4609. (SCIE)
  • Hsu, H-J., Tsai, K-C., Sun, Y-K., Chang, H-J., Huang, Y-J., Yu, H-M., Lin, C-H., Mao, S-S., and Yang, A-S, 2008, “Factor Xa Active Site Substrate Specificity with Substrate Phage Display and Computional Molecular Modeling”, JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 12343-12353. (SCIE)
  • Mao, S-S., DiMuzio, J., McHale, C., Burlein, C., Olsen, D., and Carroll, S. , 2007, “A Time-Resolved Fluorescence Assay to Characterize Inhibition of Hepatitis C Virus Nonstructural Protein 3-4A Protease at Low Enzyme Concentrations”, ANALYTICAL BIOCHEMISTRY, 373, 1-8. (SCIE)
  • Mao, S.-S., Holahan, M. A., Bailey, C., Wu, G., Colussi, D., Carroll, S. S., and Cook, J. J., 2005, “Demonstration of Enhanced Endogenous Fibrinolysis in Thrombin Activatable Fibrinolysis Inhibitor-Deficient Mice”, BLOOD COAGULATION & FIBRINOLYSIS, 16, 407-425. (SCIE)
  • Nantermet, P., Barrow, J. C., Lindsley, S. R., Young, M, Mao, S-S., Carroll, S., Bailey, C., Bosserman, M., Colussi, D., McMaster, D. R., Vacca, J. P., and Selnick, H. G., 2004, “Imidazole Acetic Acid TAFIa Inhibitors: SAR Studies Centered around the Basic P1’ Group”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14, 2141-2145. (SCIE)
  • Mao, S-S., Colussi, D., Bailey, C. M., Bosserman, M., Burlein, C., Gardell, S. J., and Carroll, S. S. , 2003, “An Electrochemiluminescence Assay for Basic Carboxypeptidases: Inhibition of Basic Carboxypeptidases and Activation of Thrombin-Activatable Fibrinolysis Inhibitor”, ANALYTICAL BIOCHEMISTRY, 319, 159-170. (SCIE)
  • Ferrer, M, Zuck, P., Kolodin, G., Mao, S-S., Peltier, R. R., Bailey, C., Gardell, S. J., Strulovici, B., and Inglese, J. , 2003, “Miniaturizable Homogeneous Time-resolved Fluorescence Assay for Carboxypeptidase B Activity”, ANALYTICAL BIOCHEMISTRY, 317, 94-98. (SCIE)
  • Barrow, J. C. et al, 2003, “Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activatable Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics”, JOURNAL OF MEDICINAL CHEMISTRY, 46, 5294-5297. (SCIE)
  • Mao, S-S., Cooper, C. M., Wood, T., Shafer, J. A., and Gardell, S. J., 1999, “Characterization of Plasmin-Mediated Activation of Plasma Procarboxypeptidase B: Modulation by Glycosaminoglycans”, JOURNAL OF BIOLOGICAL CHEMISTRY, 274, 35046-35052. (SCIE)
  • Lewis, S. D., Lukas, B. J., Brady, S. F., Sisko, J. T., Cutrona, K. J., Sanderson, P. E., Freidinger, R. M., Mao, S-S., Gardell, S. J., and Shafer, J. A. , 1998, “Characterization of the Two-step Pathway for Inhibition of Thrombin with a-Ketoamide Transition State Analogs”, JOURNAL OF BIOLOGICAL CHEMISTRY, 273, 4843-4854. (SCIE)
  • Cook, J. C., Schultz, L. D., Huang, J., George, H. A., Herber, W. K., Ip, C., Joyce, J. G., Mao, S-S., Markus, H. Z., Miller, W. J., Sardana, M. K., and Lehman, E. D., 1998, “Expression and Purification of Recombinant Tick Anticoagulant Peptide (Y1W/D10R) Double Mutant Secreted by Saccharomyces cerevisiae”, PROTEIN EXPRESSION AND PURIFICATION, 13, 291-300. (SCIE)
  • Mao, S-S., Przysiecki, C. T., Krueger, J. A., Cooper, C. M., Lewis, S. D., Joyce, J., Lellis, C., Garsky, V. M., Sardana, M., and Shafer, J. A. , 1998, “Selective Inhibition of Factor Xa in the Prothrombinase Complex by the Carboxy-Terminal Domain of Antistasin”, JOURNAL OF BIOLOGICAL CHEMISTRY, 273, 30086-3009`. (SCIE)
  • Feng, D-M. et al, 1997, “Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position”, JOURNAL OF MEDICINAL CHEMISTRY, 40, 3726-3733. (SCIE)
  • Mao, S.-S., Huang, J., Welebob, C., Neeper, M. P., Garsky, V. M., and Shafer, J. A., 1995, “Identification and Characterization of Tick Anticoagulant Peptide with Increased Inhibitory Potency Toward Human Factor Xa”, BIOCHEMISTRY, 34, 5098-5103. (SCIE)
  • Lewis, S. D. et al, 1995, “Inhibition of Thrombin by Peptides Containing Lysyl-a-Keto Carbonyl Derivatives”, THROMBOSIS AND HAEMOSTASIS, 74, 1107-1112. (SCIE)
  • Mao, S.S., 1994, “Factor Xa Inhibitors”, Perspectives in Drug Discovery and Design, 1, 423-429.
  • Mao, S. S., Holler, T. P., Yu, G. X., Bollinger, J. M., Booker, S., Johnston, M. I., and Stubbe, J. , 1992, “A Model for the Role of Multiple Cysteine Residues involved in Ribonucleotide Reduction: Amazing and still Confusing”, BIOCHEMISTRY, 31, 9733-9743. (SCIE)
  • Mao, S. S., Yu, G. X., Chalfoun, D., and Stubbe, J., 1992, “Characterization of C439SR1, a Mutant of Escherichia coli Ribonucleotide Diphosphate Reductase: Evidence that C439 Is a Residue Essential for Nucleotide Reduction and C439SR1 Is a Protein Possessing Novel Thioredoxin-like Activity”, BIOCHEMISTRY, 32, 9752-9759. (SCIE)
  • Mao, S. S., Holler, T. P., Bollinger, J. M., Yu, G. X., Johnston, M. I., and Stubbe, J. , 1992, “Interaction of C225SR1 Mutant Subunit of Ribonucleotide Reductase with R2 and Nucleotide Diphosphates: Tales of a Suicidal Enzyme”, BIOCHEMISTRY, 32, 9744-9751. (SCIE)
  • Jordan, S. P., Mao, S. S., Lewis, S. D., and Shafer, J. A.*, 1992, “Reaction Pathway for Inhibition of Blood Coagulation Factor Xa by Tick Anticoagulant Peptide”, BIOCHEMISTRY, 56, 728-731. (SCIE)
  • Krol, W. J., Mao, S. S., Steele, D. L. and Townsend, C. A.*, 1991, “Stereochemical Correlation of Proclavaminic Acid and Synthesis of erythro- and threo-L-Hydroxyornithine from an Improved Vinylglycine Synthon”, JOURNAL OF ORGANIC CHEMISTRY, 56, 728-731. (SCIE)
  • Mao, S.-S., Johnston, M. I., Bollinger, J. M., and Stubbe, J. , 1989, “Mechanism-based Inhibition of A Mutant Escherichia coli Ribonucleotide Reductase (cysteine-225->Serine) By Its Substrate CDP”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 86, 1485-1489. (SCIE)
  • Townsend, C. A.*, and Mao, S.-S., 1987, “Clavulanic Acid Biosynthesis: The Stereochemical Course of b-Lactam Formation from Chiral Glycerol”, Chem. Comm., 86-89.
  • Townsend, C. A.*, Ho, M-F., and Mao, S.-S., 1986, “The Stereochemical Fate of (2RS,5R)- and (2RS,5S)-[5-3H]-Ornithine in Clavulanic Acid Biosynthesis”, Chem. Comm., 638-639.