研究技師
EDUCATION AND POSITIONS HELD:
- Ph.D., Chemistry, Iowa State University (1985)
- Postdoctoral Fellow, Ames National Laboratory (1986-1987)
- Assistant Chemist, Ames National Laboratory (1988-1992)
- Associate Chemist, Ames National Laboratory (1993-1997)
- Chemist, Ames National Laboratory (1997-2001)
- Principal Investigator of R&D Core Facility (Chemical/Isotope Labeling for Quantitative Proteomics) at National Program for Genomic Medicine (2001-2004)
- Research Scientist, supervise mass spectrometry facilities and coordinate mass spectrometry-related technical development of Key Technology division at Genomics Research Center.
RESEARCH INTERESTS:
Proteomics
The combined technologies of separation science and mass spectrometry are the current workhorse in proteomics. A large scale and unbiased non-gel based quantitative proteomics platform which incorporates multi-dimensional chromatography, isotope labeling techniques and mass spectrometry to elucidate protein identification and differential protein expression for the discovery of diagnostic and/or prognostic markers of disease and cancer studies. Our interests are mainly focusing on developing technologies platform to characterize low abundance proteins and elucidate proteins post-translational modifications and provide quantitative protein information at the same time.
我們的研究工作主要著重於結合多維層析分離與質譜檢測技術，再配合同位素標識方法，提供蛋白質體研究上一個全面性高效能的非二維膠式蛋白質鑑定及相對定量 的技術平台。在疾病與癌症診斷上可作為依據的標示物的發現，和低含量蛋白質之檢測與蛋白質之後轉譯修飾，將是主要的研發課題。