特聘研究員

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EDUCATION AND POSITIONS HELD:

• M.D., National Yang-Ming University, 1984
• D.Phil., University of Oxford, UK, 1992
• Postdoctoral fellow, Stanford University, 1993
• Director, Institute of Clinical Medicine, Natl. Yang-Ming Univ., Taipei,Taiwan, 2010-2013
• Distinguished Professor, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan, 2007-2013
• Professor, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan ,2001-2013
• Director, Immunology Research Center, Natl. Yang-Ming Univ., Taiwan, 2000-2013
• Director, Immunology Research Center, Taipei Veterans’ General Hospital, Taiwan, 2005-present
• Co-appointed Senior Investigator, National Health Research Center, Taipei, Taiwan ,2004-present
• Co-appointed Senior Investigator, Academia Sinica, Taipei, Taiwan, 2004-present
• Adjunct Research Fellow, Academia Sinica, Taipei, Taiwan, 2009-2013
• Distinguished Professor, Academia Sinica, Taipei, Taiwan, 2013-present
• Adjunct Distinguished Professor, Institute of Clinical Medicine, Natl. Yang-Ming Univ., Taipei, Taiwan ,2013-present
• Adjunct Professor, National Taiwan University ,2014-present
• Director, IRB on Biomedical Science Research, Academia Sinica, 2018-present

HONORS:

• 2021    Outstanding Research Fellow award from the Ministry of Science and Technology (科技部109年度傑出特約研究員)
• 2020    The 18^th Y. Z. Hsu Scientific Chair Professor (第十八屆有庠科技講座)
• 2013    The 8^th Session TienTe Lee Award (第八屆永信李天德卓越醫藥科技獎)
• 2012    The 16^th National Chair Professor Award, Ministry of Education (教育部第16屆國家講座)
• 2010    Outstanding Researcher Award from the National Science Council (國科會傑出獎)
• 2009    The 4^th Long-Term Award from Acer Foundation (第四屆宏碁基金會龍騰微笑得獎人)
• 2009    The 53^th Academic Achievement Award, Ministry of Education (教育部第53屆學術獎)
• 2009    Tsungming Tu Award, Taiwan Medical Society (台灣醫學會杜聰明獎)
• 2008    The 18^th Outstanding research Achievement to National Health, “Ming-Ning Wang Memorial Foundation” (第十八屆王民寧獎-傑出貢獻獎得獎人)
• 2004    The 1^st Outstanding Alumni, National Yang-Ming University (第一屆陽明大學 傑出校友)
• 2003    Outstanding Researcher Award from the National Science Council (國科會傑出獎)
• 1999    Outstanding Researcher Award from the National Science Council (國科會傑出獎)
• 1992    Irvington Medial Foundation post-doctoral fellowship ‘Robert Wood Johnson Fellow
• 1989    Oversea Research Scholarship (ORS) from the University of Oxford
• 1989    Oversea PhD studentship from the Ministry of Education, Taiwan

RESEARCH INTERESTS:

我的實驗室對於闡明病原體引起細胞激素風暴以及致死的分子機轉，和確認預防免疫治療的潛在目標，以預防組織損傷及纖維化。我們從兩個方向探討這些問題:宿主與病原體交互作用以及免疫調節。

Host-Pathogen Interaction

發炎反應的啟動是經由自然殺手細胞、單核球細胞、巨噬細胞、嗜中性白血球以及血小板上的先天免疫受體受到感染因子、外來抗原或是異常表現的內源性抗原的活化。因此，了解外源性以及內源性抗原在先天免疫反應的分子機轉將能夠開發新的治療策略以治療諸多人類疾病，例如感染症、自體免疫以及過敏反應。我們開發了先天免疫受體陣列(innate immunity receptor array / IIR-EIA)以及C型凝集素受體陣列(C-type lectin receptor array /CLRA)來鑑定病毒引起之細胞激素風暴以及宿主防禦機制中的重要受體。我們系統性的經由基因缺陷小鼠鑑定新型C型凝集素的功能，並生產人類抗C行凝集素抗體以及其他先天免疫受體潛力治療因子以治療人類疾病。我們已經鑑定脾酪氨酸激酶（Syk）耦合的C型凝集素受體CLEC5A和CLEC2是登革熱病毒誘導的細胞激素風暴和血小板低下症中的關鍵受體，且針對CLEC5A以及CLEC2的拮抗抗體正在開發為治療劑。

Immunomodulation

我們開發了一系列的重組蛋白，能將單核球分化成M2巨噬細胞以促進組織再生及修復，同時減緩感染性和非感染性發炎反應。兩種重組蛋白(DcR3.Fc及 HBD.Fc)已經被證實能經由表關遺傳誘導M2巨噬細胞分化。這些蛋白對於 類澱粉蛋白質引起的神經發炎具有強力的免疫抑制作用，促進神經元再生且在阿茲海默症小鼠模式中維持記憶力。

SELECTED PUBLICATIONS:

• Wang HW, Li HH, Wu SC, Tang CK, Yu HY, Chang YC, Sung PS, Liu WL, Su MP, Yu GY, Huang LR, Chen CH*, Hsieh SL*, 2023, “CLEC5A mediates Zika virus‑induced testicular damage”, JOURNAL OF BIOMEDICAL SCIENCE, 30: 12, 1-16. (SCIE)
• Sung PS, Peng YC, Yang SP, Chiu CH, Hsieh SL*, 2022, “CLEC5A is critical in Pseudomonas aeruginosa-induced NET formation and acute lung injury”, JCI INSIGHT, 7(18), e156613. (SCIE)
• Sung PS, Yang SP, Perng YC, Sun CP, Tao MH, Hsieh SL*, 2022, “CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation”, JOURNAL OF BIOMEDICAL SCIENCE, 29(1), 52. (SCIE)
• Hsu YW, Huang H CH, Huang WC, Yeh YH, Hsiao CD, Chang WC**, Hsieh SL**, 2022, “Human rs75776403 Polymorphism Links Differential Phenotypic and Clinical Outcomes to a CLEC18A p.T151M-Driven Multiomics”, JOURNAL OF BIOMEDICAL SCIENCE, 29(1), 43. (SCIE)
• Sung PS, Hsieh SL*, 2021, “C-type lectins and extracellular vesicles in virus-induced NETosis”, JOURNAL OF BIOMEDICAL SCIENCE, 28(1), 46. (SCIE)
• Tsai TY, Huang MT, Sung PS, Peng CY, Tao MH, Yang HI, Chang WC, Yang AS, Yu CM, Lin YP, Ching-Yu Bau3, Huang CJ, Pan MH, Wu CY, Hsiao CD, Yeh YH, Shiteng Duan, James C Paulson, Hsieh SL*, 2021, “Siglec-3 (CD33) is the immune checkpoint receptor in HBV infection”, JOURNAL OF CLINICAL INVESTIGATION, 131(11), 141965. (SCIE)
• Pan YG, Huang MT, P. Sekar, Huang DY, Lin WW, Hsieh SL*, 2021, “Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture”, FRONTIERS IN IMMUNOLOGY, 12: 638676, 1-16. (SCIE)
• Huang YL , Huang MT, Sung PS, Chou TY, Yang RB, Yang AS, Yu CM, Hsu YW, Chang WC, Hsieh SL*, 2021, “Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection”, Communications biology, 4(1): 229, 1-13. (SCIE)
• Hsieh SL, 2020, Lectin in Host Defense Against Microbial Infections, Advances in Experimental Medicine and Biology, 230 pages, Singapore: Springer Nature Singapore Pte Ltd.
• Sung PS, Chang WC, Hsieh SL*, 2020, “CLEC5A: A Promiscuous Pattern Recognition Receptor to Microbes and Beyond”, editor(s): (Hsieh SL), Lectin in Host Defense Against Microbial Infections, Advances in Experimental Medicine and Biology, pp. 1204: 57-73, 新加坡: Springer Nature Singapore Pte Ltd.
• Sung PS, Hsieh SL*, 2019, “CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections”, FRONTIERS IN IMMUNOLOGY, 10: 2867, 1-9. (SCIE)
• Sung PS, Huang TF, Hsieh SL*, 2019, “Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2”, NATURE COMMUNICATIONS, 10(1): 2402, 1-13. (SCIE)
• Tsai TY, Peng CY, Yang HI, Huang YL, Tao MH, Yuan SS, Lai HC, Hsieh SL*, 2018, “The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection”, JOURNAL OF BIOMEDICAL SCIENCE, 25(1): 59, 1-10. (SCIE)
• Tsai HW, Huang MT, Wang PH, Huang BS, Chen YJ, Hsieh SL*., 2018, “Decoy receptor 3 promotes cell adhesion and enhances endometriosis development”, JOURNAL OF PATHOLOGY, 244(2), 189-202. (SCIE)
• Chen ST, Chen JW, Wu WC, Chou TY, Yang CY, Hsieh SL*, 2017, “CLEC5A is a critical receptor in innate immunity against Listeria infection”, NATURE COMMUNICATIONS, 8(1): 299, 1-13. (SCIE)
• Chiu CW, Cheng H, Hsieh SL*, 2017, “Contusion spinal cord injury rat model”, Bio-protocol, 7(12), e2337.
• Lai JH, Lin YL, Hsieh SL* , 2017, “Pharmacological intervention for dengue virus infection”, BIOCHEMICAL PHARMACOLOGY, 129, 14-25. (SCIE)
• Teng, O, Chen, ST, Hsu TL, Sia SF, Cole S, Valkenburg SA, Hsu TY, Zheng JT, Tu W, Bruzzone R, Peiris JSM, Hsieh SL*, Yen HL*, 2017, “CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo”, JOURNAL OF VIROLOGY, 91(1), e01813-e01816. (SCIE)
• Shie-Liang Hsieh, 2016, “Chapter 3: The DAP12-Associated Myeloid C-Type Lectin 5A (CLEC5A).”, editor(s): Sho Yamasaki, C-type Lectin Receptors in Immunity, pp. 35-48, Japan: Springer Japan.
• Tung YL, Wu MF, Wang GJ*, Hsieh SL*, 2014, “Nanostructured electrochemical biosensor for the detection of the weak binding between the dengue virus and the CLEC5A receptor”, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 10(6), 1335-1341. (SCIE)
• Chen DY, Yao L, Chen YM, Lin CC, Huang KC, Chen ST, Lan JL*, Hsieh SL*, 2014, “A Potential Role of Myeloid DAP12-Associating Lectin (MDL)-1 in the Regulation of Inflammation in Rheumatoid Arthritis Patients”, PLoS One, 9(1): e86105, 1-11. (SCIE)
• Yang CY, Chen JB, Tsai TF, Tsai YC, Tsai CY, Liang PH, Hsu TL, Wu CY, Netea MG, Wong CH, Hsieh SL*, 2013, “CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver”, PLoS One, 8(6): e65070, 1-14. (SCIE)
• Wu MF, Chen ST, Hsieh SL*, 2013, “Distinct regulation of dengue virus-induced inflammasome activation in human macrophage subsets”, JOURNAL OF BIOMEDICAL SCIENCE, 20(1): 36, 1-9. (SCIE)
• Wu MF, Chen ST, Yang AH, Lin WW, Lin YL, Chen NJ, Tsai IS, Li L, Hsieh SL*, 2013, “CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages”, BLOOD, 121(1), 95-106. (SCIE)
• Chen ST, Liu RS, Wu MF, Lin YL, Chen SY, Tan DT, Chou TY, Tsai IS, Li L, Hsieh SL*, 2012, “CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality”, PLOS PATHOGENS, 8(4): e1002655, 1-18. (SCIE)
• Tai SK, Chang HC, Lan KL, Lee CT, Yang CY, Chen NJ, Chou TY, Tarng DC, Hsieh SL*, 2012, “Decoy receptor 3 enhances tumor progression via induction of tumor-associated macrophages”, JOURNAL OF IMMUNOLOGY, 188(5), 2464-2471. (SCIE)
• Chen ST , Lin YL , Huang MT , Wu MF , Hsieh SL*, 2011, “Targeting C-type lectin for the treatment of flaviviral infections.”, editor(s): Albert M. Wu, The Molecular Immunology of Complex Carbohydrates-3, pp. 769-776, USA: Springer.
• Lin WW, Hsieh SL*, 2011, “Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer”, BIOCHEMICAL PHARMACOLOGY, 81(7), 838-847. (SCIE)
• Lee RT, Hsu TL, Huang SK, Hsieh SL, Wong CH, Lee YC*, 2011, “Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities”, GLYCOBIOLOGY, 21(4), 512-520. (SCIE)
• Hsu TL, Cheng SC, Yang WB, Chin SW, Chen BH, Huang MT, Hsieh SL*, Wong CH*, 2009, “Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins”, JOURNAL OF BIOLOGICAL CHEMISTRY, 284(50), 34479-34489. (SCIE)
• Chen CY, Yang KY, Chen MY, Chen HY, Lin MT, Lee YC, Perng RP, Hsieh SL, Yang PC, Chou TY*, 2009, “Decoy receptor 3 levels in peripheral blood predict outcomes of acute respiratory distress syndrome”, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180(8), 751-760. (SCIE)
• Wu MF, Yang CY, Lin TL, Wang JT, Yang FL, Wu SH, Hu BS, Chou TY, Tsai MD, Lin CH, Hsieh SL*, 2009, “Humoral immunity against capsule polysaccharide protects the host from magA+ Klebsiella pneumoniae-induced lethal disease by evading Toll-like receptor 4 signaling”, INFECTION AND IMMUNITY, 77(2), 615-621. (SCIE)
• Tsai CM, Chiu YK, Hsu TL, Lin IY, Hsieh SL, Lin KI*, 2008, “Galectin-1 promotes immunoglobulin production during plasma cell differentiation”, JOURNAL OF IMMUNOLOGY, 181(7), 4570-4579. (SCIE)
• Chang PM, Chen PM, Hsieh SL, Tzeng CH, Liu JH, Chiou TJ, Wang WS, Yen CC, Gau JP, Yang MH*, 2008, “Expression of a soluble decoy receptor 3 in patients with diffuse large B-cell lymphoma predicts clinical outcome”, INTERNATIONAL JOURNAL OF ONCOLOGY, 33(3), 549-554. (SCIE)
• Hsieh SL*, 2008, “Decoy Receptor 3 (DcR3): A Pleiotropic Immunomodulator”, BLOOD, 112(3), 916-917. (SCIE)
• Chen ST, Lin YL, Huang MT, Wu MF, Cheng SC, Lei HY, Lee CK, Chiou TW, Wong CH, Hsieh SL*, 2008, “CLEC5A is critical for dengue-virus-induced lethal disease”, NATURE, 453(7195), 672-676. (SCIE)
• Chang YC, Chen TC, Lee CT, Yang CY, Wang HW, Wang CC, Hsieh SL*, 2008, “Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3”, BLOOD, 111(10), 5054-5063. (SCIE)
• Lee CS, Hu CY, Tsai HF, Wu CS, Hsieh SL, Liu LC, Hsu PN*, 2008, “Elevated serum decoy receptor 3 with enhanced T cell activation in systemic lupus erythematosus”, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 151(3), 383-390. (SCIE)
• Wang SK, Liang PH, Astronomo RD, Hsu TL, Hsieh SL, Burton DR, Wong CH*, 2008, “Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(10), 3690-3695. (SCIE)
• You RI, Chang YC, Chen PM, Wang WS, Hsu TL, Yang CY, Lee CT, Hsieh SL*, 2008, “Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3)”, BLOOD, 111(3), 1480-1488. (SCIE)
• Tang CH, Hsu TL, Lin WW, Lai MZ, Yang RS, Hsieh SL*, Fu WM*, 2007, “Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice”, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(4), 2346-2354. (SCIE)
• You RI, Chen MC, Wang HW, Chou YC, Lin CH, Hsieh SL*, 2006, “Inhibition of Lymphotoxin-{beta} Receptor-Mediated Cell Death by Survivin-{Delta}Ex3”, CANCER RESEARCH, 66(6), 3051-3061. (SCIE)
• Su WB, Chang YH, Lin WW, Hsieh SL*, 2006, “Differential regulation of interleukin-8 gene transcription by deathreceptor 3 (DR3) and type I TNF receptor (TNFRI)”, EXPERIMENTAL CELL RESEARCH, 312(3), 266-277. (SCIE)
• Chang YC, Chan YH, David G Jackson, Hsieh SL*, 2006, “The glycosaminoglycan-binding domain of decoy receptor 3 is essential forinduction of monocyte adhesion”, JOURNAL OF IMMUNOLOGY, 176(1), 173-180. (SCIE)
• Hsu TL, Wu YY, Chang YC, Yang CY, Lai MZ, Su WB, Hsieh SL*, 2005, “Attenuation of Th1 response in decoy receptor 3 transgenic mice”, JOURNAL OF IMMUNOLOGY, 175(8), 5135-5145. (SCIE)
• Chang YH, Chao Y, Hsieh SL, Lin WW*, 2004, “Mechanism of LIGHT/interferon-gamma-induced cell death in HT-29 cell”, JOURNAL OF CELLULAR BIOCHEMISTRY, 93(6), 1188-1202. (SCIE)
• Wu YY, Chang YC, Hsu TL, Hsieh SL, Lai MZ*, 2004, “Sensitization of cells to TRAIL-induced apoptosis by decoy receptor 3”, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(42), 44211-44218. (SCIE)
• Yang CR, Wang JH, Hsieh SL, Wang SM, Hsu TL, Lin WW*, 2004, “Decoy receptor 3 (DcR3) induces osteoclast formation frommonocyte/macrophage lineage precursor cells”, CELL DEATH AND DIFFERENTIATION, 11(1), 97-107. (SCIE)
• Chen CC, Yang YH, Lin YT, Hsieh SL, Chiang BL*, 2004, “Soluble decoy receptor 3: increased levels in atopic patients”, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 114(1), 195-197. (SCIE)
• Sung HH, Juang JH, Lin YC, Kuo CH, Hung JT, Chen A, Chang DM, Chang SY, Hsieh SL, Sytwu HK*, 2004, “Transgenic expression of decoy receptor 3 protects islets from spontaneousand chemical-induced autoimmune destruction in nonobese diabetic mice”, JOURNAL OF EXPERIMENTAL MEDICINE, 199(8), 1143-1151. (SCIE)
• Lee OK, Kuo TK, Chen WM, Lee KD, Hsieh SL, Chen TH*, 2004, “Isolation of multipotent mesenchymal stem cells from umbilical cord blood”, BLOOD, 103(5), 1669-1675. (SCIE)
• Chang YC, Hsu TL, Lin HH, Chio CC, Chiu AW, Chen NJ, Lin CH, Hsieh SL*, 2004, “Modulation of macrophage differentiation and activation by decoy receptor 3”, JOURNAL OF LEUKOCYTE BIOLOGY, 75(3), 486-494. (SCIE)
• Wu SF, Liu TM, Lin YC, Sytwu HK, Juan HF, Chen ST, Shen KL, Hsi SC, Hsieh SL*, 2004, “Immunomodulatory effect of decoy receptor 3 on the differentiation andfunction of bone marrow-derived dendritic cells in nonobese diabetic mice”, JOURNAL OF LEUKOCYTE BIOLOGY, 75(2), 293-306. (SCIE)
• Yang CR, Hsieh SL, Teng CM, Ho FM, Su WL, Lin WW*, 2004, “Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, acytokine belonging to tumor necrosis factor superfamily and exhibitin”, CANCER RESEARCH, 64(3), 1122-1129. (SCIE)
• Hsu MJ, Lin WW, Tsao WC, Chang YC, Hsu TL, Chiu AW, Chio CC, Hsieh SL*, 2004, “Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3”, EXPERIMENTAL CELL RESEARCH, 292(2), 241-251. (SCIE)
• Chen MC, Hwang MJ, Chou YC, Chen WH, Cheng G, Hiroyasu Nakano, Luh TY, Mai SC, Hsieh SL*, 2003, “The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death”, JOURNAL OF BIOLOGICAL CHEMISTRY, 278(18), 16073-16081. (SCIE)
• Huang YL, Liu CJ, Chiu AW, Wang YC, Huan SK, Lee FL, Chen SJ, Hsu WM, Hsieh SL*., 2002, “A feasible tool to detect mRNA expression of matrix metalloproteinases and their tissue inhibitors in human Tenon's capsule”, OPHTHALMIC RESEARCH, 34(6), 375-379. (SCIE)
• Chang YH, Hsieh SL, Chen MC, Lin WW*, 2002, “Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation”, EXPERIMENTAL CELL RESEARCH, 278(2), 166-174. (SCIE)
• Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL*, 2002, “Modulation of dendritic cell differentiation and maturation by decoy receptor 3”, JOURNAL OF IMMUNOLOGY, 168(10), 4846-4853. (SCIE)
• Chen BC, Hsieh SL, Lin WW*, 2001, “Involvement of protein kinases in the potentiation of lipopolysaccharide-induced inflammatory mediator formation by thapsigargin in peritoneal macrophages”, JOURNAL OF LEUKOCYTE BIOLOGY, 69(2), 280-288. (SCIE)
• Chen NJ, Huang MW, Hsieh SL*, 2001, “Enhanced secretion of IFN-gamma by activated Th1 cells occurs via reverse signaling through TNF-related activation-induced cytokine”, JOURNAL OF IMMUNOLOGY, 166(1), 270-276. (SCIE)
• Huang TH, Wu PY, Lee CN, Huang HI, Hsieh SL, Kung J, Tao MH*, 2000, “Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen”, BLOOD, 96(12), 3663-3670. (SCIE)
• Chen MC, Hsu TL, Luh TY, Hsieh SL*, 2000, “Overexpression of bcl-2 enhances LIGHT- and interferon-gamma -mediatedapoptosis in Hep3BT2 cells”, JOURNAL OF BIOLOGICAL CHEMISTRY, 275(49), 38794-38801. (SCIE)
• K Tamada, K Shimozaki, AI Chapoval, Zhai Y, Su J, Chen SF, Hsieh SL, S Nagata, Ni J, Chen L*, 2000, “LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response”, JOURNAL OF IMMUNOLOGY, 164(8), 4105-4110. (SCIE)
• Hsieh SL*, Chen N, K Tarbell, Liao N, Lai Y, Lee K, Lee K, Wu S, Sytwu H, Han SH, H McDevitt., 2000, “Transgenic mice expressing surface markers for IFN-γ and IL-4 producing cells”, MOLECULAR IMMUNOLOGY, 37(6), 281-293. (SCIE)
• Wu MY, Wang PY, Han SH, Hsieh SL*, 1999, “The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells”, JOURNAL OF BIOLOGICAL CHEMISTRY, 274(17), 11868-11873. (SCIE)
• N Gomez-Escobar, Chou CF, Lin WW, Hsieh SL, RD Campbell*, 1998, “The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase”, JOURNAL OF BIOLOGICAL CHEMISTRY, 273(47), 30954-30960. (SCIE)
• Zhai Y, R. Guo, Hsu TL, Yu GL, Ni J, Kwon BS, Jiang GW, Lu Tan JJ, M. Ugustus, K. Carter, L. Rojas, Zhu F, C. Lincoln, G. Endress, Xing L, Wang S, K. O. Oh, R. Gentz, S. Ruben, M. E. Lippman, Hsieh SL, Yang D*, 1998, “LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM inducesapoptosis and suppresses in vivo tumor formation via gene transfer”, JOURNAL OF CLINICAL INVESTIGATION, 102(6), 1142-1151. (SCIE)
• Wu MY, Hsu TL, Lin WW, RD Campbell, Hsieh SL*, 1997, “Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells”, JOURNAL OF BIOLOGICAL CHEMISTRY, 272(27), 17154-17159. (SCIE)
• Hsieh SL, RE March, A Khanna, SJ Cross, RD Campbell*, 1997, “Mapping of 10 novel microsatellites in the MHC class III region:application to the study of autoimmune disease”, JOURNAL OF RHEUMATOLOGY, 24(1), 220-222. (SCIE)
• CA Sargent, MJ Anderson, Hsieh SL, E Kendall, N Gomez-Escobar, RD Campbell*, 1994, “Characterisation of the novel gene G11 lying adjacent to the complementC4A gene in the human major histocompatibility complex”, HUMAN MOLECULAR GENETICS, 3(3), 481-488. (SCIE)
• Zhu ZB, Hsieh SL, DR Bentley, RD Campbell, JE Volanakis*, 1992, “A variable number of tandem repeats locus within the human complement C2gene is associated with a retroposon derived from a human endogenou”, JOURNAL OF EXPERIMENTAL MEDICINE, 175(6), 1783-1787. (SCIE)
• Hsieh SL, RD Campbell*, 1991, “Evidence that gene G7a in the human major histocompatibility complexencodes valyl-tRNA synthetase”, The Biochemical journal, 278(3), 809-816. (SCIE)

BOOK:

• Shie-Liang Hsieh*: Lectins in Host-Pathogen Interaction (Editor, Springer Publisher, to be completed in 2018)

BOOK CHAPTER:

• Shie-Liang Hsieh* "C-Type Lectin Receptors in Immunity" Chapter 3: C-type lectin member 5A. 2016 (editor: Sho Yamasaki) Springer Publisher Ltd. ISBN 978-4-431-56015-9
• Szu-Ting Chen, Yi-Ling Lin, Ming-Ting Huang, Ming-Fang Wu, Shie-Liang Hsieh*(2011). "The Molecular Immunology of Complex Carbohydrates-3" Chapter 40: Targeting C-Type Lectin for the Treatment of Flavivirus Infections. Springer Publisher Ltd. ISBN 978-1-4419-7877-6