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Hsiao, Michael 蕭宏昇

MHsiao6x7研究員


mhsiaogateEmail
02-27871243

 

 

EDUCATION AND POSITIONS HELD:

  • D.V.M., National Taiwan University, 1983
  • Ph.D., Pathology, University of Southern California, 1991 Postdoctoral Fellow, University of California at San Diego, 1991–1993
  • Postgraduate Biochemist, University of California at San Diego, 1993–1994
  • Senior Research Associate, Stanford University, 1994–1998
  • Associate Investigator of Medical Education and Research, Kaohsiung Veterans General Hospital, 1998–2005
  • Adjunct Associate Professor of Veterinary Medicine, National Taiwan University, 1998-present
  • Associate Professor, Genomics Research Center, Academia Sinica, 2005-2015
  • Adjunct Associate Professor of Biology, National Defense Medical College, 2006-present
  • Professor, Genomics Research Center, Academia Sinica, 2015-present

HONORS:

  • National Cancer Institute Post-Doctoral Fellowship, 1991-1993
  • First Prize, Tumor Section, Congress for the Neurological Surgeons, 1997
  • Young Investigator Award, American Association for the Neurological Surgeons and Congress for Neurological Surgeons 1998
  • First prize, Taiwan Association for Veterinary Medicine, 1999
  • Second Prize, Asia-Pacific Congress on Oral cavity Cancer, 2008
  • Editorial Board, Am J Cancer Res, 2011
  • ad hoc reviewer for Ann Surg Oncol., BBA-Mol Cell Res, Brit J Cancer, Brit J Dermatol, Cancer, Cancer Gene Therapy, Cancer Lett., Clin Exp Metastas, Gene Ther, Gut, Histol Histopathol, Int J Cancer, J Biomed Biotech, J Cancer Mol, J Phys Chem C, Oncogene, Oral Oncol

RESEARCH INTERESTS:

  • Targeting tumor growth/survival pathways to enhance tumor chemosensitivity and/or radiosensitivity.
  • Novel strategies to overcome tumor metastasis
    • Novel microarray based gene discovery associated with tumor metastasis
    • Viral or pharmacological compounds based inhibition of PI3K/Akt pathway to inhibit tumor invasion and migration
    • Therapeutical interventions using tumor metastasis suppressor genes in preclinical trial settings
    • Establishment of novel real-time 3D quantifiable metastatic tumor models to investigate tumor metastasis dynamics and evaluate therapeutical efficacy
    • Utilization of high-throughput proteomic analysis for the identification of novel tumor metastasis markers and therapeutical evaluations.
  • Development of nanoparticle-mediated high-throughput transfection platforms to identify and characterize novel gene expression functional consequences.

SELECTED PUBLICATIONS:

  • Li Chien‐Hsiu, Fang Chih‐Yeu, Chan Ming‐Hsien, Lu Pei‐Jung, Ger Luo‐Ping, Chu Jan‐Show, Chang Yu‐Chan, Chen Chi‐Long, Hsiao Michael*, 2023, “The Activation of EP300 by F11R Leads to EMT And Acts As A Prognostic Factor in Triple‐negative Breast Cancers”, The Journal of Pathology: Clinical Research, In Press, 1-1. (SCIE)
  • Li Chien‐Hsiu, Fang Chih‐Yeu, Chan Ming‐Hsien, Chen Chi‐Long, Chang Yu‐Chan, Hsiao Michael*, 2023, “The Cytoplasmic Expression of FSTL3 Correlates with Colorectal Cancer Progression, Metastasis Status and Prognosis”, Journal of Cellular and Molecular Medicine, Mar;27(5), 672-686. (SCIE)
  • Chan Ming-Hsien, Chen Bo-Gu, Huang Wen-Tse, Su Ting-Yi, Hsiao Michael*, Liu Ru-Shi, 2023, “Tunable Single-atom Nanozyme Catalytic System for Biological Applications of Therapy and Diagnosis”, Materials Today Advances, 17, 100342. (SCIE)
  • Li Chien-Hsiu, Chan Ming-Hsien, Chang Yu-Chan, Hsiao Michael*, 2023, “Gold Nanoparticles as a Biosensor for Cancer Biomarker Determination”, Molecules, Jan 2;28(1), 364. (SCIE)
  • Chang Yu‐Chan, Li Chien‐Hsiu, Chan Ming‐Hsien, Fang Chih‐Yeu, Zhang Zhi‐Xuan, Chen Chi‐Long, Hsiao Michael*, 2023, “Overexpression of Synaptic Vesicle Protein Rab GTPase 3C Promotes Vesicular Exocytosis and Drug Resistance in Colorectal Cancer Cells”, Molecular Oncology, 17(3), 422-444. (SCIE)
  • Huang WT, Rejandran V, Chan MH, Hsiao M*, Chang H, Liu RS, 2022, “Near-Infrared Windows I and II Phosphors for Theranostic Applications: Spectroscopy, Bioimaging, and Light-Emitting Diode Photobiomodulation”, ADVANCED OPTICAL MATERIALS, 1, 1. (SCIE)
  • Chan MH, Li CH, Chang YC, Hsiao M*, 2022, “Iron-based Ceramic Composite Nanomaterials for Magnetic Fluid Hyperthermia and Drug Delivery”, PHARMACEUTICS, 14(12), 2584. (SCIE)
  • Chang WM, Li LJ, Chiu IA, Lai TC, Chang YC, Tsai HF, Yang CJ, Huang MS, Su CY, Lai TL, Jan YH, Hsiao M*, 2022, “The Aberrant Cancer Metabolic Gene Carbohydrate Sulfotransferase 11 Promotes Non-small Cell Lung Cancer Cell Metastasis via Dysregulation of Ceruloplasmin and Intracellular Iron Balance”, TRANSLATIONAL ONCOLOGY, 25, 101508. (SCIE)
  • Li CH, Chan MH, Chang YC, Hsiao M*, 2022, “The CHST11 Gene Is Linked to Lung Cancer and Pulmonary Fibrosis”, JOURNAL OF GENE MEDICINE, e3451, 1. (SCIE)
  • Li CH, Chang YC, Chan MH, Liang SM, Hsiao M*, 2022, “Noncanonical Functions of Fascin-1 and Therapeutic Implications for Fascin-1 Protein in Cancer Progression”, BIOCHIMICA ET BIOPHYSICA ACTA - ADVANCES, In Press, 1.
  • Li CH, Chang YC, Hsiao M*, Chan MH, 2022, “Ultrasound and Nanomedicine for Cancer-Targeted Drug Delivery: Screening, Cellular Mechanisms and Therapeutic Opportunities”, PHARMACEUTICS, June 16;14(6), 1282. (SCIE)
  • Chan MH, Huang WT, Chen KC, Su TY, Chan YC, Hsiao M*, Liu RS, 2022, “The Optical Research Progress of Nanophosphors Composed of Transition Elements in the Fourth Period of Near-infrared Windows I and II for Deep-tissue Theranostics [COVER STORY]”, NANOSCALE, May21;14(19), 7123-7136. (SCIE)
  • Chan MH, Chang ZX, Huang CYF, Lee LJ, Liu RS, Hsiao M*, 2022, “Integrated Therapy Platform of Exosomal System: Hybrid Inorganic/Organic Nanoparticles with Exosomes for Cancer Treatment [COVER STORY]”, NANOSCALE HORIZONS, 7(4), 352-367. (SCIE)
  • Chang YC, Li C, Chan MH, Chen MH, Yeh CN, Hsiao M*, 2022, “Regorafenib Inhibits Epithelial-mesenchymal Transition and Suppresses Cholangiocarcinoma Metastasis via YAP1-AREG Axis”, CELL DEATH & DISEASE, 13(4), 391. (SCIE)
  • Chang YC, Chang PM, Li CH, Chan MH, Lee YJ, Chen MH, Hsiao M*, 2022, “Aldolase A and Phospholipase D1 Synergistically Resist Alkylating Agents and Radiation in Lung Cancer.”, FRONTIERS IN ONCOLOGY, Jan 21;11, 811635. (SCIE)
  • Chan MH, Huang WT, Hsiao M*, Liu RS, 2022, “Experimental Methods for Phosphor Evaluation and Characterization”, editor(s): Liu Ru-Shi, Wang Xiao-Jun, Phosphor Handbook, pp. Jan 31: 333-362, United States: CRC PRESS, TAYLOR & FRANCIS GROUP.
  • Chang ZX, Li CH, Chang YC, Huang CYF, Chan MH, Hsiao M*, 2022, “Novel Monodisperse FePt Nanocomposites for T2-weighted Magnetic Resonance Imaging: Biomedical Theranostics Applications [COVER STORY]”, NANOSCALE ADVANCES, 4(2), 377-386. (SCIE)
  • Chan MH, Lu CN, Chung YL, Chang YC, Li CH, Chen CL, Wei DH, Hsiao M*, 2021, “Magnetically Guided Theranostics: Montmorillonite-based Iron/platinum Nanoparticles for Enhancing In Situ MRI Contrast and Hepatocellular Carcinoma Treatment”, JOURNAL OF NANOBIOTECHNOLOGY, Oct 9;19(1), 308. (SCIE)
  • Tsai HF, Chang YC, Li CH, Chan MH, Chen CL, Tsai WC, Hsiao M*, 2021, “Type V Collagen Alpha 1 Chain Promotes the Malignancy of Glioblastoma through PPRC1-ESM1 Axis Activation and Extracellular Matrix Remodeling”, CELL DEATH DISCOVERY, Oct. 26;7(1), 313. (SCIE)
  • Li CH, Chang YC, Chan MH, Yang YF, Liang SM, Hsiao M*, 2021, “Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives [INVITED REVIEW]”, BIONMEDICINES, Sep 4;9(9), 1159.
  • Li CH, Hsu TI, Chang YC, Chan MH, Lu PJ, Hsiao M*, 2021, “Stationed or Relocating: The Seesawing EMT/MET Determinants from Embryonic Development to Cancer Metastasis [INVITED REVIEW]”, BIOMEDICINES, Sep 18;9(9), 1265. (SCIE)
  • Chang YC, Chan MH, Li CH, Fang CY, Hsiao M*, Chen CL, 2021, “Exosomal Components and Modulators in Colorectal Cancer: Novel Diagnosis and Prognosis Biomarkers [INVITED REVIEW]”, BIOMEDICINES, 9(8), 931. (SCIE)
  • Chan MH, Chen W, Li CH, Fang CY, Chang YC, Wei DH, Liu RS, Hsiao M*, 2021, “An Advanced In Situ Magnetic Resonance Imaging and Ultrasonic Theranostics Nanocomposite Platform: Crossing the Blood–Brain Barrier and Improving the Suppression of Glioblastoma Using Iron-Platinum Nanoparticles in Nanobubbles”, ACS APPLIED MATERIALS & INTERFACES, Jun 16;13(23), 26759-26769. (SCIE)
  • Chang YC, Chan MH, Li CH, Yang CJ, Tseng YW, Tsai HF, Chiou J, Hsiao M*, 2021, “Metabolic Protein Phosphoglycerate Kinase 1 Confers Lung Cancer Migration by Directly Binding to HIV Tat Specific Factor 1”, CELL DEATH DISCOVERY, Jun 5;7(1), 135. (SCIE)
  • Yang YC, Chien MH, Lai TC, Tung MC, Jan YH, Chang WM, Jung SM, Chen MH, Yeh CN, Hsiao M*, 2021, “Proteomics-based Identification of TMED9 Is Linked to Vascular Invasion and Poor Prognoses in Patients with Hepatocellular Carcinoma”, JOURNAL OF BIOMEDICAL SCIENCE, Apr 22;28(1), 29. (SCIE)
  • Lin TC, Hsiao M*, 2021, “Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments - [INVITED REVIEW]”, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Mar 11;22(6), 2870. (SCIE)
  • Huang WT, Su TY, Chan MH, Tsai JY, Do YY, Huang PL, Hsiao M*, Liu RS, 2021, “Near-infrared Nanophosphor Embedded in Mesoporous Silica Nanoparticle with High Light-Harvesting Efficiency to Promote Dual Photosystem”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 60(13), 6955-6959. (SCIE)
  • Li LJ, Chang WM, Hsiao M*, 2021, “Aberrant Expression of microRNA Clusters in Head and Neck Cancer Development and Progression: Current and Future Translational Impacts - [INVITED REVIEW]”, PHARMACEUTICALS, Feb 27;14(3), 194. (SCIE)
  • Cheng CL, Chan MH, Feng SJ, Hsiao M*, Liu RS, 2021, “Long-Term Near-Infrared Signal Tracking of the Therapeutic Changes of Glioblastoma Cells in Brain Tissue with Ultrasound-Guided Persistent Luminescent Nanocomposites”, ACS APPLIED MATERIALS & INTERFACES, 13(5), 6099-6108. (SCIE)
  • Chan MH, Chan YC, Liu RS, Hsiao M*, 2020, “A selective drug delivery system based on phospholipid-type nanobubbles for lung cancer therapy”, Nanomedicine, 15(27), 2689-2705. (SCIE)
  • Lai TC, Fang CY, Jan YH, Hsieh HL, Yang YF, Liu CY, Chang PM, Hsiao M*, 2020, “Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-κB signaling pathway”, Cell Communication and Signaling, 18(1), 164. (SCIE)
  • Chang YC, Chen MH, Yeh CN, Hsiao M*, 2020, “Omics-based Platforms: Current Status and Potential Use for Cholangiocarcinoma - [Invited Reviews]”, Biomolecules, 10(10), 1377. (SCIE)
  • Yang YF, Chang YC, Jan YH, Yang CJ, Huang MS, Hsiao M*, 2020, “Squalene synthase promotes the invasion of lung cancer cells via the osteopontin/ERK pathway”, Oncogenesis, Aug 29; 9(8):78. (SCIE)
  • Fan CC, Tsai ST, Yang JC, Chang LC, Chen GY, Sher YP, Wang SC, Hsiao M*, Chang WC, 2020, “EFHD2 Contributes to Non-small Cell Lung Cancer Cisplatin Resistance by the Activation of NOX4-ROS-ABCC1 Axis”, Redox Biology, Jul; 34:101571. (SCIE)
  • Chan MH, Huang WT, Wang J, Liu RS, Hsiao M*, 2020, “Next‐Generation Cancer‐Specific Hybrid Theranostic Nanomaterials: MAGE‐A3 NIR Persistent Luminescence Nanoparticles Conjugated to Afatinib for In Situ Suppression of Lung Adenocarcinoma Growth and Metastasis”, Advanced Science, May 6; 7(9):1903741. (SCIE)
  • Chang YC, Yang YF, Chiou J, Tsai HF, Fang CY, Yang CJ, Chen CL, Hsiao M*, 2020, “Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness”, Cell Death & Disease, Mar 18; 11(3):195. (SCIE)
  • Chan MH, Hsieh MR, Liu RS, Wei DH, Hsiao M*, 2020, “Magnetically Guided Theranostics: Optimizing Magnetic Resonance Imaging with Sandwich-Like Kaolinite-Based Iron/Platinum Nanoparticles for Magnetic Fluid Hyperthermia and Chemotherapy”, Chemistry of Materials, 32(2) 697-708. (SCIE)
  • Huang WT, Chan MH, Chen X, Hsiao M*, Liu RS, 2020, “Theranostic Nanobubble Encapsulating A Plasmon-enhanced Upconversion Hybrid Nanosystem for Cancer Therapy”, Theranostics, Jan 1;10(2):782-796. (SCIE)
  • Chiou J, Chang YC, Tsai HF, Lin YF, Huang MS, Yang CJ, Hsiao M*, 2019, “Follistatin-like protein 1 inhibits lung cancer metastasis by preventing proteolytic activation of osteopontin”, Cancer Research, 79(24),6113-6125. (SCIE)
  • Chang YC, Chiou J, Yang YF, Su CY, Lin YF, Yang CN, Lu PJ, Huang MS, Yang CJ, Hsiao M*, 2019, “Therapeutic targeting of aldolase A interactions inhibits lung cancer metastasis and prolongs survival”, Cancer Research, 79(18),4754-4766. (SCIE)
  • Chan MH, Liu RS, Hsiao M*, 2019, “Graphitic carbon nitride-based nanocomposites and their biological applications: a review.”, Nanoscale, 11(32),14993-15003, Cite 2. (SCIE)
  • Jan YH, Lai TC, Yang CJ, Lin YF, Huang MS, Hsiao M*, 2019, “Adenylate kinase-4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis”, Journal of Hematology and Oncology, 12(1):12, Cite 3. (SCIE)
  • Wang PS, Chou CH, Lin CH, Yao YC, Cheng HC, Li HY, Ger LP, Chen YC, Lin FC, Hsiao M*, Lu PJ, 2018, “A novel long non-coding RNA linc-ZNF469-3 promotes lung metastasis through miR-574-5p-ZEB1 axis in triple negative breast cancer”, Oncogene, 37(34), 4662-4678, Cite 14. (SCIE)
  • Chang YC, Yang YC, Tien CP, Yang CJ, Hsiao M*, 2018, “Roles of aldolase family genes in human cancers and diseases - [Invited Review]”, Trends in Endocrinology and Metabolism, Aug;29(8), 549-559. (SCIE)
  • Chan MH, Pan YT, Chan YC, Hsiao M*, Chen CH, Sun L, Liu RS, 2018, “Nanobubble-embedded inorganic 808 nm excited-upconversion nanocomposites for tumorous multiple imaging and treatment”, Chemical Science, Feb 9; 9(12), 3141-3151, Cite 20. (SCIE)
  • Chang YC, Chan YC, Chang MW, Lin YF, Yang CJ, Su CY, Huang MS, Wu AT, Hsiao M*, 2017, “Feedback regulation of ALDOA activates HIF-1α/MMP9 axis to promote lung cancer progression”, Cancer Letters, 403, 28-36, Cite 21. (SCIE)
  • Lin TC, Hsiao M*, 2017, “Ghrelin and cancer progression”, Biochimica et Biophysica Acta-Reviews on Cancer, 1868, 51-57, Cite 23. (SCIE)
  • Chang YC, Su CY, Chen MH, Chen WS, Chen CL, Hsiao M*, 2017, “Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promotes colon cancer metastasis and is associated with poor prognosis”, Molecular Cancer, 16(1), 135, Cite 12. (SCIE)
  • Chien MH, Lee WJ, Chang YC, Chang WM, Lai TC, Chan DV, Sharma R, Lin YF, Hsiao M*, 2017, “A Fas ligand (FasL)-fused humanized antibody against tumor-associated glycoprotein 72 (hcc49scFV-FasL) selectively exhibits the cytotoxic effect against oral cancer cells with a low FasL/Fas ratio”, Molecular Cancer Therapeutics, 16(6), 1102-1113, Cite 5. (SCIE)
  • Chan MH, Pan YT, Lee IJ, Chen CW, Chan YC, Hsiao M*, Wang F, Sun L, Chen X, Liu RS, 2017, “Minimizing the heat effect of photodynamic therapy based on inorganic nanocomposites mediated by 808 nm near-infrared light”, Small, 13(21), 1700038, Cite 44. (SCIE)
  • Chang YC, Chi LH, Chang MW, Su CY, Lin YF, Chen CL, Chen MH, Chang PM, Wu AT, Hsiao M*, 2017, “Glucose transporter 4 promotes head and neck cancer metastasis through TRIM24-DDX58 axis”, Journal of Hematology & Oncology, 10(1), 11, Cite 10. (SCIE)
  • Chang WM, Lin YF, Su CY, Peng HY, Chang YC, Lai TC, Wu GH, Hsu YM, Chi LH, Hsiao JR, Chen CL, Chang JY, Shieh YS, Hsiao M*, Shiah SG, 2016, “Dysregulation of Runx2/Activin A axis upon miR376c downregulation promotes lymph node metastasis in head and neck squamous cell carcinoma.”, Cancer Research, 76(24),7140-7150, Cite 16. (SCIE)
  • Chen CW, Chan YC, Hsiao M*, Liu RS, 2016, “Plasmon-enhanced photodynamic cancer therapy by upconversion nanoparticles conjugated with Au nanorods”, ACS Applied Materials & Interfaces, 8(47), 32108-32119, Cite 35. (SCIE)
  • Chan YC, Chen CW, Chan MH, Chang YC, Chang MW, Chi LH, Yu HM, Lin YF, Tsai DP, Liu RS, Hsiao M*, 2016, “MMP2-sensing up-conversion nanoparticle for fluorescence biosensing in head and neck cancer cells”, Biosensors & Bioelectronics, Jun 15;80:131-139, Cite 17. (SCIE)
  • Hsu CY, Lin CH, Jan YH, Su CY, Yao YC, Cheng HC, Hsu TI, Wang PS, Su WP, Yang CJ, Huang MS, Calkins MJ, Hsiao M*, Lu PJ, 2016, “Huntingtin-Interacting Protein-1 Is an Early-stage Prognostic Biomarker of Lung Adenocarcinoma and Suppresses Metastasis via Akt-mediated EMT.”, American Journal of Respiratory and Critical Care Medicine, Apr 15;193(8):869-880, Cite 10. (SCIE)
  • Lin TC, Su CY, Lai TC, Pan WA, Jan YH, Yeh CT, Chen CL, Ger LP, Chang HT, Yang CJ, Huang MS, Shyy JY, Tsai MD, Hsiao M*, 2016, “NIFK promotes cancer metastasis through Runx1-dependent repression of casein kinase 1α to activate Wnt/b-catenin signaling”, eLife, Mar 17;5:e11288, Cite 15. (SCIE)
  • Lin TC, Liu YP, Chan YC, Su CY, Lin YF, Hsu SL, Yang CS, Hsiao M*, 2015, “Ghrelin promotes renal cell carcinoma metastasis via snail activation and is associated with poor prognosis”, The Journal of Pathology, 237(1), 50-61. Cite 21. (SCIE)
  • Yang YF, Jan YH, Liu YP, Yang CJ, Su CY, Lin YF, Chang YC, Lai TC, Chiou J, Tsai HY, Lu J, Shen CN, Shew JY, Lu PJ, Huang MS, Hsiao M*, 2014, “Squalene Synthase Induces TNFR1 Enrichment in Lipid Rafts to Promote Lung Cancer Metastasis.”, American Journal of Respiratory and Critical Care Medicine, 190(6), 675-687. Cite 16. (SCIE)
  • Liu YP, Liao WC, Ger LP, Chen JC, Hsu TI, Lee YC, Chang HT, Chen YC, Jan YH, Lee KH, Zeng YH, Hsiao M*, Lu PJ, 2013, “Carboxyl-terminal modulator protein positively regulates Akt phosphorylation and acts as an oncogenic driver in breast cancer.”, Cancer Research, 73(20), 6194-6205. Cite 13. (SCIE)
  • Tsai HY, Yang YF, Wu AT, Yang CJ, Liu YP, Jan YH, Lee CH, Hsiao YW, Yeh CT, Shen CN, Lu PJ, Huang MS, Hsiao M*, 2013, “Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78.”, Oncogene, 32(41), 4921-4931. Cite 40. (SCIE)
  • Liu YP, Hsiao M*, 2013, “Exercise-induced SPARC prevents tumorigenesis of colon cancer”, Gut, 62(6), 810-811. Cite 7. (SCIE)
  • Liu CH, Chen TC, Chau GY, Jan YH, Chen CH, Hsu CN, Lin KT, Juang YL, Lu PJ, Cheng HC, Chen MH, Chang CF, Ting YS, Kao CY, Hsiao M*, Huang CY, 2013, “An analysis of protein-protein interactions in cross-talk pathways reveals CRKL as a novel prognostic marker in hepatocellular carcinoma.”, Mol Cel Proteomics, 12(5), 1335-1349. Cite 22. (SCIE)
  • Cheng LC, Chen HM, Lai TC, Liu RS, Sung JC, Hsiao M*, Chen CH, Her LJ, Tsai DP, 2013, “Targeting polymeric fluorescent nanodiamond-gold/silver multi-functional nanoparticles as a light-transforming hyperthermia reagent for cancer cell”, Nanoscale, May 7;5(9):3931-40. Cite 38. (SCIE)
  • Liu YP, Yang CJ, Huang MS, Yeh CT, Wu AT, Lee YC, Lai TC, Lee CH, Hsiao YW, Lu J, Shen CN, Lu PJ, Hsiao M*, 2013, “Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling”, Cancer Research, 73(1), 406-416. Cite 129. (SCIE)
  • Jan YH, Tsai HY, Yang CJ, Huang MS, Yang YF, Lai TC, Lee CH, Jeng YM, Huang CY, Su JL, Chuang YJ, Hsiao M*, 2012, “Adenylate Kinase-4 Is a Marker of Poor Clinical Outcomes That Promotes Metastasis of Lung Cancer by Downregulating the Transcription Factor ATF3.”, Cancer Res, 72(19), 5119-5129. Cite 14. (SCIE)
  • Lin FC, Liu YP, Lai CH, Shan YS, Cheng HC, Hsu PI, Lee CH, Lee YC, Wang HY, Wang CH, Cheng JQ, Hsiao M*, Lu PJ, 2012, “RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells.”, Oncogene, 31(39), 4302-4316. Cite 42. (SCIE)
  • Tsai WC, Hsu SD, Hsu CS, Lai TC, Chen SJ, Shen R, Huang Y, Chen HC, Lee CH, Tsai TF, Hsu MT, Wu JC, Huang HD, Shiao MS, Hsiao M*, Tsou AP, 2012, “MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis.”, Journal of Clinical Investigation, 122(8), 2884-2897. Cite 483. (SCIE)
  • Cheng LC, Huang JH, Chen HM, lai TC, Liu RS, Hsiao M*, Chen CH, Her LJ, Tsai DP, 2012, “Seedless, silver-induced synthesis of star-shaped gold/silver bimetallic nanoparticles as high efficiency photothermal therapy reagent”, Journal of Materials Chemistry, 22(5), 2244-2253. Cite 129.
  • Hua KT, Tan CT, Johansson G, Lee JM, Yang PW, Lu HY, Chen CK, Su JL, Chen PB, Wu YL, Chi CC, Kao HJ, Shih HJ, Chen MW, Chien MH, Chen PS, Lee WJ, Cheng TY, Rosenberger G, Chai CY, Yang CJ, Huang MS, Lai TC, Chou TY, Hsiao M*, Kuo ML, 2011, “N-alpha-Acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity”, Cancer Cell, 19(2), 218-231. Cited 62. (SCIE)
  • Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G, Shiah SG, Chen PS, Jeng YM, Cheng TY, Lai TC, Chang JS, Jan YH, Chien MH, Yang CJ, Huang MS, Hsiao M*, Kuo ML, 2010, “H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM.”, Cancer Research, 70(20), 7830-7840. Cite 201. (SCIE)
  • Cheng WH, Lu PJ, Ho WY, Tung CS, Cheng PW, Hsiao M*, Tseng CJ, 2010, “Angiotensin II Inhibits Neuronal Nitric Oxide Synthase Activation Through the ERK1/2-RSK Signaling Pathway to Modulate Central Control of Blood Pressure.”, Circulation Research, Mar 5;106(4):788-95. Cite 56. (SCIE)
  • Tsai WC, Hsu PW, Lai TC, Chau GY, Lin CW, Chen CM, Lin CD, Liao YL, Wang JL, Chau YP, Hsu MT, Hsiao M*, Huang HD, Tsou AP, 2009, “MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma.”, Hepatology, May; 49(5), 1571-1582. Cite 410. (SCIE)
  • Liao YL, Sun YM, Chau GY, Chau YP, Lai TC, Wang JL, Horng JT, Hsiao M*, Tsou AP, 2008, “Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma.”, Oncogene, Sep 18;27(42):5578-5589. Cite 136. (SCIE)