Chen, Yun-Ru Ruby 陳韻如






  • B.S., Department of Agricultural Chemistry, National Taiwan University, Taiwan, 1992-1996
  • Ph.D., Department of Molecular and Structural Biochemistry, North Carolina State University, USA, 1998-2003
  • Research Assistant, Institute of Botany, Academia Sinica, 1996-1998
  • Teaching Assistant, Dept. of Molecular and Structural Biochemistry, North Carolina State University, USA, 1998-1999
  • Postdoctoral Fellow, Dept. of Molecular Biology & Biochemistry, University of California, Irvine, USA, 2004-2006
  • Postdoctoral Fellow, Genomics Research Center, Academia Sinica, Taiwan, 2006-2007
  • Assistant Professor, Genomics Research Center, Academia Sinica, Taiwan, 2007-2014
  • Council Member of Asia Pacific Protein Association (APPA), 2014-2017
  • The World Academy of Sciences (TWAS) Young Affiliate, 2015-2019
  • Associate Professor, The Genomics Research Center, Academia Sinica, 2014-2021
  • Adjunct Associate Professor, Dept. of Biochemical Science & Technology, National Taiwan University, Taiwan, 2015-present
  • Professor, The Genomics Research Center, Academia Sinica, 2021-present
  • Adjunct Professor, Dept. of Biochemical Science & Technology, National Taiwan University, Taiwan, 2021-present
  • President-elect, Asia Pacific Protein Association (APPA), 2022-2025
  • Adjunct Professor/ Adjunct Research Fellow, Biomedical Translation Research Center, Academia Sinica, Taiwan, 2022-present


  • Chung Hwa Rotary Education Foundation Outstanding Award, 2022-2023
    2023 中華扶輪教育基金會2022-23年度「傑出/特殊人才」獎
  • The 19th National Innovation Award. “A novel conformation-dependent monoclonal antibody against ALS and related neurodegenerative diseases”, 2022
    2022 第19屆國家新創獎,「對抗漸凍人及相關神經退化疾病的結構專一型單株抗體」。
  • The 19th Y. Z. Hsu Scientific Paper Award, Far Eastern Y. Z. Hsu Science and Technology Memorial Foundation, 2021
  • National China Youth Corps Youth Medal, Taiwan, 2019
  • Selected work for Future Tech Exhibition “A novel potential therapeutic antibody to combat ALS and related neurodegenerative diseases”, 2018
  • The 14th Young Investigator Award, TienTe Lee Biomedical Foundation, 2018
  • Young Chemists Award of the Chemical Society, Taipei, 2016
  • Ta-You Wu Memorial Award, 2015
  • TWAS Young Affiliate, East & Southeast Asia and Pacific Region, 2015-2019
  • The 13th Y.Z. Hsu Scientific Paper Award, 2015
  • Academia Sinica Research Award for Junior Research Investigators, 2015
  • Junior Faculty Award, the 12th International Conference on Alzheimer’s Disease and Parkinson’s Disease, 2015(國際獎項)
  • Promising Women in Science Award, Wu Chieh Shiung Education Foundation, 2014
  • Young Investigator Award, Biophysical Society of R.O.C., 2013 
  • Taiwan Dementia Society, LiFu Medical Research Foundation Academic Award, Advisor of the 1st Price, 2012, and 2nd Price, 2011
    台灣臨床失智症學會財團法人立夫醫藥文教基金會學術獎第一名之指導教授2012及第 二名之指導教授2011
  • The Taiwan Society for Biochemistry and Molecular Biology Traveling Fellowship, 2012
    台灣生物化學及分子生物學會年輕學者出國研習優秀論文獎助2012 FAOBMB Congress
  • Academia Sinica Postdoctoral Fellowship, 2006-2007



Protein Folding/Misfolding, Amyloids, and Neurodegenerative Diseases

My research focuses on understanding the mechanism of protein misfolding diseases, amyloidosis, by various techniques including biochemical, biophysical, molecular, and cellular methods. Our long-term goal is to elucidate the disease mechanisms of amyloidosis in the aspects of protein folding and structure, pathogenic protein interactions, and relate the results to the medical consequences. We further utilize the knowledge to develop novel diagnostic means and therapeutic modalities. Many ageing-related neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) belong to amyloidosis. Among them, AD is the most serious problem in the 21st century. Amyloidosis is caused by aggregation of misfolded proteins to form amyloid fibrils comprising specific cross-β structures. Amyloid oligomers that exist in several neurodegenerative diseases imply a common toxicity mechanism in different neurodegenerative diseases. Currently, we are working on three amyloid and amyloid-like proteins and their interacting partners in neurodegenerative diseases. They are amyloid-β (Aβ) peptide and tau protein, the major substance in senile plaques and neurofibrillary tangles of AD patients respectively, α-synuclein, the component of Lewy bodies in PD, and TDP-43, a novel inclusion found in a subtype of frontotemporal lobar dementia (FTLD-U), amyotrophic lateral sclerosis (ALS), and AD. We start from elucidating the mechanism of such aggregation and further developing the diagnostic method, antibodies, and small molecule inhibitors. Moreover, we study the structure, function, and interactions of the related glycan conjugates, precursor proteins, and modifiers. The major research interests are listed as follows:

  • Protein folding and misfolding of amyloids in neurodegenerative diseases.
  • Amyloid protein oligomerization and the toxicity mechanisms in neurodegenerative diseases.
  • Interactions of proteins, glycans, and lipids with the proteins involved in pathogenesis of the neurodegenerative diseases.
  • Drug screening, diagnostic, and therapeutic developments in neurodegenerative diseases.

Amyloid formation, a detrimental protein aggregation, is initiated by protein 
misfolding followed by self-association to ultimately form amyloid fibrils.
The discovery of cytotoxic pre-fibrillar oligomers in many neurodegenerative 
diseases underscores the importance of understanding the folding, aggregation,
and pathogenic mechanisms as well as developing diagnostic and therapeutic




  • 蛋白質在神經退化疾病中的摺疊與錯誤摺疊機制
  • 類澱粉蛋白多倍體及在神經退化疾病中引發之毒性機制
  • 類澱粉蛋白之醣化修飾及其調節物之影響與交互作用
  • 針對神經退化疾病發展藥物篩選、診斷及治療策略