Chen, Chung-Hsuan 陳仲瑄






  • Ph.D., Chemistry, University of Chicago, 1974
  • Postdoctoral Fellow, Oak Ridge National Laboratory, 1974-1976
  • Research Scientist, Oak Ridge National Laboratory, 1976-1989
  • Senior Scientist & Project Leader, Oak Ridge National Laboratory, 1989-2005
  • Adjunct Professor, Department of Physics and Astronomy, Vanderbilt University, 1990-2005
  • Adjunct Professor, Department of Physics, University of Tennessee, Knoxville, 1993-2005
  • Research Fellow and Key Technology Division Head, Genomics Research Center; Academia Sinica, 2005-2006
  • Distinguished Research Fellow and Acting Director, Genomics Research Center; Academia Sinica, 2006-2007
  • Director, Genomics Research Center, Academia Sinica, 2007-2016


  • R & D-100 Award (top 100 Inventions of the year):
    • Rare Gas Atom Counter, 1984
    • Crystal Laser Beam Monitor, 1987
    • Non-CFC Freon Leak Detector, 1992
  • Editorial Board: Rapid Communication in Mass Spectrometry
  • American Physical Society Fellow, 1995
  • Advancement of Outstanding Scholarship Award, 2004-2009
  • Fellow, American Association for the Advancement of Science (AAAS, USA), 2009
  • Academician, Academia Sinica, 2010 


Chemical Physics and its application in technology development

Research work in Chen laboratory covers a broad spectrum of atomic, molecular and solid state physics as well as their applications in ultra-sensitive detection technology development. The major research interests are listed in the follows:

  • Genomic and Proteomic Technology
  • Biomolecular Mass Spectrometry
  • Microarray hybridization detection
  • DNA typing for forensic applications
  • Instrumentation Development for Ultra-low Level Pollutants Detection
  • Nanoscience for biomedical applications
  • High Temperature Superconductors
  • Atomic and Molecular Spectroscopy
  • Crossed Molecular Beam for Reaction Dynamics Studies
  • Kinetics of F-centers and Self-trapped Excitons in Alkali Halide Crystals


  • 基因體和蛋白體科技
  • 生物分子質譜
  • 微米排列雜交測量
  • 核酸測定在犯罪學的應用
  • 超微量污染物測量
  • 奈米生物醫學
  • 高溫超導體
  • 原子和分子光譜
  • 分子束和化學動力學


  • Kent J. Gillig and C.H. Chen, 2013, “A critical examination of gas-phase protein conformation/multimer ion formations by Electrospray Ion Mobility-Mass Spectrometry”, ANALYTICAL CHEMISTRY, 85(4), 2177-2182. (SCIE) (IF: 6.785; SCIE ranking: 8.1%)
  • T.Y. Lin , B.R. Li , S.T. Tsai , C.W. Chen , C.H. Chen , Y.T. Chen and C.Y. Pan, 2013, “Improved silicon nanowire field-effect transistors for fast protein–protein interaction screening”, LAB ON A CHIP, 13(4), 676-684. (SCIE) (IF: 6.774; SCIE ranking: 4.7%,9.3%,26.2%,6.5%,16.9%)
  • S.H. Lai , K.H. Chang, J.L. Lin, C.L. Wu, C.H. Chen, 2013, “Sinapinic acid clusters distribution from monomer to mega Dalton’s region in MALDI process”, CHEMICAL PHYSICS LETTERS, 561-562, 142-146. (SCIE) (IF: 2.029; SCIE ranking: 66.7%,54.1%)
  • Cheng LC, Chen HM, Lai TC, Chan YC, Liu RS, Sung JC, Hsiao M, Chen CH, Her LJ, Tsai DP, 2013, “Targeting polymeric fluorescent nanodiamond-gold/silver multi-functional nanoparticles as a light-transforming hyperthermia reagent for cancer cells.”, Nanoscale, 5(9), 3931-3940. (SCIE) (IF: 6.895; SCIE ranking: 15.8%,24.3%,14.8%,15.9%)
  • A. Özdemir, J.L. Lin, K. J. Gillig, C.H. Chen, 2013, “Triboelectric spray ionization”, JOURNAL OF MASS SPECTROMETRY, 48(2), 154-163. (SCIE) (IF: 1.671; SCIE ranking: 79.2%,69.8%,57.1%)
  • S. T. Tsai, C. N. Shen, C.C. Tsou, W. Y. Mao , W. C. Chang , W. L. Hsu, and C. H. Chen, 2012, “Label-free quantitative proteomics of CD133-positive liver cancer stem cells”, Proteome Science, 10(1), 69. (SCIE) (IF: 2.811; SCIE ranking: 46.2%,84.8%)
  • PR Sudhir, CH Chen, KM Pavana, MJ Wang, CC Tsou, TY Sung, JY Chen, CH Chen , 2012, “Label-free quantitative proteomics and N-glycoproteomics analysis of KRAS-activated human bronchial epithelial cells”, Molecular and cellular proteomics, 11(10), 901-915. (SCIE) (IF: 4.87; SCIE ranking: 10.4%)
  • H. C. Lin, J. L. Lin, H. H. Lin, S. W. Tsai, Alice L. Yu, R. Chen, C. H. Chen, 2012, “High Speed Mass Measurement of Nanoparticle and Virus”, ANALYTICAL CHEMISTRY, 84(11), 4965-4969. (SCIE) (IF: 6.785; SCIE ranking: 8.1%)
  • M. Liu, D.F. Lee, C.T. Chen, C.J. Yen, L.Y. Li, H.J. Lee, C.J. Chang, W.C. Chang, J.M. Hsu, H.P. Kuo, W. Xia, Y. Wei, P.C. Chiu, C.K. Chou, Y. Du, D. Dhar, M. Karin, C.H. Chen, M.C. Hung, 2012, “IKKalpha activation of NOTCH links tumorigenesis via FOXA2 suppression”, MOLECULAR CELL, 45(2), 171-184. (SCIE) (IF: 15.584; SCIE ranking: 1.3%,5.6%)
  • Y. F. Hsu, J. L. Lin, M. L. Chu, Y. S. Wang, Y. T. Lee, C. H. Chen, 2012, “Macromolecular Ion Accelerator”, ANALYTICAL CHEMISTRY, 84(13), 5765-5769. (SCIE) (IF: 6.785; SCIE ranking: 8.1%)
  • Y.L. Yu, R.H. Chou, C.H. Wu, Y.N. Wang, W.J. Chang, Y.J. Tseng. W.C. Chang, C.C. Lai, H.J. Lee, L. Huo, C.H. Chen, M.C. Hung, 2012, “Nuclear EGFR Suppresses Ribonuclease Activity of Polynucleotide Phosphorylase through DNAPK-mediated Phosphorylation at Serine 776”, The Journal of Biological Chemistry, 287(37), 31015-31026. (SCIE) (IF: 4.238; SCIE ranking: 29.3%)
  • L.C. Cheng, J.H. Huang, H.M. Chen, T.C. Lai, K.Y. Yang, R.S. Liu, M. Hsiao, C.H. Chen, L.J. Here and D. P. Tsai, 2012, “Seedless, silver-induced synthesis of star-shaped gold/silver bimetallic nanoparticles as high efficiency photothermal therapy reagent”, JOURNAL OF MATERIALS CHEMISTRY, 22(5), 2244-2253.
  • Y. Wang, Q. Ding, C.J. Yen, W. Xia, J. G. Izzo, J.Y. Lang, C.W. Li, J. L. Hsu, S. A. Miller, X. Wang, D.F. Lee, J.M. Hsu,. L. Huo, A. M. LaBaff, D. Liu, T.H. Huang, C.C. Lai, F.J. Tsai, W.C Chang, C.H. Chen, T.T. Wu, N.S. Buttar, K.K. Wang, Y. Wu, H. Wang, J. Ajani and M.C. Hung, 2012, “The Crosstalk of mTOR/S6K1and Hedgehog Pathways”, CANCER CELL, 21(3), 374-387. (SCIE) (IF: 26.602; SCIE ranking: 2.9%,2.1%)
  • C.Y. Wang, T.H. Hsiao, L.H. Chu, Y.L. Lin, J.L. Huang, C.H. Chen and K. Peck, 2012, “Unraveling Virus Identity by Detection of Depleted Probes with Capillary Electrophoresis”, ANALYTICA CHIMICA ACTA, 734, 88-92. (SCIE) (IF: 5.977; SCIE ranking: 11.6%)
  • H. Parab, J.H. Huang, T.C. Lai, Y.H. Jan, R.S. Liu, J.L. Wang, M. Hsiao, C.H. Chen, Y.K. Hwu, D.P. Tsai, S.Y. Chuang and J.S. Pang, 2011, “Biocompatible transferrin-conjugated sodium hexametaphosphate-stabilized gold nanoparticles: synthesis, characterization, cytotoxicity and cellular uptake”, NANOTECHNOLOGY, 22(39), 395706. (SCIE) (IF: 3.551; SCIE ranking: 49.5%,25.8%,34.7%)
  • Y. L. Chang, Y. C. Lee, W. B. Yang and C. H. Chen, 2011, “Ionic Liquid Assisted Electrospray Ionization of Polysaccharides”, JOURNAL OF MASS SPECTROMETRY, 46(4), 367-375. (SCIE) (IF: 1.671; SCIE ranking: 79.2%,69.8%,57.1%)
  • J.H. Huang, T.C. Lai, L.C. Cheng, R.S. Liu, C.H. Lee, M. Hsiao, C.H. Chen, L.J. Herd and D.P. Tsai, 2011, “Modulating cell-uptake behavior of Au-based nanomaterials via quantitative biomolecule modification”, Journal of Material Chemistry, 21(38), 14821-14829.
  • W.C. Huang, Y.J. Chen, L.Y. Li, Y.L. Wei, S.C. Hsu, S.L. Tsai, P.C. Chiu, W.P. Huang, Y.N. Wang, C.H. Chen, W.C. Chang, W.C. Chang, A.J.E. Chen, C.H. Tsai and M.C. Hung, 2011, “Nuclear Translocation of Epidermal Growth Factor Receptor by Akt-dependent Phosphorylation Enhances Breast Cancer-resistant Protein Expression in Gefitinib-resistant Cells”, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(23), 20558-20568. (SCIE) (IF: 4.238; SCIE ranking: 29.3%)
  • H. H. Lin, Y. C. Li, C. H. Chang, C. Liu, Alice L Yu, C. H. Chen, 2011, “Single Nuclei Raman spectroscopy for Drug Evaluation”, ANALYTICAL CHEMISTRY, 84(1), 113-120. (SCIE) (IF: 6.785; SCIE ranking: 8.1%)
  • C. Y. Wu, Y.S. Wang, N.G. Chen, C.Y. Wu and C. H. Chen*, 2010, “Ultrasound Ionization of Biomolecules”, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 24(17), 2569-2574.. (SCIE) (IF: 2.2; SCIE ranking: 50%,59.7%,35.7%)
  • W. C. Chang, M. S. Huang, C. J. Yang, T. C. Lai, M. Hsiao and C. H. Chen*, 2010, “Dermicidin Identification from Exhaled Air for Lung Cancer Diagnosis”, European respiratory journal, 35(5), 1182-1185.. (SCIE) (IF: 12.339; SCIE ranking: 6.3%)
  • Huan-Chang Lin, Hsin-Hung Lin, Cai-Yu Kao, Alice L. Yu, Wen-Ping Peng, Chung-Hsuan Chen, 2010, “Quantitative Measurement of Nano/Micro Particle Endocytosis with Cell Mass Spectrometry”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 49(20), 3460-3464.. (SCIE) (IF: 12.959; SCIE ranking: 8.5%)
  • Wei-Chao Chang, Chuan-Kai Chou, Chih-Chiang Tsou, Sheng-Hsiang Li, Chein-Hung Chen, Yu-Xing Zhuo, Wen-Lian Hsu, and Chung-Hsuan Chen*, 2010, “Comparative Proteomic Analysis of Proteins Involved in the Tumorigenic Process of Seminal Vesicle Carcinoma in Transgenic Mice”, International journal of proteomics, 1-14.
  • P. I. Hsu, C. H. Chen*, M. Hsiao, D. C. Wu, C. Y. Lin, K. H. Lai, P. J. L, 2010, “Diagnosis of gastric malignancy using gastric juice alpha1-antitrypsin”, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 19(2), 405-11. (SCIE) (IF: 4.344; SCIE ranking: 13%,32.4%)
  • H. Y. Liao, C. H. Hsu, S. C. Wang, C. H. Liang, H. Y. Yen. C. Y. Su, C. H. Chen, J. T. Jan, C. T. Ren, C. H. Chen, T. J. Cheng, C. Y. Wu, and C. H. Wong, 2010, “Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(42), 14849-14856. (SCIE) (IF: 14.612; SCIE ranking: 7.3%)
  • Lu PJ, Hsu PI, Chen CH, Hsiao M, Chang WC, Tseng HH, Lin KH, Chuah SK, Chen HC, 2010, “Gastric juice acidity in upper gastrointestinal diseases.”, World journal of gastroenterology : WJG, 16(43), 5496-5501. (SCIE) (IF: 3.665; SCIE ranking: 39.8%)
  • Huo L, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL, Huang TH, Ding Q, Chen CH, Tsai CH, Hung MC, 2010, “RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus.”, Proceedings of the National Academy of Sciences of the United States of America, 107(37), 16125-16130. (SCIE) (IF: 9.412; SCIE ranking: 11.3%)
  • J. S. Yang, J. L. Yan, C. K. Lin, C. Y. Chen, Z. Y. Xie and "C. H. Chen", 2009, “Pentiptycene-Derived Oligo(p-phenyleneethynylene)s: Conformational Control, Chain-Length Effects, Localization of Excitation, and Intrachain Resonance Energy Transfer”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48, 9936-9939. (SCIE) (IF: 12.959; SCIE ranking: 8.5%)
  • H. Parab, H. M. Chen, T. Lai, J. Huang, P. H. Chen, R. S. Liu, M. Hsiao, "C. H. Chen", D. Tsai, Y. Hwu, 2009, “Biosensing, Cytotoxicity and Cellular Uptake Studies of Surface Modified Gold Nanorods”, JOURNAL OF PHYSICAL CHEMISTRY C, 113, 7574-7578. (SCIE) (IF: 4.189; SCIE ranking: 42.7%,35.8%,28.7%)
  • C. R. Hsiao and C. H. Chen, 2009, “Characterization of DNA Chips by nanogold staining”, Analytical Biochemistry, 389, 118-123. (SCIE) (IF: 2.877; SCIE ranking: 41.6%,38.4%,56.6%)
  • Hwang-Verslues WW, Kuo WH, Chang PH, Pan CC, Wang HH, Tsai ST, Jeng YM, Shew JY, Kung JT, Chen CH, Lee EY, Chang KJ, Lee WH, 2009, “Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers.”, PloS one, 4(12), e8377. (SCIE) (IF: 2.74; SCIE ranking: 38%)
  • Z. Nie, F. Cui, M. Chu, "C. H. Chen" and H. C. Chang, 2008, “Calibration of a Frequency-Scan Quadrupole Ion Trap Mass Spectrometer for Microparticle Mass Analysis”, INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 270, 8-15. (SCIE) (IF: 2.09; SCIE ranking: 51.4%,38.1%)
  • W. P. Peng, H. C. Lin, M. L. Chu, H. C. Chang, H. H. Lin, Alice L. Yu and C. H. Chen, 2008, “Charge Monitoring Cell Mass Spectrometry”, ANALYTICAL CHEMISTRY, 80, 2524-2530. (SCIE) (IF: 6.785; SCIE ranking: 8.1%)
  • N. Y. Hsu, S. Y. Tseng, C. Y. Wu, C. H. Wong, and C. H. Chen*, 2008, “Desorption Ionization of Biomolecules on Metals”, ANALYTICAL CHEMISTRY, 80(13), 5203-5210. (SCIE) (IF: 6.785; SCIE ranking: 8.1%)
  • J. H. Huang, H.J. Parab, R.S. Liu, T.C. Lai, M. Hsiao, C.H. Chen, H.S. Sheu, J.M. Chen, D.P. Tsai and Y.K. Hwu, 2008, “Investigation of the growth mechanism of iron oxide Nanoparticles via a seed-mediated method and its cytotoxicity studies”, JOURNAL OF PHYSICAL CHEMISTRY, 112(40), 15684-15690.
  • L. Jessome, N. Y. Hsu, Y. S. Wang and C. H. Chen, 2008, “Matrix-assisted laser desorption/ionization mechanism study with dihydroxybenzoic acid isomers as matrices”, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 22, 130. (SCIE) (IF: 2.2; SCIE ranking: 50%,59.7%,35.7%)
  • W. C. Chang, P. I. Hsu, Y. Y. Chen, M. Hsiao, P. J. Lu and C. H. Chen, 2008, “Observation of peptide differences between cancer and control in gastric juice”, Proteomics Clinical applications, 2(1), 55-62. (SCIE) (IF: 2.489; SCIE ranking: 54.5%)
  • J. Susanto, Y. H. Lin, Y. N. Chen, C. R. Shen, Y. T. Yan, S. T. Tsai, "C. H. Chen", and C. N. Shen, 2008, “Porphyrin Homeostasis Maintained by ABCG2 Regulates Self-Renewal of Embryonic Stem Cells”, Plos One, 3, e4023. (SCIE) (IF: 2.74; SCIE ranking: 38%)
  • Chen CH, 2008, “Review of a current role of mass spectrometry for proteome research.”, Analytica chimica acta, 624(1), 16-36. (SCIE) (IF: 5.977; SCIE ranking: 11.6%)
  • C.H. Chen, 2007, “Novel physical biotechnology development for biomedical applications”, paper presented at International Symposium on Bio-inspired Engineering, Dead Sea, Israel, 2007-10-08 ~ 2007-10-10.
  • M. H. Li and C. H. Chen, 2007, “Bipolar ion detector with enhanced sensitivity by sequential conversion reactions”, paper presented at 55th ASMS Conference on Mass Spectrometry, Indianapolis, IN, 2007-06-03 ~ 2007-06-07.
  • C.H. Chen, 2007, “Novel physical biotechnology development for biomedical applications”, paper presented at 1st International Symposium on Nanomedicine, Okazaki, Japan, 2007-04-19 ~ 2007-04-22.
  • P. I. Hsu, C. H. Chen, C. S. Hsieh, W. C. Chang, K. H. Lai, G. H. Lo, , P. N. Hsu, F. W. Tsay, Y. S. Chen, M. Hsiao, H. C. Chen and P. J. Lu, 2007, “Alpha 1-antitrypsin precursor in gastric juice is a novel biomarker for gastric cancer and ulcer”, Clinical Cancer Research, 13(3), 876-883. (SCIE) (IF: 10.107; SCIE ranking: 7.4%)
  • W. P. Peng, H. C. Lin, H. H. Lin, M. Chu, A. L. Yu, H. C. Chang and C. H. Chen, 2007, “Charge-monitoring laser-induced acoustic desorption mass spectrometry for cell and microparticle mass distribution measurement”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(21), 3865-3869. (SCIE) (IF: 12.959; SCIE ranking: 8.5%)
  • Z. Nie, F. Cui, Y. K. Tzeng, H. C. Chang, M. Chu, H. C. Lin, C. H. Chen, H. H. Lin and A. L. Yu, 2007, “High-Speed Mass Analysis of Whole Erythrocytes by Charge-Detection Quadrupole Ion Trap Mass Spectrometry”, Analytical Chemistry, 79(19), 7401-7407. (SCIE) (IF: 6.785; SCIE ranking: 8.1%)
  • W. C. Chang, L. C. L. Huang, Y. S. Wang, W. P. Peng, H. C. Chang, N. Y. Hsu, W. B. Yang and C. H. Chen, 2007, “Matrix-assisted laser desorption/ionization (MALDI) mechanism revisited”, Anal Chim Acta, 582, 1-9. (SCIE) (IF: 5.977; SCIE ranking: 11.6%)
  • N. Y. Hsu, W. B. Yang, C. H. Wong, Y. C. Lee, R. T. Lee, Y. S. Wang and C. H. Chen, 2007, “Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix”, Rapid Communications in Mass Spectrometry, 21(13), 2137-2146. (SCIE) (IF: 2.2; SCIE ranking: 50%,59.7%,35.7%)