Chen, Chung-Hsuan 陳仲瑄

客座講座


winschengateEmail
02-27871260

 

 

EDUCATION AND POSITIONS HELD:

  • Ph.D., Chemistry, University of Chicago, 1974
  • Postdoctoral Fellow, Oak Ridge National Laboratory, 1974-1976
  • Research Scientist, Oak Ridge National Laboratory, 1976-1989
  • Senior Scientist & Project Leader, Oak Ridge National Laboratory, 1989-2005
  • Adjunct Professor, Department of Physics and Astronomy, Vanderbilt University, 1990-2005
  • Adjunct Professor, Department of Physics, University of Tennessee, Knoxville, 1993-2005
  • Research Fellow and Key Technology Division Head, Genomics Research Center; Academia Sinica, 2005-2006
  • Distinguished Research Fellow and Acting Director, Genomics Research Center; Academia Sinica, 2006-2007
  • Director, Genomics Research Center, Academia Sinica, 2007-2016

HONORS:

  • R & D-100 Award (top 100 Inventions of the year):
    • Rare Gas Atom Counter, 1984
    • Crystal Laser Beam Monitor, 1987
    • Non-CFC Freon Leak Detector, 1992
  • Editorial Board: Rapid Communication in Mass Spectrometry
  • American Physical Society Fellow, 1995
  • Advancement of Outstanding Scholarship Award, 2004-2009
  • Fellow, American Association for the Advancement of Science (AAAS, USA), 2009
  • Academician, Academia Sinica, 2010 

RESEARCH INTERESTS:

Chemical Physics and its application in technology development

Research work in Chen laboratory covers a broad spectrum of atomic, molecular and solid state physics as well as their applications in ultra-sensitive detection technology development. The major research interests are listed in the follows:

  • Genomic and Proteomic Technology
  • Biomolecular Mass Spectrometry
  • Microarray hybridization detection
  • DNA typing for forensic applications
  • Instrumentation Development for Ultra-low Level Pollutants Detection
  • Nanoscience for biomedical applications
  • High Temperature Superconductors
  • Atomic and Molecular Spectroscopy
  • Crossed Molecular Beam for Reaction Dynamics Studies
  • Kinetics of F-centers and Self-trapped Excitons in Alkali Halide Crystals

陳仲瑄博士實驗室主要研究方向如下:

  • 基因體和蛋白體科技
  • 生物分子質譜
  • 微米排列雜交測量
  • 核酸測定在犯罪學的應用
  • 超微量污染物測量
  • 奈米生物醫學
  • 高溫超導體
  • 原子和分子光譜
  • 分子束和化學動力學

SELECTED PUBLICATIONS:

  • C. H. Chen, Y. P. Lin, J. L. Lin, S. T. Li, C. T. Ren, C. Y. Wu and C. H. Chen, 2015, “Rapid identification of terminal sialic acid linkage isomers by pseudo-MS3 mass spectrometry”, ISRAEL JOURNAL OF CHEMISTRY, 55(3-4), 412-422. (SCIE)
  • Lee HJ, Lan L, Peng G, Chang WC, Hsu MC, Wang YN, Cheng CC, Wei L, Nakajima S, Chang SS, Liao HW, Chen CH, Lavin M, Ang KK, Lin SY, Hung MC, 2015, “Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response.”, Cell research, 25(2), 225-36. (SCIE)
  • Chin-Yu Wang, Chung-Yi Wu, Ting-Jiun Hung, Chi-Huey Wong, Chung-Hsuan Chen, 2014, “Sequence-constructive SELEX: A new strategy for screening DNA aptamer binding to Globo H”, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 452(3), 484-489. (SCIE)
  • Abdil Ozdemir, J.L. Lin, Y. S. Wang, C.H. Chen, 2014, “A deeper look into sonic spray ionization”, RSC Advances, 106(4), 61290-61297. (SCIE)
  • Huo L, Li CW, Huang TH, Lam YC, Xia W, Tu C, Chang WC, Hsu JL, Lee DF, Nie L, Yamaguchi H, Wang Y, Lang J, Li LY, Chen CH, Mishra L, Hung MC, 2014, “Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells.”, American Journal of Translational Research, 6(6), 649-663. (SCIE)
  • I.C. Lee, T.L. Lo, T.H. Young, Y.C. Li, N.G. Chen, C.H. Chen, 2014, “Differentiation of Neural Stem/Progenitor Cells Using Low Intensity Ultrasound ”, ULTRASOUND IN MEDICINE AND BIOLOGY, 40(9), 2195-2206. (SCIE)
  • Chou RH, Wang YN, Hsieh YH, Li LY, Xia W, Chang WC, Chang LC, Cheng CC, Lai CC, Hsu JL, Chang WJ, Chiang SY, Lee HJ, Liao HW, Chuang PH, Chen HY, Wang HL, Kuo SC, Chen CH, Yu YL, Hung MC, 2014, “EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4.”, Developmental cell, 30(2), 224-37. (SCIE)
  • K. J. Gillig and C. H. Chen, 2014, “Increasing the performance of portable ion mobility analyzers- development of the Periodic Focusing Differential Mobility Analyzer (PFDMA)”, The Mass Spectrometry Society of Japan, vol.3, S0032.
  • Thirumurthi U, Shen J, Xia W, LaBaff AM, Wei Y, Li CW, Chang WC, Chen CH, Lin HK, Yu D, Hung MC, 2014, “MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.”, Science signaling, 7(336), ra71. (SCIE)
  • N. G Chen, J.L. Lin, C.Y. Wu, K.J. Gillig, A. Ozdemir, and .H. Chen, 2013, “Novel Atmospheric Biomolecule ionization technologies”, Journal of Analytical & Bioanalytical Techniques, S2: 003. doi:10.4172/2155-9872.S2-003.
  • Kent J. Gillig and C.H. Chen, 2013, “A critical examination of gas-phase protein conformation/multimer ion formations by Electrospray Ion Mobility-Mass Spectrometry”, ANALYTICAL CHEMISTRY, 85(4), 2177-2182. (SCIE)
  • Hsu YF, Lin JL, Chu ML, Chen CH, 2013, “Biomolecular dual-ion-trap mass analyzer.”, The Analyst, 138(17), 4823-4829. (SCIE)
  • I. Baginskiy, T.C., Lai, L. C. Cheng, Y. C. Chan, K. Y. Yang, R. S. Liu, M. Hsiao, C. H. Chen, S. F. Hu, L. J. Her, D. P. Tsai, 2013, “Chitosan-Modified Stable Colloidal Gold Nanostars for the Photothermolysis of Cancer Cells”, Journal of Physical Chemistry C, 117(5), 2396-2410. (SCIE)
  • J. Shen, W. Xia, Y.a B. Khotskaya, L. Huo, K. Nakanishi, S.O. Lim, Y. Du, Y. Wang, W.C. Chang, C.H. Chen, J.L. Hsu, Y. Wu, Y. C. Lam, B. P. James, X. Liu, C.G. Liu, D. J. Patel, and M.C. Hung, 2013, “EGFR Modulates miRNA Maturation in Response to Hypoxia through Phosphorylation of Ago2”, NATURE, 497, 383-387. (SCIE)
  • Huang TH, Huo L, Wang YN, Xia W, Wei Y, Chang SS, Chang WC, Fang YF, Chen CT, Lang JY, Tu C, Wang Y, Hsu MC, Kuo HP, Ko HW, Shen J, Lee HH, Lee PC, Wu Y, Chen CH, Hung MC, 2013, “Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers.”, Cancer cell, 23(6), 796-810. (SCIE)
  • T.Y. Lin , B.R. Li , S.T. Tsai , C.W. Chen , C.H. Chen , Y.T. Chen and C.Y. Pan, 2013, “Improved silicon nanowire field-effect transistors for fast protein–protein interaction screening”, LAB ON A CHIP, 13(4), 676-684. (SCIE)
  • Ozdemir A, Lin JL, Gillig KJ, Chen CH, 2013, “Kelvin spray ionization.”, The Analyst, 138(22), 6913-6923. (SCIE)
  • Ozdemir A, Lin JL, Gillig KJ, Chen CH, 2013, “Kelvin spray ionization.”, The Analyst, 138(22), 6913-23. (SCIE)
  • Hsu YF, Lin JL, Chu ML, Wang YS, Chen CH, 2013, “Macromolecular ion accelerator mass spectrometer.”, The Analyst, 138(24), 7384-7391. (SCIE)
  • Sudhir PR, Kumari MP, Hsu WT, Massiot J, Chen CH, Kuo HC, Chen CH, 2013, “Quantitative proteomics of protein complexes and their implications for cell reprograming and pluripotency.”, Journal of proteome research, 12(12), 5878-5890. (SCIE)
  • K. C. Chang, W. C. Chang, Y. Chang, L.Y. Hung, C. H. Lai, Y. M. Yeh, Y. W.i Chou, C. H. Chen , 2013, “Ran GTPase-Activating Protein 1 Is a Therapeutic Target in Diffuse Large B-Cell Lymphoma”, PLoS One, 8(11), e79863. (SCIE)
  • T. Y. Luh, L. Zhu, N. T. Lin, Z. Y. Xie, S. L. Lee, S. L. Huang, Y. D. Lee, C. H. Chen, C. H. Chen and J. H. Yang, 2013, “Ruthenium-catalyzed cascade metathetical cyclopolymerisation (CMCP) of bisnorbornenes with flexible linkers”, MACROMOLECULES, 46, 656-663. (SCIE)
  • S.H. Lai , K.H. Chang, J.L. Lin, C.L. Wu, C.H. Chen, 2013, “Sinapinic acid clusters distribution from monomer to mega Dalton’s region in MALDI process”, CHEMICAL PHYSICS LETTERS, 561-562, 142-146. (SCIE)
  • W.T. Hung, S.H.y Wang, C.H. Chen, C.H. Chen, J.M. Fang, W.B. Yang, 2013, “Tagging N-Linked Glycan with 2,3-Naphthalenediamine for Mass Spectrometric Analysis”, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 60, 955-960. (SCIE)
  • L. C. Cheng, H. M. Chen, T. C. Lai, Y. C. Chan, R. S. Liu, J. C. Sung, M. Hsiao, C. H. Chen, L. J. Her, and D. P. Tsai, 2013, “Targeting Polymeric Fluorescent Nanodiamond-Gold/Silver Multi-functional Nanoparticles as a Light-Transforming Hyperthermia Reagent for Cancer Cell”, Nanoscale, 5, 3931-3940. (SCIE)
  • Cheng LC, Chen HM, Lai TC, Chan YC, Liu RS, Sung JC, Hsiao M, Chen CH, Her LJ, Tsai DP, 2013, “Targeting polymeric fluorescent nanodiamond-gold/silver multi-functional nanoparticles as a light-transforming hyperthermia reagent for cancer cells.”, Nanoscale, 5(9), 3931-3940. (SCIE)
  • A. Özdemir, J.L. Lin, K. J. Gillig, C.H. Chen, 2013, “Triboelectric spray ionization”, JOURNAL OF MASS SPECTROMETRY, 48(2), 154-163. (SCIE)
  • S. T. Tsai, C. N. Shen, C.C. Tsou, W. Y. Mao , W. C. Chang , W. L. Hsu, and C. H. Chen, 2012, “Label-free quantitative proteomics of CD133-positive liver cancer stem cells”, Proteome Science, 10(1), 69. (SCIE)
  • PR Sudhir, CH Chen, KM Pavana, MJ Wang, CC Tsou, TY Sung, JY Chen, CH Chen , 2012, “Label-free quantitative proteomics and N-glycoproteomics analysis of KRAS-activated human bronchial epithelial cells”, Molecular and cellular proteomics, 11(10), 901-915. (SCIE)
  • H. C. Lin, J. L. Lin, H. H. Lin, S. W. Tsai, Alice L. Yu, R. Chen, C. H. Chen, 2012, “High Speed Mass Measurement of Nanoparticle and Virus”, ANALYTICAL CHEMISTRY, 84(11), 4965-4969. (SCIE)
  • M. Liu, D.F. Lee, C.T. Chen, C.J. Yen, L.Y. Li, H.J. Lee, C.J. Chang, W.C. Chang, J.M. Hsu, H.P. Kuo, W. Xia, Y. Wei, P.C. Chiu, C.K. Chou, Y. Du, D. Dhar, M. Karin, C.H. Chen, M.C. Hung, 2012, “IKKalpha activation of NOTCH links tumorigenesis via FOXA2 suppression”, MOLECULAR CELL, 45(2), 171-184. (SCIE)
  • Y. F. Hsu, J. L. Lin, M. L. Chu, Y. S. Wang, Y. T. Lee, C. H. Chen, 2012, “Macromolecular Ion Accelerator”, ANALYTICAL CHEMISTRY, 84(13), 5765-5769. (SCIE)
  • Y.L. Yu, R.H. Chou, C.H. Wu, Y.N. Wang, W.J. Chang, Y.J. Tseng. W.C. Chang, C.C. Lai, H.J. Lee, L. Huo, C.H. Chen, M.C. Hung, 2012, “Nuclear EGFR Suppresses Ribonuclease Activity of Polynucleotide Phosphorylase through DNAPK-mediated Phosphorylation at Serine 776”, The Journal of Biological Chemistry, 287(37), 31015-31026. (SCIE)
  • L.C. Cheng, J.H. Huang, H.M. Chen, T.C. Lai, K.Y. Yang, R.S. Liu, M. Hsiao, C.H. Chen, L.J. Here and D. P. Tsai, 2012, “Seedless, silver-induced synthesis of star-shaped gold/silver bimetallic nanoparticles as high efficiency photothermal therapy reagent”, JOURNAL OF MATERIALS CHEMISTRY, 22(5), 2244-2253.
  • Y. Wang, Q. Ding, C.J. Yen, W. Xia, J. G. Izzo, J.Y. Lang, C.W. Li, J. L. Hsu, S. A. Miller, X. Wang, D.F. Lee, J.M. Hsu,. L. Huo, A. M. LaBaff, D. Liu, T.H. Huang, C.C. Lai, F.J. Tsai, W.C Chang, C.H. Chen, T.T. Wu, N.S. Buttar, K.K. Wang, Y. Wu, H. Wang, J. Ajani and M.C. Hung, 2012, “The Crosstalk of mTOR/S6K1and Hedgehog Pathways”, CANCER CELL, 21(3), 374-387. (SCIE)
  • C.Y. Wang, T.H. Hsiao, L.H. Chu, Y.L. Lin, J.L. Huang, C.H. Chen and K. Peck, 2012, “Unraveling Virus Identity by Detection of Depleted Probes with Capillary Electrophoresis”, ANALYTICA CHIMICA ACTA, 734, 88-92. (SCIE)
  • J. P. Huang, P. H. Chen. W. L. Hwu, C. Y. Chuang, Y. H. Chien, L. Stone, C. L. Chien, L. T. Li, H. F. Chen, H. N. Ho, "C. H. Chen", and H. C. Kuo, 2011, “Human Pompe disease inducedpluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification”, HUMAN MOLECULAR GENETICS, 20(24), 4851-4864. (SCIE)
  • H. Parab, J.H. Huang, T.C. Lai, Y.H. Jan, R.S. Liu, J.L. Wang, M. Hsiao, C.H. Chen, Y.K. Hwu, D.P. Tsai, S.Y. Chuang and J.S. Pang, 2011, “Biocompatible transferrin-conjugated sodium hexametaphosphate-stabilized gold nanoparticles: synthesis, characterization, cytotoxicity and cellular uptake”, NANOTECHNOLOGY, 22(39), 395706. (SCIE)
  • I. C. Lu, J. L. Lin, S. H. Lai and "C. H. Chen", 2011, “Frequency-scanning MALDI Linear Ion Trap Mass Spectrometer for Large Biomolecular Ion Detection”, ANALYTICAL CHEMISTRY, 83(21), 8273-8277. (SCIE)
  • Y. L. Chang, Y. C. Lee, W. B. Yang and C. H. Chen, 2011, “Ionic Liquid Assisted Electrospray Ionization of Polysaccharides”, JOURNAL OF MASS SPECTROMETRY, 46(4), 367-375. (SCIE)
  • J.H. Huang, T.C. Lai, L.C. Cheng, R.S. Liu, C.H. Lee, M. Hsiao, C.H. Chen, L.J. Herd and D.P. Tsai, 2011, “Modulating cell-uptake behavior of Au-based nanomaterials via quantitative biomolecule modification”, Journal of Material Chemistry, 21(38), 14821-14829.
  • W.C. Huang, Y.J. Chen, L.Y. Li, Y.L. Wei, S.C. Hsu, S.L. Tsai, P.C. Chiu, W.P. Huang, Y.N. Wang, C.H. Chen, W.C. Chang, W.C. Chang, A.J.E. Chen, C.H. Tsai and M.C. Hung, 2011, “Nuclear Translocation of Epidermal Growth Factor Receptor by Akt-dependent Phosphorylation Enhances Breast Cancer-resistant Protein Expression in Gefitinib-resistant Cells”, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(23), 20558-20568. (SCIE)
  • Liu YC, Yen HY, Chen CY, Chen CH, Cheng PF, Juan YH, Chen CH, Khoo KH, Yu CJ, Yang PC, Hsu TL, Wong CH, 2011, “Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells.”, Proceedings of the National Academy of Sciences of the United States of America, 108(28), 11332-11337. (SCIE)
  • H. H. Lin, Y. C. Li, C. H. Chang, C. Liu, Alice L Yu, C. H. Chen, 2011, “Single Nuclei Raman spectroscopy for Drug Evaluation”, ANALYTICAL CHEMISTRY, 84(1), 113-120. (SCIE)
  • Y. L Chang, S. K. S. Liao, Y. C. Chen, W. T. Hung, H. M. Yu, W. B. Yang, J. M. Fang, "C. H. Chen", and Y. C. Lee, 2011, “Tagging saccharides for Signal Enhancement in Mass Spectrometric Analysis”, JOURNAL OF MASS SPECTROMETRY, 46(3), 247-255. (SCIE)
  • O. P. Charkin, N. M. Klimenko, I.S. Wang, C.C Wang, "C.H. Chen", S. H. Lin, and Y.T. Lee, 2011, “Theoretical and Experimental Study of Fullerenol Molecules and Ions C60(OH)24 – n(OL)n and C60(OH)24 – n(OL)nL+ Successively Substituted by Alkali Metal Atoms L (n = 1–24)”, Russian Journal of Inorganic Chemistry, 56(4), 580-590. (SCIE)
  • O. P. Charkina, N. M. Klimenko, B. G. Chen, S. H. Lin, and C. H. Chen, 2011, “Theoretical and Experimental Study of the Structure and Stability”, RUSSIAN JOURNAL OF INORGANIC CHEMISTRY, 56(1), 61-70. (SCIE)
  • Abdil Ozdemir, C.H. Chen, 2010, “Electrode-Assisted Desorption Electrospray Ionization Mass Spectrometry”, JOURNAL OF MASS SPECTROMETRY, 45(10), 1203-1211. (SCIE)
  • C. Y. Wu, Y.S. Wang, N.G. Chen, C.Y. Wu and C. H. Chen*, 2010, “Ultrasound Ionization of Biomolecules”, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 24(17), 2569-2574.. (SCIE) (IF: 2.2; SCI ranking: 50%,59.7%,35.7%)
  • W. C. Chang, M. S. Huang, C. J. Yang, T. C. Lai, M. Hsiao and C. H. Chen*, 2010, “Dermicidin Identification from Exhaled Air for Lung Cancer Diagnosis”, European respiratory journal, 35(5), 1182-1185.. (SCIE)
  • Huan-Chang Lin, Hsin-Hung Lin, Cai-Yu Kao, Alice L. Yu, Wen-Ping Peng, Chung-Hsuan Chen, 2010, “Quantitative Measurement of Nano/Micro Particle Endocytosis with Cell Mass Spectrometry”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 49(20), 3460-3464.. (SCIE)
  • B Ankamwar, T C Lai, J H Huang, R S Liu, M Hsiao, CH Chen* and Y K Hwu, 2010, “Biocompatibility of Fe3O4 nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells”, Nanotechnology, 21(7), 75102. (SCIE)
  • Wei-Chao Chang, Chuan-Kai Chou, Chih-Chiang Tsou, Sheng-Hsiang Li, Chein-Hung Chen, Yu-Xing Zhuo, Wen-Lian Hsu, and Chung-Hsuan Chen*, 2010, “Comparative Proteomic Analysis of Proteins Involved in the Tumorigenic Process of Seminal Vesicle Carcinoma in Transgenic Mice”, International journal of proteomics, 1-14.
  • P. I. Hsu, C. H. Chen*, M. Hsiao, D. C. Wu, C. Y. Lin, K. H. Lai, P. J. L, 2010, “Diagnosis of gastric malignancy using gastric juice alpha1-antitrypsin”, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 19(2), 405-11. (SCIE)
  • Chunchi Lin, Wei-Ting Hung, Chung-Hsuan Chen, Jim-Min Fang and Wen-Bin Yang, 2010, “A new naphthimidazole derivative for saccharide labeling with enhanced sensitivity in mass spectrometry detection”, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 24(1), 85-94.. (SCIE) (IF: 2.2; SCI ranking: 50%,59.7%,35.7%)
  • H. Y. Liao, C. H. Hsu, S. C. Wang, C. H. Liang, H. Y. Yen. C. Y. Su, C. H. Chen, J. T. Jan, C. T. Ren, C. H. Chen, T. J. Cheng, C. Y. Wu, and C. H. Wong, 2010, “Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(42), 14849-14856. (SCIE)
  • Lu PJ, Hsu PI, Chen CH, Hsiao M, Chang WC, Tseng HH, Lin KH, Chuah SK, Chen HC, 2010, “Gastric juice acidity in upper gastrointestinal diseases.”, World journal of gastroenterology : WJG, 16(43), 5496-5501. (SCIE)
  • C. H. Chen, J. L. Lin, M. L. Chu, Y. S. Wang, and C. H. Chen, 2010, “MALDI Ion Trap Mass Spectrometer for Quantitative Large Biomolecular Ion Detection”, ANALYTICAL CHEMISTRY, 82(24), 10125-10128. (SCIE)
  • Huo L, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL, Huang TH, Ding Q, Chen CH, Tsai CH, Hung MC, 2010, “RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus.”, Proceedings of the National Academy of Sciences of the United States of America, 107(37), 16125-16130. (SCIE)
  • J. S. Yang, J. L. Yan, C. K. Lin, C. Y. Chen, Z. Y. Xie and "C. H. Chen", 2009, “Pentiptycene-Derived Oligo(p-phenyleneethynylene)s: Conformational Control, Chain-Length Effects, Localization of Excitation, and Intrachain Resonance Energy Transfer”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48, 9936-9939. (SCIE)
  • H. Parab, H. M. Chen, T. Lai, J. Huang, P. H. Chen, R. S. Liu, M. Hsiao, "C. H. Chen", D. Tsai, Y. Hwu, 2009, “Biosensing, Cytotoxicity and Cellular Uptake Studies of Surface Modified Gold Nanorods”, JOURNAL OF PHYSICAL CHEMISTRY C, 113, 7574-7578. (SCIE)
  • C. R. Hsiao and C. H. Chen, 2009, “Characterization of DNA Chips by nanogold staining”, Analytical Biochemistry, 389, 118-123. (SCIE)
  • Liang CH, Wang CC, Lin YC, Chen CH, Wong CH, Wu CY, 2009, “Iron oxide/gold core/shell nanoparticles for ultrasensitive detection of carbohydrate-protein interactions.”, Analytical chemistry, 81(18), 7750-6. (SCIE)
  • Hwang-Verslues WW, Kuo WH, Chang PH, Pan CC, Wang HH, Tsai ST, Jeng YM, Shew JY, Kung JT, Chen CH, Lee EY, Chang KJ, Lee WH, 2009, “Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers.”, PloS one, 4(12), e8377. (SCIE)
  • D. Y. Wang, T. S. Teng, Y. C. Wu, Y. C. Lee, K. H. Chen, "C. H. Chen", Y. C. Chang, and C. C. Chen, 2009, “Silver-Nanoparticle-Conjugated Polypeptide Brushes for Surface-Enhanced Raman Scattering”, J. Phys. Chem. C, 113, 13498-13504. (SCIE)
  • Z. Nie, F. Cui, M. Chu, "C. H. Chen" and H. C. Chang, 2008, “Calibration of a Frequency-Scan Quadrupole Ion Trap Mass Spectrometer for Microparticle Mass Analysis”, INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 270, 8-15. (SCIE)
  • W. P. Peng, H. C. Lin, M. L. Chu, H. C. Chang, H. H. Lin, Alice L. Yu and C. H. Chen, 2008, “Charge Monitoring Cell Mass Spectrometry”, ANALYTICAL CHEMISTRY, 80, 2524-2530. (SCIE)
  • S. T. Tsai, C. H. Chen, Y. T. Lee, Y. S. Wang, 2008, “Desorption dynamics of neutral molecules in matrix-assisted laser desorption/ionization.”, MOLECULAR PHYSICS, 106, 239-247. (SCIE)
  • N. Y. Hsu, S. Y. Tseng, C. Y. Wu, C. H. Wong, and C. H. Chen*, 2008, “Desorption Ionization of Biomolecules on Metals”, ANALYTICAL CHEMISTRY, 80(13), 5203-5210. (SCIE)
  • Tseng SY, Wang CC, Lin CW, Chen CL, Yu WY, Chen CH, Wu CY, Wong CH, 2008, “Glycan arrays on aluminum-coated glass slides.”, Chemistry, an Asian journal, 3(8-9), 1395-1405.
  • Jhan JW, Chang WT, Chen HC, Wu MF, Lee YT, Chen CH, Liau I, 2008, “Integrated multiple multi-photon imaging and Raman spectroscopy for characterizing structure-constituent correlation of tissues.”, Optics express, 16(21), 16431-16441. (SCIE)
  • J. H. Huang, H.J. Parab, R.S. Liu, T.C. Lai, M. Hsiao, C.H. Chen, H.S. Sheu, J.M. Chen, D.P. Tsai and Y.K. Hwu, 2008, “Investigation of the growth mechanism of iron oxide Nanoparticles via a seed-mediated method and its cytotoxicity studies”, JOURNAL OF PHYSICAL CHEMISTRY, 112(40), 15684-15690.
  • L. Jessome, N. Y. Hsu, Y. S. Wang and C. H. Chen, 2008, “Matrix-assisted laser desorption/ionization mechanism study with dihydroxybenzoic acid isomers as matrices”, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 22, 130. (SCIE) (IF: 2.2; SCI ranking: 50%,59.7%,35.7%)
  • W. C. Chang, P. I. Hsu, Y. Y. Chen, M. Hsiao, P. J. Lu and C. H. Chen, 2008, “Observation of peptide differences between cancer and control in gastric juice”, Proteomics Clinical applications, 2(1), 55-62. (SCIE)
  • J. Susanto, Y. H. Lin, Y. N. Chen, C. R. Shen, Y. T. Yan, S. T. Tsai, "C. H. Chen", and C. N. Shen, 2008, “Porphyrin Homeostasis Maintained by ABCG2 Regulates Self-Renewal of Embryonic Stem Cells”, Plos One, 3, e4023. (SCIE)
  • Chen CH, 2008, “Review of a current role of mass spectrometry for proteome research.”, Analytica chimica acta, 624(1), 16-36. (SCIE)
  • Hung, W.T., Wang, S.H., "Chen C.H.", Yang Y.B., 2008, “Structure Determination of beta-Glucans from Ganoderma lucidum with Matrix-assisted laser desorption/ionization (MALDI) Mass Spectrometry”, Molecules, 13(8), 1538-1550. (SCIE)
  • C.H. Chen, 2007, “Novel physical biotechnology development for biomedical applications”, paper presented at International Symposium on Bio-inspired Engineering, Dead Sea, Israel, 2007-10-08 ~ 2007-10-10.
  • M. H. Li and C. H. Chen, 2007, “Bipolar ion detector with enhanced sensitivity by sequential conversion reactions”, paper presented at 55th ASMS Conference on Mass Spectrometry, Indianapolis, IN, 2007-06-03 ~ 2007-06-07.
  • C.H. Chen, 2007, “Novel physical biotechnology development for biomedical applications”, paper presented at 1st International Symposium on Nanomedicine, Okazaki, Japan, 2007-04-19 ~ 2007-04-22.
  • P. I. Hsu, C. H. Chen, C. S. Hsieh, W. C. Chang, K. H. Lai, G. H. Lo, , P. N. Hsu, F. W. Tsay, Y. S. Chen, M. Hsiao, H. C. Chen and P. J. Lu, 2007, “Alpha 1-antitrypsin precursor in gastric juice is a novel biomarker for gastric cancer and ulcer”, Clinical Cancer Research, 13(3), 876-883. (SCIE)
  • Li, M. H.; Tsai, S. T.; Chen, C. H.; Chen, C. W.; Lee, Y. T.; Wang, Y. S., 2007, “Bipolar ion detector based on sequential conversion reactions.”, Analytical Chemistry, 79, 1277-1282. (SCIE)
  • W. P. Peng, H. C. Lin, H. H. Lin, M. Chu, A. L. Yu, H. C. Chang and C. H. Chen, 2007, “Charge-monitoring laser-induced acoustic desorption mass spectrometry for cell and microparticle mass distribution measurement”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(21), 3865-3869. (SCIE)
  • N. T. Lin, S. Y. Lin, S. L. Lee, C. H. Chen, C. H. Hsu, L. P. Hwang, Z. Y. Xie, C. H. Chen, S. L. Huang and T. Y. Luh, 2007, “From Polynorbornene to the Complementary Polynorbornene by Replication”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46, 4481-4485. (SCIE)
  • Z. Nie, F. Cui, Y. K. Tzeng, H. C. Chang, M. Chu, H. C. Lin, C. H. Chen, H. H. Lin and A. L. Yu, 2007, “High-Speed Mass Analysis of Whole Erythrocytes by Charge-Detection Quadrupole Ion Trap Mass Spectrometry”, Analytical Chemistry, 79(19), 7401-7407. (SCIE)
  • W. C. Chang, L. C. L. Huang, Y. S. Wang, W. P. Peng, H. C. Chang, N. Y. Hsu, W. B. Yang and C. H. Chen, 2007, “Matrix-assisted laser desorption/ionization (MALDI) mechanism revisited”, Anal Chim Acta, 582, 1-9. (SCIE)
  • N. Y. Hsu, W. B. Yang, C. H. Wong, Y. C. Lee, R. T. Lee, Y. S. Wang and C. H. Chen, 2007, “Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix”, Rapid Communications in Mass Spectrometry, 21(13), 2137-2146. (SCIE) (IF: 2.2; SCI ranking: 50%,59.7%,35.7%)
  • Peng WP, Yang YC, Kang MW, Tzeng YK, Nie Z, Chang HC, Chang W, Chen CH, 2006, “Laser-induced acoustic desorption mass spectrometry of single bioparticles.”, Angewandte Chemie-International Edition, 45(9), 1423-1426. (SCIE)
  • S. T. Tsai, C. W. Chen, L. C. Huang, M. C. Huang, C. H. Chen and Y. S. Wang, 2006, “Simultaneous mass analysis of positive and negative ions using a dual-polarity time-of-flight mass spectrometer”, Analytical Chemistry, 78, 7729-7734. (SCIE)
  • Chou, C. H., Wu, C. S., Chen, C. H., Lu, L. D., Kulkarni, S. S., Wong, C. H. and Hung, S. C., 2004, “Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues.”, Org Lett, 6(4), 585-588. (SCIE)