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Shen, Chia-Ning 沈家寧

ShenCN 6x7研究員


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02-2787-1220
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EDUCATION AND POSITIONS HELD:

  • Ph.D., Developmental Biology Program, University of Bath, 2002
  • Postdoctoral Fellow, Centre For Regenerative Medicine, University of Bath, 2002-2004
  • Assistant Professor, Genomics Research Center, Academia Sinica, 2004-2012
  • Associate Professor, Genomics Research Center, Academia Sinica, 2012-2022
  • Deputy Director and Associate Research Fellow, Genomics Research Center, Academia Sinica, 2013-2019
  • Acting Division Director of Biotechnology Incubation Center, Genomics Research Center, Academia Sinica, 2018-2021
  • Acting Chief Executive Officer, Innovation & Incubation Center, Biomedical Translation Research Center, Academia Sinica, Taiwan, 2019-present
  • Professor, Genomics Research Center, Academia Sinica, 2022-present

HONORS:

  • ORS Award, Committee of Vice-chancellors and Principals of Universities of United Kingdom, 1999-2002
  • Conference Scholarship of International Federation of Cell Biology, 2000
  • Entrant of Santa Cruz Investigator Award, 2001
  • Conference Scholarship of British Society of Developmental Biology, 2000, 2001
  • Conference Scholarship of International Society of Differentiation, 2002
  • Travel award of Japan Society for the promotion of science for attending NPG Nature Asia-Pacific network meeting, 2007
  • Academia Sinica Significant Research Achievements, 2010
  • Travel award of International Society of Stem Cell Research, 2012
  • Rotary International Presidential Charity Award 2014-2015
  • Keystone Symposia Best Poster Prize (Regenerative Biology and Applications), 2017

RESEARCH INTERESTS:

Dr. Chia-Ning Shen is currently a research fellow in the Genomics Research Center, Academia Sinica, Taiwan. Dr. Shen earned his PhD from Developmental Biology Program, Department of Biology and Biochemistry, University of Bath, United Kingdom in 2002. From 2002 to 2004, Dr. Shen worked as a research officer in the Centre for Regenerative Medicine in University of Bath. Dr. Shen came back to Taiwan and joined the Genomics Research Center of Academia Sinica in the summer of 2004. Dr. Shen's research interest primarily focuses on two fields, cancer stem cells and regenerative medicine. He currently focuses on investigating mechanisms involved in naturally occurring somatic cell reprogramming. Based dissecting the basis of cell differentiation and transdifferentiation, Dr. Shen aims to develop methodologies to trigger tissue regeneration and to identify the initial factors for neoplastic transformation in somatic cells. As of today, Dr. Shen has published over 90 articles in world-renowned journals which have been cited for more than 3300 times.

Dr. Shen had spared time to attend several training courses. For example, in 2008, he has completed the course program in legal studies in National Taiwan University. In 2012, he also attended the international training program of Multidisciplinary Management of Technology in National Cheng-Chi University. Aside from conducting research, Dr. Shen has also been responsible for coordinating academic activities and overseeing administrative work at the Genomics Research Center as the Deputy Director from 2013 to 2019. He has also served as Acting Division Director of Biotechnology Incubation Center in the Genomics Research Center for incubating biotechnology companies that licensed technologies from Academia Sinica. Dr. Shen was involved in the establishment of Taiwan Society for stem cell research (TSSCR) in 2005 aiming at providing opportunities for close interactions among stem cell researchers in Taiwan. Dr. Shen has been served as TSSCR president from 2017 to 2021. TSSCR cooperates with the government to implement relevant cell therapy legislation and policies, and jointly establish a cell therapy physician training course with Taiwan Association for Cell Therapy (TACT) and Formosa Association for Regenerative Medicine (FARM).Currently, Dr. Shen is a chief PI managing the core facilities for translational medicine at National Biotechnology Research Park. Dr. Shen joined Biomedical Translation Research Center in September 2019 as Acting CEO of BioHub Taiwan (Innovation & Incubation Center, Biomedical Translation Research Center) to aid to incubate biotech startups at National Biotechnology Research Park.

沈家寧博士致力於幹細胞及再生醫學兩大研究領域,透過研究體細胞重新編程的機轉,探討細胞分化及轉化的關鍵機制,以發展組織再生的方法及發現細胞轉化瘤變的早期起始因素,研究至今共計發表90篇期刊論文並被引用近3300次。沈博士主要研究體細胞重新編程,除可找尋細胞分化的關鍵,並進而可解構組織修復的機制外,亦可應用於解析疾病產生過程及細胞轉化原因。

主要的研究方向包括:
(1)利用體細胞重新編程技術,發展糖尿病細胞治療策略;
(2)應用病患誘導性多能幹細胞解構代謝疾病機轉,開發調控血糖之新穎藥物;
(3) 結合三維組織影像技術及解析胰臟腫瘤幹細胞的代謝體重編程特性,進行胰腺組織瘤變轉化機制探索;
(4) 結合基因及細胞治療技術,開發胰臟癌治療策略。

除了研究工作,沈博士利用公餘時間進入台灣大學法律學分班及政治大學科管與智財研究所之「跨領域產業創新科技管理與智財運用人才培訓班」進修,並且參與多項學術服務並擔任行政主管。沈博士曾擔任基因體研究中心副主任並代理生技育成專題中心執行長,負責統整協調中心內學術行政及育成等事務;此外,沈博士曾參與臺灣幹細胞學會創建並擔任首任秘書長,建構以促進幹細胞研究之發展並強化幹細胞研究交流平台;並曾在2017年至2021擔任臺灣幹細胞學會理事長,目前為常務監事並同時在台灣細胞醫療協會擔任常務理事及再生醫學學會但任理事,參與推行相關細胞治療之立法及政策,並規劃開設細胞治療醫師訓練課程。沈博士從2019年1月起主持生醫轉譯核心共儀設施,建構核心共儀多項關鍵技術平台,以服務進駐國家生技研究園區研究團隊、育成產業及國內外學研及生技研發單位醫藥產業。從2019年9月起代理中研院生醫轉譯研究中心創服育成中心的執行長,協助國家生技研究園區創服育成業務執行,培育台灣生技新創產業。

POPULAR SCIENCE ARTICLE AND BOOK

1. 沈家寧等著 2013 您不可不知道的幹細胞科技 五南圖書公司

2. 吳瑞仁、沈家寧 2012 體細胞重新編程技術開發與應用 中央研究院週報(知識天地) 1390: 8-10.

3. 沈家寧、陳志龍 2010. 體細胞重新編程技術與應用前景 中榮醫訊 142: 9-11

4. 沈家寧、謝綺哲、廖紋瑩 2009. 腫瘤幹細胞與癌症治療 科學月刊 40(7): 535-539.

5. 沈家寧 2007. 人造幹細胞 科學發展 414: 34-39.

SELECTED PUBLICATIONS:

  • C.W. Lee, C.C. Kuo, C.J. Liang , H.J. Pan, C.N. Shen*, C.H. Lee*, 2022, “Effects of the media conditioned by various macrophage subtypes derived from THP-1 cells on tunneling nanotube formation in pancreatic cancer cells”, BMC Molecular and Cell Biology, 23(1), 26. (SCIE)
  • Khamushavalli, G., Guo, J.Y., C.N. Shen, J.K. Jiang, C.S.J. Fann, M.J. Hwang, J.W. Shui, H.T. Lin, M.J. Wang, H.C. Shih, A. F.Y. Li, S.C. Chang, S.H. Yang*, and J.Y. Chen*., 2022, “Patient-derived organoids serves as a platform for personalized chemotherapy in advanced colorectal cancer patients.”, Frontiers in Oncology, 12, 883437. (SCIE)
  • W.A. Chen, Y.H. Chen, C.Y. Hsieh, P.F. Hung, C.W. Chen, C.H. Chen, J.L. Lin, T.J. R. Cheng, T.L. Hsu, Y.T. Wu, C.N. Shen* and W.C. Cheng*., 2022, “Harnessing Natural-Product-Inspired Combinatorial Chemistry and Computation-Guided Synthesis to Develop N-Glycan Modulators as Anticancer Agents.”, Chemical Science, 13, 6233-6243. (SCIE)
  • Hsu, F. C., H.L. Lee, Y.J. Chen, Y.A. Shen, M.H. Wu, W.S. Huang, Y.C. Tsai, S.D. Yeh, C.C. Kuo, L.S. Lu, C.N. Shen* and J.F. Chiou*, 2022, “A Few-Shot Learning Approach Assists in the Prognosis Prediction of Magnetic Resonance-Guided Focused Ultrasound for the Local Control of Bone Metastatic Lesions”, Cancers, 12, 445. (SCIE)
  • Lo, S.M., S.H.Hwang, C.L. Liu, C.N. Shen, W.H. Hong, W.C. Yang, M.H. Lee, C.R.Shen, 2022, “Inhibiting TLR7 Expression in the Retinal Pigment Epithelium Suppresses Experimental Autoimmune Uveitis”, Frontiers in Immunology, 12, 736251. (SCIE)
  • C.W. Lin, Y.J. Wang, T.Y. Lai, T.L. Hsu, S.Y. Han, H.C. Wu, C.N. Shen, V. Dang, M.W. Chen, L.B. Chen, C.H. Wong*, 2021, “Homogeneous antibody and CAR-T cell with improved effector functions targeting SSEA-4 glycan on pancreatic cancer”, Proceedings of The National Academy of Sciences of the United States of America, 118(50), e2114774118. (SCIE)
  • Hsu, L.J., C.L. Liu, M.L.Kuo, C.N. Shen, C.R.Shen*, 2021, “An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells”, Biomedicines, 9, 1323. (SCIE)
  • Hsu HJ, Tung CP, Yu CM, Chen CY, Chen HS, Huang YC, Tsai PH, Lin SI, Peng HP, Chiu YK, Tsou YL, Kuo WY, Jian JW, Hung FH, Hsieh CY, Hsiao M, Chuang SS, Shen CN, Wang YA, Yang AS, 2021, “Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody-drug conjugates from synthetic antibody libraries.”, Scientific reports, 11(1), 15430. (SCIE)
  • Wu, H.H., L.H. Tsai, C.K. Huang, S.C. Huang, P.H. Hsu, M.Y. Chen, Y.I. Chen, C.M. Hu, C.N.Shen, C.C. Lee, M.C. Chang, Y.T. Chang, Y.W. Tien, Y.M. Jeng, E. Lee, and W.H. Lee*, 2021, “Characterization of initial key steps of IL-17 receptor B oncogenic signaling for targeted therapy of pancreatic cancer”, Science Translational Medicine, 13, eabc2823. (SCIE)
  • Chu, E.P.F., C.H.H. Cho, W.J. Lee, I.T.Lee, I.F. Cheng, T.C. Kuo, R.Y. Chen, W.H.H. Sheu, C.N. Shen*, 2020, “Generation of three induced pluripotent stem cell lines from type 2 diabetic patients with ocular complications.”, Stem Cell Research, 49, 102109. (SCIE)
  • Lee, H.L., J.F. Chiou, P.Y. Wang, L.S. Lu, C.N. Shen, H.L. Hsu, T. Burnouf, L.L.Ting, P.C. Chou, C.L. Chung, K.L.Lee, H.S. Shiah, Y.L. Liu, Y.J.Chen*, 2020, “Ex vivo expansion and drug sensitivity profiling of circulating tumor cells from patients with small cell lung cancer”, Cancers, 12(11), 3394. (SCIE)
  • E.P.F. Chu, C.H. Lin, C.H.H. Cho, I.F. Cheng, T.C. Kuo R.Y. Chen, C.N. Liao, J.C. Cheng, J.I.S. Tsai, P.C. Wang, S.J. Chang, C.N. Shen*, 2020, “Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity”, Stem Cell Research, 49, 102029. (SCIE)
  • Huang, C.Y. L.H. Li ,W.T. Hsu, Y.C. Cheng, M.W. Nicholson, C.L. Liu, C.Y. Ting, H.W. Ko, S.H. Hsu, C.H. Wen, Z. Yan, H.P. Huang, H.L. Su, P.M. Chiang, C.N. Shen, H.F. Chen, B. L.J. Yen, H.E. Lu, S.M. Hwang, S.H. Chiou, H.N. Ho, J.Y. Wu, T. J. Kamp, J.C. Wu and P. C. H. Hsieh*, 2020, “Copy Number Variant Hotspots in Han Taiwanese Population Induced Pluripotent Stem Cell Lines - Lessons from Establishing the Taiwan Human Disease iPSC Consortium Bank”, Journal of Biomedical Science, 27(1), 92. (SCIE)
  • J.N.Sudhaker, H.H Lu, H.Y. Chang, C.S. Suen, M.J.Hwang, S.Y. Wu, C.N.Shen, Y.M. Chang, F.A. Li, F.T. Liu, and J.W. Shue*, 2020, “Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas”, Nature Communications, 11(1), 4286. (SCIE)
  • Lee, H.L., J.T.Tsai, C.Y. Chen, Y.C. Lin, C.B. Ho, L.L.Ting, C.C. Kuo, I.C. Lai, C.Y. Lin, J.H.Tang, Y.M. Huang, W.Y. Kao, S.W. Cheng, C.N. Shen*, S.W.Chen*, J.F. Chiou*, 2019, “Effectiveness of stereotactic ablative radiotherapy in patients with advanced hepatocellular carcinoma unsuitable for transarterial chemoembolization”, Therapeutic Advances in Medical Oncology, 11, 1758835919889002. (SCIE)
  • Shen CN, Goh KS, Huang CR, Chiang TC, Lee CY, Jeng YM, Peng SJ, Chien HJ, Chung MH, Chou YH, Hsieh CC, Kulkarni S, Pasricha PJ, Tien YW, Tang SC, 2019, “Lymphatic vessel remodeling and invasion in pancreatic cancer progression.”, EBioMedicine, 47, 98-113. (SCIE)
  • Chuang, T.J., Chen, Y.J., Chen, C.Y., Mai, T.L., Wang, Y.D., Yeh, C.S., Yang, M.Y., Hsiao, Y.T., Chang, T.H., Kuo, H.C., Cho, H.H., Shen, C.N., Kuo, H.C., Lu, M.Y., Chen, Y.H., Hsieh, S.C, Chiang, T.W.,, 2018, “Integrative transcriptome sequencing reveals extensive alternative trans-splicing and cis-backsplicing in human cells”, Nucleic Acids Research, 46(7), 3671-3691. (SCIE)
  • T.L. Chen, Y.W. Lin, Y.B. Chen, J.J. Lin, T.L. Su, C.N. Shen*, T.C. Lee*, 2018, “A low-toxicity DNA-alkylating N-mustard-quinoline conjugate with preferential sequence specificity exerts potent antitumor activity against colorectal cancer”, Neoplasia, 20(2), 119-130. (SCIE)
  • S.C.Tang, L. Baeyens, C.N. Shen, S.J. Peng, H.J. Chien, D.W. Scheel, C.E. Chamberlain, M.S.German., 2018, “Human pancreatic neuro-insular network in health and fatty infiltration.”, Diabetologia, 61(1), 168-181. (SCIE)
  • S.C.Tang, C.N. Shen*, P.Y. Lin, S.J. Peng, H.J. Chien, Y.H. Chou, C.E. Chamberlain, P.J. Pasricha., 2018, “Pancreatic neuro-insular network in young mice revealed by 3D panoramic histology.”, Diabetologia, 61(10), 158-167. (SCIE)
  • W.C. Yang, Y.S. Hwang, Y.Y. Chen, C.L. Liu, C.N. Shen, W.H. Hong, S.M. Lo, C.R. Shen, 2017, “Interleukin-4 supports the suppressive immune responses elicited by regulatory T cells”, Frontiers in Immunology, 8, 1508. (SCIE)
  • C.L. Hsieh, C.M. Liu, H.A. Chen, S.T. Yang, K. Shigemura, K. Kitagawa, F. Yamamichi, M. Fujisawa, Y.R. Liu, W.H. Lee, K.C. Chen, C.N. Shen, C.C. Lin, L. Chung and S.Y. Sung., 2017, “Reactive oxygen species-mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression.”, Scientific reports, 7(1), 9065. (SCIE)
  • Y.T. Lin, C.K. Wang, S.C. Yang, S.C. Hsu, H. Lin, F.P. Chang, T. C. Kuo, C.N. Shen, M. Hsiao, P.M. Chiang, F. L. Lu, and J. Lu, 2017, “Elimination of undifferentiated human embryonic stem cells by cardiac glycosides”, Scientific Reports, 7(1), 5289. (SCIE)
  • Hsieh, C.C., I.M. Shyu, W.Y. Liao, T.H. Chen, S.E. Wang, P.C. Lu, P.Y. Lin, Y.B. Chen, W.Y. Mao, H.Y. Han, M. Hsiao, W.B. Yang, W.S. Li, Y.P. Sher, C.N. Shen*, 2017, “Elevation of beta-galactoside alpha 2,6-sialyltransferase 1 modulated in a fructose-responsive manner promotes pancreatic cancer metastasis”, Oncotarget, 8(5), 7691-7709.
  • F.P. Chang, C.H. Cho, C.R. Shen, C.Y. Chien, L.W.Ting, H.S. Lee, C.N. Shen*, 2016, “PDGF Facilitates Direct Lineage Reprogramming of Hepatocytes to Functional ß-Like Cells Induced by Pdx1 and Ngn3”, Cell transplantation, 25(10), 1893-1909. (SCIE)
  • Chien, C.Y., T.A. Yuan, Candy.H.H. Cho, F.P. Chang, W.Y. Mao, R.R. Wu, H.S. Lee*, C.N. Shen*, 2016, “All-trans retinoic acid ameliorates glycemic control in diabetic mice via modulating pancreatic islet production of vascular endothelial growth factor-A”, Biochemical and Biophysical Research Communications, 477(4), 874-880.. (SCIE)
  • Liu CM, Hsieh CL, Shen CN, Lin CC, Shigemura K, Sung SY, 2016, “Exosomes from the tumor microenvironment as reciprocal regulators that enhance prostate cancer progression.”, International journal of urology, 23(9), 734-744. (SCIE)
  • Lin PY, Peng SJ, Shen CN*, Pasricha PJ, Tang SC, 2016, “PanIN-associated pericyte, glial, and islet remodeling in mice revealed by 3-D pancreatic duct lesion histology.”, American Journal of Physiology-Gastrointestinal and Liver Physiology, 311(3), G412-G422. (SCIE)
  • Chien, C.Y., H.S. Lee*, Candy.H.H. Cho, K.I. Lin, D. Tosh, R.R. Wu, W.Y. Mao, C.N. Shen*, 2016, “Maternal Vitamin A deficiency during pregnancy affects vascularized islet development”, Journal of Nutritional Biochemistry, 36, 51-59. (SCIE)
  • Lien HW, Yuan RY, Chou CM, Chen YC, Hung CC, Hu CH, Hwang SP, Hwang PP, Shen CN, Chen CL, Cheng CH, Huang CJ, 2016, “Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2alpha.”, Scientific reports, 6, 28297. (SCIE)
  • Chang HM, Huang WY, Lin SJ, Huang WC, Shen CR, Mao WY, Shen CN*, 2016, “ABCG2 deficiency in skin impairs re-epithelialization in cutaneous wound healing.”, Experimental dermatology, 25(5), 355-361. (SCIE)
  • Cheung SK, Chuang PK, Huang HW, Hwang-Verslues WW, Cho CH, Yang WB, Shen CN, Hsiao M, Hsu TL, Chang CF, Wong CH, 2016, “Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells.”, Proceedings of the National Academy of Sciences of the United States of America, 113(4), 960-965. (SCIE)
  • Chen CY, Lee DS, Yan YT, Shen CN, Hwang SM, Tone Lee S, Hsieh PC, 2015, “Bcl3 Bridges LIF-STAT3 to Oct4 Signaling in the Maintenance of Naive Pluripotency.”, Stem cells, 33(12), 3468-3480. (SCIE)
  • Chang JS, Su CY, Yu WH, Lee WJ, Liu YP, Lai TC, Jan YH, Yang YF, Shen CN, Shew JY, Lu J, Yang CJ, Huang MS, Lu PJ, Lin YF, Kuo ML, Hua KT, Hsiao M, 2015, “GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis.”, Oncotarget, 6(34), 36278-36291.
  • Liaw CC, Yang YL, Lin CK, Lee JC, Liao WY, Shen CN, Sheu JH, Wu SH., 2015, “New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression”, Organic Letters, 17(10), 2330-2333. (SCIE)
  • Lee IC, Liu YC, Tsai HA, Shen CN, Chang YC, 2014, “Promoting the selection and maintenance of fetal liver stem/ progenitor cell colonies by layer-by-layer polypeptide tethered supported lipid bilayer.”, ACS applied materials & interfaces, 6(23), 20654-20663. (SCIE)
  • CL Chen, LJ Wang, YT Yan, HW Hsu, HL Su, FP Chang, PCH Hsieh, SM Hwang, CN Shen*, 2014, “Cyclin D1 Acts as a Barrier to Pluripotent Reprogramming by Promoting Neural Progenitor Fate Commitment”, FEBS Letters, 588(21), 4008-4017. (SCIE)
  • Yang YF, Jan YH, Liu YP, Yang CJ, Su CY, Chang YC, Lai TC, Chiou J, Tsai HY, Lu J, Shen CN, Shew JY, Lu PJ, Lin YF, Huang MS, Hsiao M, 2014, “Squalene synthase induces tumor necrosis factor receptor 1 enrichment in lipid rafts to promote lung cancer metastasis.”, American journal of respiratory and critical care medicine, 190(6), 675-687. (SCIE)
  • Tsai HY, Yang YF, Wu AT, Yang CJ, Liu YP, Jan YH, Lee CH, Hsiao YW, Yeh CT, Shen CN, Lu PJ, Huang MS, Hsiao M, 2013, “Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78.”, Oncogene, 32(41), 4921-4931. (SCIE)
  • Lin YH, Chang HM, Chang FP, Shen CR, Liu CL, Mao WY, Lin CC, Lee HS, Shen CN*, 2013, “Protoporphyrin IX accumulation disrupts mitochondrial dynamics and function in ABCG2-deficient hepatocytes.”, FEBS letters, 587(19), 3202-3209. (SCIE)
  • WY Liao, CC Liaw, YC Huang, HY Han, HW Hsu, SM Hwang, SC Kuo and CN Shen*, 2013, “Cyclohexylmethyl flavonoids suppress propagation of breast cancer stem cells via downregulation of NANOG”, Evidence-based Complementary and Alternative Medicine, 2013, 170261. (SCIE)
  • Liu YP, Yang CJ, Huang MS, Yeh CT, Wu AT, Lee YC, Lai TC, Lee CH, Hsiao YW, Lu J, Shen CN, Lu PJ, Hsiao M, 2013, “Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling.”, Cancer Research, 73(1), 406-416. (SCIE)
  • Tsai ST, Tsou CC, Mao WY, Chang WC, Han HY, Hsu WL, Li CL, Shen CN*, Chen CH*, 2012, “Label-free quantitative proteomics of CD133-positive liver cancer stem cells.”, Proteome science, 10(1), 69. (SCIE)
  • Tsai HA, Shen CN, Chang YC, 2012, “The Use of Surface Properties to Control the Growth and Differentiation of Mouse Fetal Liver Stem/Progenitor Cell Colonies.”, Biomacromolecules, 13(11), 3483-3493. (SCIE)
  • Wu YC, Ling TY, Lu SH, Kuo HC, Ho HN, Yeh SD, Shen CN*, Huang YH*, 2012, “Chemotherapeutic Sensitivity of Testicular Germ Cell Tumors Under Hypoxic Conditions Is Negatively Regulated by SENP1-Controlled Sumoylation of OCT4.”, Cancer Research, 72(19), 4963-4973. (SCIE)
  • Chu CY, Chen CF, Rajendran RS, Shen CN, Chen TH, Yen CC, Chuang CK, Lin DS, Hsiao CD, 2012, “Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish.”, PloS One, 7(5), e36474. (SCIE)
  • Liao WY, Shen CN, Lin LH, Yang YL, Han HY, Chen JW, Kuo SC, Wu SH, Liaw CC, 2012, “Asperjinone, a Nor-Neolignan, and Terrein, a Suppressor of ABCG2-Expressing Breast Cancer Cells, from Thermophilic Aspergillus terreus.”, Journal of Natural Products, 75(4), 630-635. (SCIE)
  • Liang YJ, Yang BC, Chen JM, Lin YH, Huang CL, Cheng YY, Hsu CY, Khoo KH, Shen CN, Yu J, 2011, “Changes in Glycosphingolipid Composition During Differentiation of Human Embryonic Stem Cells to Ectodermal or Endodermal Lineages.”, Stem Cells, 29(12), 1995-2004. (SCIE)
  • Liaw CC, Liao WY, Chen CS, Jao SC, Wu YC, Shen CN*, Wu SH*, 2011, “The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins.”, Angewandte Chemie-International Edition, 50(34), 7885-7891. (SCIE)
  • C.F.Chen, C.Y. Chu, T.H. Chen, S.J. Lee, C.N. Shen*, and C.D. Hsiao*, 2011, “Establishment of a Transgenic Zebrafish Line for Superficial Skin Ablation and for Functionally Validation of Anti-Apoptotic Pathways in vivo”, PLoS One, 6(5), e20654. (SCIE)
  • Al-Adsani A, Burke ZD, Eberhard D, Lawrence KL, Shen CN, Rustgi AK, Sakaue H, Farrant JM, Tosh D, 2010, “Dexamethasone Treatment Induces the Reprogramming of Pancreatic Acinar Cells to Hepatocytes and Ductal Cells.”, PLoS ONE, 5(10), e13650. (SCIE)
  • Wu SY, Hsieh CC, Wu RR, Susanto J, Liu TT, Shen CR, Chen Y, Su CC, Chang FP, Chang HM, Tosh D, Shen CN*, 2010, “Differentiation of pancreatic acinar cells to hepatocytes requires an intermediate cell type.”, Gastroenterology, 138, 2519-2530. (SCIE)
  • Tsai HA, Wu RR, Lee IC, Chang HY, Shen CN*, Chang YC*, 2010, “Selection, Enrichment, and Maintenance of Self-Renewal Liver Stem/Progenitor Cells Utilizing Polypeptide Polyelectrolyte Multilayer Films.”, Biomacromolecules, 11, 994-1001. (SCIE)
  • Shen CN*, Tosh D, 2010, “Transdifferentiation of pancreatic cells to hepatocytes”, Methods in molecular biology, 640, 273-280.
  • Yang CJ, Liu YK, Liu CL, Shen CN, Kuo ML, Su CC, Tseng CP, Yen TC, Shen CR, 2009, “Inhibition of Acidic Mammalian Chitinase by RNA Interference Suppresses OVA-sensitized Allergic Asthma.”, Human gene therapy, 20(12),1597–1606. (SCIE)
  • Yang YL, Liao WY, Liu WY, Liaw CC, Shen CN, Huang ZY, Wu SH, 2009, “Discovery of New Natural Products by Intact-Cell Mass Spectrometry and LC-SPE-NMR: Malbranpyrroles, Novel Polyketides from Thermophilic Fungus Malbranchea sulfurea.”, Chemistry-A European Journal, 15(43), 11573-11580. (SCIE)
  • Huang YC, Hwang TL, Chang CS, Yang YL, Shen CN, Liao WY, Chen SC, Liaw CC, 2009, “Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica.”, Journal of natural products, 72(7), 1273-1278. (SCIE)
  • Huang YH, Chin CC, Ho HN, Chou CK, Shen CN, Kuo HC, Wu TJ, Wu YC, Hung YC, Chang CC, Ling TY, 2009, “Pluripotency of mouse spermatogonial stem cells maintained by IGF-1- dependent pathway.”, FASEB Journal, 23(7), 2076-2087. (SCIE)
  • J. Susanto, Y. H. Lin, Y. N. Chen, C. R. Shen, Y. T. Yan, S. T. Tsai, C. H. Chen and C. N. Shen*, 2008, “Porphyrin homeostasis maintained by ABCG2 regulates self-renewal of embryonic stem cells”, PLoS ONE, 3(12), e4023. (SCIE)
  • C.N. Shen, A. Petiot, C.Y. Chien, C. Dickson, J. M.W. Slack and D. Tosh, 2007, “All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas”, Differentiation, 75, 62-74. (SCIE)
  • D. Tosh, C.N. Shen, M.R. Alison, C.E. Sarraf and J.M.W. Slack, 2007, “Copper deprivation in rats induces islet hyperplasia and hepatic metaplasia in the pancreas”, Biology of the cell, 99, 37-44. (SCIE)
  • Z. D. Burke, C. N. Shen, K. L. Ralphs and D. Tosh, 2006, “Characterization of liver function in transdifferentiated hepatocytes”, Journal of cellular physiology, 206(1), 147-159. (SCIE)
  • R.Y.L. Wang, C. N. Shen, M. H. Lin, D. Tosh and C. H. Shih, 2005, “Hepatocyte-like cells transdifferentiated from a pancreatic origin can support replication of hepatitis B virus”, Journal of virology, 79, 13116-13128. (SCIE)
  • C. N. Shen, Z. D. Burke and D. Tosh, 2004, “Transdifferentiation, metaplasia, and tissue regeneration”, Organogenesis, 1(2), 36-44. (SCIE) (IF: 2.5; SCI ranking: 75.8%,51.2%,67.8%)
  • C. N. Shen, J. K. Kurash and D. Tosh, 2004, “Induction and regulation of acute phase proteins in transdifferentiated hepatocytes”, Experimental cell research, 292, 342-358. (SCIE)
  • M. E. Horb, C. N. Shen, D. Tosh and J. M. Slack, 2003, “Experimental conversion of liver to pancreas”, Current biology, 13, 105-115. (SCIE)
  • C. N. Shen, J. R. Seckl, J. M. Slack and D. Tosh, 2003, “Glucocorticoids suppress beta-cell development and induce hepatic metaplasia in embryonic pancreas”, Biochemical journal, 375, 41-50. (SCIE)
  • Shen CN, Horb ME, Slack JM, Tosh D, 2003, “Transdifferentiation of pancreas to liver.”, Mechanisms of development, 120(1), 107-16. (SCIE)
  • D. Tosh, C. N. Shen and J. M. Slack, 2002, “Differentiated properties of hepatocytes induced from pancreatic cells”, Hepatology, 36, 534-543. (SCIE)
  • C. N. Shen, J. M. Slack and D. Tosh, 2000, “Molecular basis of transdifferentiation of pancreas to liver”, Nature Cell Biology, 2, 879-887. (SCIE)